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Protein

WD repeat-containing protein 46

Gene

WDR46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiO15213

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 46
Alternative name(s):
WD repeat-containing protein BING4
Gene namesi
Name:WDR46
Synonyms:BING4, C6orf11
ORF Names:FP221
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000227057.7
HGNCiHGNC:13923 WDR46
MIMi611440 gene
neXtProtiNX_O15213

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9277
OpenTargetsiENSG00000227057
PharmGKBiPA25924

Polymorphism and mutation databases

BioMutaiWDR46

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513951 – 610WD repeat-containing protein 46Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15213
MaxQBiO15213
PaxDbiO15213
PeptideAtlasiO15213
PRIDEiO15213
ProteomicsDBi48513

PTM databases

iPTMnetiO15213
PhosphoSitePlusiO15213
SwissPalmiO15213

Expressioni

Gene expression databases

BgeeiENSG00000227057 Expressed in 203 organ(s), highest expression level in adenohypophysis
CleanExiHS_WDR46
ExpressionAtlasiO15213 baseline and differential
GenevisibleiO15213 HS

Organism-specific databases

HPAiHPA043004

Interactioni

Subunit structurei

Interacts with DDX21, NCL, NOP2 and EBNA1BP2.1 Publication

Protein-protein interaction databases

BioGridi114694, 112 interactors
IntActiO15213, 5 interactors
MINTiO15213
STRINGi9606.ENSP00000363746

Structurei

3D structure databases

ProteinModelPortaliO15213
SMRiO15213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati193 – 234WD 1Add BLAST42
Repeati235 – 272WD 2Add BLAST38
Repeati274 – 312WD 3Add BLAST39
Repeati315 – 354WD 4Add BLAST40
Repeati357 – 396WD 5Add BLAST40
Repeati399 – 436WD 6Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1272 Eukaryota
ENOG410XP5D LUCA
GeneTreeiENSGT00390000007075
HOVERGENiHBG050687
InParanoidiO15213
KOiK14768
OMAiREGRYMV
OrthoDBiEOG091G09WH
PhylomeDBiO15213
TreeFamiTF300861

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR012952 BING4_C_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08149 BING4CT, 1 hit
SMARTiView protein in SMART
SM01033 BING4CT, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O15213-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN
60 70 80 90 100
RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG
110 120 130 140 150
PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE
160 170 180 190 200
LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR
210 220 230 240 250
LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL
260 270 280 290 300
LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT
310 320 330 340 350
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE
360 370 380 390 400
PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL
410 420 430 440 450
PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV
460 470 480 490 500
HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW
510 520 530 540 550
EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF
560 570 580 590 600
QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA
610
RPSALDRFVR
Length:610
Mass (Da):68,071
Last modified:November 30, 2010 - v3
Checksum:i0C11DA8ED92CA39E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6G3H0Y6G3_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:
A0A140T9L0A0A140T9L0_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:
A0A0G2JJL1A0A0G2JJL1_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05343394T → A3 PublicationsCorresponds to variant dbSNP:rs3130257Ensembl.1
Natural variantiVAR_053434124S → Y. Corresponds to variant dbSNP:rs34704405Ensembl.1
Natural variantiVAR_022025341V → A1 PublicationCorresponds to variant dbSNP:rs14398Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447870 mRNA Translation: AAQ04645.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
Z97184, AL031228 Genomic DNA Translation: CAB09994.2
BC000388 mRNA Translation: AAH00388.1
CCDSiCCDS4772.1
RefSeqiNP_001157739.1, NM_001164267.1
NP_005443.3, NM_005452.5
UniGeneiHs.520063
Hs.671763

Genome annotation databases

EnsembliENST00000374617; ENSP00000363746; ENSG00000227057
ENST00000383208; ENSP00000372695; ENSG00000206284
ENST00000432609; ENSP00000402869; ENSG00000236222
ENST00000432933; ENSP00000399454; ENSG00000204221
ENST00000457382; ENSP00000405614; ENSG00000226916
GeneIDi9277
KEGGihsa:9277
UCSCiuc003ods.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447870 mRNA Translation: AAQ04645.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
Z97184, AL031228 Genomic DNA Translation: CAB09994.2
BC000388 mRNA Translation: AAH00388.1
CCDSiCCDS4772.1
RefSeqiNP_001157739.1, NM_001164267.1
NP_005443.3, NM_005452.5
UniGeneiHs.520063
Hs.671763

3D structure databases

ProteinModelPortaliO15213
SMRiO15213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114694, 112 interactors
IntActiO15213, 5 interactors
MINTiO15213
STRINGi9606.ENSP00000363746

PTM databases

iPTMnetiO15213
PhosphoSitePlusiO15213
SwissPalmiO15213

Polymorphism and mutation databases

BioMutaiWDR46

Proteomic databases

EPDiO15213
MaxQBiO15213
PaxDbiO15213
PeptideAtlasiO15213
PRIDEiO15213
ProteomicsDBi48513

Protocols and materials databases

DNASUi9277
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374617; ENSP00000363746; ENSG00000227057
ENST00000383208; ENSP00000372695; ENSG00000206284
ENST00000432609; ENSP00000402869; ENSG00000236222
ENST00000432933; ENSP00000399454; ENSG00000204221
ENST00000457382; ENSP00000405614; ENSG00000226916
GeneIDi9277
KEGGihsa:9277
UCSCiuc003ods.4 human

Organism-specific databases

CTDi9277
DisGeNETi9277
EuPathDBiHostDB:ENSG00000227057.7
GeneCardsiWDR46
H-InvDBiHIX0058254
HGNCiHGNC:13923 WDR46
HPAiHPA043004
MIMi611440 gene
neXtProtiNX_O15213
OpenTargetsiENSG00000227057
PharmGKBiPA25924
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1272 Eukaryota
ENOG410XP5D LUCA
GeneTreeiENSGT00390000007075
HOVERGENiHBG050687
InParanoidiO15213
KOiK14768
OMAiREGRYMV
OrthoDBiEOG091G09WH
PhylomeDBiO15213
TreeFamiTF300861

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiO15213

Miscellaneous databases

ChiTaRSiWDR46 human
GeneWikiiWDR46
GenomeRNAii9277
PROiPR:O15213
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000227057 Expressed in 203 organ(s), highest expression level in adenohypophysis
CleanExiHS_WDR46
ExpressionAtlasiO15213 baseline and differential
GenevisibleiO15213 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR012952 BING4_C_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08149 BING4CT, 1 hit
SMARTiView protein in SMART
SM01033 BING4CT, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR46_HUMAN
AccessioniPrimary (citable) accession number: O15213
Secondary accession number(s): A6NDP5
, Q5HYZ0, Q5STK5, Q5STR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 30, 2010
Last modified: October 10, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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