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UniProtKB - O15260 (SURF4_HUMAN)

Entry version 179 (02 Dec 2020)
Sequence version 3 (01 Dec 2000)
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Protein

Surfeit locus protein 4

Gene

SURF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15260

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.214.1.2, the er to golgi transport factor (er/g-tf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Surfeit locus protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SURF4
Synonyms:SURF-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 9, Unplaced

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000148248.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:11476, SURF4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		185660, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi265 – 267KKK → SSS: Targeted to the Golgi. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		6836

Open Targets

More...OpenTargetsi		ENSG00000148248

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36261

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15260, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SURF4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001276642 – 269Surfeit locus protein 4Add BLAST268

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15260

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15260

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15260

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15260

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15260

PeptideAtlas

More...PeptideAtlasi		O15260

PRoteomics IDEntifications database

More...PRIDEi		O15260

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48549 [O15260-1]
48550 [O15260-2]
6763

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O15260-1 [O15260-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O15260

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15260

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O15260

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15260

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O15260

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148248, Expressed in prostate gland and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15260, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15260, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148248, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). May interact with LMAN1 (PubMed:18287528).

Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).

Interacts with STING1 (PubMed:29251827).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112703, 78 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15260

Protein interaction database and analysis system

More...IntActi		O15260, 62 interactors

Molecular INTeraction database

More...MINTi		O15260

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361057

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15260, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15260

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi266 – 269Di-lysine motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3998, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_056195_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15260

Identification of Orthologs from Complete Genome Data

More...OMAi		DQLWYLQ

Database of Orthologous Groups

More...OrthoDBi		1443136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15260

TreeFam database of animal gene trees

More...TreeFami		TF300001

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002995, Surf4

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02077, SURF4, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01339, SURF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE 
        60         70         80         90        100
QRDYIDTTWN CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI 
       110        120        130        140        150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE 
       160        170        180        190        200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIVQNIVGTA LMILVAIGFK 
       210        220        230        240        250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL 
       260 
LVVALGPGGV SMDEKKKEW
Length:269
Mass (Da):30,394
Last modified:December 1, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03366E29882B97A5
GO
Isoform 2 (identifier: O15260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-159: MQL → LPG
     160-269: Missing.

Show »
Length:159
Mass (Da):17,970
Checksum:i0073439E58A7E274
GO
Isoform 3 (identifier: O15260-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-128: NLALGGGLL → LSRTSWAQL
     129-269: Missing.

Show »
Length:128
Mass (Da):14,854
Checksum:i109C00EB530DECD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1G8B7Z1G8_HUMAN
Surfeit locus protein 4
SURF4 hCG_28148
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8U5Q5T8U5_HUMAN
Surfeit locus protein 4
SURF4 RP11-244N20.4-004
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130L → V in CAA75099 (PubMed:7540914).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054686120 – 128NLALGGGLL → LSRTSWAQL in isoform 3. 1 Publication9
Alternative sequenceiVSP_054687129 – 269Missing in isoform 3. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_006307157 – 159MQL → LPG in isoform 2. 1 Publication3
Alternative sequenceiVSP_006308160 – 269Missing in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF078866 mRNA Translation: AAD44498.1
AF078867 mRNA Translation: AAD44499.1
AK300004 mRNA Translation: BAH13190.1
AK315488 mRNA Translation: BAG37872.1
AL158826 Genomic DNA Translation: CAI12840.1
CH471090 Genomic DNA Translation: EAW88071.1
CH471090 Genomic DNA Translation: EAW88074.1
BC018741 mRNA Translation: AAH18741.1
BC111023 mRNA Translation: AAI11024.1
Y14820 mRNA Translation: CAA75099.1
Y17214 Genomic DNA Translation: CAA76692.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS65177.1 [O15260-3]
CCDS65178.1 [O15260-2]
CCDS6968.1 [O15260-1]

NCBI Reference Sequences

More...RefSeqi		NP_001267718.1, NM_001280789.1 [O15260-2]
NP_001267721.1, NM_001280792.1 [O15260-3]
NP_149351.1, NM_033161.3 [O15260-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1]
ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2]
ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3]
ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2]
ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3]
ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6836

UCSC genome browser

More...UCSCi		uc004cdj.5, human [O15260-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078866 mRNA Translation: AAD44498.1
AF078867 mRNA Translation: AAD44499.1
AK300004 mRNA Translation: BAH13190.1
AK315488 mRNA Translation: BAG37872.1
AL158826 Genomic DNA Translation: CAI12840.1
CH471090 Genomic DNA Translation: EAW88071.1
CH471090 Genomic DNA Translation: EAW88074.1
BC018741 mRNA Translation: AAH18741.1
BC111023 mRNA Translation: AAI11024.1
Y14820 mRNA Translation: CAA75099.1
Y17214 Genomic DNA Translation: CAA76692.1
CCDSiCCDS65177.1 [O15260-3]
CCDS65178.1 [O15260-2]
CCDS6968.1 [O15260-1]
RefSeqiNP_001267718.1, NM_001280789.1 [O15260-2]
NP_001267721.1, NM_001280792.1 [O15260-3]
NP_149351.1, NM_033161.3 [O15260-1]

3D structure databases

SMRiO15260
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112703, 78 interactors
CORUMiO15260
IntActiO15260, 62 interactors
MINTiO15260
STRINGi9606.ENSP00000361057

Protein family/group databases

TCDBi9.B.214.1.2, the er to golgi transport factor (er/g-tf) family

PTM databases

CarbonylDBiO15260
iPTMnetiO15260
MetOSiteiO15260
PhosphoSitePlusiO15260
SwissPalmiO15260

Polymorphism and mutation databases

BioMutaiSURF4

Proteomic databases

EPDiO15260
jPOSTiO15260
MassIVEiO15260
MaxQBiO15260
PaxDbiO15260
PeptideAtlasiO15260
PRIDEiO15260
ProteomicsDBi48549 [O15260-1]
48550 [O15260-2]
6763
TopDownProteomicsiO15260-1 [O15260-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31854, 134 antibodies

The DNASU plasmid repository

More...DNASUi		6836

Genome annotation databases

EnsembliENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1]
ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2]
ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3]
ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2]
ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3]
ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1]
GeneIDi6836
KEGGihsa:6836
UCSCiuc004cdj.5, human [O15260-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6836
DisGeNETi6836
EuPathDBiHostDB:ENSG00000148248.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		SURF4
HGNCiHGNC:11476, SURF4
HPAiENSG00000148248, Low tissue specificity
MIMi185660, gene
neXtProtiNX_O15260
OpenTargetsiENSG00000148248
PharmGKBiPA36261

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3998, Eukaryota
GeneTreeiENSGT00530000064123
HOGENOMiCLU_056195_0_0_1
InParanoidiO15260
OMAiDQLWYLQ
OrthoDBi1443136at2759
PhylomeDBiO15260
TreeFamiTF300001

Enzyme and pathway databases

PathwayCommonsiO15260
ReactomeiR-HSA-6798695, Neutrophil degranulation
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6836, 40 hits in 848 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SURF4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SURF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6836
PharosiO15260, Tbio

Protein Ontology

More...PROi		PR:O15260
RNActiO15260, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148248, Expressed in prostate gland and 215 other tissues
ExpressionAtlasiO15260, baseline and differential
GenevisibleiO15260, HS

Family and domain databases

InterProiView protein in InterPro
IPR002995, Surf4
PfamiView protein in Pfam
PF02077, SURF4, 1 hit
PROSITEiView protein in PROSITE
PS01339, SURF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSURF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15260
Secondary accession number(s): B7Z6A4
, O60923, Q5T8U6, Q9UNZ0, Q9UNZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 1, 2000
Last modified: December 2, 2020
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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