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Protein

Centrin-3

Gene

CETN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi38 – 491PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi147 – 1582CuratedAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microtubule binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

SIGNORiO15182

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-3
Gene namesi
Name:CETN3
Synonyms:CEN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153140.8
HGNCiHGNC:1868 CETN3
MIMi602907 gene
neXtProtiNX_O15182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1070
OpenTargetsiENSG00000153140
PharmGKBiPA26421

Polymorphism and mutation databases

BioMutaiCETN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735631 – 167Centrin-3Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15182
MaxQBiO15182
PaxDbiO15182
PeptideAtlasiO15182
PRIDEiO15182
ProteomicsDBi48497

PTM databases

iPTMnetiO15182
PhosphoSitePlusiO15182

Expressioni

Gene expression databases

BgeeiENSG00000153140 Expressed in 238 organ(s), highest expression level in testis
CleanExiHS_CETN3
ExpressionAtlasiO15182 baseline and differential
GenevisibleiO15182 HS

Organism-specific databases

HPAiHPA035608
HPA063704

Interactioni

Subunit structurei

Monomer (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107497, 31 interactors
IntActiO15182, 21 interactors
STRINGi9606.ENSP00000283122

Structurei

3D structure databases

ProteinModelPortaliO15182
SMRiO15182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini61 – 96EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 167EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the centrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiO15182
KOiK16466
PhylomeDBiO15182
TreeFamiTF101141

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O15182-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL
60 70 80 90 100
KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH
110 120 130 140 150
EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG
160
DGEINQEEFI AIMTGDI
Length:167
Mass (Da):19,550
Last modified:February 20, 2007 - v2
Checksum:iEF67724B2D6C2680
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJF8E5RJF8_HUMAN
Centrin-3
CETN3
191Annotation score:
E5RK82E5RK82_HUMAN
Centrin-3
CETN3
156Annotation score:
E5RFM2E5RFM2_HUMAN
Centrin-3
CETN3
153Annotation score:
E5RH67E5RH67_HUMAN
Centrin-3
CETN3
111Annotation score:
H0YBL5H0YBL5_HUMAN
Centrin-3
CETN3
81Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03084610V → L1 PublicationCorresponds to variant dbSNP:rs4873Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12473 mRNA Translation: CAA73077.1
BT006688 mRNA Translation: AAP35334.1
AC093510 Genomic DNA No translation available.
BC005383 mRNA Translation: AAH05383.1
BC093793 mRNA Translation: AAH93793.1
BC112040 mRNA Translation: AAI12041.1
CCDSiCCDS4066.1
RefSeqiNP_001284697.1, NM_001297768.1
NP_004356.2, NM_004365.3
UniGeneiHs.591767

Genome annotation databases

EnsembliENST00000283122; ENSP00000283122; ENSG00000153140
GeneIDi1070
KEGGihsa:1070
UCSCiuc003kjo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12473 mRNA Translation: CAA73077.1
BT006688 mRNA Translation: AAP35334.1
AC093510 Genomic DNA No translation available.
BC005383 mRNA Translation: AAH05383.1
BC093793 mRNA Translation: AAH93793.1
BC112040 mRNA Translation: AAI12041.1
CCDSiCCDS4066.1
RefSeqiNP_001284697.1, NM_001297768.1
NP_004356.2, NM_004365.3
UniGeneiHs.591767

3D structure databases

ProteinModelPortaliO15182
SMRiO15182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107497, 31 interactors
IntActiO15182, 21 interactors
STRINGi9606.ENSP00000283122

PTM databases

iPTMnetiO15182
PhosphoSitePlusiO15182

Polymorphism and mutation databases

BioMutaiCETN3

Proteomic databases

EPDiO15182
MaxQBiO15182
PaxDbiO15182
PeptideAtlasiO15182
PRIDEiO15182
ProteomicsDBi48497

Protocols and materials databases

DNASUi1070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283122; ENSP00000283122; ENSG00000153140
GeneIDi1070
KEGGihsa:1070
UCSCiuc003kjo.4 human

Organism-specific databases

CTDi1070
DisGeNETi1070
EuPathDBiHostDB:ENSG00000153140.8
GeneCardsiCETN3
HGNCiHGNC:1868 CETN3
HPAiHPA035608
HPA063704
MIMi602907 gene
neXtProtiNX_O15182
OpenTargetsiENSG00000153140
PharmGKBiPA26421
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiO15182
KOiK16466
PhylomeDBiO15182
TreeFamiTF101141

Enzyme and pathway databases

SIGNORiO15182

Miscellaneous databases

GeneWikiiCETN3
GenomeRNAii1070
PROiPR:O15182
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153140 Expressed in 238 organ(s), highest expression level in testis
CleanExiHS_CETN3
ExpressionAtlasiO15182 baseline and differential
GenevisibleiO15182 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCETN3_HUMAN
AccessioniPrimary (citable) accession number: O15182
Secondary accession number(s): Q53YD2, Q9BS23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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