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Protein

Solute carrier family 22 member 1

Gene

SLC22A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.8 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.47 mM for metformin3 Publications
  2. KM=229 µM for TEA3 Publications
  3. KM=14.6 µM for MPP3 Publications
  1. Vmax=396 pmol/min/mg enzyme for metformin uptake3 Publications
  2. Vmax=2.89 nmol/min/mg enzyme for TEA uptake3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei450Involved in affinity and selectivity of cations as well as in translocationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112311 Neurotransmitter clearance
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.29 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 1
Alternative name(s):
Organic cation transporter 1
Short name:
hOCT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A1
Synonyms:OCT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175003.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10963 SLC22A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602607 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 149ExtracellularSequence analysisAdd BLAST107
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 176CytoplasmicSequence analysis6
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 206ExtracellularSequence analysis9
Transmembranei207 – 229HelicalSequence analysisAdd BLAST23
Topological domaini230 – 235CytoplasmicSequence analysis6
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 262ExtracellularSequence analysis6
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 347CytoplasmicSequence analysisAdd BLAST64
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 376ExtracellularSequence analysis8
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 402CytoplasmicSequence analysis5
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 431ExtracellularSequence analysis8
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 464CytoplasmicSequence analysisAdd BLAST12
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 492ExtracellularSequence analysis7
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 554CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi465G → A: No changes in the MPP uptake. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6580

Open Targets

More...
OpenTargetsi
ENSG00000175003

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA329

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5685

Drug and drug target database

More...
DrugBanki
DB01193 Acebutolol
DB01614 Acepromazine
DB03128 Acetylcholine
DB00787 Aciclovir
DB08838 Agmatine
DB00915 Amantadine
DB00594 Amiloride
DB00345 Aminohippuric acid
DB04830 Buformin
DB00520 Caspofungin
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00122 Choline
DB00501 Cimetidine
DB00242 Cladribine
DB00575 Clonidine
DB00318 Codeine
DB00987 Cytarabine
DB04485 Deoxythymidine
DB01151 Desipramine
DB09555 Dexchlorpheniramine maleate
DB00917 Dinoprostone
DB01075 Diphenhydramine
DB00280 Disopyramide
DB00988 Dopamine
DB00668 Epinephrine
DB00783 Estradiol
DB04574 Estrone sulfate
DB01004 Ganciclovir
DB00406 Gentian Violet
DB00536 Guanidine
DB05381 Histamine
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00709 Lamivudine
DB00654 Latanoprost
DB00331 Metformin
DB00683 Midazolam
DB00220 Nelfinavir
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB01337 Pancuronium
DB00914 Phenformin
DB00925 Phenoxybenzamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00457 Prazosin
DB01032 Probenecid
DB01035 Procainamide
DB00396 Progesterone
DB00908 Quinidine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB00728 Rocuronium
DB01232 Saquinavir
DB03566 Spermidine
DB00127 Spermine
DB04348 Taurocholic Acid
DB00624 Testosterone
DB08837 Tetraethylammonium
DB00152 Thiamine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01199 Tubocurarine
DB01339 Vecuronium
DB00661 Verapamil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1019

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003338751 – 554Solute carrier family 22 member 1Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineBy similarity1
Modified residuei541PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15245

PeptideAtlas

More...
PeptideAtlasi
O15245

PRoteomics IDEntifications database

More...
PRIDEi
O15245

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48536
48537 [O15245-2]
48538 [O15245-3]
48539 [O15245-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15245

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15245

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175003 Expressed in 102 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC22A1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15245 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15245 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029846

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172714,EBI-1057080

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112467, 1 interactor

Protein interaction database and analysis system

More...
IntActi
O15245, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355930

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15245

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15245

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234568

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061545

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15245

KEGG Orthology (KO)

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KOi
K08198

Identification of Orthologs from Complete Genome Data

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OMAi
LMYLWFS

Database of Orthologous Groups

More...
OrthoDBi
988547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15245

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00898 2A0119, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15245-1) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L554

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC
60 70 80 90 100
QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL
110 120 130 140 150
SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL
160 170 180 190 200
FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM
210 220 230 240 250
SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA
260 270 280 290 300
LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK
310 320 330 340 350
IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL
360 370 380 390 400
MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV
410 420 430 440 450
GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC
460 470 480 490 500
LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA
510 520 530 540 550
VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE

PSGT
Length:554
Mass (Da):61,154
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55206B897DE32202
GO
Isoform 2 (identifier: O15245-2) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L506

The sequence of this isoform differs from the canonical sequence as follows:
     462-506: RNLGVMVCSS...ILFAVLGLLA → SGVGPACRGS...SKAQRKHDLP
     507-554: Missing.

Show »
Length:506
Mass (Da):56,094
Checksum:iFDD376F7F8547B5D
GO
Isoform 3 (identifier: O15245-3) [UniParc]FASTAAdd to basket
Also known as: hOCT1G483

The sequence of this isoform differs from the canonical sequence as follows:
     462-532: Missing.

Show »
Length:483
Mass (Da):53,593
Checksum:i843CF89CFB1D9827
GO
Isoform 4 (identifier: O15245-4) [UniParc]FASTAAdd to basket
Also known as: hOCT1G353

The sequence of this isoform differs from the canonical sequence as follows:
     354-554: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:353
Mass (Da):39,224
Checksum:i88073B911A5E5633
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H5P3F5H5P3_HUMAN
Solute carrier family 22 member 1
SLC22A1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY86F5GY86_HUMAN
Solute carrier family 22 member 1
SLC22A1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04331914S → F Exclusively found in the African American population; increase of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34447885Ensembl.1
Natural variantiVAR_04332041F → L1 PublicationCorresponds to variant dbSNP:rs2297373Ensembl.1
Natural variantiVAR_04332161R → C Affects transporter activity; reduction of the MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant dbSNP:rs12208357Ensembl.1
Natural variantiVAR_04332285L → F No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs35546288Ensembl.1
Natural variantiVAR_04332388C → R1 PublicationCorresponds to variant dbSNP:rs55918055Ensembl.1
Natural variantiVAR_043324160L → F No changes in both TEA and MPP uptake; abolishes MPP uptake when associated with S-401; largely localized to the plasma membrane. 7 PublicationsCorresponds to variant dbSNP:rs683369Ensembl.1
Natural variantiVAR_043325189S → L No changes in the MPP uptake. 1 PublicationCorresponds to variant dbSNP:rs34104736Ensembl.1
Natural variantiVAR_043326220G → V Affects MPP uptake; reduction of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs36103319Ensembl.1
Natural variantiVAR_043327283P → L1 PublicationCorresponds to variant dbSNP:rs4646277Ensembl.1
Natural variantiVAR_043328287R → G1 PublicationCorresponds to variant dbSNP:rs4646278Ensembl.1
Natural variantiVAR_043329341P → L Affects transporter activity; reduction of the TEA uptake; reduction of the MPP uptake when associated with V-408; largely localized to the plasma membrane. 3 PublicationsCorresponds to variant dbSNP:rs2282143Ensembl.1
Natural variantiVAR_043330342R → H No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34205214Ensembl.1
Natural variantiVAR_043331401G → S Affects transporter activity; reduction of the serotonin uptake; no MPP uptake when associated with L-160. 2 PublicationsCorresponds to variant dbSNP:rs34130495Ensembl.1
Natural variantiVAR_043332408M → V Does not affect transporter activity; no changes in the MPP uptake when associated with F-14; no changes in the MPP uptake when associated with F-85; no changes in the MPP uptake when associated with L-189; no changes in the MPP uptake when associated with His-342; no changes in the MPP uptake when associated with M-420 del; no changes in the MPP uptake when associated with I-440; no changes in the MPP uptake when associated with I-461; no changes in the MPP uptake when associated with M-488; reduction of the MPP uptake when associated with C-61; no MPP uptake when associated with V-220; reduction of the MPP uptake when associated with L-341; no MPP uptake when associated with S-401; no MPP uptake when associated with R-465. 3 PublicationsCorresponds to variant dbSNP:rs628031Ensembl.1
Natural variantiVAR_043333420Missing No changes in the MPP uptake when associated with V-408. 3 Publications1
Natural variantiVAR_043334440M → I1 PublicationCorresponds to variant dbSNP:rs35956182Ensembl.1
Natural variantiVAR_043335461V → I No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs34295611Ensembl.1
Natural variantiVAR_043336465G → R Reduction of the localization to the basolateral membrane; no MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant dbSNP:rs34059508Ensembl.1
Natural variantiVAR_043337488R → M No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant dbSNP:rs35270274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033587354 – 554Missing in isoform 4. CuratedAdd BLAST201
Alternative sequenceiVSP_033588462 – 532Missing in isoform 3. CuratedAdd BLAST71
Alternative sequenceiVSP_033589462 – 506RNLGV…LGLLA → SGVGPACRGSDATSSRDQGG RFARDHEGRREPWEKSKAQR KHDLP in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_033590507 – 554Missing in isoform 2. CuratedAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X98332 mRNA Translation: CAA66977.1
U77086 mRNA Translation: AAB67703.1
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA Translation: CAB95971.1
AK289887 mRNA Translation: BAF82576.1
AL353625 Genomic DNA No translation available.
BC126364 mRNA Translation: AAI26365.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5274.1 [O15245-1]
CCDS5275.1 [O15245-2]

NCBI Reference Sequences

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RefSeqi
NP_003048.1, NM_003057.2 [O15245-1]
NP_694857.1, NM_153187.1 [O15245-2]
XP_006715615.1, XM_006715552.1 [O15245-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.117367

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324965; ENSP00000318103; ENSG00000175003 [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003 [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003 [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003 [O15245-4]
ENST00000642587; ENSP00000495844; ENSG00000175003 [O15245-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6580

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6580

UCSC genome browser

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UCSCi
uc003qtc.4 human [O15245-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98332 mRNA Translation: CAA66977.1
U77086 mRNA Translation: AAB67703.1
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA Translation: CAB95971.1
AK289887 mRNA Translation: BAF82576.1
AL353625 Genomic DNA No translation available.
BC126364 mRNA Translation: AAI26365.1
CCDSiCCDS5274.1 [O15245-1]
CCDS5275.1 [O15245-2]
RefSeqiNP_003048.1, NM_003057.2 [O15245-1]
NP_694857.1, NM_153187.1 [O15245-2]
XP_006715615.1, XM_006715552.1 [O15245-3]
UniGeneiHs.117367

3D structure databases

ProteinModelPortaliO15245
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112467, 1 interactor
IntActiO15245, 2 interactors
STRINGi9606.ENSP00000355930

Chemistry databases

BindingDBiO15245
ChEMBLiCHEMBL5685
DrugBankiDB01193 Acebutolol
DB01614 Acepromazine
DB03128 Acetylcholine
DB00787 Aciclovir
DB08838 Agmatine
DB00915 Amantadine
DB00594 Amiloride
DB00345 Aminohippuric acid
DB04830 Buformin
DB00520 Caspofungin
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB00122 Choline
DB00501 Cimetidine
DB00242 Cladribine
DB00575 Clonidine
DB00318 Codeine
DB00987 Cytarabine
DB04485 Deoxythymidine
DB01151 Desipramine
DB09555 Dexchlorpheniramine maleate
DB00917 Dinoprostone
DB01075 Diphenhydramine
DB00280 Disopyramide
DB00988 Dopamine
DB00668 Epinephrine
DB00783 Estradiol
DB04574 Estrone sulfate
DB01004 Ganciclovir
DB00406 Gentian Violet
DB00536 Guanidine
DB05381 Histamine
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00709 Lamivudine
DB00654 Latanoprost
DB00331 Metformin
DB00683 Midazolam
DB00220 Nelfinavir
DB00184 Nicotine
DB00368 Norepinephrine
DB00526 Oxaliplatin
DB01337 Pancuronium
DB00914 Phenformin
DB00925 Phenoxybenzamine
DB01621 Pipotiazine
DB00413 Pramipexole
DB00457 Prazosin
DB01032 Probenecid
DB01035 Procainamide
DB00396 Progesterone
DB00908 Quinidine
DB00468 Quinine
DB00863 Ranitidine
DB00206 Reserpine
DB00728 Rocuronium
DB01232 Saquinavir
DB03566 Spermidine
DB00127 Spermine
DB04348 Taurocholic Acid
DB00624 Testosterone
DB08837 Tetraethylammonium
DB00152 Thiamine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01199 Tubocurarine
DB01339 Vecuronium
DB00661 Verapamil
GuidetoPHARMACOLOGYi1019

Protein family/group databases

TCDBi2.A.1.19.29 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO15245
PhosphoSitePlusiO15245

Polymorphism and mutation databases

BioMutaiSLC22A1

Proteomic databases

PaxDbiO15245
PeptideAtlasiO15245
PRIDEiO15245
ProteomicsDBi48536
48537 [O15245-2]
48538 [O15245-3]
48539 [O15245-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6580
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003 [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003 [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003 [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003 [O15245-4]
ENST00000642587; ENSP00000495844; ENSG00000175003 [O15245-1]
GeneIDi6580
KEGGihsa:6580
UCSCiuc003qtc.4 human [O15245-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6580
DisGeNETi6580
EuPathDBiHostDB:ENSG00000175003.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC22A1
HGNCiHGNC:10963 SLC22A1
HPAiHPA029846
MIMi602607 gene
neXtProtiNX_O15245
OpenTargetsiENSG00000175003
PharmGKBiPA329

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000162065
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO15245
KOiK08198
OMAiLMYLWFS
OrthoDBi988547at2759
PhylomeDBiO15245
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-112311 Neurotransmitter clearance
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127 Organic cation transport

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC22A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6580

Protein Ontology

More...
PROi
PR:O15245

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175003 Expressed in 102 organ(s), highest expression level in liver
CleanExiHS_SLC22A1
ExpressionAtlasiO15245 baseline and differential
GenevisibleiO15245 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15245
Secondary accession number(s): A6NFF3
, A8K1H2, C9JSU6, O15395, Q9NQD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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