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Protein

G-protein coupled receptor 182

Gene

GPR182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

Caution

Was originally thought to be a receptor for adrenomedullin.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 182
Gene namesi
Name:GPR182
Synonyms:ADMR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166856.2
HGNCiHGNC:13708 GPR182
MIMi605307 gene
neXtProtiNX_O15218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 79Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini80 – 90CytoplasmicSequence analysisAdd BLAST11
Transmembranei91 – 113Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini114 – 127ExtracellularSequence analysisAdd BLAST14
Transmembranei128 – 149Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini150 – 170CytoplasmicSequence analysisAdd BLAST21
Transmembranei171 – 193Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini194 – 217ExtracellularSequence analysisAdd BLAST24
Transmembranei218 – 239Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini240 – 258CytoplasmicSequence analysisAdd BLAST19
Transmembranei259 – 280Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini281 – 299ExtracellularSequence analysisAdd BLAST19
Transmembranei300 – 320Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini321 – 404CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11318
OpenTargetsiENSG00000166856
PharmGKBiPA162390165

Chemistry databases

ChEMBLiCHEMBL4356

Polymorphism and mutation databases

BioMutaiGPR182

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691121 – 404G-protein coupled receptor 182Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15218
PeptideAtlasiO15218
PRIDEiO15218
ProteomicsDBi48515

PTM databases

PhosphoSitePlusiO15218

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver.1 Publication

Gene expression databases

BgeeiENSG00000166856 Expressed in 92 organ(s), highest expression level in spleen
CleanExiHS_GPR182
ExpressionAtlasiO15218 baseline and differential
GenevisibleiO15218 HS

Organism-specific databases

HPAiHPA027037

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300098

Structurei

3D structure databases

ProteinModelPortaliO15218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEW Eukaryota
ENOG4111H1T LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000220818
HOVERGENiHBG097691
InParanoidiO15218
KOiK04242
OMAiHYFYFAN
OrthoDBiEOG091G0DFG
PhylomeDBiO15218
TreeFamiTF333489

Family and domain databases

CDDicd14988 7tmA_GPR182, 1 hit
InterProiView protein in InterPro
IPR001350 G10D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00643 G10DORPHANR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS
60 70 80 90 100
TKRVVLFALY LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL
110 120 130 140 150
GIVLSLPVWM LEVTLDYTWL WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD
160 170 180 190 200
RYVTLTSASP SWQRYQHRVR RAMCAGIWVL SAIIPLPEVV HIQLVEGPEP
210 220 230 240 250
MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL TACRLRQPGQ
260 270 280 290 300
PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
310 320 330 340 350
FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA
360 370 380 390 400
SSSSCSTQHS IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP

LTPS
Length:404
Mass (Da):45,323
Last modified:January 1, 1998 - v1
Checksum:iEF187ECFDF2DC6C1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z4H2Q7Z4H2_HUMAN
G-protein-coupled receptor 182
GPR182 HBCBP
196Annotation score:
A0A0D9SG31A0A0D9SG31_HUMAN
G-protein-coupled receptor 182
GPR182
55Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033464349C → R. Corresponds to variant dbSNP:rs35493121Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13583 mRNA Translation: CAA73910.1
AY268434 Genomic DNA Translation: AAP23201.1
BC034761 mRNA Translation: AAH34761.1
CCDSiCCDS8927.1
PIRiJC5784
RefSeqiNP_009195.1, NM_007264.3
XP_011536126.1, XM_011537824.2
XP_011536127.1, XM_011537825.2
XP_011536129.1, XM_011537827.2
UniGeneiHs.483909

Genome annotation databases

EnsembliENST00000300098; ENSP00000300098; ENSG00000166856
GeneIDi11318
KEGGihsa:11318
UCSCiuc001smk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13583 mRNA Translation: CAA73910.1
AY268434 Genomic DNA Translation: AAP23201.1
BC034761 mRNA Translation: AAH34761.1
CCDSiCCDS8927.1
PIRiJC5784
RefSeqiNP_009195.1, NM_007264.3
XP_011536126.1, XM_011537824.2
XP_011536127.1, XM_011537825.2
XP_011536129.1, XM_011537827.2
UniGeneiHs.483909

3D structure databases

ProteinModelPortaliO15218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300098

Chemistry databases

ChEMBLiCHEMBL4356

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO15218

Polymorphism and mutation databases

BioMutaiGPR182

Proteomic databases

PaxDbiO15218
PeptideAtlasiO15218
PRIDEiO15218
ProteomicsDBi48515

Protocols and materials databases

DNASUi11318
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300098; ENSP00000300098; ENSG00000166856
GeneIDi11318
KEGGihsa:11318
UCSCiuc001smk.4 human

Organism-specific databases

CTDi11318
DisGeNETi11318
EuPathDBiHostDB:ENSG00000166856.2
GeneCardsiGPR182
HGNCiHGNC:13708 GPR182
HPAiHPA027037
MIMi605307 gene
neXtProtiNX_O15218
OpenTargetsiENSG00000166856
PharmGKBiPA162390165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEW Eukaryota
ENOG4111H1T LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000220818
HOVERGENiHBG097691
InParanoidiO15218
KOiK04242
OMAiHYFYFAN
OrthoDBiEOG091G0DFG
PhylomeDBiO15218
TreeFamiTF333489

Miscellaneous databases

GeneWikiiGPR182
GenomeRNAii11318
PROiPR:O15218
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166856 Expressed in 92 organ(s), highest expression level in spleen
CleanExiHS_GPR182
ExpressionAtlasiO15218 baseline and differential
GenevisibleiO15218 HS

Family and domain databases

CDDicd14988 7tmA_GPR182, 1 hit
InterProiView protein in InterPro
IPR001350 G10D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00643 G10DORPHANR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP182_HUMAN
AccessioniPrimary (citable) accession number: O15218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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