UniProtKB - O15204 (ADEC1_HUMAN)
Protein
ADAM DEC1
Gene
ADAMDEC1
Organism
Homo sapiens (Human)
Status
Functioni
May play an important role in the control of the immune response and during pregnancy.By similarity
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 352 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 353 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 356 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 362 | Zinc; catalyticSequence analysis | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- immune response Source: UniProtKB
- negative regulation of cell adhesion Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O15204 |
Protein family/group databases
MEROPSi | M12.219 |
Names & Taxonomyi
Protein namesi | Recommended name: ADAM DEC1 (EC:3.4.24.-)Alternative name(s): A disintegrin and metalloproteinase domain-like protein decysin-1 Short name: ADAM-like protein decysin-1 |
Gene namesi | Name:ADAMDEC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16299, ADAMDEC1 |
MIMi | 606393, gene |
neXtProti | NX_O15204 |
VEuPathDBi | HostDB:ENSG00000134028.14 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 27299 |
OpenTargetsi | ENSG00000134028 |
PharmGKBi | PA24535 |
Miscellaneous databases
Pharosi | O15204, Tbio |
Genetic variation databases
BioMutai | ADAMDEC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
PropeptideiPRO_0000029146 | 31 – 205 | Sequence analysisAdd BLAST | 175 | |
ChainiPRO_0000029147 | 206 – 470 | ADAM DEC1Add BLAST | 265 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Glycosylationi | 237 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 328 ↔ 407 | By similarity | ||
Disulfide bondi | 369 ↔ 374 | By similarity | ||
Glycosylationi | 466 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | O15204 |
jPOSTi | O15204 |
MassIVEi | O15204 |
PaxDbi | O15204 |
PeptideAtlasi | O15204 |
PRIDEi | O15204 |
ProteomicsDBi | 48507 [O15204-1] 48508 [O15204-2] |
PTM databases
GlyConnecti | 1910, 16 N-Linked glycans (3 sites) |
GlyGeni | O15204, 6 sites, 5 N-linked glycans (1 site) |
iPTMneti | O15204 |
PhosphoSitePlusi | O15204 |
Expressioni
Tissue specificityi
Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.2 Publications
Inductioni
Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.2 Publications
Gene expression databases
Bgeei | ENSG00000134028, Expressed in small intestine and 130 other tissues |
ExpressionAtlasi | O15204, baseline and differential |
Genevisiblei | O15204, HS |
Organism-specific databases
HPAi | ENSG00000134028, Group enriched (intestine, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
IntActi | O15204, 1 interactor |
STRINGi | 9606.ENSP00000256412 |
Miscellaneous databases
RNActi | O15204, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 412 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 195 | |
Domaini | 420 – 470 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00900000141143 |
HOGENOMi | CLU_012714_8_0_1 |
InParanoidi | O15204 |
OMAi | SCRAHFE |
PhylomeDBi | O15204 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033613, ADAMDEC1 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF125, PTHR11905:SF125, 1 hit |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O15204-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL
60 70 80 90 100
HILHKREIKN NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP
110 120 130 140 150
DYTETLYSPR GEEITTKPEN MEHCYYKGNI LNEKNSVASI STCDGLRGYF
160 170 180 190 200
THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ DPANHTCGVK STDGKQGPIR
210 220 230 240 250
ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL IRSFVFDVMN
260 270 280 290 300
LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK
310 320 330 340 350
KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM
360 370 380 390 400
SHELGHVLGM PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL
410 420 430 440 450
LSQKPKCLLQ APIPTNIMTT PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL
460 470
TCKLKPGTDC GGDAPNHTTE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RK05 | E5RK05_HUMAN | ADAM DEC1 | ADAMDEC1 | 41 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024598 | 121 | M → T. Corresponds to variant dbSNP:rs7007084EnsemblClinVar. | 1 | |
Natural variantiVAR_021848 | 444 | N → S. Corresponds to variant dbSNP:rs3765124Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043124 | 1 – 79 | Missing in isoform 2. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13323 mRNA Translation: CAA73764.2 AK316320 mRNA Translation: BAH14691.1 AK316322 mRNA Translation: BAH14693.1 AC120193 Genomic DNA No translation available. BC069582 mRNA Translation: AAH69582.1 BC074877 mRNA Translation: AAH74877.1 BC074878 mRNA Translation: AAH74878.1 |
CCDSi | CCDS55212.1 [O15204-2] CCDS6044.1 [O15204-1] |
RefSeqi | NP_001138743.1, NM_001145271.1 [O15204-2] NP_001138744.1, NM_001145272.1 [O15204-2] NP_055294.1, NM_014479.3 [O15204-1] |
Genome annotation databases
Ensembli | ENST00000256412; ENSP00000256412; ENSG00000134028 [O15204-1] ENST00000522298; ENSP00000428993; ENSG00000134028 [O15204-2] |
GeneIDi | 27299 |
KEGGi | hsa:27299 |
UCSCi | uc003xdz.2, human [O15204-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13323 mRNA Translation: CAA73764.2 AK316320 mRNA Translation: BAH14691.1 AK316322 mRNA Translation: BAH14693.1 AC120193 Genomic DNA No translation available. BC069582 mRNA Translation: AAH69582.1 BC074877 mRNA Translation: AAH74877.1 BC074878 mRNA Translation: AAH74878.1 |
CCDSi | CCDS55212.1 [O15204-2] CCDS6044.1 [O15204-1] |
RefSeqi | NP_001138743.1, NM_001145271.1 [O15204-2] NP_001138744.1, NM_001145272.1 [O15204-2] NP_055294.1, NM_014479.3 [O15204-1] |
3D structure databases
SMRi | O15204 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O15204, 1 interactor |
STRINGi | 9606.ENSP00000256412 |
Protein family/group databases
MEROPSi | M12.219 |
PTM databases
GlyConnecti | 1910, 16 N-Linked glycans (3 sites) |
GlyGeni | O15204, 6 sites, 5 N-linked glycans (1 site) |
iPTMneti | O15204 |
PhosphoSitePlusi | O15204 |
Genetic variation databases
BioMutai | ADAMDEC1 |
Proteomic databases
EPDi | O15204 |
jPOSTi | O15204 |
MassIVEi | O15204 |
PaxDbi | O15204 |
PeptideAtlasi | O15204 |
PRIDEi | O15204 |
ProteomicsDBi | 48507 [O15204-1] 48508 [O15204-2] |
Protocols and materials databases
Antibodypediai | 22827, 156 antibodies |
Genome annotation databases
Ensembli | ENST00000256412; ENSP00000256412; ENSG00000134028 [O15204-1] ENST00000522298; ENSP00000428993; ENSG00000134028 [O15204-2] |
GeneIDi | 27299 |
KEGGi | hsa:27299 |
UCSCi | uc003xdz.2, human [O15204-1] |
Organism-specific databases
CTDi | 27299 |
DisGeNETi | 27299 |
GeneCardsi | ADAMDEC1 |
HGNCi | HGNC:16299, ADAMDEC1 |
HPAi | ENSG00000134028, Group enriched (intestine, lymphoid tissue) |
MIMi | 606393, gene |
neXtProti | NX_O15204 |
OpenTargetsi | ENSG00000134028 |
PharmGKBi | PA24535 |
VEuPathDBi | HostDB:ENSG00000134028.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00900000141143 |
HOGENOMi | CLU_012714_8_0_1 |
InParanoidi | O15204 |
OMAi | SCRAHFE |
PhylomeDBi | O15204 |
TreeFami | TF314733 |
Enzyme and pathway databases
PathwayCommonsi | O15204 |
Miscellaneous databases
BioGRID-ORCSi | 27299, 3 hits in 874 CRISPR screens |
ChiTaRSi | ADAMDEC1, human |
GenomeRNAii | 27299 |
Pharosi | O15204, Tbio |
PROi | PR:O15204 |
RNActi | O15204, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134028, Expressed in small intestine and 130 other tissues |
ExpressionAtlasi | O15204, baseline and differential |
Genevisiblei | O15204, HS |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033613, ADAMDEC1 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF125, PTHR11905:SF125, 1 hit |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADEC1_HUMAN | |
Accessioni | O15204Primary (citable) accession number: O15204 Secondary accession number(s): B7ZAK5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with genetic variants
List of human entries with genetic variants