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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

ACOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity1 Publication

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

  • acyl-CoA oxidase activity Source: GO_Central
  • FAD binding Source: InterPro
  • fatty acid binding Source: GO_Central
  • flavin adenine dinucleotide binding Source: GO_Central
  • pristanoyl-CoA oxidase activity Source: GO_Central
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import
UniPathwayi
UPA00661

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:ACOX3
Synonyms:BRCOX, PRCOX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000087008.15
HGNCiHGNC:121 ACOX3
MIMi603402 gene
neXtProtiNX_O15254

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8310
OpenTargetsiENSG00000087008
PharmGKBiPA24445

Polymorphism and mutation databases

BioMutaiACOX3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002046852 – 700Peroxisomal acyl-coenzyme A oxidase 3Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei281PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO15254
MaxQBiO15254
PaxDbiO15254
PeptideAtlasiO15254
PRIDEiO15254
ProteomicsDBi48541
48542 [O15254-2]

PTM databases

iPTMnetiO15254
PhosphoSitePlusiO15254

Expressioni

Gene expression databases

BgeeiENSG00000087008 Expressed in 178 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ACOX3
ExpressionAtlasiO15254 baseline and differential
GenevisibleiO15254 HS

Organism-specific databases

HPAiHPA035840
HPA035841

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113907, 11 interactors
IntActiO15254, 2 interactors
MINTiO15254
STRINGi9606.ENSP00000348775

Structurei

3D structure databases

ProteinModelPortaliO15254
SMRiO15254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi698 – 700Microbody targeting signalBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi340 – 343Poly-Glu4

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000245077
HOVERGENiHBG101107
InParanoidiO15254
KOiK00232
OMAiVIKGCFS
OrthoDBiEOG091G04U6
PhylomeDBiO15254
TreeFamiTF314226

Family and domain databases

CDDicd01150 AXO, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15254-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT
60 70 80 90 100
IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP
110 120 130 140 150
LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM
160 170 180 190 200
EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM
210 220 230 240 250
GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK
260 270 280 290 300
LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS
310 320 330 340 350
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP
360 370 380 390 400
MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI
410 420 430 440 450
HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY
460 470 480 490 500
EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF
510 520 530 540 550
EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC
560 570 580 590 600
QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL
610 620 630 640 650
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV
660 670 680 690 700
LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL
Length:700
Mass (Da):77,629
Last modified:February 20, 2007 - v2
Checksum:i40D1CD3DC6A620C1
GO
Isoform 2 (identifier: O15254-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
     625-700: Missing.

Note: No experimental confirmation available.
Show »
Length:624
Mass (Da):69,575
Checksum:i1894338CCBF1939A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ89D6RJ89_HUMAN
Peroxisomal acyl-coenzyme A oxidase...
ACOX3
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35EL → DV in CAA72214 (PubMed:9271077).Curated2
Sequence conflicti44 – 45ML → NV in CAA72214 (PubMed:9271077).Curated2
Sequence conflicti95D → A in CAA72214 (PubMed:9271077).Curated1
Sequence conflicti365A → G in CAA72214 (PubMed:9271077).Curated1
Sequence conflicti601S → K in CAA72214 (PubMed:9271077).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03080234E → A. Corresponds to variant dbSNP:rs12513296EnsemblClinVar.1
Natural variantiVAR_030803497D → N. Corresponds to variant dbSNP:rs13434465EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023355610 – 624GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023356625 – 700Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11411 mRNA Translation: CAA72214.1
BC017053 mRNA Translation: AAH17053.1
CCDSiCCDS3401.1 [O15254-1]
CCDS47017.1 [O15254-2]
RefSeqiNP_001095137.1, NM_001101667.1 [O15254-2]
NP_003492.2, NM_003501.2 [O15254-1]
XP_005248068.1, XM_005248011.4 [O15254-1]
XP_005248070.1, XM_005248013.3 [O15254-2]
XP_011511867.1, XM_011513565.2 [O15254-1]
UniGeneiHs.479122

Genome annotation databases

EnsembliENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1]
ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2]
ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1]
GeneIDi8310
KEGGihsa:8310
UCSCiuc003glc.5 human [O15254-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11411 mRNA Translation: CAA72214.1
BC017053 mRNA Translation: AAH17053.1
CCDSiCCDS3401.1 [O15254-1]
CCDS47017.1 [O15254-2]
RefSeqiNP_001095137.1, NM_001101667.1 [O15254-2]
NP_003492.2, NM_003501.2 [O15254-1]
XP_005248068.1, XM_005248011.4 [O15254-1]
XP_005248070.1, XM_005248013.3 [O15254-2]
XP_011511867.1, XM_011513565.2 [O15254-1]
UniGeneiHs.479122

3D structure databases

ProteinModelPortaliO15254
SMRiO15254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113907, 11 interactors
IntActiO15254, 2 interactors
MINTiO15254
STRINGi9606.ENSP00000348775

PTM databases

iPTMnetiO15254
PhosphoSitePlusiO15254

Polymorphism and mutation databases

BioMutaiACOX3

Proteomic databases

EPDiO15254
MaxQBiO15254
PaxDbiO15254
PeptideAtlasiO15254
PRIDEiO15254
ProteomicsDBi48541
48542 [O15254-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356406; ENSP00000348775; ENSG00000087008 [O15254-1]
ENST00000413009; ENSP00000413994; ENSG00000087008 [O15254-2]
ENST00000503233; ENSP00000421625; ENSG00000087008 [O15254-1]
GeneIDi8310
KEGGihsa:8310
UCSCiuc003glc.5 human [O15254-1]

Organism-specific databases

CTDi8310
DisGeNETi8310
EuPathDBiHostDB:ENSG00000087008.15
GeneCardsiACOX3
HGNCiHGNC:121 ACOX3
HPAiHPA035840
HPA035841
MIMi603402 gene
neXtProtiNX_O15254
OpenTargetsiENSG00000087008
PharmGKBiPA24445
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000245077
HOVERGENiHBG101107
InParanoidiO15254
KOiK00232
OMAiVIKGCFS
OrthoDBiEOG091G04U6
PhylomeDBiO15254
TreeFamiTF314226

Enzyme and pathway databases

UniPathwayi
UPA00661

ReactomeiR-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSiACOX3 human
GeneWikiiACOX3
GenomeRNAii8310
PROiPR:O15254
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087008 Expressed in 178 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ACOX3
ExpressionAtlasiO15254 baseline and differential
GenevisibleiO15254 HS

Family and domain databases

CDDicd01150 AXO, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACOX3_HUMAN
AccessioniPrimary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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