CLIC2

Functionⁱ

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.3 Publications

GO - Molecular functionⁱ

chloride channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glutathione peroxidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15147738
voltage-gated ion channel activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of ryanodine-sensitive calcium-release channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15147738
- 15916532
positive regulation of binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 15916532
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Source: BHF-UCL
Inferred by curatorⁱ
- 15147738
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Source: BHF-UCL
Inferred from direct assayⁱ
- 15147738
- 15916532
signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 16130169

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel, Voltage-gated channel
Biological process	Ion transport, Transport
Ligand	Chloride

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels R-HSA-5578775 Ion homeostasis

Reactomeⁱ

R-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

Protein family/group databases

TCDBⁱ	1.A.12.1.5 the intracellular chloride channel (clic) family

TCDBⁱ

1.A.12.1.5 the intracellular chloride channel (clic) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chloride intracellular channel protein 2 Alternative name(s): XAP121
Gene namesⁱ	Name:CLIC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155962.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2063 CLIC2
MIMⁱ	300138 gene
neXtProtⁱ	NX_O15247

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	32 – 52	Helical; Note=After insertion into the membraneSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, X-linked, syndromic, 32 (MRXS32)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mental retardation syndrome characterized by profound intellectual deficit, delayed psychomotor development beginning in infancy and little or no speech development. Additional features include seizures, large joint contractures, and abnormal positioning of the thumbs. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1193
MalaCards human disease database More...MalaCardsⁱ	CLIC2
MIMⁱ	300886 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000155962
Orphanetⁱ	324410 X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome
PharmGKBⁱ	PA26589

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144205	1 – 247	Chloride intracellular channel protein 2Add BLAST		247

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	30 ↔ 33	In soluble form2 Publications

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	O15247
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15247
PaxDbⁱ	O15247
PeptideAtlas More...PeptideAtlasⁱ	O15247
PRIDEⁱ	O15247
ProteomicsDBⁱ	48540

PTM databases

iPTMnetⁱ	O15247
PhosphoSitePlusⁱ	O15247

Expressionⁱ

Tissue specificityⁱ

Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000155962 Expressed in 180 organ(s), highest expression level in lymph node
CleanExⁱ	HS_CLIC2
ExpressionAtlasⁱ	O15247 baseline and differential
Genevisibleⁱ	O15247 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047381 HPA060101

HPAⁱ

HPA047381
HPA060101

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with TRAPPC2 and RYR2.4 Publications

Protein-protein interaction databases

BioGridⁱ	107605, 6 interactors
IntActⁱ	O15247, 2 interactors
STRINGⁱ	9606.ENSP00000358460

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	14 – 20	Combined sources	7
Beta strandⁱ	24 – 27	Combined sources	4
Helixⁱ	31 – 43	Combined sources	13
Beta strandⁱ	48 – 52	Combined sources	5
Helixⁱ	57 – 60	Combined sources	4
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	72 – 75	Combined sources	4
Beta strandⁱ	78 – 80	Combined sources	3
Helixⁱ	83 – 93	Combined sources	11
Turnⁱ	96 – 98	Combined sources	3
Helixⁱ	108 – 111	Combined sources	4
Turnⁱ	112 – 115	Combined sources	4
Helixⁱ	116 – 125	Combined sources	10
Helixⁱ	129 – 131	Combined sources	3
Helixⁱ	132 – 151	Combined sources	20
Turnⁱ	160 – 162	Combined sources	3
Beta strandⁱ	163 – 165	Combined sources	3
Beta strandⁱ	172 – 178	Combined sources	7
Helixⁱ	181 – 201	Combined sources	21
Helixⁱ	210 – 220	Combined sources	11
Helixⁱ	223 – 226	Combined sources	4
Helixⁱ	232 – 239	Combined sources	8
Turnⁱ	240 – 242	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O15247
SMRⁱ	O15247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O15247

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	99 – 239	GST C-terminalAdd BLAST		141

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 96	Required for insertion into the membraneBy similarityAdd BLAST	96
Regionⁱ	1 – 94	N-terminalAdd BLAST	94
Regionⁱ	95 – 106	Joint loopAdd BLAST	12
Regionⁱ	107 – 247	C-terminalAdd BLAST	141
Regionⁱ	151 – 171	Foot loopAdd BLAST	21

Domainⁱ

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

Sequence similaritiesⁱ

Belongs to the chloride channel CLIC family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1422 Eukaryota ENOG410ZRK6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074477
HOGENOMⁱ	HOG000231548
HOVERGENⁱ	HBG050994
InParanoidⁱ	O15247
KEGG Orthology (KO) More...KOⁱ	K05022
OMAⁱ	FTNQRET
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IHT
PhylomeDBⁱ	O15247
TreeFamⁱ	TF315438

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946 CLIC IPR030253 CLIC-2 IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR43920:SF4 PTHR43920:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13409 GST_N_2, 1 hit
PRINTSⁱ	PR01263 INTCLCHANNEL
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR00862 O-ClC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O15247-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT 
        60         70         80         90        100
TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP 
       110        120        130        140        150
HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL 
       160        170        180        190        200
NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY 
       210        220        230        240 
RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS

Length:247

Mass (Da):28,356

Last modified:September 13, 2005 - v3

Checksum:ⁱ9DB896034DD103E8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A6PVS0	A6PVS0_HUMAN		Chloride intracellular channel 2 Chloride intracellular channel 2 (Chloride intracellular channel protein 2)	CLIC2 RP13-228J13.7-004	133	Annotation score:

Sequence cautionⁱ

The sequence CAA73228 differs from that shown. Reason: Frameshift at position 244.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	109	S → C in CAA03948 (PubMed:9339381).Curated		1
Sequence conflictⁱ	164	E → G in CAA73228 (PubMed:9339381).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_068898	101	H → Q in MRXS32; results in stimulation of RYR channels activity with channels remaining open for longer times; the mutation may impair insertion of the protein into the membrane to form a functioning ion channel. 1 PublicationCorresponds to variant dbSNP:rs398122917EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y12696 mRNA Translation: CAA73228.1 Frameshift. AJ000217, AJ000218, AJ000219 Genomic DNA Translation: CAA03948.1 AK292785 mRNA Translation: BAF85474.1 AL356738 Genomic DNA Translation: CAI41464.1 CH471172 Genomic DNA Translation: EAW72624.1 BC022305 mRNA Translation: AAH22305.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14767.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001280.3, NM_001289.5
UniGeneⁱ	Hs.655445

Genome annotation databases

Ensemblⁱ	ENST00000369449; ENSP00000358460; ENSG00000155962
GeneIDⁱ	1193
KEGGⁱ	hsa:1193
UCSC genome browser More...UCSCⁱ	uc004fnf.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15247	Chloride intracellular channel protein		PANTR		247	UniRef100_O15247
Chloride intracellular channel protein		PANPA		247
Chloride intracellular channel protein		GORGO		247
UPI000181CDEC		HUMAN		267

Protein	Similar proteins		Species	Score	Length	Source
O15247	Chloride intracellular channel protein 2		RAT		245	UniRef90_O15247
Chloride intracellular channel protein		PANTR		247
Chloride intracellular channel protein		PANPA		247
Chloride intracellular channel protein		GORGO		247
LOW QUALITY PROTEIN: chloride intracellular channel protein 2-like		BALAS		248
+113

Protein	Similar proteins		Species	Score	Length	Source
O15247	Chloride intracellular channel protein 1	)	HUMAN		241	UniRef50_O00299
Chloride intracellular channel protein 1		MOUSE		241
Chloride intracellular channel protein 1		RABIT		241
Chloride intracellular channel protein 1		RAT		241
Chloride intracellular channel protein		PANTR		241
+378

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y12696 mRNA Translation: CAA73228.1 Frameshift. AJ000217, AJ000218, AJ000219 Genomic DNA Translation: CAA03948.1 AK292785 mRNA Translation: BAF85474.1 AL356738 Genomic DNA Translation: CAI41464.1 CH471172 Genomic DNA Translation: EAW72624.1 BC022305 mRNA Translation: AAH22305.1
CCDSⁱ	CCDS14767.1
RefSeqⁱ	NP_001280.3, NM_001289.5
UniGeneⁱ	Hs.655445

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2PER	X-ray	2.00	A	1-247	[»]
	2R4V	X-ray	1.85	A	1-247	[»]
	2R5G	X-ray	1.86	A	1-247	[»]
ProteinModelPortalⁱ	O15247
SMRⁱ	O15247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107605, 6 interactors
IntActⁱ	O15247, 2 interactors
STRINGⁱ	9606.ENSP00000358460

Protein family/group databases

TCDBⁱ	1.A.12.1.5 the intracellular chloride channel (clic) family

TCDBⁱ

1.A.12.1.5 the intracellular chloride channel (clic) family

PTM databases

iPTMnetⁱ	O15247
PhosphoSitePlusⁱ	O15247

Proteomic databases

EPDⁱ	O15247
MaxQBⁱ	O15247
PaxDbⁱ	O15247
PeptideAtlasⁱ	O15247
PRIDEⁱ	O15247
ProteomicsDBⁱ	48540

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1193
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369449; ENSP00000358460; ENSG00000155962
GeneIDⁱ	1193
KEGGⁱ	hsa:1193
UCSCⁱ	uc004fnf.5 human

Organism-specific databases

CTDⁱ	1193
DisGeNETⁱ	1193
EuPathDBⁱ	HostDB:ENSG00000155962.12
GeneCardsⁱ	CLIC2
HGNCⁱ	HGNC:2063 CLIC2
HPAⁱ	HPA047381 HPA060101
MalaCardsⁱ	CLIC2
MIMⁱ	300138 gene 300886 phenotype
neXtProtⁱ	NX_O15247
OpenTargetsⁱ	ENSG00000155962
Orphanetⁱ	324410 X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome
PharmGKBⁱ	PA26589
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1422 Eukaryota ENOG410ZRK6 LUCA
GeneTreeⁱ	ENSGT00550000074477
HOGENOMⁱ	HOG000231548
HOVERGENⁱ	HBG050994
InParanoidⁱ	O15247
KOⁱ	K05022
OMAⁱ	FTNQRET
OrthoDBⁱ	EOG091G0IHT
PhylomeDBⁱ	O15247
TreeFamⁱ	TF315438

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels R-HSA-5578775 Ion homeostasis

Reactomeⁱ

R-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

Miscellaneous databases

EvolutionaryTraceⁱ	O15247
GeneWikiⁱ	CLIC2
GenomeRNAiⁱ	1193
Protein Ontology More...PROⁱ	PR:O15247
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155962 Expressed in 180 organ(s), highest expression level in lymph node
CleanExⁱ	HS_CLIC2
ExpressionAtlasⁱ	O15247 baseline and differential
Genevisibleⁱ	O15247 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946 CLIC IPR030253 CLIC-2 IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR43920:SF4 PTHR43920:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF13409 GST_N_2, 1 hit
PRINTSⁱ	PR01263 INTCLCHANNEL
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR00862 O-ClC, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLIC2_HUMAN
Accessionⁱ	O15247Primary (citable) accession number: O15247 Secondary accession number(s): A8K9S0 , O15174, Q5JT80, Q8TCE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 13, 2005
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O15247 (CLIC2_HUMAN)

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Chloride intracellular channel protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ