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Protein

Endoplasmic reticulum export factor CTAGE5

Gene

CTAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.3 Publications

Caution

It is unclear whether MIA2 and CTAGE5 constitute 2 distinct genes or a single one similar to MIA3.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme activator activity Source: ProtInc
  • lipoprotein transporter activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5694530 Cargo concentration in the ER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum export factor CTAGE5Curated
Alternative name(s):
CTAGE family member 5 ER export factorImported
Short name:
Protein cTAGE-5Curated
Meningioma-expressed antigen 6/111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTAGE5Imported
Synonyms:MEA11, MEA6, MGEA11, MGEA6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000150527.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7057 CTAGE5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602132 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38LumenalCuratedAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 804CytoplasmicCuratedAdd BLAST745

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71Y → A: No effect on interaction with PERB. 1 Publication1
Mutagenesisi89K → A: Loss of interaction with PERB. Unable to recruit PERB to the endoplasmic reticulum exit sites. Loss of function in collagen VII transport. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi97S → A: Decreased interaction with PERB. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi112L → A: No effect on interaction with PERB. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4253

Open Targets

More...
OpenTargetsi
ENSG00000150527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30788

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTAGE5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895411 – 804Endoplasmic reticulum export factor CTAGE5Add BLAST804

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15320

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15320

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15320

PeptideAtlas

More...
PeptideAtlasi
O15320

PRoteomics IDEntifications database

More...
PRIDEi
O15320

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48581
48582 [O15320-2]
48583 [O15320-3]
48584 [O15320-4]
48585 [O15320-5]
48586 [O15320-6]
48587 [O15320-7]
48588 [O15320-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15320

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15320

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150527 Expressed in 161 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CTAGE5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15320 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15320 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000387
HPA000922

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MIA3 (PubMed:21525241, PubMed:25202031, PubMed:27170179). Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C (PubMed:21525241, PubMed:27551091). Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179). May interact with APOB (PubMed:27138255).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110409, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O15320

Protein interaction database and analysis system

More...
IntActi
O15320, 15 interactors

Molecular INTeraction database

More...
MINTi
O15320

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280083

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15320

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15320

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 650Mediates interaction with MIA31 PublicationAdd BLAST590
Regioni651 – 804Proline-rich domain (PRD); mediates interaction with the COPII coat subunits SEC23A and SEC23B2 PublicationsAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili117 – 242Sequence analysisAdd BLAST126
Coiled coili340 – 494Sequence analysisAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi689 – 800Pro-richPROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B.2 Publications
The coiled coil domains mediate interaction with MIA3 (PubMed:21525241). The first coiled coil domain mediates interaction with PREB (PubMed:25202031).2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJV2 Eukaryota
ENOG410ZUJU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153207

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112043

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051216

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15320

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PEA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15320

TreeFam database of animal gene trees

More...
TreeFami
TF333137

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform MEA6 (identifier: O15320-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV
60 70 80 90 100
GFFAVLFFLW RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ
110 120 130 140 150
KEYEGYEVES SLKDASFEKE ATEAQSLEAT CEKLNRSNSE LEDEILCLEK
160 170 180 190 200
ELKEEKSKHS EQDELMADIS KRIQSLEDES KSLKSQVAEA KMTFKIFQMN
210 220 230 240 250
EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN KQKVTFEDSK
260 270 280 290 300
VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE
310 320 330 340 350
NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL
360 370 380 390 400
TEHIKNLQTE QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL
410 420 430 440 450
TVEENYRLEK EEKLSKVDEK ISHATEELET YRKRAKDLEE ELERTIHSYQ
460 470 480 490 500
GQIISHEKKA HDNWLAARNA ERNLNDLRKE NAHNRQKLTE TELKFELLEK
510 520 530 540 550
DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL LEGPLRLSPL
560 570 580 590 600
LPGGGGRGSR GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD
610 620 630 640 650
QDRRMMFPPP GQSYPDSALP PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK
660 670 680 690 700
MDGSMPSEME SSRNDTKDDL GNLNVPDSSL PAENEATGPG FVPPPLAPIR
710 720 730 740 750
GPLFPVDARG PFLRRGPPFP PPPPGAMFGA SRDYFPPGDF PGPPPAPFAM
760 770 780 790 800
RNVYPPRGFP PYLPPRPGFF PPPPHSEGRS EFPSGLIPPS NEPATEHPEP

QQET
Length:804
Mass (Da):90,996
Last modified:November 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB2CAC59C4ED7867
GO
Isoform MEA11 (identifier: O15320-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-556: Missing.

Note: No experimental confirmation available.
Show »
Length:761
Mass (Da):86,532
Checksum:iB101FD49659A2F30
GO
Isoform 5A (identifier: O15320-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:775
Mass (Da):87,837
Checksum:i46C11CD859A408FF
GO
Isoform 5B (identifier: O15320-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-771: MRNVYPPRGFPPYLPPRPGFFP → SARSPPGAGAPASGRGLGGPQK
     772-804: Missing.

Show »
Length:771
Mass (Da):86,811
Checksum:i2E5D4546606E6EC3
GO
Isoform 6 (identifier: O15320-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVENQM

Show »
Length:809
Mass (Da):91,598
Checksum:i93E6E1B2E908306B
GO
Isoform 7 (identifier: O15320-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     128-128: E → EVENQM

Show »
Length:729
Mass (Da):82,443
Checksum:i31620F247C9CF9A1
GO
Isoform 8 (identifier: O15320-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     515-557: Missing.

Show »
Length:732
Mass (Da):83,373
Checksum:i3A7C4AC2B3D65396
GO
Isoform 9 (identifier: O15320-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:724
Mass (Da):81,841
Checksum:iAFE56681C351F234
GO
Isoform 10 (identifier: O15320-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE
     103-128: Missing.
     647-717: Missing.
     725-747: Missing.

Show »
Length:672
Mass (Da):76,880
Checksum:iCA742CB43201E4FE
GO
Isoform 11 (identifier: O15320-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE

Note: Gene prediction based on EST data.
Show »
Length:792
Mass (Da):89,647
Checksum:i0C9C6951D420A590
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB86589 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90S → N in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti145I → M in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti195K → Q in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti195K → Q in AAB86589 (PubMed:9356211).Curated1
Sequence conflicti198Q → P in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti546R → T in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti589P → L in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti594S → F in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti604R → M in AAN77610 (PubMed:12839582).Curated1
Sequence conflicti776S → F in AAN77610 (PubMed:12839582).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0478896V → A2 PublicationsCorresponds to variant dbSNP:rs7140561Ensembl.1
Natural variantiVAR_04789011Y → D1 PublicationCorresponds to variant dbSNP:rs17855895Ensembl.1
Natural variantiVAR_047891205K → N1 PublicationCorresponds to variant dbSNP:rs17855896Ensembl.1
Natural variantiVAR_047892250K → E. Corresponds to variant dbSNP:rs10162564Ensembl.1
Natural variantiVAR_047893360E → Q4 PublicationsCorresponds to variant dbSNP:rs1950952Ensembl.1
Natural variantiVAR_047894375N → S. Corresponds to variant dbSNP:rs17109109Ensembl.1
Natural variantiVAR_047895699I → V3 PublicationsCorresponds to variant dbSNP:rs1140952Ensembl.1
Natural variantiVAR_047896738G → R3 PublicationsCorresponds to variant dbSNP:rs1060878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0359611 – 80Missing in isoform 7 and isoform 9. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_0125451 – 29Missing in isoform 5A and isoform 8. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0472343 – 21EPGVT…EELRR → LKSPEEE in isoform 10 and isoform 11. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_047235103 – 128Missing in isoform 10. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_035962128E → EVENQM in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_004322514 – 556Missing in isoform MEA11. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_035963515 – 557Missing in isoform 8. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_047236647 – 717Missing in isoform 10. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_047237725 – 747Missing in isoform 10. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_012546750 – 771MRNVY…PGFFP → SARSPPGAGAPASGRGLGGP QK in isoform 5B. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_012547772 – 804Missing in isoform 5B. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73682 mRNA Translation: AAB86589.1 Different initiation.
U94780 mRNA Translation: AAB86593.1
AF338233 mRNA Translation: AAN77610.1
AF338234 mRNA Translation: AAN77611.1
AK091252 mRNA Translation: BAG52318.1
AK298935 mRNA Translation: BAG61038.1
BX640994 mRNA Translation: CAE45997.1
AL132639 Genomic DNA No translation available.
AL157791 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65808.1
CH471078 Genomic DNA Translation: EAW65812.1
CH471078 Genomic DNA Translation: EAW65813.1
CH471078 Genomic DNA Translation: EAW65814.1
BC051363 mRNA Translation: AAH51363.2
BC064355 mRNA Translation: AAH64355.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58316.1 [O15320-5]
CCDS58317.1 [O15320-6]
CCDS86385.1 [O15320-4]
CCDS86386.1 [O15320-8]
CCDS9673.1 [O15320-10]
CCDS9674.1 [O15320-1]
CCDS9675.1 [O15320-2]
CCDS9676.1 [O15320-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001234917.1, NM_001247988.1 [O15320-7]
NP_001234918.1, NM_001247989.1 [O15320-5]
NP_001234919.1, NM_001247990.1 [O15320-6]
NP_005921.2, NM_005930.3 [O15320-1]
NP_976229.1, NM_203354.2 [O15320-10]
NP_976231.1, NM_203356.2 [O15320-3]
XP_006720211.1, XM_006720148.2
XP_011535086.1, XM_011536784.2
XP_011535087.1, XM_011536785.2 [O15320-8]
XP_016876809.1, XM_017021320.1
XP_016876814.1, XM_017021325.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.287694
Hs.509200
Hs.540038
Hs.741763

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4253

UCSC genome browser

More...
UCSCi
uc001wuy.5 human [O15320-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73682 mRNA Translation: AAB86589.1 Different initiation.
U94780 mRNA Translation: AAB86593.1
AF338233 mRNA Translation: AAN77610.1
AF338234 mRNA Translation: AAN77611.1
AK091252 mRNA Translation: BAG52318.1
AK298935 mRNA Translation: BAG61038.1
BX640994 mRNA Translation: CAE45997.1
AL132639 Genomic DNA No translation available.
AL157791 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65808.1
CH471078 Genomic DNA Translation: EAW65812.1
CH471078 Genomic DNA Translation: EAW65813.1
CH471078 Genomic DNA Translation: EAW65814.1
BC051363 mRNA Translation: AAH51363.2
BC064355 mRNA Translation: AAH64355.1
CCDSiCCDS58316.1 [O15320-5]
CCDS58317.1 [O15320-6]
CCDS86385.1 [O15320-4]
CCDS86386.1 [O15320-8]
CCDS9673.1 [O15320-10]
CCDS9674.1 [O15320-1]
CCDS9675.1 [O15320-2]
CCDS9676.1 [O15320-3]
RefSeqiNP_001234917.1, NM_001247988.1 [O15320-7]
NP_001234918.1, NM_001247989.1 [O15320-5]
NP_001234919.1, NM_001247990.1 [O15320-6]
NP_005921.2, NM_005930.3 [O15320-1]
NP_976229.1, NM_203354.2 [O15320-10]
NP_976231.1, NM_203356.2 [O15320-3]
XP_006720211.1, XM_006720148.2
XP_011535086.1, XM_011536784.2
XP_011535087.1, XM_011536785.2 [O15320-8]
XP_016876809.1, XM_017021320.1
XP_016876814.1, XM_017021325.1
UniGeneiHs.287694
Hs.509200
Hs.540038
Hs.741763

3D structure databases

ProteinModelPortaliO15320
SMRiO15320
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110409, 62 interactors
CORUMiO15320
IntActiO15320, 15 interactors
MINTiO15320
STRINGi9606.ENSP00000280083

PTM databases

iPTMnetiO15320
PhosphoSitePlusiO15320

Polymorphism and mutation databases

BioMutaiCTAGE5

Proteomic databases

EPDiO15320
MaxQBiO15320
PaxDbiO15320
PeptideAtlasiO15320
PRIDEiO15320
ProteomicsDBi48581
48582 [O15320-2]
48583 [O15320-3]
48584 [O15320-4]
48585 [O15320-5]
48586 [O15320-6]
48587 [O15320-7]
48588 [O15320-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4253
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4253
UCSCiuc001wuy.5 human [O15320-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4253
DisGeNETi4253
EuPathDBiHostDB:ENSG00000150527.16

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0021193
HGNCiHGNC:7057 CTAGE5
HPAiHPA000387
HPA000922
MIMi602132 gene
neXtProtiNX_O15320
OpenTargetsiENSG00000150527
PharmGKBiPA30788

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJV2 Eukaryota
ENOG410ZUJU LUCA
GeneTreeiENSGT00940000153207
HOGENOMiHOG000112043
HOVERGENiHBG051216
InParanoidiO15320
OrthoDBiEOG091G0PEA
PhylomeDBiO15320
TreeFamiTF333137

Enzyme and pathway databases

ReactomeiR-HSA-5694530 Cargo concentration in the ER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MIA2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CTAGE5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4253

Protein Ontology

More...
PROi
PR:O15320

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150527 Expressed in 161 organ(s), highest expression level in right lobe of liver
CleanExiHS_CTAGE5
ExpressionAtlasiO15320 baseline and differential
GenevisibleiO15320 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTGE5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15320
Secondary accession number(s): B3KRA6
, B4DQS6, D3DSA6, G3XAC5, O00169, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 2, 2010
Last modified: December 5, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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