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Protein

Solute carrier family 22 member 1

Gene

SLC22A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.8 Publications

Kineticsi

  1. KM=1.47 mM for metformin3 Publications
  2. KM=229 µM for TEA3 Publications
  3. KM=14.6 µM for MPP3 Publications
  1. Vmax=396 pmol/min/mg enzyme for metformin uptake3 Publications
  2. Vmax=2.89 nmol/min/mg enzyme for TEA uptake3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei450Involved in affinity and selectivity of cations as well as in translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-112311 Neurotransmitter clearance
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport

Protein family/group databases

TCDBi2.A.1.19.29 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 1
Alternative name(s):
Organic cation transporter 1
Short name:
hOCT1
Gene namesi
Name:SLC22A1
Synonyms:OCT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000175003.12
HGNCiHGNC:10963 SLC22A1
MIMi602607 gene
neXtProtiNX_O15245

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 149ExtracellularSequence analysisAdd BLAST107
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 176CytoplasmicSequence analysis6
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 206ExtracellularSequence analysis9
Transmembranei207 – 229HelicalSequence analysisAdd BLAST23
Topological domaini230 – 235CytoplasmicSequence analysis6
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 262ExtracellularSequence analysis6
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 347CytoplasmicSequence analysisAdd BLAST64
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 376ExtracellularSequence analysis8
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 402CytoplasmicSequence analysis5
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 431ExtracellularSequence analysis8
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 464CytoplasmicSequence analysisAdd BLAST12
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 492ExtracellularSequence analysis7
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 554CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi465G → A: No changes in the MPP uptake. 1 Publication1

Organism-specific databases

DisGeNETi6580
OpenTargetsiENSG00000175003
PharmGKBiPA329

Chemistry databases

ChEMBLiCHEMBL5685
DrugBankiDB01193 Acebutolol
DB01614 Acepromazine
DB03128 Acetylcholine
DB00787 Aciclovir
DB08838 Agmatine
DB00915 Amantadine
DB00594 Amiloride
DB00345 Aminohippuric acid
DB04830 Buformin
DB00520 Caspofungin
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00122 Choline
DB00501 Cimetidine
DB00242 Cladribine
DB00575 Clonidine
DB00318 Codeine
DB00987 Cytarabine
DB04485 Deoxythymidine
DB01151 Desipramine
DB09555 Dexchlorpheniramine maleate
DB00917 Dinoprostone
DB01075 Diphenhydramine
DB00280 Disopyramide
DB00988 Dopamine
DB00668 Epinephrine
DB00783 Estradiol
DB04574 Estrone sulfate
DB01004 Ganciclovir
DB00406 Gentian Violet
DB00536 Guanidine
DB05381 Histamine
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00709 Lamivudine
DB00654 Latanoprost
DB00331 Metformin
DB00683 Midazolam
DB00220 Nelfinavir
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB01337 Pancuronium
DB00914 Phenformin
DB00925 Phenoxybenzamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00457 Prazosin
DB01032 Probenecid
DB01035 Procainamide
DB00396 Progesterone
DB00908 Quinidine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB00728 Rocuronium
DB01232 Saquinavir
DB03566 Spermidine
DB00127 Spermine
DB04348 Taurocholic Acid
DB00624 Testosterone
DB08837 Tetraethylammonium
DB00152 Thiamine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01199 Tubocurarine
DB01339 Vecuronium
DB00661 Verapamil
GuidetoPHARMACOLOGYi1019

Polymorphism and mutation databases

BioMutaiSLC22A1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338751 – 554Solute carrier family 22 member 1Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei333PhosphoserineBy similarity1
Modified residuei541PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO15245
PeptideAtlasiO15245
PRIDEiO15245
ProteomicsDBi48536
48537 [O15245-2]
48538 [O15245-3]
48539 [O15245-4]

PTM databases

iPTMnetiO15245
PhosphoSitePlusiO15245

Expressioni

Tissue specificityi

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.3 Publications

Inductioni

In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells.2 Publications

Gene expression databases

BgeeiENSG00000175003 Expressed in 102 organ(s), highest expression level in liver
CleanExiHS_SLC22A1
ExpressionAtlasiO15245 baseline and differential
GenevisibleiO15245 HS

Organism-specific databases

HPAiHPA029846

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172714,EBI-1057080

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112467, 1 interactor
IntActiO15245, 2 interactors
STRINGi9606.ENSP00000355930

Chemistry databases

BindingDBiO15245

Structurei

3D structure databases

ProteinModelPortaliO15245
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO15245
KOiK08198
OMAiILMYLWF
OrthoDBiEOG091G05AC
PhylomeDBiO15245
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15245-1) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L554

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC
60 70 80 90 100
QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL
110 120 130 140 150
SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL
160 170 180 190 200
FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM
210 220 230 240 250
SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA
260 270 280 290 300
LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK
310 320 330 340 350
IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL
360 370 380 390 400
MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV
410 420 430 440 450
GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC
460 470 480 490 500
LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA
510 520 530 540 550
VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE

PSGT
Length:554
Mass (Da):61,154
Last modified:November 30, 2010 - v2
Checksum:i55206B897DE32202
GO
Isoform 2 (identifier: O15245-2) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L506

The sequence of this isoform differs from the canonical sequence as follows:
     462-506: RNLGVMVCSS...ILFAVLGLLA → SGVGPACRGS...SKAQRKHDLP
     507-554: Missing.

Show »
Length:506
Mass (Da):56,094
Checksum:iFDD376F7F8547B5D
GO
Isoform 3 (identifier: O15245-3) [UniParc]FASTAAdd to basket
Also known as: hOCT1G483

The sequence of this isoform differs from the canonical sequence as follows:
     462-532: Missing.

Show »
Length:483
Mass (Da):53,593
Checksum:i843CF89CFB1D9827
GO
Isoform 4 (identifier: O15245-4) [UniParc]FASTAAdd to basket
Also known as: hOCT1G353

The sequence of this isoform differs from the canonical sequence as follows:
     354-554: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:353
Mass (Da):39,224
Checksum:i88073B911A5E5633
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H5P3F5H5P3_HUMAN
Solute carrier family 22 member 1
SLC22A1
140Annotation score:
F5GY86F5GY86_HUMAN
Solute carrier family 22 member 1
SLC22A1
48Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04331914S → F Exclusively found in the African American population; increase of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34447885Ensembl.1
Natural variantiVAR_04332041F → L1 PublicationCorresponds to variant dbSNP:rs2297373Ensembl.1
Natural variantiVAR_04332161R → C Affects transporter activity; reduction of the MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant dbSNP:rs12208357Ensembl.1
Natural variantiVAR_04332285L → F No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs35546288Ensembl.1
Natural variantiVAR_04332388C → R1 PublicationCorresponds to variant dbSNP:rs55918055Ensembl.1
Natural variantiVAR_043324160L → F No changes in both TEA and MPP uptake; abolishes MPP uptake when associated with S-401; largely localized to the plasma membrane. 7 PublicationsCorresponds to variant dbSNP:rs683369Ensembl.1
Natural variantiVAR_043325189S → L No changes in the MPP uptake. 1 PublicationCorresponds to variant dbSNP:rs34104736Ensembl.1
Natural variantiVAR_043326220G → V Affects MPP uptake; reduction of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs36103319Ensembl.1
Natural variantiVAR_043327283P → L1 PublicationCorresponds to variant dbSNP:rs4646277Ensembl.1
Natural variantiVAR_043328287R → G1 PublicationCorresponds to variant dbSNP:rs4646278Ensembl.1
Natural variantiVAR_043329341P → L Affects transporter activity; reduction of the TEA uptake; reduction of the MPP uptake when associated with V-408; largely localized to the plasma membrane. 3 PublicationsCorresponds to variant dbSNP:rs2282143Ensembl.1
Natural variantiVAR_043330342R → H No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34205214Ensembl.1
Natural variantiVAR_043331401G → S Affects transporter activity; reduction of the serotonin uptake; no MPP uptake when associated with L-160. 2 PublicationsCorresponds to variant dbSNP:rs34130495Ensembl.1
Natural variantiVAR_043332408M → V Does not affect transporter activity; no changes in the MPP uptake when associated with F-14; no changes in the MPP uptake when associated with F-85; no changes in the MPP uptake when associated with L-189; no changes in the MPP uptake when associated with His-342; no changes in the MPP uptake when associated with M-420 del; no changes in the MPP uptake when associated with I-440; no changes in the MPP uptake when associated with I-461; no changes in the MPP uptake when associated with M-488; reduction of the MPP uptake when associated with C-61; no MPP uptake when associated with V-220; reduction of the MPP uptake when associated with L-341; no MPP uptake when associated with S-401; no MPP uptake when associated with R-465. 3 PublicationsCorresponds to variant dbSNP:rs628031Ensembl.1
Natural variantiVAR_043333420Missing No changes in the MPP uptake when associated with V-408. 3 Publications1
Natural variantiVAR_043334440M → I1 PublicationCorresponds to variant dbSNP:rs35956182Ensembl.1
Natural variantiVAR_043335461V → I No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34295611Ensembl.1
Natural variantiVAR_043336465G → R Reduction of the localization to the basolateral membrane; no MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant dbSNP:rs34059508Ensembl.1
Natural variantiVAR_043337488R → M No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs35270274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033587354 – 554Missing in isoform 4. CuratedAdd BLAST201
Alternative sequenceiVSP_033588462 – 532Missing in isoform 3. CuratedAdd BLAST71
Alternative sequenceiVSP_033589462 – 506RNLGV…LGLLA → SGVGPACRGSDATSSRDQGG RFARDHEGRREPWEKSKAQR KHDLP in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_033590507 – 554Missing in isoform 2. CuratedAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98332 mRNA Translation: CAA66977.1
U77086 mRNA Translation: AAB67703.1
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA Translation: CAB95971.1
AK289887 mRNA Translation: BAF82576.1
AL353625 Genomic DNA No translation available.
BC126364 mRNA Translation: AAI26365.1
CCDSiCCDS5274.1 [O15245-1]
CCDS5275.1 [O15245-2]
RefSeqiNP_003048.1, NM_003057.2 [O15245-1]
NP_694857.1, NM_153187.1 [O15245-2]
XP_006715615.1, XM_006715552.1 [O15245-3]
UniGeneiHs.117367

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003 [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003 [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003 [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003 [O15245-4]
ENST00000642587; ENSP00000495844; ENSG00000175003 [O15245-1]
GeneIDi6580
KEGGihsa:6580
UCSCiuc003qtc.4 human [O15245-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98332 mRNA Translation: CAA66977.1
U77086 mRNA Translation: AAB67703.1
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA Translation: CAB95971.1
AK289887 mRNA Translation: BAF82576.1
AL353625 Genomic DNA No translation available.
BC126364 mRNA Translation: AAI26365.1
CCDSiCCDS5274.1 [O15245-1]
CCDS5275.1 [O15245-2]
RefSeqiNP_003048.1, NM_003057.2 [O15245-1]
NP_694857.1, NM_153187.1 [O15245-2]
XP_006715615.1, XM_006715552.1 [O15245-3]
UniGeneiHs.117367

3D structure databases

ProteinModelPortaliO15245
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112467, 1 interactor
IntActiO15245, 2 interactors
STRINGi9606.ENSP00000355930

Chemistry databases

BindingDBiO15245
ChEMBLiCHEMBL5685
DrugBankiDB01193 Acebutolol
DB01614 Acepromazine
DB03128 Acetylcholine
DB00787 Aciclovir
DB08838 Agmatine
DB00915 Amantadine
DB00594 Amiloride
DB00345 Aminohippuric acid
DB04830 Buformin
DB00520 Caspofungin
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00122 Choline
DB00501 Cimetidine
DB00242 Cladribine
DB00575 Clonidine
DB00318 Codeine
DB00987 Cytarabine
DB04485 Deoxythymidine
DB01151 Desipramine
DB09555 Dexchlorpheniramine maleate
DB00917 Dinoprostone
DB01075 Diphenhydramine
DB00280 Disopyramide
DB00988 Dopamine
DB00668 Epinephrine
DB00783 Estradiol
DB04574 Estrone sulfate
DB01004 Ganciclovir
DB00406 Gentian Violet
DB00536 Guanidine
DB05381 Histamine
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00709 Lamivudine
DB00654 Latanoprost
DB00331 Metformin
DB00683 Midazolam
DB00220 Nelfinavir
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB01337 Pancuronium
DB00914 Phenformin
DB00925 Phenoxybenzamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00457 Prazosin
DB01032 Probenecid
DB01035 Procainamide
DB00396 Progesterone
DB00908 Quinidine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB00728 Rocuronium
DB01232 Saquinavir
DB03566 Spermidine
DB00127 Spermine
DB04348 Taurocholic Acid
DB00624 Testosterone
DB08837 Tetraethylammonium
DB00152 Thiamine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01199 Tubocurarine
DB01339 Vecuronium
DB00661 Verapamil
GuidetoPHARMACOLOGYi1019

Protein family/group databases

TCDBi2.A.1.19.29 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO15245
PhosphoSitePlusiO15245

Polymorphism and mutation databases

BioMutaiSLC22A1

Proteomic databases

PaxDbiO15245
PeptideAtlasiO15245
PRIDEiO15245
ProteomicsDBi48536
48537 [O15245-2]
48538 [O15245-3]
48539 [O15245-4]

Protocols and materials databases

DNASUi6580
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003 [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003 [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003 [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003 [O15245-4]
ENST00000642587; ENSP00000495844; ENSG00000175003 [O15245-1]
GeneIDi6580
KEGGihsa:6580
UCSCiuc003qtc.4 human [O15245-1]

Organism-specific databases

CTDi6580
DisGeNETi6580
EuPathDBiHostDB:ENSG00000175003.12
GeneCardsiSLC22A1
HGNCiHGNC:10963 SLC22A1
HPAiHPA029846
MIMi602607 gene
neXtProtiNX_O15245
OpenTargetsiENSG00000175003
PharmGKBiPA329
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO15245
KOiK08198
OMAiILMYLWF
OrthoDBiEOG091G05AC
PhylomeDBiO15245
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-112311 Neurotransmitter clearance
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport

Miscellaneous databases

GeneWikiiSLC22A1
GenomeRNAii6580
PROiPR:O15245
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175003 Expressed in 102 organ(s), highest expression level in liver
CleanExiHS_SLC22A1
ExpressionAtlasiO15245 baseline and differential
GenevisibleiO15245 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22A1_HUMAN
AccessioniPrimary (citable) accession number: O15245
Secondary accession number(s): A6NFF3
, A8K1H2, C9JSU6, O15395, Q9NQD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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