UniProtKB - O15258 (RER1_HUMAN)
Protein
Protein RER1
Gene
RER1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.By similarity
GO - Molecular functioni
- acetylcholine receptor binding Source: Ensembl
GO - Biological processi
- positive regulation of protein localization to plasma membrane Source: Ensembl
- protein retention in ER lumen Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
- skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
Protein family/group databases
TCDBi | 9.B.82.1.2 the endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein RER1 |
Gene namesi | Name:RER1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157916.18 |
HGNCi | HGNC:30309 RER1 |
neXtProti | NX_O15258 |
Subcellular locationi
Golgi apparatus
Endoplasmic reticulum
- endoplasmic reticulum Source: GOC
Golgi apparatus
- Golgi apparatus Source: HPA
- integral component of Golgi membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GOC
Other locations
- cell surface Source: Ensembl
- endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 63 – 83 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11079 |
OpenTargetsi | ENSG00000157916 |
PharmGKBi | PA134901074 |
Polymorphism and mutation databases
BioMutai | RER1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000207589 | 2 – 196 | Protein RER1Add BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 6 | PhosphoserineCombined sources | 1 | |
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O15258 |
jPOSTi | O15258 |
PaxDbi | O15258 |
PeptideAtlasi | O15258 |
PRIDEi | O15258 |
ProteomicsDBi | 48544 |
PTM databases
iPTMneti | O15258 |
PhosphoSitePlusi | O15258 |
SwissPalmi | O15258 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157916 Expressed in 233 organ(s), highest expression level in lower esophagus mucosa |
ExpressionAtlasi | O15258 baseline and differential |
Genevisiblei | O15258 HS |
Organism-specific databases
HPAi | CAB037240 HPA051400 |
Interactioni
GO - Molecular functioni
- acetylcholine receptor binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 116262, 39 interactors |
IntActi | O15258, 17 interactors |
MINTi | O15258 |
STRINGi | 9606.ENSP00000302088 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RER1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1688 Eukaryota COG5249 LUCA |
GeneTreei | ENSGT00510000047137 |
HOVERGENi | HBG002871 |
InParanoidi | O15258 |
OMAi | LPEWQFW |
OrthoDBi | 1458086at2759 |
PhylomeDBi | O15258 |
TreeFami | TF300029 |
Family and domain databases
InterProi | View protein in InterPro IPR004932 Rer1 |
PANTHERi | PTHR10743 PTHR10743, 1 hit |
Pfami | View protein in Pfam PF03248 Rer1, 1 hit |
PIRSFi | PIRSF016013 AtER_Rer1p, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O15258-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEGDSVGES VHGKPSVVYR FFTRLGQIYQ SWLDKSTPYT AVRWVVTLGL
60 70 80 90 100
SFVYMIRVYL LQGWYIVTYA LGIYHLNLFI AFLSPKVDPS LMEDSDDGPS
110 120 130 140 150
LPTKQNEEFR PFIRRLPEFK FWHAATKGIL VAMVCTFFDA FNVPVFWPIL
160 170 180 190
VMYFIMLFCI TMKRQIKHMI KYRYIPFTHG KRRYRGKEDA GKAFAS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T092 | Q5T092_HUMAN | Protein RER1 | RER1 | 158 | Annotation score: | ||
Q5T091 | Q5T091_HUMAN | Protein RER1 | RER1 hCG_24604 | 187 | Annotation score: | ||
A0A0A0MR06 | A0A0A0MR06_HUMAN | Protein RER1 | RER1 | 177 | Annotation score: | ||
Q5T093 | Q5T093_HUMAN | Protein RER1 | RER1 | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 123 – 196 | HAATK…KAFAS → DASVCGDGRCSCKAGGGRQC PVLAADAALTFSPHLKACGY QGHPCGYGLYFLRRFQRPGV LADSGDVLHHALLYHDEEAN QAHD in AAC72940 (Ref. 2) CuratedAdd BLAST | 74 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001421 mRNA Translation: CAA04754.1 AF091071 mRNA Translation: AAC72940.1 BC004965 mRNA Translation: AAH04965.1 |
CCDSi | CCDS41232.1 |
RefSeqi | NP_008964.3, NM_007033.4 XP_006710369.1, XM_006710306.2 XP_011538844.1, XM_011540542.1 XP_011538845.1, XM_011540543.1 XP_016855622.1, XM_017000133.1 XP_016855623.1, XM_017000134.1 XP_016855624.1, XM_017000135.1 |
UniGenei | Hs.525527 |
Genome annotation databases
Ensembli | ENST00000488353; ENSP00000464222; ENSG00000157916 ENST00000605895; ENSP00000475168; ENSG00000157916 |
GeneIDi | 11079 |
KEGGi | hsa:11079 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001421 mRNA Translation: CAA04754.1 AF091071 mRNA Translation: AAC72940.1 BC004965 mRNA Translation: AAH04965.1 |
CCDSi | CCDS41232.1 |
RefSeqi | NP_008964.3, NM_007033.4 XP_006710369.1, XM_006710306.2 XP_011538844.1, XM_011540542.1 XP_011538845.1, XM_011540543.1 XP_016855622.1, XM_017000133.1 XP_016855623.1, XM_017000134.1 XP_016855624.1, XM_017000135.1 |
UniGenei | Hs.525527 |
3D structure databases
ProteinModelPortali | O15258 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 116262, 39 interactors |
IntActi | O15258, 17 interactors |
MINTi | O15258 |
STRINGi | 9606.ENSP00000302088 |
Protein family/group databases
TCDBi | 9.B.82.1.2 the endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family |
PTM databases
iPTMneti | O15258 |
PhosphoSitePlusi | O15258 |
SwissPalmi | O15258 |
Polymorphism and mutation databases
BioMutai | RER1 |
Proteomic databases
EPDi | O15258 |
jPOSTi | O15258 |
PaxDbi | O15258 |
PeptideAtlasi | O15258 |
PRIDEi | O15258 |
ProteomicsDBi | 48544 |
Protocols and materials databases
DNASUi | 11079 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000488353; ENSP00000464222; ENSG00000157916 ENST00000605895; ENSP00000475168; ENSG00000157916 |
GeneIDi | 11079 |
KEGGi | hsa:11079 |
Organism-specific databases
CTDi | 11079 |
DisGeNETi | 11079 |
EuPathDBi | HostDB:ENSG00000157916.18 |
GeneCardsi | RER1 |
HGNCi | HGNC:30309 RER1 |
HPAi | CAB037240 HPA051400 |
neXtProti | NX_O15258 |
OpenTargetsi | ENSG00000157916 |
PharmGKBi | PA134901074 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1688 Eukaryota COG5249 LUCA |
GeneTreei | ENSGT00510000047137 |
HOVERGENi | HBG002871 |
InParanoidi | O15258 |
OMAi | LPEWQFW |
OrthoDBi | 1458086at2759 |
PhylomeDBi | O15258 |
TreeFami | TF300029 |
Miscellaneous databases
ChiTaRSi | RER1 human |
GenomeRNAii | 11079 |
PROi | PR:O15258 |
Gene expression databases
Bgeei | ENSG00000157916 Expressed in 233 organ(s), highest expression level in lower esophagus mucosa |
ExpressionAtlasi | O15258 baseline and differential |
Genevisiblei | O15258 HS |
Family and domain databases
InterProi | View protein in InterPro IPR004932 Rer1 |
PANTHERi | PTHR10743 PTHR10743, 1 hit |
Pfami | View protein in Pfam PF03248 Rer1, 1 hit |
PIRSFi | PIRSF016013 AtER_Rer1p, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | RER1_HUMAN | |
Accessioni | O15258Primary (citable) accession number: O15258 Secondary accession number(s): O95322 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 13, 2019 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM