MAPK13

Functionⁱ

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.8 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Activity regulationⁱ

Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	54	ATPPROSITE-ProRule annotation		1
Active siteⁱ	150	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	31 – 39	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
- 9731215
protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15850461

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cellular response to anisomycin
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
cellular response to hydrogen peroxide
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
cellular response to interleukin-1
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
cellular response to organic substance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to sodium arsenite
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
cellular response to sorbitol
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
cellular response to UV
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15850461
positive regulation of inflammatory response
Source: BHF-UCL
Inferred by curatorⁱ
- 19279008
positive regulation of interleukin-6 production
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19279008
regulation of gene expression
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to osmotic stress
Source: UniProtKB
Inferred from direct assayⁱ
- 9731215
stress-activated MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 9218798

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle, Stress response, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.24 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-171007 p38MAPK events R-HSA-376172 DSCAM interactions R-HSA-4420097 VEGFA-VEGFR2 Pathway
SignaLinkⁱ	O15264
SIGNORⁱ	O15264

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase 13 (EC:2.7.11.24) Short name: MAP kinase 13 Short name: MAPK 13 Alternative name(s): Mitogen-activated protein kinase p38 delta Short name: MAP kinase p38 delta Stress-activated protein kinase 4
Gene namesⁱ	Name:MAPK13 Synonyms:PRKM13, SAPK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156711.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6875 MAPK13
MIMⁱ	602899 gene
neXtProtⁱ	NX_O15264

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	180	T → A: Loss of kinase activity. 1 Publication		1
Mutagenesisⁱ	182	Y → A: Loss of kinase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5603
Open Targets More...OpenTargetsⁱ	ENSG00000156711
PharmGKBⁱ	PA30620

Chemistry databases

ChEMBLⁱ	CHEMBL2939
Drug and drug target database More...DrugBankⁱ	DB05157 KC706
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1502

Polymorphism and mutation databases

BioMutaⁱ	MAPK13

BioMutaⁱ

MAPK13

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186286	1 – 365	Mitogen-activated protein kinase 13Add BLAST		365

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	180	Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and MAP2K71 Publication	1
Modified residueⁱ	182	Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and MAP2K71 Publication	1
Modified residueⁱ	350	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15264
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15264
PaxDbⁱ	O15264
PeptideAtlas More...PeptideAtlasⁱ	O15264
PRIDEⁱ	O15264
ProteomicsDBⁱ	48552

PTM databases

iPTMnetⁱ	O15264
PhosphoSitePlusⁱ	O15264

Expressionⁱ

Tissue specificityⁱ

Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000156711 Expressed in 187 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MAPK13
ExpressionAtlasⁱ	O15264 baseline and differential
Genevisibleⁱ	O15264 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025854 HPA007667

HPAⁱ

CAB025854
HPA007667

Interactionⁱ

Subunit structureⁱ

Interacts with MAPK8IP2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FPR1	P21462	3	EBI-2116951,EBI-2869495
PRKD1	Q15139	6	EBI-2116951,EBI-1181072

Protein-protein interaction databases

BioGridⁱ	111589, 17 interactors
IntActⁱ	O15264, 90 interactors
Molecular INTeraction database More...MINTⁱ	O15264
STRINGⁱ	9606.ENSP00000211287

Chemistry databases

BindingDBⁱ

O15264

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 8	Combined sources	5
Beta strandⁱ	9 – 14	Combined sources	6
Beta strandⁱ	17 – 22	Combined sources	6
Beta strandⁱ	25 – 33	Combined sources	9
Beta strandⁱ	35 – 44	Combined sources	10
Turnⁱ	45 – 47	Combined sources	3
Beta strandⁱ	50 – 56	Combined sources	7
Helixⁱ	63 – 78	Combined sources	16
Beta strandⁱ	88 – 91	Combined sources	4
Beta strandⁱ	95 – 97	Combined sources	3
Beta strandⁱ	104 – 108	Combined sources	5
Beta strandⁱ	111 – 113	Combined sources	3
Helixⁱ	114 – 117	Combined sources	4
Helixⁱ	124 – 143	Combined sources	20
Helixⁱ	153 – 155	Combined sources	3
Beta strandⁱ	156 – 158	Combined sources	3
Beta strandⁱ	164 – 166	Combined sources	3
Helixⁱ	186 – 188	Combined sources	3
Helixⁱ	191 – 195	Combined sources	5
Turnⁱ	196 – 198	Combined sources	3
Helixⁱ	204 – 218	Combined sources	15
Beta strandⁱ	222 – 226	Combined sources	5
Helixⁱ	228 – 239	Combined sources	12
Helixⁱ	244 – 247	Combined sources	4
Helixⁱ	253 – 261	Combined sources	9
Helixⁱ	270 – 273	Combined sources	4
Helixⁱ	279 – 288	Combined sources	10
Turnⁱ	293 – 295	Combined sources	3
Helixⁱ	299 – 303	Combined sources	5
Helixⁱ	306 – 308	Combined sources	3
Turnⁱ	309 – 311	Combined sources	3
Helixⁱ	314 – 316	Combined sources	3
Helixⁱ	327 – 329	Combined sources	3
Helixⁱ	335 – 347	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	O15264
SMRⁱ	O15264
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O15264

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 308	Protein kinasePROSITE-ProRule annotationAdd BLAST		284

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	180 – 182	TXY		3

Domainⁱ

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0660 Eukaryota ENOG410XNY0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074271
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG014652
InParanoidⁱ	O15264
KEGG Orthology (KO) More...KOⁱ	K04441
OMAⁱ	WELPRRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08QL
PhylomeDBⁱ	O15264
TreeFamⁱ	TF105100

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07879 STKc_p38delta, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR003527 MAP_kinase_CS IPR008352 MAPK_p38-like IPR038785 p38delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR01773 P38MAPKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS01351 MAPK, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O15264-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK 
        60         70         80         90        100
VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF 
       110        120        130        140        150
YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD 
       160        170        180        190        200
LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY 
       210        220        230        240        250
NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL 
       260        270        280        290        300
NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA 
       310        320        330        340        350
QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS 
       360 
PIARKDSRRR SGMKL

Length:365

Mass (Da):42,090

Last modified:January 1, 1998 - v1

Checksum:ⁱ52E749EDB2973DDF

GO

Isoform 2 (identifier: O15264-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
204-256: VDIWSVGCIM...VQKLNDKAAK → GQILHPVPAT...DGRAGPHPSL
257-364: Missing.

« Hide

        10         20         30         40         50
MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK 
        60         70         80         90        100
VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF 
       110        120        130        140        150
YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD 
       160        170        180        190        200
LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY 
       210        220        230        240        250
NQTGQILHPV PATDPQEGFH SAVPTGQPPG CGPAGEDAGA RRGQAPDGRA 

GPHPSLL

Note: No experimental confirmation available.

Show »

Length:257

Mass (Da):28,779

Checksum:ⁱBDCA13CF80344118

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5R3E6	Q5R3E6_HUMAN		Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 13	MAPK13	152	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13 – 14	DV → EL in AAC51374 (PubMed:9207191).Curated	2
Sequence conflictⁱ	39	V → W in AAC51374 (PubMed:9207191).Curated	1
Sequence conflictⁱ	56	L → P in AAC51758 (PubMed:9295308).Curated	1
Sequence conflictⁱ	166	I → V in AAC51758 (PubMed:9295308).Curated	1
Sequence conflictⁱ	224	K → R in AAC51758 (PubMed:9295308).Curated	1
Sequence conflictⁱ	224	K → R in AAD23377 (PubMed:10066767).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042267	41	S → L1 PublicationCorresponds to variant dbSNP:rs55776345Ensembl.	1
Natural variantⁱVAR_042268	282	A → V1 PublicationCorresponds to variant dbSNP:rs55990045Ensembl.	1
Natural variantⁱVAR_042269	300	A → T1 PublicationCorresponds to variant dbSNP:rs41270090Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056558	204 – 256	VDIWS…DKAAK → GQILHPVPATDPQEGFHSAV PTGQPPGCGPAGEDAGARRG QAPDGRAGPHPSL in isoform 2. 1 PublicationAdd BLAST		53
Alternative sequenceⁱVSP_056559	257 – 364	Missing in isoform 2. 1 PublicationAdd BLAST		108

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10488 mRNA Translation: CAA71512.1 U93232 mRNA Translation: AAB87639.1 AF015256 mRNA Translation: AAC51758.1 AF004709 mRNA Translation: AAC51374.1 AF092535 mRNA Translation: AAD23377.1 AF100546 mRNA Translation: AAF36772.1 BT007221 mRNA Translation: AAP35885.1 CR536490 mRNA Translation: CAG38729.1 Z95152 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03874.1 CH471081 Genomic DNA Translation: EAX03875.1 BC000433 mRNA Translation: AAH00433.1 BC001641 mRNA Translation: AAH01641.1 BC004428 mRNA Translation: AAH04428.1 BC085196 mRNA Translation: AAH85196.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4818.1 [O15264-1]
PIRⁱ	JC5528
NCBI Reference Sequences More...RefSeqⁱ	NP_002745.1, NM_002754.4 [O15264-1]
UniGeneⁱ	Hs.178695

Genome annotation databases

Ensemblⁱ	ENST00000211287; ENSP00000211287; ENSG00000156711 [O15264-1] ENST00000373766; ENSP00000362871; ENSG00000156711 [O15264-2]
GeneIDⁱ	5603
KEGGⁱ	hsa:5603
UCSC genome browser More...UCSCⁱ	uc003ols.5 human [O15264-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O15264	Mitogen-activated protein kinase		HUMAN		365	UniRef100_O15264
UPI000D0C8C67		HUMAN		287
O15264-2	Mitogen-activated protein kinase 13		HUMAN		152	UniRef100_Q5R3E6

Protein	Similar proteins		Species	Score	Length	Source
O15264	Mitogen-activated protein kinase 13		PANTR		365	UniRef90_O15264
Mitogen-activated protein kinase		HUMAN		365
Mitogen-activated protein kinase		PAPAN		386
Mitogen-activated protein kinase		NOMLE		365
Mitogen-activated protein kinase		MACNE		365
+35
O15264-2	Mitogen-activated protein kinase		FELCA		257	UniRef90_M3VX74
Mitogen-activated protein kinase		PANTR		257
Mitogen-activated protein kinase		PROCO		257
Mitogen-activated protein kinase		CALJA		257
Mitogen-activated protein kinase		MACMU		257
+18

Protein	Similar proteins		Species	Score	Length	Source
O15264	Mitogen-activated protein kinase 14	)	HUMAN		360	UniRef50_Q16539
Mitogen-activated protein kinase 14		XENLA		361
Mitogen-activated protein kinase 14		PANTR		360
Mitogen-activated protein kinase 14		CANLF		360
Mitogen-activated protein kinase 14		RAT		360
+445
O15264-2	Mitogen-activated protein kinase		CHICK		169	UniRef50_A0A1D5PIQ5
Mitogen-activated protein kinase		Cebus capucinus imitator		173
Mitogen-activated protein kinase		PONAB		173
Mitogen-activated protein kinase		HUMAN		173
Mitogen-activated protein kinase		PANTR		173
+59

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10488 mRNA Translation: CAA71512.1 U93232 mRNA Translation: AAB87639.1 AF015256 mRNA Translation: AAC51758.1 AF004709 mRNA Translation: AAC51374.1 AF092535 mRNA Translation: AAD23377.1 AF100546 mRNA Translation: AAF36772.1 BT007221 mRNA Translation: AAP35885.1 CR536490 mRNA Translation: CAG38729.1 Z95152 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03874.1 CH471081 Genomic DNA Translation: EAX03875.1 BC000433 mRNA Translation: AAH00433.1 BC001641 mRNA Translation: AAH01641.1 BC004428 mRNA Translation: AAH04428.1 BC085196 mRNA Translation: AAH85196.1
CCDSⁱ	CCDS4818.1 [O15264-1]
PIRⁱ	JC5528
RefSeqⁱ	NP_002745.1, NM_002754.4 [O15264-1]
UniGeneⁱ	Hs.178695

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3COI	X-ray	2.09	A	2-352	[»]
	4EYJ	X-ray	2.10	A	1-352	[»]
	4EYM	X-ray	2.35	A	1-352	[»]
	4MYG	X-ray	2.59	A/B	1-352	[»]
	4YNO	X-ray	1.70	A	1-352	[»]
	5EKN	X-ray	2.59	A	1-352	[»]
	5EKO	X-ray	2.00	A	1-352	[»]
ProteinModelPortalⁱ	O15264
SMRⁱ	O15264
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111589, 17 interactors
IntActⁱ	O15264, 90 interactors
MINTⁱ	O15264
STRINGⁱ	9606.ENSP00000211287

Chemistry databases

BindingDBⁱ	O15264
ChEMBLⁱ	CHEMBL2939
DrugBankⁱ	DB05157 KC706
GuidetoPHARMACOLOGYⁱ	1502

PTM databases

iPTMnetⁱ	O15264
PhosphoSitePlusⁱ	O15264

Polymorphism and mutation databases

BioMutaⁱ	MAPK13

BioMutaⁱ

MAPK13

Proteomic databases

EPDⁱ	O15264
MaxQBⁱ	O15264
PaxDbⁱ	O15264
PeptideAtlasⁱ	O15264
PRIDEⁱ	O15264
ProteomicsDBⁱ	48552

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5603
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000211287; ENSP00000211287; ENSG00000156711 [O15264-1] ENST00000373766; ENSP00000362871; ENSG00000156711 [O15264-2]
GeneIDⁱ	5603
KEGGⁱ	hsa:5603
UCSCⁱ	uc003ols.5 human [O15264-1]

Organism-specific databases

CTDⁱ	5603
DisGeNETⁱ	5603
EuPathDBⁱ	HostDB:ENSG00000156711.16
GeneCardsⁱ	MAPK13
HGNCⁱ	HGNC:6875 MAPK13
HPAⁱ	CAB025854 HPA007667
MIMⁱ	602899 gene
neXtProtⁱ	NX_O15264
OpenTargetsⁱ	ENSG00000156711
PharmGKBⁱ	PA30620
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0660 Eukaryota ENOG410XNY0 LUCA
GeneTreeⁱ	ENSGT00550000074271
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG014652
InParanoidⁱ	O15264
KOⁱ	K04441
OMAⁱ	WELPRRY
OrthoDBⁱ	EOG091G08QL
PhylomeDBⁱ	O15264
TreeFamⁱ	TF105100

Enzyme and pathway databases

BRENDAⁱ	2.7.11.24 2681
Reactomeⁱ	R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-171007 p38MAPK events R-HSA-376172 DSCAM interactions R-HSA-4420097 VEGFA-VEGFR2 Pathway
SignaLinkⁱ	O15264
SIGNORⁱ	O15264

Miscellaneous databases

EvolutionaryTraceⁱ	O15264
GeneWikiⁱ	MAPK13
GenomeRNAiⁱ	5603
Protein Ontology More...PROⁱ	PR:O15264
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000156711 Expressed in 187 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MAPK13
ExpressionAtlasⁱ	O15264 baseline and differential
Genevisibleⁱ	O15264 HS

Family and domain databases

CDDⁱ	cd07879 STKc_p38delta, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR003527 MAP_kinase_CS IPR008352 MAPK_p38-like IPR038785 p38delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR01773 P38MAPKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS01351 MAPK, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MK13_HUMAN
Accessionⁱ	O15264Primary (citable) accession number: O15264 Secondary accession number(s): O14739 , O15124, Q5U4A5, Q6FI46, Q9UNU0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - O15264 (MK13_HUMAN)

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Mitogen-activated protein kinase 13

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ