UniProtKB - O15260 (SURF4_HUMAN)
Protein
Surfeit locus protein 4
Gene
SURF4
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.1 Publication
GO - Biological processi
- Golgi organization Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of organelle organization Source: UniProtKB
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | O15260 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Protein family/group databases
TCDBi | 9.B.214.1.2, the er to golgi transport factor (er/g-tf) family |
Names & Taxonomyi
Protein namesi | Recommended name: Surfeit locus protein 4 |
Gene namesi | Name:SURF4 Synonyms:SURF-4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148248.13 |
HGNCi | HGNC:11476, SURF4 |
MIMi | 185660, gene |
neXtProti | NX_O15260 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Cycles between the endoplasmic reticulum and the Golgi.1 Publication
Cytosol
- cytosol Source: GOC
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi membrane Source: Reactome
Lysosome
- azurophil granule membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- transport vesicle Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 265 – 267 | KKK → SSS: Targeted to the Golgi. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 6836 |
OpenTargetsi | ENSG00000148248 |
PharmGKBi | PA36261 |
Miscellaneous databases
Pharosi | O15260, Tbio |
Polymorphism and mutation databases
BioMutai | SURF4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000127664 | 2 – 269 | Surfeit locus protein 4Add BLAST | 268 |
Proteomic databases
EPDi | O15260 |
jPOSTi | O15260 |
MassIVEi | O15260 |
MaxQBi | O15260 |
PaxDbi | O15260 |
PeptideAtlasi | O15260 |
PRIDEi | O15260 |
ProteomicsDBi | 48549 [O15260-1] 48550 [O15260-2] 6763 |
TopDownProteomicsi | O15260-1 [O15260-1] |
PTM databases
CarbonylDBi | O15260 |
iPTMneti | O15260 |
MetOSitei | O15260 |
PhosphoSitePlusi | O15260 |
SwissPalmi | O15260 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148248, Expressed in prostate gland and 215 other tissues |
ExpressionAtlasi | O15260, baseline and differential |
Genevisiblei | O15260, HS |
Organism-specific databases
HPAi | ENSG00000148248, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsO15260
With | #Exp. | IntAct |
---|---|---|
LMAN1 [P49257] | 3 | EBI-1044848,EBI-1057738 |
STING1 [Q86WV6] | 3 | EBI-1044848,EBI-2800345 |
Unc93b1 [Q8VCW4] from Mus musculus. | 2 | EBI-1044848,EBI-6116986 |
Protein-protein interaction databases
BioGRIDi | 112703, 78 interactors |
CORUMi | O15260 |
IntActi | O15260, 62 interactors |
MINTi | O15260 |
STRINGi | 9606.ENSP00000361057 |
Miscellaneous databases
RNActi | O15260, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 266 – 269 | Di-lysine motif1 Publication | 4 |
Domaini
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.1 Publication
Sequence similaritiesi
Belongs to the SURF4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3998, Eukaryota |
GeneTreei | ENSGT00530000064123 |
HOGENOMi | CLU_056195_0_0_1 |
InParanoidi | O15260 |
OMAi | DQLWYLQ |
OrthoDBi | 1443136at2759 |
PhylomeDBi | O15260 |
TreeFami | TF300001 |
Family and domain databases
InterProi | View protein in InterPro IPR002995, Surf4 |
Pfami | View protein in Pfam PF02077, SURF4, 1 hit |
PROSITEi | View protein in PROSITE PS01339, SURF4, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15260-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE
60 70 80 90 100
QRDYIDTTWN CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI
110 120 130 140 150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE
160 170 180 190 200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIVQNIVGTA LMILVAIGFK
210 220 230 240 250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL
260
LVVALGPGGV SMDEKKKEW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z1G8 | B7Z1G8_HUMAN | Surfeit locus protein 4 | SURF4 hCG_28148 | 226 | Annotation score: | ||
Q5T8U5 | Q5T8U5_HUMAN | Surfeit locus protein 4 | SURF4 RP11-244N20.4-004 | 186 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | L → V in CAA75099 (PubMed:7540914).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054686 | 120 – 128 | NLALGGGLL → LSRTSWAQL in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_054687 | 129 – 269 | Missing in isoform 3. 1 PublicationAdd BLAST | 141 | |
Alternative sequenceiVSP_006307 | 157 – 159 | MQL → LPG in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_006308 | 160 – 269 | Missing in isoform 2. 1 PublicationAdd BLAST | 110 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078866 mRNA Translation: AAD44498.1 AF078867 mRNA Translation: AAD44499.1 AK300004 mRNA Translation: BAH13190.1 AK315488 mRNA Translation: BAG37872.1 AL158826 Genomic DNA Translation: CAI12840.1 CH471090 Genomic DNA Translation: EAW88071.1 CH471090 Genomic DNA Translation: EAW88074.1 BC018741 mRNA Translation: AAH18741.1 BC111023 mRNA Translation: AAI11024.1 Y14820 mRNA Translation: CAA75099.1 Y17214 Genomic DNA Translation: CAA76692.1 |
CCDSi | CCDS65177.1 [O15260-3] CCDS65178.1 [O15260-2] CCDS6968.1 [O15260-1] |
RefSeqi | NP_001267718.1, NM_001280789.1 [O15260-2] NP_001267721.1, NM_001280792.1 [O15260-3] NP_149351.1, NM_033161.3 [O15260-1] |
Genome annotation databases
Ensembli | ENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1] ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2] ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3] ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2] ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3] ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1] |
GeneIDi | 6836 |
KEGGi | hsa:6836 |
UCSCi | uc004cdj.5, human [O15260-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078866 mRNA Translation: AAD44498.1 AF078867 mRNA Translation: AAD44499.1 AK300004 mRNA Translation: BAH13190.1 AK315488 mRNA Translation: BAG37872.1 AL158826 Genomic DNA Translation: CAI12840.1 CH471090 Genomic DNA Translation: EAW88071.1 CH471090 Genomic DNA Translation: EAW88074.1 BC018741 mRNA Translation: AAH18741.1 BC111023 mRNA Translation: AAI11024.1 Y14820 mRNA Translation: CAA75099.1 Y17214 Genomic DNA Translation: CAA76692.1 |
CCDSi | CCDS65177.1 [O15260-3] CCDS65178.1 [O15260-2] CCDS6968.1 [O15260-1] |
RefSeqi | NP_001267718.1, NM_001280789.1 [O15260-2] NP_001267721.1, NM_001280792.1 [O15260-3] NP_149351.1, NM_033161.3 [O15260-1] |
3D structure databases
SMRi | O15260 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112703, 78 interactors |
CORUMi | O15260 |
IntActi | O15260, 62 interactors |
MINTi | O15260 |
STRINGi | 9606.ENSP00000361057 |
Protein family/group databases
TCDBi | 9.B.214.1.2, the er to golgi transport factor (er/g-tf) family |
PTM databases
CarbonylDBi | O15260 |
iPTMneti | O15260 |
MetOSitei | O15260 |
PhosphoSitePlusi | O15260 |
SwissPalmi | O15260 |
Polymorphism and mutation databases
BioMutai | SURF4 |
Proteomic databases
EPDi | O15260 |
jPOSTi | O15260 |
MassIVEi | O15260 |
MaxQBi | O15260 |
PaxDbi | O15260 |
PeptideAtlasi | O15260 |
PRIDEi | O15260 |
ProteomicsDBi | 48549 [O15260-1] 48550 [O15260-2] 6763 |
TopDownProteomicsi | O15260-1 [O15260-1] |
Protocols and materials databases
Antibodypediai | 31854, 134 antibodies |
DNASUi | 6836 |
Genome annotation databases
Ensembli | ENST00000371989; ENSP00000361057; ENSG00000148248 [O15260-1] ENST00000485435; ENSP00000419853; ENSG00000148248 [O15260-2] ENST00000545297; ENSP00000446061; ENSG00000148248 [O15260-3] ENST00000626303; ENSP00000487537; ENSG00000280951 [O15260-2] ENST00000629119; ENSP00000486869; ENSG00000280951 [O15260-3] ENST00000629578; ENSP00000486049; ENSG00000280951 [O15260-1] |
GeneIDi | 6836 |
KEGGi | hsa:6836 |
UCSCi | uc004cdj.5, human [O15260-1] |
Organism-specific databases
CTDi | 6836 |
DisGeNETi | 6836 |
EuPathDBi | HostDB:ENSG00000148248.13 |
GeneCardsi | SURF4 |
HGNCi | HGNC:11476, SURF4 |
HPAi | ENSG00000148248, Low tissue specificity |
MIMi | 185660, gene |
neXtProti | NX_O15260 |
OpenTargetsi | ENSG00000148248 |
PharmGKBi | PA36261 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3998, Eukaryota |
GeneTreei | ENSGT00530000064123 |
HOGENOMi | CLU_056195_0_0_1 |
InParanoidi | O15260 |
OMAi | DQLWYLQ |
OrthoDBi | 1443136at2759 |
PhylomeDBi | O15260 |
TreeFami | TF300001 |
Enzyme and pathway databases
PathwayCommonsi | O15260 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 6836, 40 hits in 848 CRISPR screens |
ChiTaRSi | SURF4, human |
GeneWikii | SURF4 |
GenomeRNAii | 6836 |
Pharosi | O15260, Tbio |
PROi | PR:O15260 |
RNActi | O15260, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148248, Expressed in prostate gland and 215 other tissues |
ExpressionAtlasi | O15260, baseline and differential |
Genevisiblei | O15260, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002995, Surf4 |
Pfami | View protein in Pfam PF02077, SURF4, 1 hit |
PROSITEi | View protein in PROSITE PS01339, SURF4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SURF4_HUMAN | |
Accessioni | O15260Primary (citable) accession number: O15260 Secondary accession number(s): B7Z6A4 Q9UNZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families