UniProtKB - O15228 (GNPAT_HUMAN)

BLAST

>sp|O15228|GNPAT_HUMAN Dihydroxyacetone phosphate acyltransferase OS=Homo sapiens OX=9606 GN=GNPAT PE=1 SV=1
MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVY
KGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIR
FCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDL
PVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEF
FLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGV
PKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSE
DMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFG
GFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSA
YRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGC
YLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQY
LAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATT
KLEEMLGCKTPIGKPATAKL

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History
Entry version 174 (07 Nov 2018)
Sequence version 1 (01 Jan 1998)
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Protein

Dihydroxyacetone phosphate acyltransferase

Gene

GNPAT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.

Pathwayⁱ: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functionⁱ

glycerone-phosphate O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
palmitoyl-CoA hydrolase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8186247
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cerebellum morphogenesis Source: Ensembl
ether lipid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15687349
fatty acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
membrane organization Source: Ensembl
paranodal junction assembly Source: Ensembl
phosphatidic acid biosynthetic process Source: Reactome
phospholipid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein targeting to peroxisome Source: Reactome
response to drug Source: Ensembl
response to fatty acid Source: Ensembl
response to nutrient Source: Ensembl
response to starvation Source: Ensembl
synapse assembly Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04068-MONOMER
BRENDAⁱ	2.3.1.42 2681
Reactomeⁱ	R-HSA-1483166 Synthesis of PA R-HSA-75896 Plasmalogen biosynthesis R-HSA-9033241 Peroxisomal protein import
UniPathwayⁱ	UPA00940

Chemistry databases

SwissLipidsⁱ	SLP:000000148

SwissLipidsⁱ

SLP:000000148

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dihydroxyacetone phosphate acyltransferase (EC:2.3.1.42) Short name: DAP-AT Short name: DHAP-AT Alternative name(s): Acyl-CoA:dihydroxyacetonephosphateacyltransferase Glycerone-phosphate O-acyltransferase
Gene namesⁱ	Name:GNPAT Synonyms:DAPAT, DHAPAT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116906.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4416 GNPAT
MIMⁱ	602744 gene
neXtProtⁱ	NX_O15228

Keywords - Cellular componentⁱ

Membrane, Peroxisome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Rhizomelic chondrodysplasia punctata 2 (RCDP2)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of rhizomelic chondrodysplasia punctata, a disease characterized by severely disturbed endochondral bone formation, rhizomelic shortening of femur and humerus, vertebral disorders, dwarfism, cataract, cutaneous lesions, facial dysmorphism, and severe mental retardation with spasticity.

Keywords - Diseaseⁱ

Cataract, Disease mutation, Dwarfism, Rhizomelic chondrodysplasia punctata

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8443
MalaCards human disease database More...MalaCardsⁱ	GNPAT
MIMⁱ	222765 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116906
Orphanetⁱ	309796 Rhizomelic chondrodysplasia punctata type 2
PharmGKBⁱ	PA28795

Chemistry databases

ChEMBLⁱ	CHEMBL4494

ChEMBLⁱ

CHEMBL4494

Polymorphism and mutation databases

BioMutaⁱ	GNPAT

BioMutaⁱ

GNPAT

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000195246	1 – 680	Dihydroxyacetone phosphate acyltransferaseAdd BLAST		680

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	PhosphoserineBy similarity	1
Modified residueⁱ	17	PhosphoserineBy similarity	1
Modified residueⁱ	643	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O15228
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15228
PaxDbⁱ	O15228
PeptideAtlas More...PeptideAtlasⁱ	O15228
PRIDEⁱ	O15228
ProteomicsDBⁱ	48518

PTM databases

iPTMnetⁱ	O15228
PhosphoSitePlusⁱ	O15228
SwissPalmⁱ	O15228

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116906 Expressed in 231 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_GNPAT
ExpressionAtlasⁱ	O15228 baseline and differential
Genevisibleⁱ	O15228 HS

Interactionⁱ

Subunit structureⁱ

May be part of a heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.

GO - Molecular functionⁱ

signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114021, 45 interactors
CORUMⁱ	O15228
IntActⁱ	O15228, 11 interactors
STRINGⁱ	9606.ENSP00000355607

Chemistry databases

BindingDBⁱ

O15228

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15228
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	162 – 167	HXXXXD motif		6
Motifⁱ	678 – 680	Microbody targeting signalSequence analysis		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	3 – 9	Poly-Ser		7

Domainⁱ

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesⁱ

Belongs to the GPAT/DAPAT family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3730 Eukaryota COG2937 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055570
HOVERGENⁱ	HBG051749
InParanoidⁱ	O15228
KEGG Orthology (KO) More...KOⁱ	K00649
OMAⁱ	FFAFTLS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0378
PhylomeDBⁱ	O15228
TreeFamⁱ	TF313360

Family and domain databases

InterProⁱ	View protein in InterPro IPR028353 DHAPAT IPR022284 GPAT/DHAPAT IPR002123 Plipid/glycerol_acylTrfase
PANTHERⁱ	PTHR12563 PTHR12563, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
PIRSFⁱ	PIRSF500063 DHAPAT, 1 hit PIRSF000437 GPAT_DHAPAT, 1 hit
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15228-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSSSSNSY FSVGPTSPSA VVLLYSKELK KWDEFEDILE ERRHVSDLKF 
        60         70         80         90        100
AMKCYTPLVY KGITPCKPID IKCSVLNSEE IHYVIKQLSK ESLQSVDVLR 
       110        120        130        140        150
EEVSEILDEM SHKLRLGAIR FCAFTLSKVF KQIFSKVCVN EEGIQKLQRA 
       160        170        180        190        200
IQEHPVVLLP SHRSYIDFLM LSFLLYNYDL PVPVIAAGMD FLGMKMVGEL 
       210        220        230        240        250
LRMSGAFFMR RTFGGNKLYW AVFSEYVKTM LRNGYAPVEF FLEGTRSRSA 
       260        270        280        290        300
KTLTPKFGLL NIVMEPFFKR EVFDTYLVPI SISYDKILEE TLYVYELLGV 
       310        320        330        340        350
PKPKESTTGL LKARKILSEN FGSIHVYFGD PVSLRSLAAG RMSRSSYNLV 
       360        370        380        390        400
PRYIPQKQSE DMHAFVTEVA YKMELLQIEN MVLSPWTLIV AVLLQNRPSM 
       410        420        430        440        450
DFDALVEKTL WLKGLTQAFG GFLIWPDNKP AEEVVPASIL LHSNIASLVK 
       460        470        480        490        500
DQVILKVDSG DSEVVDGLML QHITLLMCSA YRNQLLNIFV RPSLVAVALQ 
       510        520        530        540        550
MTPGFRKEDV YSCFRFLRDV FADEFIFLPG NTLKDFEEGC YLLCKSEAIQ 
       560        570        580        590        600
VTTKDILVTE KGNTVLEFLV GLFKPFVESY QIICKYLLSE EEDHFSEEQY 
       610        620        630        640        650
LAAVRKFTSQ LLDQGTSQCY DVLSSDVQKN ALAACVRLGV VEKKKINNNC 
       660        670        680
IFNVNEPATT KLEEMLGCKT PIGKPATAKL

Length:680

Mass (Da):77,188

Last modified:January 1, 1998 - v1

Checksum:ⁱBDF624CCD4D92477

Isoform 2 (identifier: O15228-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
27-87: Missing.

« Hide

        10         20         30         40         50
MESSSSSNSY FSVGPTSPSA VVLLYSLSKE SLQSVDVLRE EVSEILDEMS 
        60         70         80         90        100
HKLRLGAIRF CAFTLSKVFK QIFSKVCVNE EGIQKLQRAI QEHPVVLLPS 
       110        120        130        140        150
HRSYIDFLML SFLLYNYDLP VPVIAAGMDF LGMKMVGELL RMSGAFFMRR 
       160        170        180        190        200
TFGGNKLYWA VFSEYVKTML RNGYAPVEFF LEGTRSRSAK TLTPKFGLLN 
       210        220        230        240        250
IVMEPFFKRE VFDTYLVPIS ISYDKILEET LYVYELLGVP KPKESTTGLL 
       260        270        280        290        300
KARKILSENF GSIHVYFGDP VSLRSLAAGR MSRSSYNLVP RYIPQKQSED 
       310        320        330        340        350
MHAFVTEVAY KMELLQIENM VLSPWTLIVA VLLQNRPSMD FDALVEKTLW 
       360        370        380        390        400
LKGLTQAFGG FLIWPDNKPA EEVVPASILL HSNIASLVKD QVILKVDSGD 
       410        420        430        440        450
SEVVDGLMLQ HITLLMCSAY RNQLLNIFVR PSLVAVALQM TPGFRKEDVY 
       460        470        480        490        500
SCFRFLRDVF ADEFIFLPGN TLKDFEEGCY LLCKSEAIQV TTKDILVTEK 
       510        520        530        540        550
GNTVLEFLVG LFKPFVESYQ IICKYLLSEE EDHFSEEQYL AAVRKFTSQL 
       560        570        580        590        600
LDQGTSQCYD VLSSDVQKNA LAACVRLGVV EKKKINNNCI FNVNEPATTK 
       610 
LEEMLGCKTP IGKPATAKL

Note: No experimental confirmation available.

Show »

Length:619

Mass (Da):69,906

Checksum:ⁱ50737E7FF854E8FB

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5TBH8	Q5TBH8_HUMAN	Dihydroxyacetone phosphate acyltran... Dihydroxyacetone phosphate acyltransferase	GNPAT	587	Annotation score:
Q5TBH6	Q5TBH6_HUMAN	Dihydroxyacetone phosphate acyltran... Dihydroxyacetone phosphate acyltransferase	GNPAT	222	Annotation score:
A0A2R8YH69	A0A2R8YH69_HUMAN	Dihydroxyacetone phosphate acyltran... Dihydroxyacetone phosphate acyltransferase	GNPAT	133	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	26	S → K AA sequence (PubMed:9536089).Curated		1
Sequence conflictⁱ	31	K → N AA sequence (PubMed:9536089).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_006357	211	R → C in RCDP2. 1 PublicationCorresponds to variant dbSNP:rs121434440EnsemblClinVar.	1
Natural variantⁱVAR_006358	211	R → H in RCDP2; complete loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121434439EnsemblClinVar.	1
Natural variantⁱVAR_030696	495	V → I. Corresponds to variant dbSNP:rs11122266EnsemblClinVar.	1
Natural variantⁱVAR_025897	519	D → G in RCDP2; 70% reduction in activity. 1 PublicationCorresponds to variant dbSNP:rs11558492EnsemblClinVar.	1
Natural variantⁱVAR_030697	586	Y → H1 PublicationCorresponds to variant dbSNP:rs17849315Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056435	27 – 87	Missing in isoform 2. 1 PublicationAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ002190 mRNA Translation: CAA05242.1 AF043937 mRNA Translation: AAC24505.1 AF218233 AF218232 Genomic DNA Translation: AAG17547.1 AK297982 mRNA Translation: BAG60291.1 AL117352 Genomic DNA No translation available. AL137801 Genomic DNA No translation available. BC000450 mRNA Translation: AAH00450.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1592.1 [O15228-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001303279.1, NM_001316350.1 [O15228-2] NP_055051.1, NM_014236.3 [O15228-1]
UniGeneⁱ	Hs.498028

Genome annotation databases

Ensemblⁱ	ENST00000366647; ENSP00000355607; ENSG00000116906 [O15228-1]
GeneIDⁱ	8443
KEGGⁱ	hsa:8443
UCSC genome browser More...UCSCⁱ	uc001hup.5 human [O15228-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15228	Dihydroxyacetone phosphate acyltransferase (Fragment)		HUMAN		383	UniRef100_O15228
UPI0000E062A7		HUMAN		571
O15228-2	Dihydroxyacetone phosphate acyltransferase (Fragment)		HUMAN		222	UniRef100_O15228-2
GNPAT isoform 1 (Fragment)		PANTR		222

Protein	Similar proteins		Species	Score	Length	Source
O15228	Dihydroxyacetone phosphate acyltransferase (Fragment)		HUMAN		383	UniRef90_O15228
Dihydroxyacetone phosphate acyltransferase		NOMLE		696
Dihydroxyacetone phosphate acyltransferase		PANTR		691
Dihydroxyacetone phosphate acyltransferase		PANPA		691
Dihydroxyacetone phosphate acyltransferase		RHIRO		684
+92

Protein	Similar proteins		Species	Score	Length	Source
O15228	Dihydroxyacetone phosphate acyltransferase		BOVIN		680	UniRef50_O15228
Dihydroxyacetone phosphate acyltransferase (Fragment)		HUMAN		383
Dihydroxyacetone phosphate acyltransferase		NOMLE		696
Dihydroxyacetone phosphate acyltransferase		PANTR		691
Dihydroxyacetone phosphate acyltransferase		PANPA		691
+312

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ002190 mRNA Translation: CAA05242.1 AF043937 mRNA Translation: AAC24505.1 AF218233 AF218232 Genomic DNA Translation: AAG17547.1 AK297982 mRNA Translation: BAG60291.1 AL117352 Genomic DNA No translation available. AL137801 Genomic DNA No translation available. BC000450 mRNA Translation: AAH00450.1
CCDSⁱ	CCDS1592.1 [O15228-1]
RefSeqⁱ	NP_001303279.1, NM_001316350.1 [O15228-2] NP_055051.1, NM_014236.3 [O15228-1]
UniGeneⁱ	Hs.498028

3D structure databases

ProteinModelPortalⁱ	O15228
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114021, 45 interactors
CORUMⁱ	O15228
IntActⁱ	O15228, 11 interactors
STRINGⁱ	9606.ENSP00000355607

Chemistry databases

BindingDBⁱ	O15228
ChEMBLⁱ	CHEMBL4494
SwissLipidsⁱ	SLP:000000148

PTM databases

iPTMnetⁱ	O15228
PhosphoSitePlusⁱ	O15228
SwissPalmⁱ	O15228

Polymorphism and mutation databases

BioMutaⁱ	GNPAT

BioMutaⁱ

GNPAT

Proteomic databases

EPDⁱ	O15228
MaxQBⁱ	O15228
PaxDbⁱ	O15228
PeptideAtlasⁱ	O15228
PRIDEⁱ	O15228
ProteomicsDBⁱ	48518

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000366647; ENSP00000355607; ENSG00000116906 [O15228-1]
GeneIDⁱ	8443
KEGGⁱ	hsa:8443
UCSCⁱ	uc001hup.5 human [O15228-1]

Organism-specific databases

CTDⁱ	8443
DisGeNETⁱ	8443
EuPathDBⁱ	HostDB:ENSG00000116906.11
GeneCardsⁱ	GNPAT
HGNCⁱ	HGNC:4416 GNPAT
MalaCardsⁱ	GNPAT
MIMⁱ	222765 phenotype 602744 gene
neXtProtⁱ	NX_O15228
OpenTargetsⁱ	ENSG00000116906
Orphanetⁱ	309796 Rhizomelic chondrodysplasia punctata type 2
PharmGKBⁱ	PA28795
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3730 Eukaryota COG2937 LUCA
GeneTreeⁱ	ENSGT00520000055570
HOVERGENⁱ	HBG051749
InParanoidⁱ	O15228
KOⁱ	K00649
OMAⁱ	FFAFTLS
OrthoDBⁱ	EOG091G0378
PhylomeDBⁱ	O15228
TreeFamⁱ	TF313360

Enzyme and pathway databases

UniPathwayⁱ	UPA00940
BioCycⁱ	MetaCyc:HS04068-MONOMER
BRENDAⁱ	2.3.1.42 2681
Reactomeⁱ	R-HSA-1483166 Synthesis of PA R-HSA-75896 Plasmalogen biosynthesis R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	GNPAT human
GenomeRNAiⁱ	8443
Protein Ontology More...PROⁱ	PR:O15228
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116906 Expressed in 231 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_GNPAT
ExpressionAtlasⁱ	O15228 baseline and differential
Genevisibleⁱ	O15228 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028353 DHAPAT IPR022284 GPAT/DHAPAT IPR002123 Plipid/glycerol_acylTrfase
PANTHERⁱ	PTHR12563 PTHR12563, 1 hit
Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
PIRSFⁱ	PIRSF500063 DHAPAT, 1 hit PIRSF000437 GPAT_DHAPAT, 1 hit
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GNPAT_HUMAN
Accessionⁱ	O15228Primary (citable) accession number: O15228 Secondary accession number(s): B4DNM9, Q5TBH7, Q9BWC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - O15228 (GNPAT_HUMAN)

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Dihydroxyacetone phosphate acyltransferase

GNPAT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerophospholipid metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Cytosol

Mitochondrion

Peroxisome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: glycerophospholipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ