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Protein

28S ribosomal protein S12, mitochondrial

Gene

MRPS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Mitochondrial small ribosomal subunit protein uS12m1 Publication
Gene namesi
Name:MRPS12
Synonyms:RPMS12, RPSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000128626.11
HGNCiHGNC:10380 MRPS12
MIMi603021 gene
neXtProtiNX_O15235

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128626
PharmGKBiPA30996

Polymorphism and mutation databases

BioMutaiMRPS12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003060630 – 13828S ribosomal protein S12, mitochondrialAdd BLAST109

Proteomic databases

EPDiO15235
MaxQBiO15235
PaxDbiO15235
PeptideAtlasiO15235
PRIDEiO15235
ProteomicsDBi48529
TopDownProteomicsiO15235

PTM databases

iPTMnetiO15235
PhosphoSitePlusiO15235

Expressioni

Gene expression databases

BgeeiENSG00000128626 Expressed in 215 organ(s), highest expression level in apex of heart
CleanExiHS_MRPS12
ExpressionAtlasiO15235 baseline and differential
GenevisibleiO15235 HS

Organism-specific databases

HPAiHPA046775
HPA050633

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-712205,EBI-1182445

Protein-protein interaction databases

BioGridi112098, 22 interactors
CORUMiO15235
IntActiO15235, 23 interactors
MINTiO15235
STRINGi9606.ENSP00000308845

Structurei

3D structure databases

ProteinModelPortaliO15235
SMRiO15235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1750 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000075103
HOGENOMiHOG000040063
HOVERGENiHBG001525
InParanoidiO15235
KOiK02950
OMAiHSLQEHH
OrthoDBiEOG091G0U3U
PhylomeDBiO15235
TreeFamiTF315095

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG
60 70 80 90 100
PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH
110 120 130
TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK
Length:138
Mass (Da):15,173
Last modified:January 1, 1998 - v1
Checksum:i893FD2CA1C7187A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0518208H → R. Corresponds to variant dbSNP:rs33988199Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11681 mRNA Translation: CAA72377.1
AF058761 Genomic DNA Translation: AAC64704.1
CR407609 mRNA Translation: CAG28537.1
CH471126 Genomic DNA Translation: EAW56849.1
BC001617 mRNA Translation: AAH01617.1
BC006424 mRNA Translation: AAH06424.1
BC007499 mRNA Translation: AAH07499.1
CCDSiCCDS12525.1
RefSeqiNP_066930.1, NM_021107.1
NP_203526.1, NM_033362.3
NP_203527.1, NM_033363.1
UniGeneiHs.411125

Genome annotation databases

EnsembliENST00000308018; ENSP00000308845; ENSG00000128626
ENST00000402029; ENSP00000384579; ENSG00000128626
ENST00000407800; ENSP00000384952; ENSG00000128626
ENST00000634246; ENSP00000488926; ENSG00000283018
ENST00000634400; ENSP00000489467; ENSG00000283018
ENST00000634704; ENSP00000489374; ENSG00000283018
GeneIDi6183
KEGGihsa:6183
UCSCiuc002okc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11681 mRNA Translation: CAA72377.1
AF058761 Genomic DNA Translation: AAC64704.1
CR407609 mRNA Translation: CAG28537.1
CH471126 Genomic DNA Translation: EAW56849.1
BC001617 mRNA Translation: AAH01617.1
BC006424 mRNA Translation: AAH06424.1
BC007499 mRNA Translation: AAH07499.1
CCDSiCCDS12525.1
RefSeqiNP_066930.1, NM_021107.1
NP_203526.1, NM_033362.3
NP_203527.1, NM_033363.1
UniGeneiHs.411125

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AJ1-138[»]
ProteinModelPortaliO15235
SMRiO15235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112098, 22 interactors
CORUMiO15235
IntActiO15235, 23 interactors
MINTiO15235
STRINGi9606.ENSP00000308845

PTM databases

iPTMnetiO15235
PhosphoSitePlusiO15235

Polymorphism and mutation databases

BioMutaiMRPS12

Proteomic databases

EPDiO15235
MaxQBiO15235
PaxDbiO15235
PeptideAtlasiO15235
PRIDEiO15235
ProteomicsDBi48529
TopDownProteomicsiO15235

Protocols and materials databases

DNASUi6183
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308018; ENSP00000308845; ENSG00000128626
ENST00000402029; ENSP00000384579; ENSG00000128626
ENST00000407800; ENSP00000384952; ENSG00000128626
ENST00000634246; ENSP00000488926; ENSG00000283018
ENST00000634400; ENSP00000489467; ENSG00000283018
ENST00000634704; ENSP00000489374; ENSG00000283018
GeneIDi6183
KEGGihsa:6183
UCSCiuc002okc.4 human

Organism-specific databases

CTDi6183
EuPathDBiHostDB:ENSG00000128626.11
GeneCardsiMRPS12
HGNCiHGNC:10380 MRPS12
HPAiHPA046775
HPA050633
MIMi603021 gene
neXtProtiNX_O15235
OpenTargetsiENSG00000128626
PharmGKBiPA30996
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1750 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000075103
HOGENOMiHOG000040063
HOVERGENiHBG001525
InParanoidiO15235
KOiK02950
OMAiHSLQEHH
OrthoDBiEOG091G0U3U
PhylomeDBiO15235
TreeFamiTF315095

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMRPS12
GenomeRNAii6183
PROiPR:O15235
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128626 Expressed in 215 organ(s), highest expression level in apex of heart
CleanExiHS_MRPS12
ExpressionAtlasiO15235 baseline and differential
GenevisibleiO15235 HS

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT12_HUMAN
AccessioniPrimary (citable) accession number: O15235
Secondary accession number(s): Q53X98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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