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Entry version 156 (08 May 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Zinc finger protein 185

Gene

ZNF185

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of cellular proliferation and/or differentiation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 185
Alternative name(s):
LIM domain protein ZNF185
P1-A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF185
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12976 ZNF185

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300381 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15231

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7739

Open Targets

More...
OpenTargetsi
ENSG00000147394

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37558

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZNF185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759111 – 689Zinc finger protein 185Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineBy similarity1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Isoform 2 (identifier: O15231-2)
Modified residuei66PhosphoserineCombined sources1
Isoform 3 (identifier: O15231-3)
Modified residuei206PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15231

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15231

MaxQB - The MaxQuant DataBase

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MaxQBi
O15231

PeptideAtlas

More...
PeptideAtlasi
O15231

PRoteomics IDEntifications database

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PRIDEi
O15231

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48523
48524 [O15231-2]
48525 [O15231-3]
48526 [O15231-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15231

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15231

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147394 Expressed in 207 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15231 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15231 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000400
HPA016438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113525, 4 interactors

Protein interaction database and analysis system

More...
IntActi
O15231, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000440847

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini627 – 689LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 165Poly-Glu7

Keywords - Domaini

LIM domain

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232182

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15231

Identification of Orthologs from Complete Genome Data

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OMAi
EQPHVYI

Database of Orthologous Groups

More...
OrthoDBi
1419858at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15231

TreeFam database of animal gene trees

More...
TreeFami
TF335114

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030637 ZNF185
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR15468:SF2 PTHR15468:SF2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00132 LIM, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15231-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG
60 70 80 90 100
RTIELPSGRS RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ
110 120 130 140 150
PQQQFPKANG TPKSAASLVR TANAGPPRPS SSGYKMTTED YKKLAPYNIR
160 170 180 190 200
RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA ASGVLRRTAP REHSYVLSAA
210 220 230 240 250
KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS TPGSNSADGG
260 270 280 290 300
RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD
310 320 330 340 350
VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV
360 370 380 390 400
GSGATGSRPE GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD
410 420 430 440 450
PKGALADYEG KDVATRVGEA WQERPGAPRG GQGDPAVPAQ QPADPSTPER
460 470 480 490 500
QSSPSGSEQL VRRESCGSSV LTDFEGKDVA TKVGEAWQDR PGAPRGGQGD
510 520 530 540 550
PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS SCMVTVTVTA
560 570 580 590 600
TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV
610 620 630 640 650
SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC
660 670 680
CHEYCFKCGI CSKPMGDLLD QIFIHRDTIH CGKCYEKLF
Length:689
Mass (Da):73,525
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CCA739701FE1423
GO
Isoform 2 (identifier: O15231-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     141-144: YKKL → MQRQ
     205-205: G → GS
     246-275: Missing.
     305-372: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:452
Mass (Da):48,621
Checksum:i9B4871D31EEEE57C
GO
Isoform 3 (identifier: O15231-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-205: G → GS

Show »
Length:690
Mass (Da):73,613
Checksum:i7E7AFDCFF902FE68
GO
Isoform 4 (identifier: O15231-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-304: Missing.

Show »
Length:630
Mass (Da):67,281
Checksum:i63CC539EF52C25A5
GO
Isoform 5 (identifier: O15231-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     177-205: RSEAASGVLRRTAPREHSYVLSAAKKSTG → SS
     246-304: Missing.

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):49,972
Checksum:i530D1C7F62C34557
GO
Isoform 6 (identifier: O15231-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: G → GRLCAAASFASFLEDQDGHSANSQSCKPRPAAI

Show »
Length:721
Mass (Da):76,857
Checksum:i177A88C27289F3A6
GO
Isoform 7 (identifier: O15231-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-304: Missing.

Show »
Length:660
Mass (Da):70,380
Checksum:i373470CD29FE5785
GO
Isoform 8 (identifier: O15231-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-304: Missing.
     372-372: G → GRLCAAASFASFLEDQDGHSANSQSCKPRPAAI

Show »
Length:692
Mass (Da):73,711
Checksum:i38B94FB3CEF11C3E
GO
Isoform 9 (identifier: O15231-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: MSISALGGRT...QEDAKADPKG → MAARDELGLG...PEELAAPSPA

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):34,954
Checksum:iCCAF1D825E0F9C1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y704H0Y704_HUMAN
Zinc finger protein 185
ZNF185
448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZT5H7BZT5_HUMAN
Zinc finger protein 185
ZNF185
552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1R1H7C1R1_HUMAN
Zinc finger protein 185
ZNF185
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13K → E in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti132S → F in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti150R → G in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti236A → V in BAH13507 (PubMed:14702039).Curated1
Sequence conflicti257A → T in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti326A → S in BAH13507 (PubMed:14702039).Curated1
Sequence conflicti406A → D in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti408Y → C in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti414A → P in ABF57657 (PubMed:16799630).Curated1
Sequence conflicti414A → P in AAY54245 (PubMed:16799630).Curated1
Sequence conflicti414A → P in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti488Q → H in ABF57660 (PubMed:16799630).Curated1
Sequence conflicti492G → R in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti517Q → R in BAC04511 (PubMed:14702039).Curated1
Sequence conflicti621S → F in ABF57657 (PubMed:16799630).Curated1
Sequence conflicti621S → F in AAY54245 (PubMed:16799630).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547731 – 403MSISA…ADPKG → MAARDELGLGGDSLEAMPVP AARGRPRITNGPEELAAPSP A in isoform 9. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_0398981 – 140Missing in isoform 2. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_0450801 – 135Missing in isoform 5. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_039899141 – 144YKKL → MQRQ in isoform 2. 1 Publication4
Alternative sequenceiVSP_045081177 – 205RSEAA…KKSTG → SS in isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_039900205G → GS in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_043405246 – 304Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST59
Alternative sequenceiVSP_039901246 – 275Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_047205276 – 304Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_039902305 – 372Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_047206372G → GRLCAAASFASFLEDQDGHS ANSQSCKPRPAAI in isoform 6 and isoform 8. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095258 mRNA Translation: BAC04511.1
AY997296 mRNA Translation: AAY54245.1
DQ508022 mRNA Translation: ABF57657.1
DQ508023 mRNA Translation: ABF57658.1
DQ508024 mRNA Translation: ABF57659.1
DQ508025 mRNA Translation: ABF57660.1
DQ508026 mRNA Translation: ABF57661.1
Y09538 mRNA Translation: CAA70733.1
AK296967 mRNA Translation: BAG59511.1
AK301530 mRNA Translation: BAH13507.1
U82671 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72895.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48184.1 [O15231-1]
CCDS55528.1 [O15231-3]
CCDS55529.1 [O15231-6]
CCDS55530.1 [O15231-8]
CCDS55531.1 [O15231-4]
CCDS55532.1 [O15231-5]
CCDS69832.1 [O15231-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001171577.1, NM_001178106.1 [O15231-6]
NP_001171578.1, NM_001178107.1 [O15231-8]
NP_001171579.1, NM_001178108.1 [O15231-3]
NP_001171580.1, NM_001178109.1 [O15231-7]
NP_001171581.1, NM_001178110.1 [O15231-4]
NP_001171584.1, NM_001178113.1 [O15231-5]
NP_001171586.1, NM_001178115.1 [O15231-9]
NP_009081.2, NM_007150.3 [O15231-1]
XP_005274788.1, XM_005274731.2 [O15231-6]
XP_005274792.1, XM_005274735.2 [O15231-8]
XP_005274794.1, XM_005274737.2 [O15231-3]
XP_005274795.1, XM_005274738.2 [O15231-1]
XP_005274798.1, XM_005274741.2 [O15231-7]
XP_005274802.1, XM_005274745.2 [O15231-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318504; ENSP00000312782; ENSG00000147394 [O15231-4]
ENST00000318529; ENSP00000313919; ENSG00000147394 [O15231-5]
ENST00000324823; ENSP00000325307; ENSG00000147394 [O15231-2]
ENST00000370268; ENSP00000359291; ENSG00000147394 [O15231-1]
ENST00000370270; ENSP00000359293; ENSG00000147394 [O15231-6]
ENST00000449285; ENSP00000395228; ENSG00000147394 [O15231-3]
ENST00000454925; ENSP00000392984; ENSG00000147394 [O15231-9]
ENST00000535861; ENSP00000440847; ENSG00000147394 [O15231-6]
ENST00000539731; ENSP00000444367; ENSG00000147394 [O15231-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7739

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7739

UCSC genome browser

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UCSCi
uc004fgw.5 human [O15231-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095258 mRNA Translation: BAC04511.1
AY997296 mRNA Translation: AAY54245.1
DQ508022 mRNA Translation: ABF57657.1
DQ508023 mRNA Translation: ABF57658.1
DQ508024 mRNA Translation: ABF57659.1
DQ508025 mRNA Translation: ABF57660.1
DQ508026 mRNA Translation: ABF57661.1
Y09538 mRNA Translation: CAA70733.1
AK296967 mRNA Translation: BAG59511.1
AK301530 mRNA Translation: BAH13507.1
U82671 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72895.1
CCDSiCCDS48184.1 [O15231-1]
CCDS55528.1 [O15231-3]
CCDS55529.1 [O15231-6]
CCDS55530.1 [O15231-8]
CCDS55531.1 [O15231-4]
CCDS55532.1 [O15231-5]
CCDS69832.1 [O15231-9]
RefSeqiNP_001171577.1, NM_001178106.1 [O15231-6]
NP_001171578.1, NM_001178107.1 [O15231-8]
NP_001171579.1, NM_001178108.1 [O15231-3]
NP_001171580.1, NM_001178109.1 [O15231-7]
NP_001171581.1, NM_001178110.1 [O15231-4]
NP_001171584.1, NM_001178113.1 [O15231-5]
NP_001171586.1, NM_001178115.1 [O15231-9]
NP_009081.2, NM_007150.3 [O15231-1]
XP_005274788.1, XM_005274731.2 [O15231-6]
XP_005274792.1, XM_005274735.2 [O15231-8]
XP_005274794.1, XM_005274737.2 [O15231-3]
XP_005274795.1, XM_005274738.2 [O15231-1]
XP_005274798.1, XM_005274741.2 [O15231-7]
XP_005274802.1, XM_005274745.2 [O15231-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi113525, 4 interactors
IntActiO15231, 10 interactors
STRINGi9606.ENSP00000440847

PTM databases

iPTMnetiO15231
PhosphoSitePlusiO15231

Polymorphism and mutation databases

BioMutaiZNF185

Proteomic databases

EPDiO15231
jPOSTiO15231
MaxQBiO15231
PeptideAtlasiO15231
PRIDEiO15231
ProteomicsDBi48523
48524 [O15231-2]
48525 [O15231-3]
48526 [O15231-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7739
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318504; ENSP00000312782; ENSG00000147394 [O15231-4]
ENST00000318529; ENSP00000313919; ENSG00000147394 [O15231-5]
ENST00000324823; ENSP00000325307; ENSG00000147394 [O15231-2]
ENST00000370268; ENSP00000359291; ENSG00000147394 [O15231-1]
ENST00000370270; ENSP00000359293; ENSG00000147394 [O15231-6]
ENST00000449285; ENSP00000395228; ENSG00000147394 [O15231-3]
ENST00000454925; ENSP00000392984; ENSG00000147394 [O15231-9]
ENST00000535861; ENSP00000440847; ENSG00000147394 [O15231-6]
ENST00000539731; ENSP00000444367; ENSG00000147394 [O15231-8]
GeneIDi7739
KEGGihsa:7739
UCSCiuc004fgw.5 human [O15231-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7739
DisGeNETi7739

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF185
HGNCiHGNC:12976 ZNF185
HPAiHPA000400
HPA016438
MIMi300381 gene
neXtProtiNX_O15231
OpenTargetsiENSG00000147394
PharmGKBiPA37558

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00530000063872
HOGENOMiHOG000232182
InParanoidiO15231
OMAiEQPHVYI
OrthoDBi1419858at2759
PhylomeDBiO15231
TreeFamiTF335114

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF185 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7739

Protein Ontology

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PROi
PR:O15231

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147394 Expressed in 207 organ(s), highest expression level in caput epididymis
ExpressionAtlasiO15231 baseline and differential
GenevisibleiO15231 HS

Family and domain databases

InterProiView protein in InterPro
IPR030637 ZNF185
IPR001781 Znf_LIM
PANTHERiPTHR15468:SF2 PTHR15468:SF2, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN185_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15231
Secondary accession number(s): A4FTV3
, A6NME5, B4DLE9, B7Z771, B8K2L9, B8K2M0, B8K2M1, B8K2M2, E9PFR6, F5GXF7, F5GZL4, F8W8V7, H0Y4M8, O00345, Q8N1R8, Q9NSD2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 5, 2010
Last modified: May 8, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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