DEFB4A

Functionⁱ

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).1 Publication

GO - Molecular functionⁱ

CCR6 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
chemoattractant activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 19109182
antimicrobial humoral response Source: Reactome
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
defense response to bacterium
Source: MGI
Inferred from mutant phenotypeⁱ
- 21115716
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 15625724
- 20068036
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 15625724
- 20068036
G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10521347
immune response
Source: ProtInc
Traceable author statementⁱ
- 10521347
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 15625724
- 19109182

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Defensin

Molecular function

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1461957 Beta defensins R-HSA-1461973 Defensins

Reactomeⁱ

R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Protein family/group databases

TCDBⁱ	1.C.85.1.2 the pore-forming -defensin (-defensin) family

TCDBⁱ

1.C.85.1.2 the pore-forming -defensin (-defensin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-defensin 4A Alternative name(s): Beta-defensin 2 Short name: BD-2 Short name: hBD-2 Defensin, beta 2 Skin-antimicrobial peptide 1 Short name: SAP1
Gene namesⁱ	Name:DEFB4A Synonyms:DEFB102, DEFB2, DEFB4 AND Name:DEFB4B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171711.2 HostDB:ENSG00000177257.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2767 DEFB4A HGNC:30193 DEFB4B
MIMⁱ	602215 gene
neXtProtⁱ	NX_O15263

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100289462 1673
Open Targets More...OpenTargetsⁱ	ENSG00000171711 ENSG00000177257
PharmGKBⁱ	PA27249

Polymorphism and mutation databases

BioMutaⁱ	DEFB4A

BioMutaⁱ

DEFB4A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
PeptideⁱPRO_0000006968	24 – 64	Beta-defensin 4AAdd BLAST		41

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	31 ↔ 60
Disulfide bondⁱ	38 ↔ 53
Disulfide bondⁱ	43 ↔ 61

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O15263
PeptideAtlas More...PeptideAtlasⁱ	O15263
PRIDEⁱ	O15263
ProteomicsDBⁱ	48551

Expressionⁱ

Tissue specificityⁱ

Expressed in the skin and respiratory tract.

Inductionⁱ

By inflammation.

Gene expression databases

Bgeeⁱ	ENSG00000171711 Expressed in 43 organ(s), highest expression level in female gonad
CleanExⁱ	HS_DEFB4
Genevisibleⁱ	O15263 HS

Interactionⁱ

GO - Molecular functionⁱ

CCR6 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
chemoattractant activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108037, 3 interactors
STRINGⁱ	9606.ENSP00000424598

Chemistry databases

BindingDBⁱ	O15263

BindingDBⁱ

O15263

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	25 – 27	Combined sources	3
Helixⁱ	28 – 33	Combined sources	6
Beta strandⁱ	37 – 41	Combined sources	5
Beta strandⁱ	48 – 52	Combined sources	5
Beta strandⁱ	53 – 55	Combined sources	3
Beta strandⁱ	59 – 62	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	O15263
SMRⁱ	O15263
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O15263

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JJAE Eukaryota ENOG411147G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111909
HOGENOMⁱ	HOG000015465
HOVERGENⁱ	HBG004834
InParanoidⁱ	O15263
KEGG Orthology (KO) More...KOⁱ	K21100
OMAⁱ	RSGAICH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1ANZ
PhylomeDBⁱ	O15263

Family and domain databases

InterProⁱ	View protein in InterPro IPR001855 Defensin_beta-typ IPR006080 Defensin_beta/alpha
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00711 Defensin_beta, 1 hit
SMARTⁱ	View protein in SMART SM00048 DEFSN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O15263-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI 
        60 
GTCGLPGTKC CKKP

Length:64

Mass (Da):7,038

Last modified:January 1, 1998 - v1

Checksum:ⁱ05D6454CE7ACD10E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z71389 mRNA Translation: CAA95992.1 AF040153 Genomic DNA Translation: AAC33549.1 AF071216 Genomic DNA Translation: AAC69554.1 AJ000152 Genomic DNA Translation: CAB65126.1 BC069285 mRNA Translation: AAH69285.1 BC093983 mRNA Translation: AAH93983.1 BC093985 mRNA Translation: AAH93985.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5971.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001192195.1, NM_001205266.1 NP_004933.1, NM_004942.3
UniGeneⁱ	Hs.105924 Hs.740237

Genome annotation databases

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15263	Beta-defensin 4A		MACMU		64	UniRef90_O15263
Beta-defensin 4A		PANTR		64
Uncharacterized protein		NOMLE		64
DEFB4A isoform 1		PANTR		64

Protein	Similar proteins		Species	Score	Length	Source
O15263	Beta-defensin 4A		PANTR		64	UniRef50_O15263
Beta-defensin 4A		MACMU		64
Uncharacterized protein		NOMLE		64
Uncharacterized protein		MANLE		64
Uncharacterized protein		COLAP		64
+30

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z71389 mRNA Translation: CAA95992.1 AF040153 Genomic DNA Translation: AAC33549.1 AF071216 Genomic DNA Translation: AAC69554.1 AJ000152 Genomic DNA Translation: CAB65126.1 BC069285 mRNA Translation: AAH69285.1 BC093983 mRNA Translation: AAH93983.1 BC093985 mRNA Translation: AAH93985.1
CCDSⁱ	CCDS5971.1
RefSeqⁱ	NP_001192195.1, NM_001205266.1 NP_004933.1, NM_004942.3
UniGeneⁱ	Hs.105924 Hs.740237

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1E4Q	NMR	-	A	28-64	[»]
	1FD3	X-ray	1.35	A/B/C/D	24-64	[»]
	1FD4	X-ray	1.70	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	24-64	[»]
	1FQQ	NMR	-	A	24-64	[»]
	6CS9	X-ray	1.85	A/B	24-64	[»]
ProteinModelPortalⁱ	O15263
SMRⁱ	O15263
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108037, 3 interactors
STRINGⁱ	9606.ENSP00000424598

Chemistry databases

BindingDBⁱ	O15263

BindingDBⁱ

O15263

Protein family/group databases

TCDBⁱ	1.C.85.1.2 the pore-forming -defensin (-defensin) family

TCDBⁱ

1.C.85.1.2 the pore-forming -defensin (-defensin) family

Polymorphism and mutation databases

BioMutaⁱ	DEFB4A

BioMutaⁱ

DEFB4A

Proteomic databases

PaxDbⁱ	O15263
PeptideAtlasⁱ	O15263
PRIDEⁱ	O15263
ProteomicsDBⁱ	48551

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302247; ENSP00000303532; ENSG00000171711 ENST00000318157; ENSP00000424598; ENSG00000177257 ENST00000617136; ENSP00000479138; ENSG00000275444 ENST00000642856; ENSP00000496499; ENSG00000285181 ENST00000644124; ENSP00000493760; ENSG00000285433
GeneIDⁱ	100289462 1673
KEGGⁱ	hsa:100289462 hsa:1673
UCSCⁱ	uc003wsd.4 human

Organism-specific databases

CTDⁱ	100289462 1673
DisGeNETⁱ	100289462 1673
EuPathDBⁱ	HostDB:ENSG00000171711.2 HostDB:ENSG00000177257.2
GeneCardsⁱ	DEFB4A DEFB4B
HGNCⁱ	HGNC:2767 DEFB4A HGNC:30193 DEFB4B
MIMⁱ	602215 gene
neXtProtⁱ	NX_O15263
OpenTargetsⁱ	ENSG00000171711 ENSG00000177257
PharmGKBⁱ	PA27249
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JJAE Eukaryota ENOG411147G LUCA
GeneTreeⁱ	ENSGT00730000111909
HOGENOMⁱ	HOG000015465
HOVERGENⁱ	HBG004834
InParanoidⁱ	O15263
KOⁱ	K21100
OMAⁱ	RSGAICH
OrthoDBⁱ	EOG091G1ANZ
PhylomeDBⁱ	O15263

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1461957 Beta defensins R-HSA-1461973 Defensins

Reactomeⁱ

R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

EvolutionaryTraceⁱ	O15263
GeneWikiⁱ	Beta-defensin_2
Protein Ontology More...PROⁱ	PR:O15263
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171711 Expressed in 43 organ(s), highest expression level in female gonad
CleanExⁱ	HS_DEFB4
Genevisibleⁱ	O15263 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001855 Defensin_beta-typ IPR006080 Defensin_beta/alpha
Pfamⁱ	View protein in Pfam PF00711 Defensin_beta, 1 hit
SMARTⁱ	View protein in SMART SM00048 DEFSN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DFB4A_HUMAN
Accessionⁱ	O15263Primary (citable) accession number: O15263 Secondary accession number(s): Q52LC0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - O15263 (DFB4A_HUMAN)

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Beta-defensin 4A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ