Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - O15198 (SMAD9_HUMAN)

Entry version 215 (23 Feb 2022)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Mothers against decapentaplegic homolog 9

Gene

SMAD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi68ZincBy similarity1
Metal bindingi113ZincBy similarity1
Metal bindingi125ZincBy similarity1
Metal bindingi130ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15198

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201451, Signaling by BMP

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15198

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15198

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 9
Short name:
MAD homolog 9
Short name:
Mothers against DPP homolog 9
Alternative name(s):
Madh6
SMAD family member 9
Short name:
SMAD 9
Short name:
Smad9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMAD9
Synonyms:MADH6, MADH9, SMAD81 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6774, SMAD9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603295, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15198

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120693

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary hypertension, primary, 2 (PPH2)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06687143K → E in PPH2; affects SMAD-mediated signaling. 1 PublicationCorresponds to variant dbSNP:rs397514715EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		4093

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SMAD9

MalaCards human disease database

More...MalaCardsi		SMAD9
MIMi615342, phenotype

Open Targets

More...OpenTargetsi		ENSG00000120693

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		275777, Heritable pulmonary arterial hypertension

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30531

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15198, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SMAD9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000908751 – 467Mothers against decapentaplegic homolog 9Add BLAST467

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15198

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15198

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15198

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15198

PeptideAtlas

More...PeptideAtlasi		O15198

PRoteomics IDEntifications database

More...PRIDEi		O15198

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48505 [O15198-1]
48506 [O15198-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15198

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15198

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120693, Expressed in endometrium and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15198, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15198, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120693, Tissue enhanced (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interaction with the co-SMAD SMAD4.

Interacts with PEBP2-alpha subunit.

Interacts with RANBP3L (PubMed:25755279).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110268, 124 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15198

Protein interaction database and analysis system

More...IntActi		O15198, 105 interactors

Molecular INTeraction database

More...MINTi		O15198

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369154

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15198, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		O15198

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15198

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 140MH1PROSITE-ProRule annotationAdd BLAST125
Domaini273 – 467MH2PROSITE-ProRule annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni174 – 246DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi192 – 221Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3701, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163092

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026736_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15198

Identification of Orthologs from Complete Genome Data

More...OMAi		CSASYPH

Database of Orthologous Groups

More...OrthoDBi		608001at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15198

TreeFam database of animal gene trees

More...TreeFami		TF314923

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.200.10, 1 hit
3.90.520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013790, Dwarfin
IPR003619, MAD_homology1_Dwarfin-type
IPR013019, MAD_homology_MH1
IPR017855, SMAD-like_dom_sf
IPR001132, SMAD_dom_Dwarfin-type
IPR008984, SMAD_FHA_dom_sf
IPR036578, SMAD_MH1_sf

The PANTHER Classification System

More...PANTHERi		PTHR13703, PTHR13703, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03165, MH1, 1 hit
PF03166, MH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00523, DWA, 1 hit
SM00524, DWB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF56366, SSF56366, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51075, MH1, 1 hit
PS51076, MH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: O15198-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSTTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG 
        60         70         80         90        100
AMDELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD 
       110        120        130        140        150
LQSHHELKPL ECCEFPFGSK QKEVCINPYH YRRVETPVLP PVLVPRHSEY 
       160        170        180        190        200
NPQLSLLAKF RSASLHSEPL MPHNATYPDS FQQPPCSALP PSPSHAFSQS 
       210        220        230        240        250
PCTASYPHSP GSPSEPESPY QHSVDTPPLP YHATEASETQ SGQPVDATAD 
       260        270        280        290        300
RHVVLSIPNG DFRPVCYEEP QHWCSVAYYE LNNRVGETFQ ASSRSVLIDG 
       310        320        330        340        350
FTDPSNNRNR FCLGLLSNVN RNSTIENTRR HIGKGVHLYY VGGEVYAECV 
       360        370        380        390        400
SDSSIFVQSR NCNYQHGFHP ATVCKIPSGC SLKVFNNQLF AQLLAQSVHH 
       410        420        430        440        450
GFEVVYELTK MCTIRMSFVK GWGAEYHRQD VTSTPCWIEI HLHGPLQWLD 
       460 
KVLTQMGSPH NPISSVS
Length:467
Mass (Da):52,493
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFC8F982945BC6DD
GO
Isoform B (identifier: O15198-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-260: Missing.

Show »
Length:430
Mass (Da):48,640
Checksum:i6C9E4BB90DEB4B1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7I2R5A4A0A7I2R5A4_HUMAN
Mothers against decapentaplegic hom...
SMAD9
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06687143K → E in PPH2; affects SMAD-mediated signaling. 1 PublicationCorresponds to variant dbSNP:rs397514715EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006182224 – 260Missing in isoform B. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D83760 mRNA Translation: BAA21128.1
D83761 mRNA Translation: BAA21129.1
AL138706 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08571.1
CH471075 Genomic DNA Translation: EAX08572.1
BC011559 mRNA Translation: AAH11559.1
BC104760 mRNA Translation: AAI04761.1
BC104762 mRNA Translation: AAI04763.1
BC143240 mRNA Translation: AAI43241.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45032.1 [O15198-1]
CCDS9360.1 [O15198-2]

NCBI Reference Sequences

More...RefSeqi		NP_001120689.1, NM_001127217.2 [O15198-1]
NP_005896.1, NM_005905.5 [O15198-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000350148; ENSP00000239885; ENSG00000120693 [O15198-2]
ENST00000379826; ENSP00000369154; ENSG00000120693

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4093

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000379826.5; ENSP00000369154.4; NM_001127217.3; NP_001120689.1

UCSC genome browser

More...UCSCi		uc001uvw.3, human [O15198-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83760 mRNA Translation: BAA21128.1
D83761 mRNA Translation: BAA21129.1
AL138706 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08571.1
CH471075 Genomic DNA Translation: EAX08572.1
BC011559 mRNA Translation: AAH11559.1
BC104760 mRNA Translation: AAI04761.1
BC104762 mRNA Translation: AAI04763.1
BC143240 mRNA Translation: AAI43241.1
CCDSiCCDS45032.1 [O15198-1]
CCDS9360.1 [O15198-2]
RefSeqiNP_001120689.1, NM_001127217.2 [O15198-1]
NP_005896.1, NM_005905.5 [O15198-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FZTX-ray2.46A/B1-140[»]
SASBDBiO15198
SMRiO15198
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110268, 124 interactors
CORUMiO15198
IntActiO15198, 105 interactors
MINTiO15198
STRINGi9606.ENSP00000369154

PTM databases

iPTMnetiO15198
PhosphoSitePlusiO15198

Genetic variation databases

BioMutaiSMAD9

Proteomic databases

jPOSTiO15198
MassIVEiO15198
MaxQBiO15198
PaxDbiO15198
PeptideAtlasiO15198
PRIDEiO15198
ProteomicsDBi48505 [O15198-1]
48506 [O15198-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3969, 344 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		4093

Genome annotation databases

EnsembliENST00000350148; ENSP00000239885; ENSG00000120693 [O15198-2]
ENST00000379826; ENSP00000369154; ENSG00000120693
GeneIDi4093
KEGGihsa:4093
MANE-SelectiENST00000379826.5; ENSP00000369154.4; NM_001127217.3; NP_001120689.1
UCSCiuc001uvw.3, human [O15198-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4093
DisGeNETi4093

GeneCards: human genes, protein and diseases

More...GeneCardsi		SMAD9
GeneReviewsiSMAD9
HGNCiHGNC:6774, SMAD9
HPAiENSG00000120693, Tissue enhanced (thyroid)
MalaCardsiSMAD9
MIMi603295, gene
615342, phenotype
neXtProtiNX_O15198
OpenTargetsiENSG00000120693
Orphaneti275777, Heritable pulmonary arterial hypertension
PharmGKBiPA30531
VEuPathDBiHostDB:ENSG00000120693

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3701, Eukaryota
GeneTreeiENSGT00940000163092
HOGENOMiCLU_026736_0_2_1
InParanoidiO15198
OMAiCSASYPH
OrthoDBi608001at2759
PhylomeDBiO15198
TreeFamiTF314923

Enzyme and pathway databases

PathwayCommonsiO15198
ReactomeiR-HSA-201451, Signaling by BMP
SignaLinkiO15198
SIGNORiO15198

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4093, 6 hits in 1063 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SMAD9, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Mothers_against_decapentaplegic_homolog_9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4093
PharosiO15198, Tbio

Protein Ontology

More...PROi		PR:O15198
RNActiO15198, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120693, Expressed in endometrium and 216 other tissues
ExpressionAtlasiO15198, baseline and differential
GenevisibleiO15198, HS

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790, Dwarfin
IPR003619, MAD_homology1_Dwarfin-type
IPR013019, MAD_homology_MH1
IPR017855, SMAD-like_dom_sf
IPR001132, SMAD_dom_Dwarfin-type
IPR008984, SMAD_FHA_dom_sf
IPR036578, SMAD_MH1_sf
PANTHERiPTHR13703, PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165, MH1, 1 hit
PF03166, MH2, 1 hit
SMARTiView protein in SMART
SM00523, DWA, 1 hit
SM00524, DWB, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
SSF56366, SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075, MH1, 1 hit
PS51076, MH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMAD9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15198
Secondary accession number(s): A2A2Y6, O14989, Q5TBA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: January 1, 1998
Last modified: February 23, 2022
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again