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UniProtKB - O15263 (DFB4A_HUMAN)

Entry version 176 (16 Oct 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Beta-defensin 4A

Gene

DEFB4A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.85.1.2 the pore-forming -defensin (-defensin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-defensin 4A
Alternative name(s):
Beta-defensin 2
Short name:
BD-2
Short name:
hBD-2
Defensin, beta 2
Skin-antimicrobial peptide 1
Short name:
SAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEFB4A
Synonyms:DEFB102, DEFB2, DEFB4
AND
Name:DEFB4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2767 DEFB4A
HGNC:30193 DEFB4B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602215 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15263

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		100289462
1673

Open Targets

More...OpenTargetsi		ENSG00000171711
ENSG00000177257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27249

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DEFB4A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000696824 – 64Beta-defensin 4AAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 60
Disulfide bondi38 ↔ 53
Disulfide bondi43 ↔ 61

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15263

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15263

PeptideAtlas

More...PeptideAtlasi		O15263

PRoteomics IDEntifications database

More...PRIDEi		O15263

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48551

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the skin and respiratory tract.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By inflammation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171711 Expressed in 43 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15263 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108037, 3 interactors

Protein interaction database and analysis system

More...IntActi		O15263, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000424598

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15263

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15263

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15263

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JJAE Eukaryota
ENOG411147G LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160995

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015465

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15263

KEGG Orthology (KO)

More...KOi		K21100

Identification of Orthologs from Complete Genome Data

More...OMAi		IRSGAIC

Database of Orthologous Groups

More...OrthoDBi		1584343at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15263

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001855 Defensin_beta-typ
IPR006080 Defensin_beta/alpha

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00711 Defensin_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00048 DEFSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O15263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI 
        60 
GTCGLPGTKC CKKP
Length:64
Mass (Da):7,038
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05D6454CE7ACD10E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z71389 mRNA Translation: CAA95992.1
AF040153 Genomic DNA Translation: AAC33549.1
AF071216 Genomic DNA Translation: AAC69554.1
AJ000152 Genomic DNA Translation: CAB65126.1
BC069285 mRNA Translation: AAH69285.1
BC093983 mRNA Translation: AAH93983.1
BC093985 mRNA Translation: AAH93985.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5971.1

NCBI Reference Sequences

More...RefSeqi		NP_001192195.1, NM_001205266.1
NP_004933.1, NM_004942.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302247; ENSP00000303532; ENSG00000171711
ENST00000318157; ENSP00000424598; ENSG00000177257
ENST00000617136; ENSP00000479138; ENSG00000275444
ENST00000642856; ENSP00000496499; ENSG00000285181
ENST00000644124; ENSP00000493760; ENSG00000285433

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100289462
1673

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100289462
hsa:1673

UCSC genome browser

More...UCSCi		uc003wsd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71389 mRNA Translation: CAA95992.1
AF040153 Genomic DNA Translation: AAC33549.1
AF071216 Genomic DNA Translation: AAC69554.1
AJ000152 Genomic DNA Translation: CAB65126.1
BC069285 mRNA Translation: AAH69285.1
BC093983 mRNA Translation: AAH93983.1
BC093985 mRNA Translation: AAH93985.1
CCDSiCCDS5971.1
RefSeqiNP_001192195.1, NM_001205266.1
NP_004933.1, NM_004942.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4QNMR-A28-64[»]
1FD3X-ray1.35A/B/C/D24-64[»]
1FD4X-ray1.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-64[»]
1FQQNMR-A24-64[»]
6CS9X-ray1.85A/B24-64[»]
SMRiO15263
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108037, 3 interactors
IntActiO15263, 1 interactor
STRINGi9606.ENSP00000424598

Chemistry databases

BindingDBiO15263

Protein family/group databases

TCDBi1.C.85.1.2 the pore-forming -defensin (-defensin) family

Polymorphism and mutation databases

BioMutaiDEFB4A

Proteomic databases

MassIVEiO15263
PaxDbiO15263
PeptideAtlasiO15263
PRIDEiO15263
ProteomicsDBi48551

Genome annotation databases

EnsembliENST00000302247; ENSP00000303532; ENSG00000171711
ENST00000318157; ENSP00000424598; ENSG00000177257
ENST00000617136; ENSP00000479138; ENSG00000275444
ENST00000642856; ENSP00000496499; ENSG00000285181
ENST00000644124; ENSP00000493760; ENSG00000285433
GeneIDi100289462
1673
KEGGihsa:100289462
hsa:1673
UCSCiuc003wsd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100289462
1673
DisGeNETi100289462
1673

GeneCards: human genes, protein and diseases

More...GeneCardsi		DEFB4A
DEFB4B
HGNCiHGNC:2767 DEFB4A
HGNC:30193 DEFB4B
MIMi602215 gene
neXtProtiNX_O15263
OpenTargetsiENSG00000171711
ENSG00000177257
PharmGKBiPA27249

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JJAE Eukaryota
ENOG411147G LUCA
GeneTreeiENSGT00940000160995
HOGENOMiHOG000015465
InParanoidiO15263
KOiK21100
OMAiIRSGAIC
OrthoDBi1584343at2759
PhylomeDBiO15263

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

EvolutionaryTraceiO15263

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Beta-defensin_2
PharosiO15263

Protein Ontology

More...PROi		PR:O15263

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171711 Expressed in 43 organ(s), highest expression level in female gonad
GenevisibleiO15263 HS

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
IPR006080 Defensin_beta/alpha
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDFB4A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15263
Secondary accession number(s): Q52LC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 16, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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