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Protein

Leptin receptor gene-related protein

Gene

LEPROT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.2 Publications

Caution

This protein is encoded by LEPR gene, but shares with LEPR only the first two 5'-UTR exons. It therefore does not share any sequence similarity with LEPR.Curated

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor gene-related protein
Alternative name(s):
Endospanin-1
Leptin receptor overlapping transcript protein
OB-R gene-related protein
Short name:
OB-RGRP
Gene namesi
Name:LEPROT
Synonyms:LEPR, OBR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213625.8
HGNCiHGNC:29477 LEPROT
MIMi613461 gene
neXtProtiNX_O15243

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54741
OpenTargetsiENSG00000213625
PharmGKBiPA134913422

Polymorphism and mutation databases

BioMutaiLEPROT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151941 – 131Leptin receptor gene-related proteinAdd BLAST131

Proteomic databases

EPDiO15243
MaxQBiO15243
PaxDbiO15243
PeptideAtlasiO15243
PRIDEiO15243
ProteomicsDBi48532

PTM databases

SwissPalmiO15243

Expressioni

Tissue specificityi

Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000213625 Expressed in 240 organ(s), highest expression level in oviduct epithelium
CleanExiHS_LEPR
ExpressionAtlasiO15243 baseline and differential
GenevisibleiO15243 HS

Organism-specific databases

HPAiHPA069444

Interactioni

Subunit structurei

Interacts with LEPR. Interacts with RAB13 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120123, 1 interactor
DIPiDIP-29969N
IntActiO15243, 10 interactors
STRINGi9606.ENSP00000360104

Structurei

3D structure databases

ProteinModelPortaliO15243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2174 Eukaryota
ENOG4111UCZ LUCA
GeneTreeiENSGT00390000006503
HOGENOMiHOG000038515
HOVERGENiHBG001034
InParanoidiO15243
PhylomeDBiO15243
TreeFamiTF313689

Family and domain databases

InterProiView protein in InterPro
IPR007262 VPS55
PANTHERiPTHR12050 PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133 Vps55, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O15243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FHAISPIPHF
60 70 80 90 100
IAKRVTYDSD ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG
110 120 130
LVLAGNAVIF LTIQGFFLIF GRGDDFSWEQ W
Length:131
Mass (Da):14,254
Last modified:January 1, 1998 - v1
Checksum:i0F9CE741C2C5ED9C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0N2A0A087X0N2_HUMAN
Leptin receptor gene-related protei...
LEPROT
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12670 mRNA Translation: CAA73211.1
CR541647 mRNA Translation: CAG46448.1
CR541737 mRNA Translation: CAG46537.1
AK074841 mRNA Translation: BAG52014.1
AC119800 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06527.1
CH471059 Genomic DNA Translation: EAX06531.1
BC011027 mRNA Translation: AAH11027.2
BC056250 mRNA Translation: AAH56250.1
CCDSiCCDS630.1
RefSeqiNP_001185612.1, NM_001198683.1
NP_059996.1, NM_017526.4
UniGeneiHs.23581
Hs.258228

Genome annotation databases

EnsembliENST00000371065; ENSP00000360104; ENSG00000213625
GeneIDi54741
KEGGihsa:54741
UCSCiuc001dcf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12670 mRNA Translation: CAA73211.1
CR541647 mRNA Translation: CAG46448.1
CR541737 mRNA Translation: CAG46537.1
AK074841 mRNA Translation: BAG52014.1
AC119800 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06527.1
CH471059 Genomic DNA Translation: EAX06531.1
BC011027 mRNA Translation: AAH11027.2
BC056250 mRNA Translation: AAH56250.1
CCDSiCCDS630.1
RefSeqiNP_001185612.1, NM_001198683.1
NP_059996.1, NM_017526.4
UniGeneiHs.23581
Hs.258228

3D structure databases

ProteinModelPortaliO15243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120123, 1 interactor
DIPiDIP-29969N
IntActiO15243, 10 interactors
STRINGi9606.ENSP00000360104

PTM databases

SwissPalmiO15243

Polymorphism and mutation databases

BioMutaiLEPROT

Proteomic databases

EPDiO15243
MaxQBiO15243
PaxDbiO15243
PeptideAtlasiO15243
PRIDEiO15243
ProteomicsDBi48532

Protocols and materials databases

DNASUi54741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371065; ENSP00000360104; ENSG00000213625
GeneIDi54741
KEGGihsa:54741
UCSCiuc001dcf.4 human

Organism-specific databases

CTDi54741
DisGeNETi54741
EuPathDBiHostDB:ENSG00000213625.8
GeneCardsiLEPROT
HGNCiHGNC:29477 LEPROT
HPAiHPA069444
MIMi613461 gene
neXtProtiNX_O15243
OpenTargetsiENSG00000213625
PharmGKBiPA134913422
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2174 Eukaryota
ENOG4111UCZ LUCA
GeneTreeiENSGT00390000006503
HOGENOMiHOG000038515
HOVERGENiHBG001034
InParanoidiO15243
PhylomeDBiO15243
TreeFamiTF313689

Miscellaneous databases

ChiTaRSiLEPROT human
GenomeRNAii54741
PROiPR:O15243
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213625 Expressed in 240 organ(s), highest expression level in oviduct epithelium
CleanExiHS_LEPR
ExpressionAtlasiO15243 baseline and differential
GenevisibleiO15243 HS

Family and domain databases

InterProiView protein in InterPro
IPR007262 VPS55
PANTHERiPTHR12050 PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133 Vps55, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOBRG_HUMAN
AccessioniPrimary (citable) accession number: O15243
Secondary accession number(s): Q6FHL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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