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UniProtKB - O15213 (WDR46_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

WD repeat-containing protein 46

Gene

WDR46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15213

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15213

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 46
Alternative name(s):
WD repeat-containing protein BING4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR46
Synonyms:BING4, C6orf11
ORF Names:FP221
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13923, WDR46

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611440, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15213

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000227057.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9277

Open Targets

More...OpenTargetsi		ENSG00000227057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25924

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15213, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WDR46

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513951 – 610WD repeat-containing protein 46Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15213

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15213

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15213

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15213

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15213

PeptideAtlas

More...PeptideAtlasi		O15213

PRoteomics IDEntifications database

More...PRIDEi		O15213

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48513

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15213

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15213

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O15213

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000227057, Expressed in adenohypophysis and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15213, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15213, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000227057, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDX21, NCL, NOP2 and EBNA1BP2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114694, 121 interactors

Protein interaction database and analysis system

More...IntActi		O15213, 9 interactors

Molecular INTeraction database

More...MINTi		O15213

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15213, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati193 – 234WD 1Add BLAST42
Repeati235 – 272WD 2Add BLAST38
Repeati274 – 312WD 3Add BLAST39
Repeati315 – 354WD 4Add BLAST40
Repeati357 – 396WD 5Add BLAST40
Repeati399 – 436WD 6Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1272, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007075

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022996_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15213

Identification of Orthologs from Complete Genome Data

More...OMAi		KYTFIYD

Database of Orthologous Groups

More...OrthoDBi		430457at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15213

TreeFam database of animal gene trees

More...TreeFami		TF300861

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012952, BING4_C_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR040315, WDR46/Utp7

The PANTHER Classification System

More...PANTHERi		PTHR14085, PTHR14085, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08149, BING4CT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01033, BING4CT, 1 hit
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O15213-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN 
        60         70         80         90        100
RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG 
       110        120        130        140        150
PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE 
       160        170        180        190        200
LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR 
       210        220        230        240        250
LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL 
       260        270        280        290        300
LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT 
       310        320        330        340        350
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE 
       360        370        380        390        400
PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL 
       410        420        430        440        450
PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV 
       460        470        480        490        500
HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW 
       510        520        530        540        550
EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF 
       560        570        580        590        600
QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA 
       610
RPSALDRFVR
Length:610
Mass (Da):68,071
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C11DA8ED92CA39E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6G3H0Y6G3_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9L0A0A140T9L0_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJL1A0A0G2JJL1_HUMAN
WD repeat-containing protein 46
WDR46
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05343394T → A3 PublicationsCorresponds to variant dbSNP:rs3130257Ensembl.1
Natural variantiVAR_053434124S → Y. Corresponds to variant dbSNP:rs34704405Ensembl.1
Natural variantiVAR_022025341V → A1 PublicationCorresponds to variant dbSNP:rs14398Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF447870 mRNA Translation: AAQ04645.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
Z97184, AL031228 Genomic DNA Translation: CAB09994.2
BC000388 mRNA Translation: AAH00388.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4772.1

NCBI Reference Sequences

More...RefSeqi		NP_001157739.1, NM_001164267.1
NP_005443.3, NM_005452.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374617; ENSP00000363746; ENSG00000227057
ENST00000383208; ENSP00000372695; ENSG00000206284
ENST00000432609; ENSP00000402869; ENSG00000236222
ENST00000432933; ENSP00000399454; ENSG00000204221
ENST00000457382; ENSP00000405614; ENSG00000226916

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9277

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9277

UCSC genome browser

More...UCSCi		uc003ods.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447870 mRNA Translation: AAQ04645.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
BX000343 Genomic DNA No translation available.
Z97184, AL031228 Genomic DNA Translation: CAB09994.2
BC000388 mRNA Translation: AAH00388.1
CCDSiCCDS4772.1
RefSeqiNP_001157739.1, NM_001164267.1
NP_005443.3, NM_005452.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114694, 121 interactors
IntActiO15213, 9 interactors
MINTiO15213
STRINGi9606.ENSP00000363746

PTM databases

iPTMnetiO15213
PhosphoSitePlusiO15213
SwissPalmiO15213

Genetic variation databases

BioMutaiWDR46

Proteomic databases

EPDiO15213
jPOSTiO15213
MassIVEiO15213
MaxQBiO15213
PaxDbiO15213
PeptideAtlasiO15213
PRIDEiO15213
ProteomicsDBi48513

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29045, 53 antibodies

The DNASU plasmid repository

More...DNASUi		9277

Genome annotation databases

EnsembliENST00000374617; ENSP00000363746; ENSG00000227057
ENST00000383208; ENSP00000372695; ENSG00000206284
ENST00000432609; ENSP00000402869; ENSG00000236222
ENST00000432933; ENSP00000399454; ENSG00000204221
ENST00000457382; ENSP00000405614; ENSG00000226916
GeneIDi9277
KEGGihsa:9277
UCSCiuc003ods.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9277
DisGeNETi9277

GeneCards: human genes, protein and diseases

More...GeneCardsi		WDR46
HGNCiHGNC:13923, WDR46
HPAiENSG00000227057, Low tissue specificity
MIMi611440, gene
neXtProtiNX_O15213
OpenTargetsiENSG00000227057
PharmGKBiPA25924
VEuPathDBiHostDB:ENSG00000227057.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1272, Eukaryota
GeneTreeiENSGT00390000007075
HOGENOMiCLU_022996_2_0_1
InParanoidiO15213
OMAiKYTFIYD
OrthoDBi430457at2759
PhylomeDBiO15213
TreeFamiTF300861

Enzyme and pathway databases

PathwayCommonsiO15213
ReactomeiR-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiO15213

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9277, 549 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WDR46, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WDR46

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9277
PharosiO15213, Tdark

Protein Ontology

More...PROi		PR:O15213
RNActiO15213, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000227057, Expressed in adenohypophysis and 214 other tissues
ExpressionAtlasiO15213, baseline and differential
GenevisibleiO15213, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR012952, BING4_C_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR040315, WDR46/Utp7
PANTHERiPTHR14085, PTHR14085, 1 hit
PfamiView protein in Pfam
PF08149, BING4CT, 1 hit
SMARTiView protein in SMART
SM01033, BING4CT, 1 hit
SM00320, WD40, 4 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR46_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15213
Secondary accession number(s): A6NDP5
, Q5HYZ0, Q5STK5, Q5STR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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