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Protein

Neurosecretory protein VGF

Gene

VGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.By similarity
NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.1 Publication
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurosecretory protein VGF
Cleaved into the following 3 chains:
Gene namesi
Name:VGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128564.6
HGNCiHGNC:12684 VGF
MIMi602186 gene
neXtProtiNX_O15240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7425
OpenTargetsiENSG00000128564
PharmGKBiPA37305

Polymorphism and mutation databases

BioMutaiVGF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002265523 – 615Neurosecretory protein VGFAdd BLAST593
PeptideiPRO_0000403364281 – 306Neuroendocrine regulatory peptide-1Add BLAST26
PeptideiPRO_0000403365310 – 347Neuroendocrine regulatory peptide-2Add BLAST38
PeptideiPRO_0000422072554 – 577Antimicrobial peptide VGF[554-577]Add BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310Pyrrolidone carboxylic acid1 Publication1
Modified residuei420Phosphoserine; by FAM20C1 Publication1
Modified residuei424Phosphothreonine; by FAM20C1 Publication1
Modified residuei577Proline amide1 Publication1

Post-translational modificationi

Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiO15240
MaxQBiO15240
PaxDbiO15240
PeptideAtlasiO15240
PRIDEiO15240
ProteomicsDBi48531

PTM databases

iPTMnetiO15240
PhosphoSitePlusiO15240

Expressioni

Tissue specificityi

Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.1 Publication

Gene expression databases

BgeeiENSG00000128564 Expressed in 140 organ(s), highest expression level in hypothalamus
CleanExiHS_VGF
ExpressionAtlasiO15240 baseline and differential
GenevisibleiO15240 HS

Organism-specific databases

HPAiHPA055177
HPA072505

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113268, 5 interactors
IntActiO15240, 2 interactors
STRINGi9606.ENSP00000249330

Structurei

3D structure databases

ProteinModelPortaliO15240
SMRiO15240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi353 – 447Asp/Glu-rich (acidic)Add BLAST95

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKTZ Eukaryota
ENOG410YR85 LUCA
GeneTreeiENSGT00390000017745
HOGENOMiHOG000120127
HOVERGENiHBG006806
InParanoidiO15240
OMAiYIRPRTL
OrthoDBiEOG091G0H7O
PhylomeDBiO15240
TreeFamiTF338498

Family and domain databases

InterProiView protein in InterPro
IPR026128 VGF
PANTHERiPTHR15159 PTHR15159, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O15240-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG
60 70 80 90 100
PKDGSAPEVR GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS
110 120 130 140 150
GSQQGPEEEA AEALLTETVR SQTHSLPAPE SPEPAAPPRP QTPENGPEAS
160 170 180 190 200
DPSEELEALA SLLQELRDFS PSSAKRQQET AAAETETRTH TLTRVNLESP
210 220 230 240 250
GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP LPETHKFGEG
260 270 280 290 300
VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG
310 320 330 340 350
LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG
360 370 380 390 400
LQEAAEERES AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ
410 420 430 440 450
NALLFAEEED GEAGAEDKRS QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ
460 470 480 490 500
TIDSLIELST KLHLPADDVV SIIEEVEEKR KRKKNAPPEP VPPPRAAPAP
510 520 530 540 550
THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP GPYHPFPNYI
560 570 580 590 600
RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ
610
EELENYIEHV LLRRP
Length:615
Mass (Da):67,258
Last modified:September 23, 2008 - v2
Checksum:i198097C5622AC087
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q05BJ3Q05BJ3_HUMAN
Neurosecretory protein VGF
VGF
377Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129 – 131PES → AGE in CAA73210 (PubMed:9344675).Curated3
Sequence conflicti282P → A in CAA73210 (PubMed:9344675).Curated1
Sequence conflicti387E → EA in CAA73210 (PubMed:9344675).Curated1
Sequence conflicti393E → D in CAA73210 (PubMed:9344675).Curated1
Sequence conflicti481K → N in CAA73210 (PubMed:9344675).Curated1
Sequence conflicti485N → K in CAA73210 (PubMed:9344675).Curated1
Sequence conflicti512 – 515APAP → PPS in CAA73210 (PubMed:9344675).Curated4
Sequence conflicti585 – 586RA → HAQ in CAA73210 (PubMed:9344675).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12661 Genomic DNA Translation: CAA73210.1
AC004876 Genomic DNA Translation: AAD45830.1
CH471197 Genomic DNA Translation: EAW50201.1
BC063835 mRNA Translation: AAH63835.1
CCDSiCCDS5712.1
RefSeqiNP_003369.2, NM_003378.3
XP_005250618.1, XM_005250561.4
XP_011514851.1, XM_011516549.2
XP_016868068.1, XM_017012579.1
UniGeneiHs.587325

Genome annotation databases

EnsembliENST00000249330; ENSP00000249330; ENSG00000128564
ENST00000445482; ENSP00000400884; ENSG00000128564
GeneIDi7425
KEGGihsa:7425
UCSCiuc003uxx.5 human

Similar proteinsi

Entry informationi

Entry nameiVGF_HUMAN
AccessioniPrimary (citable) accession number: O15240
Secondary accession number(s): Q9UDW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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