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Protein

Zinc finger and BTB domain-containing protein 22

Gene

ZBTB22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri486 – 507C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 562C2H2-type 3PROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 22
Alternative name(s):
Protein BING1
Zinc finger and BTB domain-containing protein 22A
Zinc finger protein 297
Gene namesi
Name:ZBTB22
Synonyms:BING1, ZBTB22A, ZNF297
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000236104.2
HGNCiHGNC:13085 ZBTB22
MIMi611439 gene
neXtProtiNX_O15209

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9278
OpenTargetsiENSG00000236104
PharmGKBiPA37661

Polymorphism and mutation databases

BioMutaiZBTB22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475171 – 634Zinc finger and BTB domain-containing protein 22Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15209
MaxQBiO15209
PaxDbiO15209
PeptideAtlasiO15209
PRIDEiO15209
ProteomicsDBi48510

PTM databases

iPTMnetiO15209
PhosphoSitePlusiO15209

Expressioni

Gene expression databases

BgeeiENSG00000236104 Expressed in 90 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_ZBTB22
ExpressionAtlasiO15209 baseline and differential
GenevisibleiO15209 HS

Organism-specific databases

HPAiHPA043848

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114695, 13 interactors
DIPiDIP-62047N
IntActiO15209, 17 interactors
STRINGi9606.ENSP00000404403

Structurei

3D structure databases

ProteinModelPortaliO15209
SMRiO15209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 121BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri486 – 507C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 562C2H2-type 3PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231975
HOVERGENiHBG056510
InParanoidiO15209
KOiK10502
OMAiEPPDKGE
OrthoDBiEOG09370O8X
PhylomeDBiO15209

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR029833 ZBT22
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24414:SF4 PTHR24414:SF4, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O15209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ
60 70 80 90 100
RLQGQLCDVS IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM
110 120 130 140 150
DPGAFETVLA SAYTGRLSMA AADIVNFLTV GSVLQMWHIV DKCTELLREG
160 170 180 190 200
RASATTTITT AAATSVTVPG AGVPSGSGGT VAPATMGSAR SHASSRASEN
210 220 230 240 250
QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP VFPAPVVGSG
260 270 280 290 300
GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV
310 320 330 340 350
KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG
360 370 380 390 400
GPEATLSISD VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG
410 420 430 440 450
GPTPSSYAPS HPPRPLLPLD MQGNQILVFP SSSSSSSSQA PGQPPGNQAE
460 470 480 490 500
HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG DGNKIFLCHC GKAFSHKSMR
510 520 530 540 550
DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP YECGVCAKKF
560 570 580 590 600
MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG
610 620 630
DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN
Length:634
Mass (Da):65,602
Last modified:January 1, 1998 - v1
Checksum:i9CC1867213D6DEF7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AB93A2AB93_HUMAN
Zinc finger and BTB domain-containi...
ZBTB22
149Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057457250G → A. Corresponds to variant dbSNP:rs35663442Ensembl.1
Natural variantiVAR_022702310T → A3 PublicationsCorresponds to variant dbSNP:rs3130100Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97183 Genomic DNA No translation available.
Z97184 Genomic DNA Translation: CAB09990.1
AK315747 mRNA Translation: BAG38101.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
BX248088 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03721.1
BC018541 mRNA Translation: AAH18541.1
CCDSiCCDS4775.1
RefSeqiNP_001138810.1, NM_001145338.1
NP_005444.4, NM_005453.4
UniGeneiHs.206770

Genome annotation databases

EnsembliENST00000383196; ENSP00000372683; ENSG00000206280
ENST00000416097; ENSP00000393514; ENSG00000229253
ENST00000418540; ENSP00000388191; ENSG00000227780
ENST00000418724; ENSP00000404403; ENSG00000236104
ENST00000431845; ENSP00000407545; ENSG00000236104
ENST00000445320; ENSP00000396292; ENSG00000237056
GeneIDi9278
KEGGihsa:9278
UCSCiuc003oeb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97183 Genomic DNA No translation available.
Z97184 Genomic DNA Translation: CAB09990.1
AK315747 mRNA Translation: BAG38101.1
AL662820 Genomic DNA No translation available.
AL662827 Genomic DNA No translation available.
BX248088 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR759817 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03721.1
BC018541 mRNA Translation: AAH18541.1
CCDSiCCDS4775.1
RefSeqiNP_001138810.1, NM_001145338.1
NP_005444.4, NM_005453.4
UniGeneiHs.206770

3D structure databases

ProteinModelPortaliO15209
SMRiO15209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114695, 13 interactors
DIPiDIP-62047N
IntActiO15209, 17 interactors
STRINGi9606.ENSP00000404403

PTM databases

iPTMnetiO15209
PhosphoSitePlusiO15209

Polymorphism and mutation databases

BioMutaiZBTB22

Proteomic databases

EPDiO15209
MaxQBiO15209
PaxDbiO15209
PeptideAtlasiO15209
PRIDEiO15209
ProteomicsDBi48510

Protocols and materials databases

DNASUi9278
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383196; ENSP00000372683; ENSG00000206280
ENST00000416097; ENSP00000393514; ENSG00000229253
ENST00000418540; ENSP00000388191; ENSG00000227780
ENST00000418724; ENSP00000404403; ENSG00000236104
ENST00000431845; ENSP00000407545; ENSG00000236104
ENST00000445320; ENSP00000396292; ENSG00000237056
GeneIDi9278
KEGGihsa:9278
UCSCiuc003oeb.4 human

Organism-specific databases

CTDi9278
DisGeNETi9278
EuPathDBiHostDB:ENSG00000236104.2
GeneCardsiZBTB22
HGNCiHGNC:13085 ZBTB22
HPAiHPA043848
MIMi611439 gene
neXtProtiNX_O15209
OpenTargetsiENSG00000236104
PharmGKBiPA37661
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231975
HOVERGENiHBG056510
InParanoidiO15209
KOiK10502
OMAiEPPDKGE
OrthoDBiEOG09370O8X
PhylomeDBiO15209

Miscellaneous databases

ChiTaRSiZBTB22 human
GenomeRNAii9278
PROiPR:O15209
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000236104 Expressed in 90 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_ZBTB22
ExpressionAtlasiO15209 baseline and differential
GenevisibleiO15209 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR029833 ZBT22
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24414:SF4 PTHR24414:SF4, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT22_HUMAN
AccessioniPrimary (citable) accession number: O15209
Secondary accession number(s): B0V007
, Q5HYV4, Q5STL0, Q5STR7, Q8WV82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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