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Protein

Surfeit locus protein 4

Gene

SURF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Protein family/group databases

TCDBi9.B.214.1.2 the er to golgi transport factor (er/g-tf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4
Gene namesi
Name:SURF4
Synonyms:SURF-4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148248.13
HGNCiHGNC:11476 SURF4
MIMi185660 gene
neXtProtiNX_O15260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi265 – 267KKK → SSS: Targeted to the Golgi. 1 Publication3

Organism-specific databases

DisGeNETi6836
OpenTargetsiENSG00000148248
PharmGKBiPA36261

Polymorphism and mutation databases

BioMutaiSURF4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001276642 – 269Surfeit locus protein 4Add BLAST268

Proteomic databases

EPDiO15260
MaxQBiO15260
PaxDbiO15260
PeptideAtlasiO15260
PRIDEiO15260
ProteomicsDBi48549
48550 [O15260-2]
TopDownProteomicsiO15260-1 [O15260-1]

PTM databases

CarbonylDBiO15260
iPTMnetiO15260
PhosphoSitePlusiO15260
SwissPalmiO15260

Expressioni

Gene expression databases

BgeeiENSG00000148248 Expressed in 201 organ(s), highest expression level in prostate gland
CleanExiHS_SURF4
ExpressionAtlasiO15260 baseline and differential
GenevisibleiO15260 HS

Organism-specific databases

HPAiHPA064613

Interactioni

Subunit structurei

Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1 (PubMed:18287528). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi112703, 57 interactors
CORUMiO15260
IntActiO15260, 46 interactors
MINTiO15260
STRINGi9606.ENSP00000361057

Structurei

3D structure databases

ProteinModelPortaliO15260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 269Di-lysine motif1 Publication4

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.1 Publication

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998 Eukaryota
COG2259 LUCA
GeneTreeiENSGT00530000064123
HOGENOMiHOG000206959
HOVERGENiHBG054238
InParanoidiO15260
KOiK20369
OMAiDQLWYLQ
OrthoDBiEOG091G0H3P
PhylomeDBiO15260
TreeFamiTF300001

Family and domain databases

InterProiView protein in InterPro
IPR002995 Surf4
PfamiView protein in Pfam
PF02077 SURF4, 1 hit
PROSITEiView protein in PROSITE
PS01339 SURF4, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE
60 70 80 90 100
QRDYIDTTWN CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI
110 120 130 140 150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE
160 170 180 190 200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIVQNIVGTA LMILVAIGFK
210 220 230 240 250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL
260
LVVALGPGGV SMDEKKKEW
Length:269
Mass (Da):30,394
Last modified:December 1, 2000 - v3
Checksum:i03366E29882B97A5
GO
Isoform 2 (identifier: O15260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-159: MQL → LPG
     160-269: Missing.

Show »
Length:159
Mass (Da):17,970
Checksum:i0073439E58A7E274
GO
Isoform 3 (identifier: O15260-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-128: NLALGGGLL → LSRTSWAQL
     129-269: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):14,854
Checksum:i109C00EB530DECD4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1G8B7Z1G8_HUMAN
Surfeit 4, isoform CRA_b
SURF4 hCG_28148
226Annotation score:
Q5T8U5Q5T8U5_HUMAN
Surfeit 4
SURF4 RP11-244N20.4-004
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → V in CAA75099 (PubMed:7540914).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054686120 – 128NLALGGGLL → LSRTSWAQL in isoform 3. 1 Publication9
Alternative sequenceiVSP_054687129 – 269Missing in isoform 3. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_006307157 – 159MQL → LPG in isoform 2. 1 Publication3
Alternative sequenceiVSP_006308160 – 269Missing in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078866 mRNA Translation: AAD44498.1
AF078867 mRNA Translation: AAD44499.1
AK300004 mRNA Translation: BAH13190.1
AK315488 mRNA Translation: BAG37872.1
AL158826 Genomic DNA Translation: CAI12840.1
CH471090 Genomic DNA Translation: EAW88071.1
CH471090 Genomic DNA Translation: EAW88074.1
BC018741 mRNA Translation: AAH18741.1
BC111023 mRNA Translation: AAI11024.1
Y14820 mRNA Translation: CAA75099.1
Y17214 Genomic DNA Translation: CAA76692.1
CCDSiCCDS65177.1 [O15260-3]
CCDS65178.1 [O15260-2]
CCDS6968.1 [O15260-1]
RefSeqiNP_001267718.1, NM_001280789.1 [O15260-2]
NP_001267721.1, NM_001280792.1 [O15260-3]
NP_149351.1, NM_033161.3 [O15260-1]
UniGeneiHs.512465

Genome annotation databases

EnsembliENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1]
ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2]
ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3]
ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2]
ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3]
ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1]
GeneIDi6836
KEGGihsa:6836
UCSCiuc004cdj.5 human [O15260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078866 mRNA Translation: AAD44498.1
AF078867 mRNA Translation: AAD44499.1
AK300004 mRNA Translation: BAH13190.1
AK315488 mRNA Translation: BAG37872.1
AL158826 Genomic DNA Translation: CAI12840.1
CH471090 Genomic DNA Translation: EAW88071.1
CH471090 Genomic DNA Translation: EAW88074.1
BC018741 mRNA Translation: AAH18741.1
BC111023 mRNA Translation: AAI11024.1
Y14820 mRNA Translation: CAA75099.1
Y17214 Genomic DNA Translation: CAA76692.1
CCDSiCCDS65177.1 [O15260-3]
CCDS65178.1 [O15260-2]
CCDS6968.1 [O15260-1]
RefSeqiNP_001267718.1, NM_001280789.1 [O15260-2]
NP_001267721.1, NM_001280792.1 [O15260-3]
NP_149351.1, NM_033161.3 [O15260-1]
UniGeneiHs.512465

3D structure databases

ProteinModelPortaliO15260
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112703, 57 interactors
CORUMiO15260
IntActiO15260, 46 interactors
MINTiO15260
STRINGi9606.ENSP00000361057

Protein family/group databases

TCDBi9.B.214.1.2 the er to golgi transport factor (er/g-tf) family

PTM databases

CarbonylDBiO15260
iPTMnetiO15260
PhosphoSitePlusiO15260
SwissPalmiO15260

Polymorphism and mutation databases

BioMutaiSURF4

Proteomic databases

EPDiO15260
MaxQBiO15260
PaxDbiO15260
PeptideAtlasiO15260
PRIDEiO15260
ProteomicsDBi48549
48550 [O15260-2]
TopDownProteomicsiO15260-1 [O15260-1]

Protocols and materials databases

DNASUi6836
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1]
ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2]
ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3]
ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2]
ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3]
ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1]
GeneIDi6836
KEGGihsa:6836
UCSCiuc004cdj.5 human [O15260-1]

Organism-specific databases

CTDi6836
DisGeNETi6836
EuPathDBiHostDB:ENSG00000148248.13
GeneCardsiSURF4
HGNCiHGNC:11476 SURF4
HPAiHPA064613
MIMi185660 gene
neXtProtiNX_O15260
OpenTargetsiENSG00000148248
PharmGKBiPA36261
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3998 Eukaryota
COG2259 LUCA
GeneTreeiENSGT00530000064123
HOGENOMiHOG000206959
HOVERGENiHBG054238
InParanoidiO15260
KOiK20369
OMAiDQLWYLQ
OrthoDBiEOG091G0H3P
PhylomeDBiO15260
TreeFamiTF300001

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiSURF4 human
GeneWikiiSURF4
GenomeRNAii6836
PROiPR:O15260
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148248 Expressed in 201 organ(s), highest expression level in prostate gland
CleanExiHS_SURF4
ExpressionAtlasiO15260 baseline and differential
GenevisibleiO15260 HS

Family and domain databases

InterProiView protein in InterPro
IPR002995 Surf4
PfamiView protein in Pfam
PF02077 SURF4, 1 hit
PROSITEiView protein in PROSITE
PS01339 SURF4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSURF4_HUMAN
AccessioniPrimary (citable) accession number: O15260
Secondary accession number(s): B7Z6A4
, O60923, Q5T8U6, Q9UNZ0, Q9UNZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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