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UniProtKB - O15195 (VILL_HUMAN)
Protein
Villin-like protein
Gene
VILL
Organism
Homo sapiens (Human)
Status
Functioni
Possible tumor suppressor.
GO - Molecular functioni
- actin filament binding Source: GO_Central
- phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central
- structural constituent of cytoskeleton Source: ProtInc
GO - Biological processi
- actin filament severing Source: GO_Central
- actin polymerization or depolymerization Source: GO_Central
- barbed-end actin filament capping Source: GO_Central
Keywordsi
Molecular function | Actin capping, Actin-binding |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | O15195 |
SignaLinki | O15195 |
Names & Taxonomyi
Protein namesi | Recommended name: Villin-like protein |
Gene namesi | Name:VILL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30906, VILL |
neXtProti | NX_O15195 |
VEuPathDBi | HostDB:ENSG00000136059 |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 50853 |
OpenTargetsi | ENSG00000136059 |
PharmGKBi | PA134911684 |
Miscellaneous databases
Pharosi | O15195, Tbio |
Genetic variation databases
BioMutai | VILL |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218738 | 1 – 856 | Villin-like proteinAdd BLAST | 856 |
Proteomic databases
jPOSTi | O15195 |
MassIVEi | O15195 |
MaxQBi | O15195 |
PaxDbi | O15195 |
PeptideAtlasi | O15195 |
PRIDEi | O15195 |
ProteomicsDBi | 48500 [O15195-1] 48501 [O15195-2] |
PTM databases
iPTMneti | O15195 |
PhosphoSitePlusi | O15195 |
Expressioni
Tissue specificityi
Ubiquitously expressed in 16 tissues examined.
Gene expression databases
Bgeei | ENSG00000136059, Expressed in stomach and 148 other tissues |
ExpressionAtlasi | O15195, baseline and differential |
Genevisiblei | O15195, HS |
Organism-specific databases
HPAi | ENSG00000136059, Group enriched (intestine, stomach) |
Interactioni
Binary interactionsi
Isoform 2 [O15195-2]
With | #Exp. | IntAct |
---|---|---|
LITAF [Q99732] | 3 | EBI-21845957,EBI-725647 |
MAPT [P10636] | 3 | EBI-21845957,EBI-366182 |
OPTN [Q96CV9] | 3 | EBI-21845957,EBI-748974 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119155, 6 interactors |
IntActi | O15195, 9 interactors |
STRINGi | 9606.ENSP00000283713 |
Miscellaneous databases
RNActi | O15195, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 22 – 74 | Gelsolin-like 1Add BLAST | 53 | |
Repeati | 146 – 186 | Gelsolin-like 2Add BLAST | 41 | |
Repeati | 263 – 307 | Gelsolin-like 3Add BLAST | 45 | |
Repeati | 401 – 450 | Gelsolin-like 4Add BLAST | 50 | |
Repeati | 521 – 561 | Gelsolin-like 5Add BLAST | 41 | |
Repeati | 624 – 665 | Gelsolin-like 6Add BLAST | 42 | |
Domaini | 790 – 856 | HPPROSITE-ProRule annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 762 – 796 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 762 – 795 | Polar residuesSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the villin/gelsolin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0443, Eukaryota |
GeneTreei | ENSGT00940000160253 |
HOGENOMi | CLU_002568_3_1_1 |
InParanoidi | O15195 |
OMAi | HIWITEN |
OrthoDBi | 1376537at2759 |
PhylomeDBi | O15195 |
TreeFami | TF313468 |
Family and domain databases
Gene3Di | 1.10.950.10, 1 hit 3.40.20.10, 6 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR015626, Villin-like IPR007122, Villin/Gelsolin IPR003128, Villin_headpiece IPR036886, Villin_headpiece_dom_sf |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF30, PTHR11977:SF30, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 6 hits PF02209, VHP, 1 hit |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 6 hits SM00153, VHP, 1 hit |
SUPFAMi | SSF47050, SSF47050, 1 hit SSF82754, SSF82754, 2 hits |
PROSITEi | View protein in PROSITE PS51089, HP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15195-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP
60 70 80 90 100
KATQGASSDL HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH
110 120 130 140 150
ESDCFCSYFR PGIIYRKGGL ASDLKHVETN LFNIQRLLHI KGRKHVSATE
160 170 180 190 200
VELSWNSFNK GDIFLLDLGK MMIQWNGPKT SISEKARGLA LTYSLRDRER
210 220 230 240 250
GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS KDINQLQKAN
260 270 280 290 300
VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM
310 320 330 340 350
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK
360 370 380 390 400
RRRNQKLGGR DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD
410 420 430 440 450
LHRQPVDPKR HGQLCAGNCY LVLYTYQRLG RVQYILYLWQ GHQATADEIE
460 470 480 490 500
ALNSNAEELD VMYGGVLVQE HVTMGSEPPH FLAIFQGQLV IFQERAGHHG
510 520 530 540 550
KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL LVTASVCYLW
560 570 580 590 600
FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN
610 620 630 640 650
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE
660 670 680 690 700
IFLWLGEAAS EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG
710 720 730 740 750
WFFTWDPYKW TSHPSHKEVV DGSPAAASTI SEITAEVNNL RLSRWPGNGR
760 770 780 790 800
AGAVALQALK GSQDSSENDL VRSPKSAGSR TSSSVSSTSA TINGGLRREQ
810 820 830 840 850
LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS MATWRQRQEK
KQLGFF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6R9H2 | D6R9H2_HUMAN | Villin-like protein | VILL | 574 | Annotation score: | ||
H7BZ43 | H7BZ43_HUMAN | Villin-like protein | VILL | 101 | Annotation score: | ||
E9PFV5 | E9PFV5_HUMAN | Villin-like protein | VILL | 187 | Annotation score: | ||
C9JUR8 | C9JUR8_HUMAN | Villin-like protein | VILL | 130 | Annotation score: |
Sequence cautioni
The sequence AAH00243 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH04300 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 229 | R → C in BAA21668 (PubMed:9179494).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052938 | 610 | F → L. Corresponds to variant dbSNP:rs1892814Ensembl. | 1 | |
Natural variantiVAR_052939 | 740 | L → F. Corresponds to variant dbSNP:rs9816693Ensembl. | 1 | |
Natural variantiVAR_081640 | 798 | R → Q1 PublicationCorresponds to variant dbSNP:rs147292695Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006729 | 262 – 275 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105752 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64506.1 BC000243 mRNA Translation: AAH00243.1 Different initiation. BC004300 mRNA Translation: AAH04300.1 Different initiation. D88154 mRNA Translation: BAA21668.1 |
CCDSi | CCDS2670.2 [O15195-1] |
PIRi | JC5708 |
RefSeqi | NP_056957.3, NM_015873.3 [O15195-1] XP_005265248.1, XM_005265191.3 XP_005265249.1, XM_005265192.4 XP_006713247.1, XM_006713184.3 XP_011532072.1, XM_011533770.2 |
Genome annotation databases
Ensembli | ENST00000283713; ENSP00000283713; ENSG00000136059 ENST00000383759; ENSP00000373266; ENSG00000136059 |
GeneIDi | 50853 |
KEGGi | hsa:50853 |
MANE-Selecti | ENST00000383759.7; ENSP00000373266.2; NM_015873.4; NP_056957.3 |
UCSCi | uc003chj.4, human [O15195-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105752 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64506.1 BC000243 mRNA Translation: AAH00243.1 Different initiation. BC004300 mRNA Translation: AAH04300.1 Different initiation. D88154 mRNA Translation: BAA21668.1 |
CCDSi | CCDS2670.2 [O15195-1] |
PIRi | JC5708 |
RefSeqi | NP_056957.3, NM_015873.3 [O15195-1] XP_005265248.1, XM_005265191.3 XP_005265249.1, XM_005265192.4 XP_006713247.1, XM_006713184.3 XP_011532072.1, XM_011533770.2 |
3D structure databases
SMRi | O15195 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119155, 6 interactors |
IntActi | O15195, 9 interactors |
STRINGi | 9606.ENSP00000283713 |
PTM databases
iPTMneti | O15195 |
PhosphoSitePlusi | O15195 |
Genetic variation databases
BioMutai | VILL |
Proteomic databases
jPOSTi | O15195 |
MassIVEi | O15195 |
MaxQBi | O15195 |
PaxDbi | O15195 |
PeptideAtlasi | O15195 |
PRIDEi | O15195 |
ProteomicsDBi | 48500 [O15195-1] 48501 [O15195-2] |
Protocols and materials databases
Antibodypediai | 48930, 97 antibodies from 21 providers |
DNASUi | 50853 |
Genome annotation databases
Ensembli | ENST00000283713; ENSP00000283713; ENSG00000136059 ENST00000383759; ENSP00000373266; ENSG00000136059 |
GeneIDi | 50853 |
KEGGi | hsa:50853 |
MANE-Selecti | ENST00000383759.7; ENSP00000373266.2; NM_015873.4; NP_056957.3 |
UCSCi | uc003chj.4, human [O15195-1] |
Organism-specific databases
CTDi | 50853 |
DisGeNETi | 50853 |
GeneCardsi | VILL |
HGNCi | HGNC:30906, VILL |
HPAi | ENSG00000136059, Group enriched (intestine, stomach) |
neXtProti | NX_O15195 |
OpenTargetsi | ENSG00000136059 |
PharmGKBi | PA134911684 |
VEuPathDBi | HostDB:ENSG00000136059 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0443, Eukaryota |
GeneTreei | ENSGT00940000160253 |
HOGENOMi | CLU_002568_3_1_1 |
InParanoidi | O15195 |
OMAi | HIWITEN |
OrthoDBi | 1376537at2759 |
PhylomeDBi | O15195 |
TreeFami | TF313468 |
Enzyme and pathway databases
PathwayCommonsi | O15195 |
SignaLinki | O15195 |
Miscellaneous databases
BioGRID-ORCSi | 50853, 8 hits in 1044 CRISPR screens |
ChiTaRSi | VILL, human |
GenomeRNAii | 50853 |
Pharosi | O15195, Tbio |
PROi | PR:O15195 |
RNActi | O15195, protein |
Gene expression databases
Bgeei | ENSG00000136059, Expressed in stomach and 148 other tissues |
ExpressionAtlasi | O15195, baseline and differential |
Genevisiblei | O15195, HS |
Family and domain databases
Gene3Di | 1.10.950.10, 1 hit 3.40.20.10, 6 hits |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR015626, Villin-like IPR007122, Villin/Gelsolin IPR003128, Villin_headpiece IPR036886, Villin_headpiece_dom_sf |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF30, PTHR11977:SF30, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 6 hits PF02209, VHP, 1 hit |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 6 hits SM00153, VHP, 1 hit |
SUPFAMi | SSF47050, SSF47050, 1 hit SSF82754, SSF82754, 2 hits |
PROSITEi | View protein in PROSITE PS51089, HP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VILL_HUMAN | |
Accessioni | O15195Primary (citable) accession number: O15195 Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families