UniProtKB - O15263 (DFB4A_HUMAN)
Functioni
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).1 Publication
GO - Molecular functioni
- CCR6 chemokine receptor binding Source: UniProtKB
- chemoattractant activity Source: GO_Central
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- antimicrobial humoral response Source: Reactome
- cell chemotaxis Source: GO_Central
- chemotaxis Source: UniProtKB
- defense response to bacterium Source: MGI
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: ProtInc
- immune response Source: ProtInc
- killing of cells of other organism Source: UniProtKB
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Defensin |
Enzyme and pathway databases
PathwayCommonsi | O15263 |
Reactomei | R-HSA-1461957, Beta defensins R-HSA-1461973, Defensins |
Protein family/group databases
TCDBi | 1.C.85.1.2, the pore-forming Beta-defensin (Beta-defensin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-defensin 4AAlternative name(s): Beta-defensin 2 Short name: BD-2 Short name: hBD-2 Defensin, beta 2 Skin-antimicrobial peptide 1 Short name: SAP1 |
Gene namesi | Name:DEFB4A Synonyms:DEFB102, DEFB2, DEFB4 AND Name:DEFB4B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2767, DEFB4A HGNC:30193, DEFB4B |
MIMi | 602215, gene |
neXtProti | NX_O15263 |
VEuPathDBi | HostDB:ENSG00000171711.2 HostDB:ENSG00000177257.2 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 100289462 1673 |
OpenTargetsi | ENSG00000171711 ENSG00000177257 |
PharmGKBi | PA27249 |
Miscellaneous databases
Pharosi | O15263, Tbio |
Genetic variation databases
BioMutai | DEFB4A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PeptideiPRO_0000006968 | 24 – 64 | Beta-defensin 4AAdd BLAST | 41 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 60 | |||
Disulfide bondi | 38 ↔ 53 | |||
Disulfide bondi | 43 ↔ 61 |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | O15263 |
PaxDbi | O15263 |
PeptideAtlasi | O15263 |
PRIDEi | O15263 |
ProteomicsDBi | 48551 |
Expressioni
Tissue specificityi
Expressed in the skin and respiratory tract.
Inductioni
By inflammation.
Gene expression databases
Bgeei | ENSG00000171711, Expressed in female gonad and 52 other tissues |
Genevisiblei | O15263, HS |
Organism-specific databases
HPAi | ENSG00000171711, Group enriched (esophagus, lymphoid tissue, tongue) ENSG00000177257, Group enriched (esophagus, lymphoid tissue) |
Interactioni
GO - Molecular functioni
- CCR6 chemokine receptor binding Source: UniProtKB
- chemoattractant activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108037, 3 interactors |
IntActi | O15263, 1 interactor |
STRINGi | 9606.ENSP00000424598 |
Miscellaneous databases
RNActi | O15263, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O15263 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15263 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SYUI, Eukaryota |
GeneTreei | ENSGT00940000160995 |
HOGENOMi | CLU_189296_4_1_1 |
InParanoidi | O15263 |
OMAi | IRSGAIC |
OrthoDBi | 1584343at2759 |
PhylomeDBi | O15263 |
Family and domain databases
InterProi | View protein in InterPro IPR001855, Defensin_beta-typ IPR006080, Defensin_beta/alpha |
Pfami | View protein in Pfam PF00711, Defensin_beta, 1 hit |
SMARTi | View protein in SMART SM00048, DEFSN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O15263-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI
60
GTCGLPGTKC CKKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71389 mRNA Translation: CAA95992.1 AF040153 Genomic DNA Translation: AAC33549.1 AF071216 Genomic DNA Translation: AAC69554.1 AJ000152 Genomic DNA Translation: CAB65126.1 BC069285 mRNA Translation: AAH69285.1 BC093983 mRNA Translation: AAH93983.1 BC093985 mRNA Translation: AAH93985.1 |
CCDSi | CCDS5971.1 |
RefSeqi | NP_001192195.1, NM_001205266.1 NP_004933.1, NM_004942.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71389 mRNA Translation: CAA95992.1 AF040153 Genomic DNA Translation: AAC33549.1 AF071216 Genomic DNA Translation: AAC69554.1 AJ000152 Genomic DNA Translation: CAB65126.1 BC069285 mRNA Translation: AAH69285.1 BC093983 mRNA Translation: AAH93983.1 BC093985 mRNA Translation: AAH93985.1 |
CCDSi | CCDS5971.1 |
RefSeqi | NP_001192195.1, NM_001205266.1 NP_004933.1, NM_004942.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1E4Q | NMR | - | A | 28-64 | [»] | |
1FD3 | X-ray | 1.35 | A/B/C/D | 24-64 | [»] | |
1FD4 | X-ray | 1.70 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 24-64 | [»] | |
1FQQ | NMR | - | A | 24-64 | [»] | |
6CS9 | X-ray | 1.85 | A/B | 24-64 | [»] | |
SMRi | O15263 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108037, 3 interactors |
IntActi | O15263, 1 interactor |
STRINGi | 9606.ENSP00000424598 |
Protein family/group databases
TCDBi | 1.C.85.1.2, the pore-forming Beta-defensin (Beta-defensin) family |
Genetic variation databases
BioMutai | DEFB4A |
Proteomic databases
MassIVEi | O15263 |
PaxDbi | O15263 |
PeptideAtlasi | O15263 |
PRIDEi | O15263 |
ProteomicsDBi | 48551 |
Protocols and materials databases
Antibodypediai | 22053, 214 antibodies 4918, 165 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 100289462 1673 |
DisGeNETi | 100289462 1673 |
GeneCardsi | DEFB4A DEFB4B |
HGNCi | HGNC:2767, DEFB4A HGNC:30193, DEFB4B |
HPAi | ENSG00000171711, Group enriched (esophagus, lymphoid tissue, tongue) ENSG00000177257, Group enriched (esophagus, lymphoid tissue) |
MIMi | 602215, gene |
neXtProti | NX_O15263 |
OpenTargetsi | ENSG00000171711 ENSG00000177257 |
PharmGKBi | PA27249 |
VEuPathDBi | HostDB:ENSG00000171711.2 HostDB:ENSG00000177257.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SYUI, Eukaryota |
GeneTreei | ENSGT00940000160995 |
HOGENOMi | CLU_189296_4_1_1 |
InParanoidi | O15263 |
OMAi | IRSGAIC |
OrthoDBi | 1584343at2759 |
PhylomeDBi | O15263 |
Enzyme and pathway databases
PathwayCommonsi | O15263 |
Reactomei | R-HSA-1461957, Beta defensins R-HSA-1461973, Defensins |
Miscellaneous databases
BioGRID-ORCSi | 100289462, 7 hits in 837 CRISPR screens 1673, 53 hits in 834 CRISPR screens |
EvolutionaryTracei | O15263 |
GeneWikii | Beta-defensin_2 |
Pharosi | O15263, Tbio |
PROi | PR:O15263 |
RNActi | O15263, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171711, Expressed in female gonad and 52 other tissues |
Genevisiblei | O15263, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001855, Defensin_beta-typ IPR006080, Defensin_beta/alpha |
Pfami | View protein in Pfam PF00711, Defensin_beta, 1 hit |
SMARTi | View protein in SMART SM00048, DEFSN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DFB4A_HUMAN | |
Accessioni | O15263Primary (citable) accession number: O15263 Secondary accession number(s): Q52LC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM