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Entry version 168 (07 Apr 2021)
Sequence version 3 (15 Mar 2005)
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Protein

Villin-like protein

Gene

VILL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible tumor suppressor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O15195

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Villin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VILL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30906, VILL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15195

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000136059.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50853

Open Targets

More...
OpenTargetsi
ENSG00000136059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134911684

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O15195, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VILL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187381 – 856Villin-like proteinAdd BLAST856

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15195

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O15195

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15195

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15195

PeptideAtlas

More...
PeptideAtlasi
O15195

PRoteomics IDEntifications database

More...
PRIDEi
O15195

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48500 [O15195-1]
48501 [O15195-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15195

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15195

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in 16 tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136059, Expressed in stomach and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15195, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15195, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136059, Tissue enhanced (intestine, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119155, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O15195, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O15195, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15195

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 74Gelsolin-like 1Add BLAST53
Repeati146 – 186Gelsolin-like 2Add BLAST41
Repeati263 – 307Gelsolin-like 3Add BLAST45
Repeati401 – 450Gelsolin-like 4Add BLAST50
Repeati521 – 561Gelsolin-like 5Add BLAST41
Repeati624 – 665Gelsolin-like 6Add BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini790 – 856HPPROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0443, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002568_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15195

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLWVGAQ

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15195

TreeFam database of animal gene trees

More...
TreeFami
TF313468

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR015626, Villin-like
IPR007122, Villin/Gelsolin
IPR003128, Villin_headpiece
IPR036886, Villin_headpiece_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11977, PTHR11977, 1 hit
PTHR11977:SF30, PTHR11977:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626, Gelsolin, 6 hits
PF02209, VHP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597, GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262, GEL, 6 hits
SM00153, VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050, SSF47050, 1 hit
SSF82754, SSF82754, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089, HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15195-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP
60 70 80 90 100
KATQGASSDL HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH
110 120 130 140 150
ESDCFCSYFR PGIIYRKGGL ASDLKHVETN LFNIQRLLHI KGRKHVSATE
160 170 180 190 200
VELSWNSFNK GDIFLLDLGK MMIQWNGPKT SISEKARGLA LTYSLRDRER
210 220 230 240 250
GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS KDINQLQKAN
260 270 280 290 300
VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM
310 320 330 340 350
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK
360 370 380 390 400
RRRNQKLGGR DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD
410 420 430 440 450
LHRQPVDPKR HGQLCAGNCY LVLYTYQRLG RVQYILYLWQ GHQATADEIE
460 470 480 490 500
ALNSNAEELD VMYGGVLVQE HVTMGSEPPH FLAIFQGQLV IFQERAGHHG
510 520 530 540 550
KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL LVTASVCYLW
560 570 580 590 600
FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN
610 620 630 640 650
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE
660 670 680 690 700
IFLWLGEAAS EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG
710 720 730 740 750
WFFTWDPYKW TSHPSHKEVV DGSPAAASTI SEITAEVNNL RLSRWPGNGR
760 770 780 790 800
AGAVALQALK GSQDSSENDL VRSPKSAGSR TSSSVSSTSA TINGGLRREQ
810 820 830 840 850
LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS MATWRQRQEK

KQLGFF
Length:856
Mass (Da):95,907
Last modified:March 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8B7EDEFDF11CEE1
GO
Isoform 2 (identifier: O15195-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-275: Missing.

Show »
Length:842
Mass (Da):94,417
Checksum:i2642A8BB552C2788
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9H2D6R9H2_HUMAN
Villin-like protein
VILL
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ43H7BZ43_HUMAN
Villin-like protein
VILL
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFV5E9PFV5_HUMAN
Villin-like protein
VILL
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUR8C9JUR8_HUMAN
Villin-like protein
VILL
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00243 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH04300 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229R → C in BAA21668 (PubMed:9179494).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052938610F → L. Corresponds to variant dbSNP:rs1892814Ensembl.1
Natural variantiVAR_052939740L → F. Corresponds to variant dbSNP:rs9816693Ensembl.1
Natural variantiVAR_081640798R → Q1 PublicationCorresponds to variant dbSNP:rs147292695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006729262 – 275Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC105752 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64506.1
BC000243 mRNA Translation: AAH00243.1 Different initiation.
BC004300 mRNA Translation: AAH04300.1 Different initiation.
D88154 mRNA Translation: BAA21668.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2670.2 [O15195-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5708

NCBI Reference Sequences

More...
RefSeqi
NP_056957.3, NM_015873.3 [O15195-1]
XP_005265248.1, XM_005265191.3
XP_005265249.1, XM_005265192.4
XP_006713247.1, XM_006713184.3
XP_011532072.1, XM_011533770.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283713; ENSP00000283713; ENSG00000136059 [O15195-1]
ENST00000383759; ENSP00000373266; ENSG00000136059 [O15195-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
50853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50853

UCSC genome browser

More...
UCSCi
uc003chj.4, human [O15195-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105752 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64506.1
BC000243 mRNA Translation: AAH00243.1 Different initiation.
BC004300 mRNA Translation: AAH04300.1 Different initiation.
D88154 mRNA Translation: BAA21668.1
CCDSiCCDS2670.2 [O15195-1]
PIRiJC5708
RefSeqiNP_056957.3, NM_015873.3 [O15195-1]
XP_005265248.1, XM_005265191.3
XP_005265249.1, XM_005265192.4
XP_006713247.1, XM_006713184.3
XP_011532072.1, XM_011533770.2

3D structure databases

SMRiO15195
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119155, 5 interactors
IntActiO15195, 8 interactors
STRINGi9606.ENSP00000283713

PTM databases

iPTMnetiO15195
PhosphoSitePlusiO15195

Genetic variation databases

BioMutaiVILL

Proteomic databases

jPOSTiO15195
MassIVEiO15195
MaxQBiO15195
PaxDbiO15195
PeptideAtlasiO15195
PRIDEiO15195
ProteomicsDBi48500 [O15195-1]
48501 [O15195-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48930, 93 antibodies

The DNASU plasmid repository

More...
DNASUi
50853

Genome annotation databases

EnsembliENST00000283713; ENSP00000283713; ENSG00000136059 [O15195-1]
ENST00000383759; ENSP00000373266; ENSG00000136059 [O15195-1]
GeneIDi50853
KEGGihsa:50853
UCSCiuc003chj.4, human [O15195-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
50853
DisGeNETi50853

GeneCards: human genes, protein and diseases

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GeneCardsi
VILL
HGNCiHGNC:30906, VILL
HPAiENSG00000136059, Tissue enhanced (intestine, stomach)
neXtProtiNX_O15195
OpenTargetsiENSG00000136059
PharmGKBiPA134911684
VEuPathDBiHostDB:ENSG00000136059.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0443, Eukaryota
GeneTreeiENSGT00940000160253
HOGENOMiCLU_002568_3_1_1
InParanoidiO15195
OMAiWLWVGAQ
OrthoDBi1376537at2759
PhylomeDBiO15195
TreeFamiTF313468

Enzyme and pathway databases

PathwayCommonsiO15195

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
50853, 7 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VILL, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50853
PharosiO15195, Tbio

Protein Ontology

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PROi
PR:O15195
RNActiO15195, protein

Gene expression databases

BgeeiENSG00000136059, Expressed in stomach and 147 other tissues
ExpressionAtlasiO15195, baseline and differential
GenevisibleiO15195, HS

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR015626, Villin-like
IPR007122, Villin/Gelsolin
IPR003128, Villin_headpiece
IPR036886, Villin_headpiece_dom_sf
PANTHERiPTHR11977, PTHR11977, 1 hit
PTHR11977:SF30, PTHR11977:SF30, 1 hit
PfamiView protein in Pfam
PF00626, Gelsolin, 6 hits
PF02209, VHP, 1 hit
PRINTSiPR00597, GELSOLIN
SMARTiView protein in SMART
SM00262, GEL, 6 hits
SM00153, VHP, 1 hit
SUPFAMiSSF47050, SSF47050, 1 hit
SSF82754, SSF82754, 2 hits
PROSITEiView protein in PROSITE
PS51089, HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVILL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15195
Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 15, 2005
Last modified: April 7, 2021
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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