UniProtKB - O15213 (WDR46_HUMAN)
Protein
WD repeat-containing protein 46
Gene
WDR46
Organism
Homo sapiens (Human)
Status
Functioni
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- rRNA processing Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | O15213 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | O15213 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 46Alternative name(s): WD repeat-containing protein BING4 |
Gene namesi | Name:WDR46 Synonyms:BING4, C6orf11 ORF Names:FP221 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13923, WDR46 |
MIMi | 611440, gene |
neXtProti | NX_O15213 |
VEuPathDBi | HostDB:ENSG00000227057.7 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: GO_Central
- nucleoplasm Source: Reactome
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9277 |
OpenTargetsi | ENSG00000227057 |
PharmGKBi | PA25924 |
Miscellaneous databases
Pharosi | O15213, Tdark |
Genetic variation databases
BioMutai | WDR46 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051395 | 1 – 610 | WD repeat-containing protein 46Add BLAST | 610 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O15213 |
jPOSTi | O15213 |
MassIVEi | O15213 |
MaxQBi | O15213 |
PaxDbi | O15213 |
PeptideAtlasi | O15213 |
PRIDEi | O15213 |
ProteomicsDBi | 48513 |
PTM databases
iPTMneti | O15213 |
PhosphoSitePlusi | O15213 |
SwissPalmi | O15213 |
Expressioni
Gene expression databases
Bgeei | ENSG00000227057, Expressed in adenohypophysis and 214 other tissues |
ExpressionAtlasi | O15213, baseline and differential |
Genevisiblei | O15213, HS |
Organism-specific databases
HPAi | ENSG00000227057, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DDX21, NCL, NOP2 and EBNA1BP2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 114694, 121 interactors |
IntActi | O15213, 9 interactors |
MINTi | O15213 |
STRINGi | 9606.ENSP00000363746 |
Miscellaneous databases
RNActi | O15213, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 193 – 234 | WD 1Add BLAST | 42 | |
Repeati | 235 – 272 | WD 2Add BLAST | 38 | |
Repeati | 274 – 312 | WD 3Add BLAST | 39 | |
Repeati | 315 – 354 | WD 4Add BLAST | 40 | |
Repeati | 357 – 396 | WD 5Add BLAST | 40 | |
Repeati | 399 – 436 | WD 6Add BLAST | 38 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1272, Eukaryota |
GeneTreei | ENSGT00390000007075 |
HOGENOMi | CLU_022996_2_0_1 |
InParanoidi | O15213 |
OMAi | KYTFIYD |
OrthoDBi | 430457at2759 |
PhylomeDBi | O15213 |
TreeFami | TF300861 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR012952, BING4_C_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR040315, WDR46/Utp7 |
PANTHERi | PTHR14085, PTHR14085, 1 hit |
Pfami | View protein in Pfam PF08149, BING4CT, 1 hit |
SMARTi | View protein in SMART SM01033, BING4CT, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O15213-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN
60 70 80 90 100
RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG
110 120 130 140 150
PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE
160 170 180 190 200
LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR
210 220 230 240 250
LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL
260 270 280 290 300
LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT
310 320 330 340 350
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE
360 370 380 390 400
PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL
410 420 430 440 450
PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV
460 470 480 490 500
HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW
510 520 530 540 550
EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF
560 570 580 590 600
QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA
610
RPSALDRFVR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y6G3 | H0Y6G3_HUMAN | WD repeat-containing protein 46 | WDR46 | 322 | Annotation score: | ||
A0A140T9L0 | A0A140T9L0_HUMAN | WD repeat-containing protein 46 | WDR46 | 322 | Annotation score: | ||
A0A0G2JJL1 | A0A0G2JJL1_HUMAN | WD repeat-containing protein 46 | WDR46 | 322 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053433 | 94 | T → A3 PublicationsCorresponds to variant dbSNP:rs3130257Ensembl. | 1 | |
Natural variantiVAR_053434 | 124 | S → Y. Corresponds to variant dbSNP:rs34704405Ensembl. | 1 | |
Natural variantiVAR_022025 | 341 | V → A1 PublicationCorresponds to variant dbSNP:rs14398Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447870 mRNA Translation: AAQ04645.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. AL844527 Genomic DNA No translation available. BX000343 Genomic DNA No translation available. Z97184, AL031228 Genomic DNA Translation: CAB09994.2 BC000388 mRNA Translation: AAH00388.1 |
CCDSi | CCDS4772.1 |
RefSeqi | NP_001157739.1, NM_001164267.1 NP_005443.3, NM_005452.5 |
Genome annotation databases
Ensembli | ENST00000374617; ENSP00000363746; ENSG00000227057 ENST00000383208; ENSP00000372695; ENSG00000206284 ENST00000432609; ENSP00000402869; ENSG00000236222 ENST00000432933; ENSP00000399454; ENSG00000204221 ENST00000457382; ENSP00000405614; ENSG00000226916 |
GeneIDi | 9277 |
KEGGi | hsa:9277 |
UCSCi | uc003ods.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447870 mRNA Translation: AAQ04645.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. AL844527 Genomic DNA No translation available. BX000343 Genomic DNA No translation available. Z97184, AL031228 Genomic DNA Translation: CAB09994.2 BC000388 mRNA Translation: AAH00388.1 |
CCDSi | CCDS4772.1 |
RefSeqi | NP_001157739.1, NM_001164267.1 NP_005443.3, NM_005452.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114694, 121 interactors |
IntActi | O15213, 9 interactors |
MINTi | O15213 |
STRINGi | 9606.ENSP00000363746 |
PTM databases
iPTMneti | O15213 |
PhosphoSitePlusi | O15213 |
SwissPalmi | O15213 |
Genetic variation databases
BioMutai | WDR46 |
Proteomic databases
EPDi | O15213 |
jPOSTi | O15213 |
MassIVEi | O15213 |
MaxQBi | O15213 |
PaxDbi | O15213 |
PeptideAtlasi | O15213 |
PRIDEi | O15213 |
ProteomicsDBi | 48513 |
Protocols and materials databases
Antibodypediai | 29045, 53 antibodies |
DNASUi | 9277 |
Genome annotation databases
Ensembli | ENST00000374617; ENSP00000363746; ENSG00000227057 ENST00000383208; ENSP00000372695; ENSG00000206284 ENST00000432609; ENSP00000402869; ENSG00000236222 ENST00000432933; ENSP00000399454; ENSG00000204221 ENST00000457382; ENSP00000405614; ENSG00000226916 |
GeneIDi | 9277 |
KEGGi | hsa:9277 |
UCSCi | uc003ods.4, human |
Organism-specific databases
CTDi | 9277 |
DisGeNETi | 9277 |
GeneCardsi | WDR46 |
HGNCi | HGNC:13923, WDR46 |
HPAi | ENSG00000227057, Low tissue specificity |
MIMi | 611440, gene |
neXtProti | NX_O15213 |
OpenTargetsi | ENSG00000227057 |
PharmGKBi | PA25924 |
VEuPathDBi | HostDB:ENSG00000227057.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1272, Eukaryota |
GeneTreei | ENSGT00390000007075 |
HOGENOMi | CLU_022996_2_0_1 |
InParanoidi | O15213 |
OMAi | KYTFIYD |
OrthoDBi | 430457at2759 |
PhylomeDBi | O15213 |
TreeFami | TF300861 |
Enzyme and pathway databases
PathwayCommonsi | O15213 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | O15213 |
Miscellaneous databases
BioGRID-ORCSi | 9277, 549 hits in 879 CRISPR screens |
ChiTaRSi | WDR46, human |
GeneWikii | WDR46 |
GenomeRNAii | 9277 |
Pharosi | O15213, Tdark |
PROi | PR:O15213 |
RNActi | O15213, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000227057, Expressed in adenohypophysis and 214 other tissues |
ExpressionAtlasi | O15213, baseline and differential |
Genevisiblei | O15213, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR012952, BING4_C_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR040315, WDR46/Utp7 |
PANTHERi | PTHR14085, PTHR14085, 1 hit |
Pfami | View protein in Pfam PF08149, BING4CT, 1 hit |
SMARTi | View protein in SMART SM01033, BING4CT, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR46_HUMAN | |
Accessioni | O15213Primary (citable) accession number: O15213 Secondary accession number(s): A6NDP5 Q5STR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants