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Entry version 172 (12 Aug 2020)
Sequence version 2 (30 Nov 2010)
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Protein

Solute carrier family 22 member 2

Gene

SLC22A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.14 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 mM for agmatine8 Publications
  2. KM=95 µM for amiloride8 Publications
  3. KM=24 µM for ASP8 Publications
  4. KM=34 µM for memantine8 Publications
  5. KM=27 µM for amantadine8 Publications
  6. KM=1.38 mM for metformin8 Publications
  7. KM=1.9 mM for noradrenaline8 Publications
  8. KM=1.9 mM for norepinephrine8 Publications
  9. KM=1.3 mM for histamine8 Publications
  10. KM=0.39 mM for dopamine8 Publications
  11. KM=0.08 mM for serotonin8 Publications
  12. KM=72.6 µM for cimetidine (at pH 7.4 and 37 degrees Celsius)8 Publications
  13. KM=56.1 µM for famotidine8 Publications
  14. KM=65.2 µM for ranitidine8 Publications
  15. KM=431 µM for TEA (isoform 1)8 Publications
  16. KM=63 µM for TEA (isoform 2)8 Publications
  1. Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1)8 Publications
  2. Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2)8 Publications
  3. Vmax=11.9 nmol/min/mg enzyme for metformin uptake8 Publications
  4. Vmax=2170 pmol/min/mg enzyme for cimetidine uptake8 Publications
  5. Vmax=204 pmol/min/mg enzyme for famotidine uptake8 Publications
  6. Vmax=265 pmol/min/mg enzyme for ranitidine uptake8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei451Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cationsBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O15244

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112311, Neurotransmitter clearance
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517, Abacavir transmembrane transport
R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127, Organic cation transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.30, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 2
Alternative name(s):
Organic cation transporter 2
Short name:
hOCT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A2
Synonyms:OCT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112499.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10966, SLC22A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602608, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15244

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 150ExtracellularSequence analysisAdd BLAST107
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 177CytoplasmicSequence analysis6
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 208ExtracellularSequence analysis10
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 238CytoplasmicSequence analysis9
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263ExtracellularSequence analysis4
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 348CytoplasmicSequence analysisAdd BLAST64
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 375ExtracellularSequence analysis6
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 414CytoplasmicSequence analysisAdd BLAST18
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 441ExtracellularSequence analysis6
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 464CytoplasmicSequence analysis2
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 494ExtracellularSequence analysis9
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 555CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6582

Open Targets

More...
OpenTargetsi
ENSG00000112499

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O15244, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743122

Drug and drug target database

More...
DrugBanki
DB12001, Abemaciclib
DB08838, Agmatine
DB00437, Allopurinol
DB00915, Amantadine
DB00594, Amiloride
DB00345, Aminohippuric acid
DB01118, Amiodarone
DB11901, Apalutamide
DB11817, Baricitinib
DB01156, Bupropion
DB01114, Chlorpheniramine
DB00122, Choline
DB14006, Choline salicylate
DB00501, Cimetidine
DB00515, Cisplatin
DB00758, Clopidogrel
DB00907, Cocaine
DB06637, Dalfampridine
DB01151, Desipramine
DB09555, Dexchlorpheniramine maleate
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01075, Diphenhydramine
DB00280, Disopyramide
DB00204, Dofetilide
DB08930, Dolutegravir
DB00988, Dopamine
DB04855, Dronedarone
DB13874, Enasidenib
DB00668, Epinephrine
DB12147, Erdafitinib
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00927, Famotidine
DB00690, Flurazepam
DB00365, Grepafloxacin
DB01018, Guanfacine
DB00536, Guanidine
DB05381, Histamine
DB00619, Imatinib
DB00458, Imipramine
DB11633, Isavuconazole
DB00709, Lamivudine
DB00555, Lamotrigine
DB00448, Lansoprazole
DB09078, Lenvatinib
DB01137, Levofloxacin
DB08882, Linagliptin
DB01043, Memantine
DB00331, Metformin
DB09241, Methylene blue
DB00264, Metoprolol
DB08840, N-methylnicotinamide
DB12598, Nafamostat
DB00184, Nicotine
DB00368, Norepinephrine
DB11837, Osilodrostat
DB00526, Oxaliplatin
DB01580, Oxprenolol
DB01337, Pancuronium
DB00914, Phenformin
DB00925, Phenoxybenzamine
DB05383, Pimagedine
DB00413, Pramipexole
DB01032, Probenecid
DB01035, Procainamide
DB00396, Progesterone
DB00571, Propranolol
DB01103, Quinacrine
DB00908, Quinidine
DB00468, Quinine
DB00863, Ranitidine
DB00206, Reserpine
DB12457, Rimegepant
DB00938, Salmeterol
DB08839, Serotonin
DB14754, Solriamfetol
DB06608, Tafenoquine
DB13946, Testosterone undecanoate
DB08837, Tetraethylammonium
DB00152, Thiamine
DB09343, Tipiracil
DB01199, Tubocurarine
DB11652, Tucatinib
DB15328, Ubrogepant
DB05294, Vandetanib
DB01273, Varenicline
DB00495, Zidovudine

DrugCentral

More...
DrugCentrali
O15244

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1020

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209571 – 555Solute carrier family 22 member 2Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O15244

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15244

PeptideAtlas

More...
PeptideAtlasi
O15244

PRoteomics IDEntifications database

More...
PRIDEi
O15244

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48533 [O15244-1]
48534 [O15244-2]
48535 [O15244-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O15244, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15244

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

May be down-regulated in diabetic patients.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112499, Expressed in adult mammalian kidney and 80 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15244, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15244, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112499, Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112469, 43 interactors

Protein interaction database and analysis system

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IntActi
O15244, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355920

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15244

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O15244, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155089

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_33_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15244

KEGG Orthology (KO)

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KOi
K08199

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHIGEFH

Database of Orthologous Groups

More...
OrthoDBi
326501at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15244

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR004749, Orgcat_transp/SVOP
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083, Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00898, 2A0119, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15244-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR
60 70 80 90 100
CRSPGVAELS LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST
110 120 130 140 150
FDCVDPLASL DTNRSRLPLG PCRDGWVYET PGSSIVTEFN LVCANSWMLD
160 170 180 190 200
LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL LTTVLINAAA GVLMAISPTY
210 220 230 240 250
TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF YQVAYTVGLL
260 270 280 290 300
VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM
310 320 330 340 350
RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI
360 370 380 390 400
LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR
410 420 430 440 450
IGRRYPWAAS NMVAGAACLA SVFIPGDLQW LKIIISCLGR MGITMAYEIV
460 470 480 490 500
CLVNAELYPT FIRNLGVHIC SSMCDIGGII TPFLVYRLTN IWLELPLMVF
510 520 530 540 550
GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE KMIYLQVQKL

DIPLN
Length:555
Mass (Da):62,581
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06528F9519CE211E
GO
Isoform 2 (identifier: O15244-2) [UniParc]FASTAAdd to basket
Also known as: OCT2-A

The sequence of this isoform differs from the canonical sequence as follows:
     427-483: DLQWLKIIIS...CDIGGIITPF → GKFQVKLESY...SEQIHMASLL
     484-555: Missing.

Show »
Length:483
Mass (Da):54,475
Checksum:i0AD53D9697B4E7B2
GO
Isoform 3 (identifier: O15244-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-242: ITEFVGRRYRRTVGIFYQ → SKNVCACNCENKATSLPK
     243-555: Missing.

Show »
Length:242
Mass (Da):26,685
Checksum:i510EAB0C05C06B43
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T7Q5Q5T7Q5_HUMAN
Solute carrier family 22 member 2
SLC22A2
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03932254P → S1 PublicationCorresponds to variant dbSNP:rs8177504Ensembl.1
Natural variantiVAR_039323165M → I Lower Vmax. 1 PublicationCorresponds to variant dbSNP:rs8177507Ensembl.1
Natural variantiVAR_039324201T → M1 PublicationCorresponds to variant dbSNP:rs145450955Ensembl.1
Natural variantiVAR_039325270S → A Increased Ki value for TBA inhibition of MPP. 6 PublicationsCorresponds to variant dbSNP:rs316019Ensembl.1
Natural variantiVAR_039326297A → G. Corresponds to variant dbSNP:rs8177513Ensembl.1
Natural variantiVAR_039327400R → C Lower Vmax and reduced Ki value for TBA inhibition of MPP. 1 PublicationCorresponds to variant dbSNP:rs8177516Ensembl.1
Natural variantiVAR_039328432K → Q Lower Km value for MPP and reduced Ki value for TBA inhibition of MPP. 1 PublicationCorresponds to variant dbSNP:rs8177517Ensembl.1
Natural variantiVAR_039329463R → K. Corresponds to variant dbSNP:rs3907239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031771225 – 242ITEFV…GIFYQ → SKNVCACNCENKATSLPK in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_031772243 – 555Missing in isoform 3. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_031773427 – 483DLQWL…IITPF → GKFQVKLESYLQDPGERECH GPLIGKPCNLSSKSIWKDKL EGSIWDPSEQIHMASLL in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_031774484 – 555Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X98333 mRNA Translation: CAA66978.1
AB075951 mRNA Translation: BAC02720.1
AK290787 mRNA Translation: BAF83476.1
AL162582 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47602.1
BC030978 mRNA Translation: AAH30978.1
BC039899 mRNA Translation: AAH39899.1
AJ251885 Genomic DNA Translation: CAB96133.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5276.1 [O15244-1]

NCBI Reference Sequences

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RefSeqi
NP_003049.2, NM_003058.3 [O15244-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366953; ENSP00000355920; ENSG00000112499 [O15244-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6582

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6582

UCSC genome browser

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UCSCi
uc003qtf.4, human [O15244-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98333 mRNA Translation: CAA66978.1
AB075951 mRNA Translation: BAC02720.1
AK290787 mRNA Translation: BAF83476.1
AL162582 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47602.1
BC030978 mRNA Translation: AAH30978.1
BC039899 mRNA Translation: AAH39899.1
AJ251885 Genomic DNA Translation: CAB96133.1
CCDSiCCDS5276.1 [O15244-1]
RefSeqiNP_003049.2, NM_003058.3 [O15244-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112469, 43 interactors
IntActiO15244, 8 interactors
STRINGi9606.ENSP00000355920

Chemistry databases

BindingDBiO15244
ChEMBLiCHEMBL1743122
DrugBankiDB12001, Abemaciclib
DB08838, Agmatine
DB00437, Allopurinol
DB00915, Amantadine
DB00594, Amiloride
DB00345, Aminohippuric acid
DB01118, Amiodarone
DB11901, Apalutamide
DB11817, Baricitinib
DB01156, Bupropion
DB01114, Chlorpheniramine
DB00122, Choline
DB14006, Choline salicylate
DB00501, Cimetidine
DB00515, Cisplatin
DB00758, Clopidogrel
DB00907, Cocaine
DB06637, Dalfampridine
DB01151, Desipramine
DB09555, Dexchlorpheniramine maleate
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01075, Diphenhydramine
DB00280, Disopyramide
DB00204, Dofetilide
DB08930, Dolutegravir
DB00988, Dopamine
DB04855, Dronedarone
DB13874, Enasidenib
DB00668, Epinephrine
DB12147, Erdafitinib
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00927, Famotidine
DB00690, Flurazepam
DB00365, Grepafloxacin
DB01018, Guanfacine
DB00536, Guanidine
DB05381, Histamine
DB00619, Imatinib
DB00458, Imipramine
DB11633, Isavuconazole
DB00709, Lamivudine
DB00555, Lamotrigine
DB00448, Lansoprazole
DB09078, Lenvatinib
DB01137, Levofloxacin
DB08882, Linagliptin
DB01043, Memantine
DB00331, Metformin
DB09241, Methylene blue
DB00264, Metoprolol
DB08840, N-methylnicotinamide
DB12598, Nafamostat
DB00184, Nicotine
DB00368, Norepinephrine
DB11837, Osilodrostat
DB00526, Oxaliplatin
DB01580, Oxprenolol
DB01337, Pancuronium
DB00914, Phenformin
DB00925, Phenoxybenzamine
DB05383, Pimagedine
DB00413, Pramipexole
DB01032, Probenecid
DB01035, Procainamide
DB00396, Progesterone
DB00571, Propranolol
DB01103, Quinacrine
DB00908, Quinidine
DB00468, Quinine
DB00863, Ranitidine
DB00206, Reserpine
DB12457, Rimegepant
DB00938, Salmeterol
DB08839, Serotonin
DB14754, Solriamfetol
DB06608, Tafenoquine
DB13946, Testosterone undecanoate
DB08837, Tetraethylammonium
DB00152, Thiamine
DB09343, Tipiracil
DB01199, Tubocurarine
DB11652, Tucatinib
DB15328, Ubrogepant
DB05294, Vandetanib
DB01273, Varenicline
DB00495, Zidovudine
DrugCentraliO15244
GuidetoPHARMACOLOGYi1020

Protein family/group databases

TCDBi2.A.1.19.30, the major facilitator superfamily (mfs)

PTM databases

GlyGeniO15244, 1 site
iPTMnetiO15244
PhosphoSitePlusiO15244

Polymorphism and mutation databases

BioMutaiSLC22A2

Proteomic databases

MassIVEiO15244
PaxDbiO15244
PeptideAtlasiO15244
PRIDEiO15244
ProteomicsDBi48533 [O15244-1]
48534 [O15244-2]
48535 [O15244-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
20032, 253 antibodies

Genome annotation databases

EnsembliENST00000366953; ENSP00000355920; ENSG00000112499 [O15244-1]
GeneIDi6582
KEGGihsa:6582
UCSCiuc003qtf.4, human [O15244-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6582
DisGeNETi6582
EuPathDBiHostDB:ENSG00000112499.12

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A2
HGNCiHGNC:10966, SLC22A2
HPAiENSG00000112499, Tissue enriched (kidney)
MIMi602608, gene
neXtProtiNX_O15244
OpenTargetsiENSG00000112499
PharmGKBiPA331

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255, Eukaryota
GeneTreeiENSGT00940000155089
HOGENOMiCLU_001265_33_5_1
InParanoidiO15244
KOiK08199
OMAiEHIGEFH
OrthoDBi326501at2759
PhylomeDBiO15244
TreeFamiTF315847

Enzyme and pathway databases

PathwayCommonsiO15244
ReactomeiR-HSA-112311, Neurotransmitter clearance
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-2161517, Abacavir transmembrane transport
R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters
R-HSA-549127, Organic cation transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6582, 4 hits in 867 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC22A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6582
PharosiO15244, Tchem

Protein Ontology

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PROi
PR:O15244
RNActiO15244, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112499, Expressed in adult mammalian kidney and 80 other tissues
ExpressionAtlasiO15244, baseline and differential
GenevisibleiO15244, HS

Family and domain databases

InterProiView protein in InterPro
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR004749, Orgcat_transp/SVOP
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00898, 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15244
Secondary accession number(s): Q5T7Q6
, Q6PIQ8, Q8NG62, Q9NQB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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