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UniProtKB - O15254 (ACOX3_HUMAN)

Entry version 177 (07 Apr 2021)
Sequence version 2 (20 Feb 2007)
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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

ACOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15254

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389887, Beta-oxidation of pristanoyl-CoA
R-HSA-9033241, Peroxisomal protein import

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00661

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6By similarity)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOX3
Synonyms:BRCOX, PRCOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:121, ACOX3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603402, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15254

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000087008.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8310

Open Targets

More...OpenTargetsi		ENSG00000087008

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15254, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105817

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACOX3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002046852 – 700Peroxisomal acyl-coenzyme A oxidase 3Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei281PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15254

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15254

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15254

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15254

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15254

PeptideAtlas

More...PeptideAtlasi		O15254

PRoteomics IDEntifications database

More...PRIDEi		O15254

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48541 [O15254-1]
48542 [O15254-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15254

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15254

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000087008, Expressed in lower esophagus mucosa and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15254, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15254, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000087008, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113907, 12 interactors

Protein interaction database and analysis system

More...IntActi		O15254, 9 interactors

Molecular INTeraction database

More...MINTi		O15254

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348775

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15254, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15254

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi698 – 700Microbody targeting signalBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 343Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0135, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014629_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15254

Identification of Orthologs from Complete Genome Data

More...OMAi		VIKGCFS

Database of Orthologous Groups

More...OrthoDBi		226134at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15254

TreeFam database of animal gene trees

More...TreeFami		TF314226

Family and domain databases

Conserved Domains Database

More...CDDi		cd01150, AXO, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034171, ACO
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009100, AcylCoA_DH/oxidase_NM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01756, ACOX, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000168, Acyl-CoA_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15254-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT 
        60         70         80         90        100
IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP 
       110        120        130        140        150
LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM 
       160        170        180        190        200
EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM 
       210        220        230        240        250
GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK 
       260        270        280        290        300
LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 
       310        320        330        340        350
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP 
       360        370        380        390        400
MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI 
       410        420        430        440        450
HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY 
       460        470        480        490        500
EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF 
       510        520        530        540        550
EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC 
       560        570        580        590        600
QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 
       610        620        630        640        650
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV 
       660        670        680        690        700
LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL
Length:700
Mass (Da):77,629
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40D1CD3DC6A620C1
GO
Isoform 2 (identifier: O15254-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
     625-700: Missing.

Show »
Length:624
Mass (Da):69,575
Checksum:i1894338CCBF1939A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ89D6RJ89_HUMAN
Peroxisomal acyl-coenzyme A oxidase...
ACOX3
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34 – 35EL → DV in CAA72214 (PubMed:9271077).Curated2
Sequence conflicti44 – 45ML → NV in CAA72214 (PubMed:9271077).Curated2
Sequence conflicti95D → A in CAA72214 (PubMed:9271077).Curated1
Sequence conflicti365A → G in CAA72214 (PubMed:9271077).Curated1
Sequence conflicti601S → K in CAA72214 (PubMed:9271077).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03080234E → A. Corresponds to variant dbSNP:rs12513296EnsemblClinVar.1
Natural variantiVAR_030803497D → N. Corresponds to variant dbSNP:rs13434465EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023355610 – 624GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023356625 – 700Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y11411 mRNA Translation: CAA72214.1
BC017053 mRNA Translation: AAH17053.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3401.1 [O15254-1]
CCDS47017.1 [O15254-2]

NCBI Reference Sequences

More...RefSeqi		NP_001095137.1, NM_001101667.1 [O15254-2]
NP_003492.2, NM_003501.2 [O15254-1]
XP_005248068.1, XM_005248011.4
XP_005248070.1, XM_005248013.3
XP_011511867.1, XM_011513565.2 [O15254-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1]
ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2]
ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8310

UCSC genome browser

More...UCSCi		uc003glc.5, human [O15254-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11411 mRNA Translation: CAA72214.1
BC017053 mRNA Translation: AAH17053.1
CCDSiCCDS3401.1 [O15254-1]
CCDS47017.1 [O15254-2]
RefSeqiNP_001095137.1, NM_001101667.1 [O15254-2]
NP_003492.2, NM_003501.2 [O15254-1]
XP_005248068.1, XM_005248011.4
XP_005248070.1, XM_005248013.3
XP_011511867.1, XM_011513565.2 [O15254-1]

3D structure databases

SMRiO15254
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113907, 12 interactors
IntActiO15254, 9 interactors
MINTiO15254
STRINGi9606.ENSP00000348775

Chemistry databases

ChEMBLiCHEMBL4105817

PTM databases

iPTMnetiO15254
PhosphoSitePlusiO15254

Genetic variation databases

BioMutaiACOX3

Proteomic databases

EPDiO15254
jPOSTiO15254
MassIVEiO15254
MaxQBiO15254
PaxDbiO15254
PeptideAtlasiO15254
PRIDEiO15254
ProteomicsDBi48541 [O15254-1]
48542 [O15254-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52278, 107 antibodies

Genome annotation databases

EnsembliENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1]
ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2]
ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1]
GeneIDi8310
KEGGihsa:8310
UCSCiuc003glc.5, human [O15254-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8310
DisGeNETi8310

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACOX3
HGNCiHGNC:121, ACOX3
HPAiENSG00000087008, Low tissue specificity
MIMi603402, gene
neXtProtiNX_O15254
OpenTargetsiENSG00000087008
PharmGKBiPA24445
VEuPathDBiHostDB:ENSG00000087008.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0135, Eukaryota
GeneTreeiENSGT00940000159423
HOGENOMiCLU_014629_4_2_1
InParanoidiO15254
OMAiVIKGCFS
OrthoDBi226134at2759
PhylomeDBiO15254
TreeFamiTF314226

Enzyme and pathway databases

UniPathwayiUPA00661
PathwayCommonsiO15254
ReactomeiR-HSA-389887, Beta-oxidation of pristanoyl-CoA
R-HSA-9033241, Peroxisomal protein import

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8310, 5 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACOX3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ACOX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8310
PharosiO15254, Tbio

Protein Ontology

More...PROi		PR:O15254
RNActiO15254, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000087008, Expressed in lower esophagus mucosa and 190 other tissues
ExpressionAtlasiO15254, baseline and differential
GenevisibleiO15254, HS

Family and domain databases

CDDicd01150, AXO, 1 hit
InterProiView protein in InterPro
IPR034171, ACO
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009100, AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756, ACOX, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168, Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: April 7, 2021
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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