UniProtKB - O15213 (WDR46_HUMAN)

BLAST

>sp|O15213|WDR46_HUMAN WD repeat-containing protein 46 OS=Homo sapiens OX=9606 GN=WDR46 PE=1 SV=3
METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKN
AYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRK
LPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAV
DIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVR
DIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLT
YLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRG
GVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMG
DVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGE
PNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERL
GYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGA
RPSALDRFVR

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History
Entry version 158 (10 Oct 2018)
Sequence version 3 (30 Nov 2010)
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Protein

WD repeat-containing protein 46

Gene

WDR46

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
rRNA processing Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkⁱ	O15213

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 46 Alternative name(s): WD repeat-containing protein BING4
Gene namesⁱ	Name:WDR46 Synonyms:BING4, C6orf11 ORF Names:FP221
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000227057.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13923 WDR46
MIMⁱ	611440 gene
neXtProtⁱ	NX_O15213

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9277
Open Targets More...OpenTargetsⁱ	ENSG00000227057
PharmGKBⁱ	PA25924

Polymorphism and mutation databases

BioMutaⁱ	WDR46

BioMutaⁱ

WDR46

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051395	1 – 610	WD repeat-containing protein 46Add BLAST		610

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	41	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15213
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15213
PaxDbⁱ	O15213
PeptideAtlas More...PeptideAtlasⁱ	O15213
PRIDEⁱ	O15213
ProteomicsDBⁱ	48513

PTM databases

iPTMnetⁱ	O15213
PhosphoSitePlusⁱ	O15213
SwissPalmⁱ	O15213

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000227057 Expressed in 203 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_WDR46
ExpressionAtlasⁱ	O15213 baseline and differential
Genevisibleⁱ	O15213 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043004

HPAⁱ

HPA043004

Interactionⁱ

Subunit structureⁱ

Interacts with DDX21, NCL, NOP2 and EBNA1BP2.1 Publication

Protein-protein interaction databases

BioGridⁱ	114694, 112 interactors
IntActⁱ	O15213, 5 interactors
Molecular INTeraction database More...MINTⁱ	O15213
STRINGⁱ	9606.ENSP00000363746

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15213
SMRⁱ	O15213
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	193 – 234	WD 1Add BLAST	42
Repeatⁱ	235 – 272	WD 2Add BLAST	38
Repeatⁱ	274 – 312	WD 3Add BLAST	39
Repeatⁱ	315 – 354	WD 4Add BLAST	40
Repeatⁱ	357 – 396	WD 5Add BLAST	40
Repeatⁱ	399 – 436	WD 6Add BLAST	38

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG1272 Eukaryota ENOG410XP5D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007075
HOVERGENⁱ	HBG050687
InParanoidⁱ	O15213
KEGG Orthology (KO) More...KOⁱ	K14768
OMAⁱ	REGRYMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09WH
PhylomeDBⁱ	O15213
TreeFamⁱ	TF300861

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012952 BING4_C_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08149 BING4CT, 1 hit
SMARTⁱ	View protein in SMART SM01033 BING4CT, 1 hit SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O15213-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN 
        60         70         80         90        100
RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG 
       110        120        130        140        150
PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE 
       160        170        180        190        200
LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR 
       210        220        230        240        250
LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL 
       260        270        280        290        300
LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT 
       310        320        330        340        350
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE 
       360        370        380        390        400
PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL 
       410        420        430        440        450
PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV 
       460        470        480        490        500
HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW 
       510        520        530        540        550
EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF 
       560        570        580        590        600
QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA 
       610
RPSALDRFVR

Length:610

Mass (Da):68,071

Last modified:November 30, 2010 - v3

Checksum:ⁱ0C11DA8ED92CA39E

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y6G3	H0Y6G3_HUMAN	WD repeat-containing protein 46 WD repeat-containing protein 46	WDR46	322	Annotation score:
A0A140T9L0	A0A140T9L0_HUMAN	WD repeat-containing protein 46 WD repeat-containing protein 46	WDR46	322	Annotation score:
A0A0G2JJL1	A0A0G2JJL1_HUMAN	WD repeat-containing protein 46 WD repeat-containing protein 46	WDR46	322	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053433	94	T → A3 PublicationsCorresponds to variant dbSNP:rs3130257Ensembl.	1
Natural variantⁱVAR_053434	124	S → Y. Corresponds to variant dbSNP:rs34704405Ensembl.	1
Natural variantⁱVAR_022025	341	V → A1 PublicationCorresponds to variant dbSNP:rs14398Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF447870 mRNA Translation: AAQ04645.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. AL844527 Genomic DNA No translation available. BX000343 Genomic DNA No translation available. Z97184, AL031228 Genomic DNA Translation: CAB09994.2 BC000388 mRNA Translation: AAH00388.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4772.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001157739.1, NM_001164267.1 NP_005443.3, NM_005452.5
UniGeneⁱ	Hs.520063 Hs.671763

Genome annotation databases

Ensemblⁱ	ENST00000374617; ENSP00000363746; ENSG00000227057 ENST00000383208; ENSP00000372695; ENSG00000206284 ENST00000432609; ENSP00000402869; ENSG00000236222 ENST00000432933; ENSP00000399454; ENSG00000204221 ENST00000457382; ENSP00000405614; ENSG00000226916
GeneIDⁱ	9277
KEGGⁱ	hsa:9277
UCSC genome browser More...UCSCⁱ	uc003ods.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O15213	WD repeat-containing protein 46		CAMFR		618	UniRef90_O15213
Uncharacterized protein		Cebus capucinus imitator		617
Uncharacterized protein		MYOLU		615
Uncharacterized protein		CERAT		615
Uncharacterized protein		AILME		615
+69

Protein	Similar proteins		Species	Score	Length	Source
O15213	WD repeat-containing protein 46		MOUSE		622	UniRef50_O15213
WD repeat-containing protein 46		CANLF		612
WD repeat-containing protein 46		CAMFR		618
Uncharacterized protein		Cebus capucinus imitator		617
Uncharacterized protein		MANLE		615
+194

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF447870 mRNA Translation: AAQ04645.1 AL662820 Genomic DNA No translation available. AL662827 Genomic DNA No translation available. AL844527 Genomic DNA No translation available. BX000343 Genomic DNA No translation available. Z97184, AL031228 Genomic DNA Translation: CAB09994.2 BC000388 mRNA Translation: AAH00388.1
CCDSⁱ	CCDS4772.1
RefSeqⁱ	NP_001157739.1, NM_001164267.1 NP_005443.3, NM_005452.5
UniGeneⁱ	Hs.520063 Hs.671763

3D structure databases

ProteinModelPortalⁱ	O15213
SMRⁱ	O15213
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114694, 112 interactors
IntActⁱ	O15213, 5 interactors
MINTⁱ	O15213
STRINGⁱ	9606.ENSP00000363746

PTM databases

iPTMnetⁱ	O15213
PhosphoSitePlusⁱ	O15213
SwissPalmⁱ	O15213

Polymorphism and mutation databases

BioMutaⁱ	WDR46

BioMutaⁱ

WDR46

Proteomic databases

EPDⁱ	O15213
MaxQBⁱ	O15213
PaxDbⁱ	O15213
PeptideAtlasⁱ	O15213
PRIDEⁱ	O15213
ProteomicsDBⁱ	48513

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9277
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374617; ENSP00000363746; ENSG00000227057 ENST00000383208; ENSP00000372695; ENSG00000206284 ENST00000432609; ENSP00000402869; ENSG00000236222 ENST00000432933; ENSP00000399454; ENSG00000204221 ENST00000457382; ENSP00000405614; ENSG00000226916
GeneIDⁱ	9277
KEGGⁱ	hsa:9277
UCSCⁱ	uc003ods.4 human

Organism-specific databases

CTDⁱ	9277
DisGeNETⁱ	9277
EuPathDBⁱ	HostDB:ENSG00000227057.7
GeneCardsⁱ	WDR46
H-InvDBⁱ	HIX0058254
HGNCⁱ	HGNC:13923 WDR46
HPAⁱ	HPA043004
MIMⁱ	611440 gene
neXtProtⁱ	NX_O15213
OpenTargetsⁱ	ENSG00000227057
PharmGKBⁱ	PA25924
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1272 Eukaryota ENOG410XP5D LUCA
GeneTreeⁱ	ENSGT00390000007075
HOVERGENⁱ	HBG050687
InParanoidⁱ	O15213
KOⁱ	K14768
OMAⁱ	REGRYMV
OrthoDBⁱ	EOG091G09WH
PhylomeDBⁱ	O15213
TreeFamⁱ	TF300861

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkⁱ	O15213

Miscellaneous databases

ChiTaRSⁱ	WDR46 human
GeneWikiⁱ	WDR46
GenomeRNAiⁱ	9277
Protein Ontology More...PROⁱ	PR:O15213
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000227057 Expressed in 203 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_WDR46
ExpressionAtlasⁱ	O15213 baseline and differential
Genevisibleⁱ	O15213 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012952 BING4_C_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF08149 BING4CT, 1 hit
SMARTⁱ	View protein in SMART SM01033 BING4CT, 1 hit SM00320 WD40, 4 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR46_HUMAN
Accessionⁱ	O15213Primary (citable) accession number: O15213 Secondary accession number(s): A6NDP5 , Q5HYZ0, Q5STK5, Q5STR3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	November 30, 2010
	Last modified:	October 10, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15213 (WDR46_HUMAN)

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WD repeat-containing protein 46

WDR46

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ