UniProtKB - O15254 (ACOX3_HUMAN)
Protein
Peroxisomal acyl-coenzyme A oxidase 3
Gene
ACOX3
Organism
Homo sapiens (Human)
Status
Functioni
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity
Catalytic activityi
- EC:1.3.3.6By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Cofactori
FADBy similarity
: peroxisomal fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.
GO - Molecular functioni
- acyl-CoA oxidase activity Source: GO_Central
- FAD binding Source: InterPro
- fatty acid binding Source: GO_Central
- flavin adenine dinucleotide binding Source: GO_Central
- pristanoyl-CoA oxidase activity Source: GO_Central
GO - Biological processi
- fatty acid beta-oxidation using acyl-CoA oxidase Source: GO_Central
- lipid homeostasis Source: GO_Central
- protein targeting to peroxisome Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
PathwayCommonsi | O15254 |
Reactomei | R-HSA-389887, Beta-oxidation of pristanoyl-CoA R-HSA-9033241, Peroxisomal protein import |
UniPathwayi | UPA00661 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6By similarity)Alternative name(s): Branched-chain acyl-CoA oxidase Short name: BRCACox Pristanoyl-CoA oxidaseBy similarity |
Gene namesi | Name:ACOX3 Synonyms:BRCOX, PRCOX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000087008.15 |
HGNCi | HGNC:121, ACOX3 |
MIMi | 603402, gene |
neXtProti | NX_O15254 |
Subcellular locationi
Peroxisome
- Peroxisome Curated
Cytosol
- cytosol Source: Reactome
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisome Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePathology & Biotechi
Organism-specific databases
DisGeNETi | 8310 |
OpenTargetsi | ENSG00000087008 |
PharmGKBi | PA24445 |
Miscellaneous databases
Pharosi | O15254, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105817 |
Polymorphism and mutation databases
BioMutai | ACOX3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000204685 | 2 – 700 | Peroxisomal acyl-coenzyme A oxidase 3Add BLAST | 699 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 281 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O15254 |
jPOSTi | O15254 |
MassIVEi | O15254 |
MaxQBi | O15254 |
PaxDbi | O15254 |
PeptideAtlasi | O15254 |
PRIDEi | O15254 |
ProteomicsDBi | 48541 [O15254-1] 48542 [O15254-2] |
PTM databases
iPTMneti | O15254 |
PhosphoSitePlusi | O15254 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087008, Expressed in lower esophagus mucosa and 190 other tissues |
ExpressionAtlasi | O15254, baseline and differential |
Genevisiblei | O15254, HS |
Organism-specific databases
HPAi | ENSG00000087008, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113907, 12 interactors |
IntActi | O15254, 9 interactors |
MINTi | O15254 |
STRINGi | 9606.ENSP00000348775 |
Miscellaneous databases
RNActi | O15254, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 698 – 700 | Microbody targeting signalBy similarity | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 343 | Poly-Glu | 4 |
Sequence similaritiesi
Belongs to the acyl-CoA oxidase family.Curated
Phylogenomic databases
eggNOGi | KOG0135, Eukaryota |
GeneTreei | ENSGT00940000159423 |
HOGENOMi | CLU_014629_4_2_1 |
InParanoidi | O15254 |
OMAi | VIKGCFS |
OrthoDBi | 226134at2759 |
PhylomeDBi | O15254 |
TreeFami | TF314226 |
Family and domain databases
CDDi | cd01150, AXO, 1 hit |
InterProi | View protein in InterPro IPR034171, ACO IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR012258, Acyl-CoA_oxidase IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
PIRSFi | PIRSF000168, Acyl-CoA_oxidase, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O15254-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT
60 70 80 90 100
IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP
110 120 130 140 150
LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM
160 170 180 190 200
EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM
210 220 230 240 250
GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK
260 270 280 290 300
LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS
310 320 330 340 350
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP
360 370 380 390 400
MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI
410 420 430 440 450
HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY
460 470 480 490 500
EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF
510 520 530 540 550
EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC
560 570 580 590 600
QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL
610 620 630 640 650
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV
660 670 680 690 700
LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RJ89 | D6RJ89_HUMAN | Peroxisomal acyl-coenzyme A oxidase... | ACOX3 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 – 35 | EL → DV in CAA72214 (PubMed:9271077).Curated | 2 | |
Sequence conflicti | 44 – 45 | ML → NV in CAA72214 (PubMed:9271077).Curated | 2 | |
Sequence conflicti | 95 | D → A in CAA72214 (PubMed:9271077).Curated | 1 | |
Sequence conflicti | 365 | A → G in CAA72214 (PubMed:9271077).Curated | 1 | |
Sequence conflicti | 601 | S → K in CAA72214 (PubMed:9271077).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030802 | 34 | E → A. Corresponds to variant dbSNP:rs12513296EnsemblClinVar. | 1 | |
Natural variantiVAR_030803 | 497 | D → N. Corresponds to variant dbSNP:rs13434465EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023355 | 610 – 624 | GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_023356 | 625 – 700 | Missing in isoform 2. 1 PublicationAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11411 mRNA Translation: CAA72214.1 BC017053 mRNA Translation: AAH17053.1 |
CCDSi | CCDS3401.1 [O15254-1] CCDS47017.1 [O15254-2] |
RefSeqi | NP_001095137.1, NM_001101667.1 [O15254-2] NP_003492.2, NM_003501.2 [O15254-1] XP_005248068.1, XM_005248011.4 XP_005248070.1, XM_005248013.3 XP_011511867.1, XM_011513565.2 [O15254-1] |
Genome annotation databases
Ensembli | ENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1] ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2] ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1] |
GeneIDi | 8310 |
KEGGi | hsa:8310 |
UCSCi | uc003glc.5, human [O15254-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11411 mRNA Translation: CAA72214.1 BC017053 mRNA Translation: AAH17053.1 |
CCDSi | CCDS3401.1 [O15254-1] CCDS47017.1 [O15254-2] |
RefSeqi | NP_001095137.1, NM_001101667.1 [O15254-2] NP_003492.2, NM_003501.2 [O15254-1] XP_005248068.1, XM_005248011.4 XP_005248070.1, XM_005248013.3 XP_011511867.1, XM_011513565.2 [O15254-1] |
3D structure databases
SMRi | O15254 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113907, 12 interactors |
IntActi | O15254, 9 interactors |
MINTi | O15254 |
STRINGi | 9606.ENSP00000348775 |
Chemistry databases
ChEMBLi | CHEMBL4105817 |
PTM databases
iPTMneti | O15254 |
PhosphoSitePlusi | O15254 |
Polymorphism and mutation databases
BioMutai | ACOX3 |
Proteomic databases
EPDi | O15254 |
jPOSTi | O15254 |
MassIVEi | O15254 |
MaxQBi | O15254 |
PaxDbi | O15254 |
PeptideAtlasi | O15254 |
PRIDEi | O15254 |
ProteomicsDBi | 48541 [O15254-1] 48542 [O15254-2] |
Protocols and materials databases
Antibodypediai | 52278, 101 antibodies |
Genome annotation databases
Ensembli | ENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1] ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2] ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1] |
GeneIDi | 8310 |
KEGGi | hsa:8310 |
UCSCi | uc003glc.5, human [O15254-1] |
Organism-specific databases
CTDi | 8310 |
DisGeNETi | 8310 |
EuPathDBi | HostDB:ENSG00000087008.15 |
GeneCardsi | ACOX3 |
HGNCi | HGNC:121, ACOX3 |
HPAi | ENSG00000087008, Low tissue specificity |
MIMi | 603402, gene |
neXtProti | NX_O15254 |
OpenTargetsi | ENSG00000087008 |
PharmGKBi | PA24445 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0135, Eukaryota |
GeneTreei | ENSGT00940000159423 |
HOGENOMi | CLU_014629_4_2_1 |
InParanoidi | O15254 |
OMAi | VIKGCFS |
OrthoDBi | 226134at2759 |
PhylomeDBi | O15254 |
TreeFami | TF314226 |
Enzyme and pathway databases
UniPathwayi | UPA00661 |
PathwayCommonsi | O15254 |
Reactomei | R-HSA-389887, Beta-oxidation of pristanoyl-CoA R-HSA-9033241, Peroxisomal protein import |
Miscellaneous databases
BioGRID-ORCSi | 8310, 2 hits in 841 CRISPR screens |
ChiTaRSi | ACOX3, human |
GeneWikii | ACOX3 |
GenomeRNAii | 8310 |
Pharosi | O15254, Tbio |
PROi | PR:O15254 |
RNActi | O15254, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087008, Expressed in lower esophagus mucosa and 190 other tissues |
ExpressionAtlasi | O15254, baseline and differential |
Genevisiblei | O15254, HS |
Family and domain databases
CDDi | cd01150, AXO, 1 hit |
InterProi | View protein in InterPro IPR034171, ACO IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR012258, Acyl-CoA_oxidase IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
PIRSFi | PIRSF000168, Acyl-CoA_oxidase, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACOX3_HUMAN | |
Accessioni | O15254Primary (citable) accession number: O15254 Secondary accession number(s): Q96AJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations