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Protein

Metabotropic glutamate receptor 6

Gene

GRM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei154GlutamateBy similarity1
Binding sitei225GlutamateBy similarity1
Binding sitei307GlutamateBy similarity1
Binding sitei400GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutamate receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metabotropic glutamate receptor 6
Short name:
mGluR6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRM6
Synonyms:GPRC1F, MGLUR6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113262.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4598 GRM6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604096 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15303

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 585ExtracellularSequence analysisAdd BLAST561
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei586 – 608Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini609 – 622CytoplasmicSequence analysisAdd BLAST14
Transmembranei623 – 643Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini644 – 654ExtracellularSequence analysisAdd BLAST11
Transmembranei655 – 673Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini674 – 697CytoplasmicSequence analysisAdd BLAST24
Transmembranei698 – 718Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini719 – 748ExtracellularSequence analysisAdd BLAST30
Transmembranei749 – 770Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini771 – 783CytoplasmicSequence analysisAdd BLAST13
Transmembranei784 – 806Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini807 – 819ExtracellularSequence analysisAdd BLAST13
Transmembranei820 – 845Helical; Name=7Sequence analysisAdd BLAST26
Topological domaini846 – 877CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Night blindness, congenital stationary, 1B (CSNB1B)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive retinal disorder characterized by impaired night vision. Congenital stationary night blindness type 1B is an autosomal recessive form associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced on response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
See also OMIM:257270
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06981746P → L in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638197EnsemblClinVar.1
Natural variantiVAR_06981858G → R in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638198EnsemblClinVar.1
Natural variantiVAR_030756150G → S in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638202EnsemblClinVar.1
Natural variantiVAR_069819405I → T in CSNB1B; abolishes expression at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs121434304EnsemblClinVar.1
Natural variantiVAR_069820522C → Y in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638208EnsemblClinVar.1
Natural variantiVAR_030757781E → K in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638625EnsemblClinVar.1

Keywords - Diseasei

Congenital stationary night blindness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2916

MalaCards human disease database

More...
MalaCardsi
GRM6
MIMi257270 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113262

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
215 Congenital stationary night blindness

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28995

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4573

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
294

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRM6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001293425 – 877Metabotropic glutamate receptor 6Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 99By similarity
Disulfide bondi244 ↔ 536By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi367 ↔ 383By similarity
Disulfide bondi423 ↔ 430By similarity
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi518 ↔ 537By similarity
Disulfide bondi522 ↔ 540By similarity
Disulfide bondi543 ↔ 555By similarity
Disulfide bondi558 ↔ 571By similarity
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O15303

PeptideAtlas

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PeptideAtlasi
O15303

PRoteomics IDEntifications database

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PRIDEi
O15303

ProteomicsDB human proteome resource

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ProteomicsDBi
48571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15303

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15303

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in melanocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113262 Expressed in 83 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

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CleanExi
HS_GRM6

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15303 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109173, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000231188

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15303

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15303

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15303

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni175 – 177Glutamate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1056 Eukaryota
ENOG410XR6W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153940

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000218635

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107965

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15303

KEGG Orthology (KO)

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KOi
K04608

Identification of Orthologs from Complete Genome Data

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OMAi
AGRACGQ

Database of Orthologous Groups

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OrthoDBi
EOG091G177R

Database for complete collections of gene phylogenies

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PhylomeDBi
O15303

TreeFam database of animal gene trees

More...
TreeFami
TF313240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR000112 GPCR_3_mtglu_rcpt_6
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00248 GPCRMGR
PR01056 MTABOTROPC6R
PR00593 MTABOTROPICR

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53822 SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O15303-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPRRAREP LLVALLPLAW LAQAGLARAA GSVRLAGGLT LGGLFPVHAR
60 70 80 90 100
GAAGRACGQL KKEQGVHRLE AMLYALDRVN ADPELLPGVR LGARLLDTCS
110 120 130 140 150
RDTYALEQAL SFVQALIRGR GDGDEVGVRC PGGVPPLRPA PPERVVAVVG
160 170 180 190 200
ASASSVSIMV ANVLRLFAIP QISYASTAPE LSDSTRYDFF SRVVPPDSYQ
210 220 230 240 250
AQAMVDIVRA LGWNYVSTLA SEGNYGESGV EAFVQISREA GGVCIAQSIK
260 270 280 290 300
IPREPKPGEF SKVIRRLMET PNARGIIIFA NEDDIRRVLE AARQANLTGH
310 320 330 340 350
FLWVGSDSWG AKTSPILSLE DVAVGAITIL PKRASIDGFD QYFMTRSLEN
360 370 380 390 400
NRRNIWFAEF WEENFNCKLT SSGTQSDDST RKCTGEERIG RDSTYEQEGK
410 420 430 440 450
VQFVIDAVYA IAHALHSMHQ ALCPGHTGLC PAMEPTDGRM LLQYIRAVRF
460 470 480 490 500
NGSAGTPVMF NENGDAPGRY DIFQYQATNG SASSGGYQAV GQWAETLRLD
510 520 530 540 550
VEALQWSGDP HEVPSSLCSL PCGPGERKKM VKGVPCCWHC EACDGYRFQV
560 570 580 590 600
DEFTCEACPG DMRPTPNHTG CRPTPVVRLS WSSPWAAPPL LLAVLGIVAT
610 620 630 640 650
TTVVATFVRY NNTPIVRASG RELSYVLLTG IFLIYAITFL MVAEPGAAVC
660 670 680 690 700
AARRLFLGLG TTLSYSALLT KTNRIYRIFE QGKRSVTPPP FISPTSQLVI
710 720 730 740 750
TFSLTSLQVV GMIAWLGARP PHSVIDYEEQ RTVDPEQARG VLKCDMSDLS
760 770 780 790 800
LIGCLGYSLL LMVTCTVYAI KARGVPETFN EAKPIGFTMY TTCIIWLAFV
810 820 830 840 850
PIFFGTAQSA EKIYIQTTTL TVSLSLSASV SLGMLYVPKT YVILFHPEQN
860 870
VQKRKRSLKA TSTVAAPPKG EDAEAHK
Length:877
Mass (Da):95,468
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AB27C5627B388C6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06981746P → L in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638197EnsemblClinVar.1
Natural variantiVAR_06981858G → R in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638198EnsemblClinVar.1
Natural variantiVAR_05931059Q → P No effect on location at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs2645329EnsemblClinVar.1
Natural variantiVAR_030756150G → S in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638202EnsemblClinVar.1
Natural variantiVAR_036195191S → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055876227E → V. Corresponds to variant dbSNP:rs17078898Ensembl.1
Natural variantiVAR_055877236I → F. Corresponds to variant dbSNP:rs17078896Ensembl.1
Natural variantiVAR_069819405I → T in CSNB1B; abolishes expression at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs121434304EnsemblClinVar.1
Natural variantiVAR_069820522C → Y in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638208EnsemblClinVar.1
Natural variantiVAR_055878712M → V. Corresponds to variant dbSNP:rs17078877EnsemblClinVar.1
Natural variantiVAR_030757781E → K in CSNB1B; abolishes expression at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs62638625EnsemblClinVar.1
Natural variantiVAR_055879807A → V. Corresponds to variant dbSNP:rs17078874EnsemblClinVar.1
Natural variantiVAR_055880817T → S. Corresponds to variant dbSNP:rs17078857Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U82083 Genomic DNA Translation: AAB82068.1
AC104117 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4442.1

NCBI Reference Sequences

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RefSeqi
NP_000834.2, NM_000843.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.248131

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000231188; ENSP00000231188; ENSG00000113262
ENST00000517717; ENSP00000430767; ENSG00000113262
ENST00000650031; ENSP00000497110; ENSG00000113262

Database of genes from NCBI RefSeq genomes

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GeneIDi
2916

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2916

UCSC genome browser

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UCSCi
uc003mjr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82083 Genomic DNA Translation: AAB82068.1
AC104117 Genomic DNA No translation available.
CCDSiCCDS4442.1
RefSeqiNP_000834.2, NM_000843.3
UniGeneiHs.248131

3D structure databases

ProteinModelPortaliO15303
SMRiO15303
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109173, 1 interactor
STRINGi9606.ENSP00000231188

Chemistry databases

BindingDBiO15303
ChEMBLiCHEMBL4573
GuidetoPHARMACOLOGYi294

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiO15303
PhosphoSitePlusiO15303

Polymorphism and mutation databases

BioMutaiGRM6

Proteomic databases

PaxDbiO15303
PeptideAtlasiO15303
PRIDEiO15303
ProteomicsDBi48571

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2916
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231188; ENSP00000231188; ENSG00000113262
ENST00000517717; ENSP00000430767; ENSG00000113262
ENST00000650031; ENSP00000497110; ENSG00000113262
GeneIDi2916
KEGGihsa:2916
UCSCiuc003mjr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2916
DisGeNETi2916
EuPathDBiHostDB:ENSG00000113262.14

GeneCards: human genes, protein and diseases

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GeneCardsi
GRM6

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0024983
HGNCiHGNC:4598 GRM6
HPAiHPA014511
MalaCardsiGRM6
MIMi257270 phenotype
604096 gene
neXtProtiNX_O15303
OpenTargetsiENSG00000113262
Orphaneti215 Congenital stationary night blindness
PharmGKBiPA28995

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00940000153940
HOGENOMiHOG000218635
HOVERGENiHBG107965
InParanoidiO15303
KOiK04608
OMAiAGRACGQ
OrthoDBiEOG091G177R
PhylomeDBiO15303
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Metabotropic_glutamate_receptor_6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2916

Protein Ontology

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PROi
PR:O15303

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000113262 Expressed in 83 organ(s), highest expression level in gastrocnemius
CleanExiHS_GRM6
GenevisibleiO15303 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR000112 GPCR_3_mtglu_rcpt_6
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01056 MTABOTROPC6R
PR00593 MTABOTROPICR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRM6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15303
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 16, 2009
Last modified: December 5, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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