TBXT

Functionⁱ

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	51 – 219	T-boxPROSITE-ProRule annotationAdd BLAST		169

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Non-traceable author statementⁱ
- 8963900
RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 22164283
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 21632880
RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
RNA polymerase II transcription factor binding Source: BHF-UCL
transcriptional repressor activity, RNA polymerase II transcription factor binding Source: BHF-UCL
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 21632880

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior axis specification, embryo
Source: ProtInc
Traceable author statementⁱ
- 8963900
BMP signaling pathway Source: Ensembl
bone morphogenesis Source: Ensembl
canonical Wnt signaling pathway Source: Ensembl
cellular response to retinoic acid Source: Ensembl
determination of heart left/right asymmetry Source: Ensembl
embryonic skeletal system development Source: Ensembl
heart morphogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 21632880
mesoderm development
Source: ProtInc
Traceable author statementⁱ
- 8963900
mesoderm migration involved in gastrulation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
neural plate morphogenesis Source: Ensembl
neural tube closure Source: Ensembl
notochord formation Source: Ensembl
penetration of zona pellucida Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 21632880
post-anal tail morphogenesis Source: Ensembl
primitive streak formation
Source: BHF-UCL
Non-traceable author statementⁱ
- 18593560
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 8963900
signal transduction involved in regulation of gene expression Source: Ensembl
SMAD protein signal transduction Source: Ensembl
somitogenesis Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
vasculogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	O15178

SIGNORⁱ

O15178

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-box transcription factor TCurated Alternative name(s): Brachyury proteinCurated Protein T
Gene namesⁱ	Name:TBXTImported Synonyms:T
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164458.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11515 TBXT
MIMⁱ	601397 gene
neXtProtⁱ	NX_O15178

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neural tube defects (NTD)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.

Chordoma (CHDM)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.

Disease descriptionRare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread.

Sacral agenesis with vertebral anomalies (SAVA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by abnormalities of the spine, including sacral agenesis, abnormal ossification of all vertebral bodies, and a persistent notochordal canal during development.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6862
MalaCards human disease database More...MalaCardsⁱ	TBXT
MIMⁱ	182940 phenotype 215400 phenotype 615709 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164458
Orphanetⁱ	268392 Cervical spina bifida aperta 268762 Cervical spina bifida cystica 268397 Cervicothoracic spina bifida aperta 268766 Cervicothoracic spina bifida cystica 178 Chordoma 268388 Lumbosacral spina bifida aperta 268758 Lumbosacral spina bifida cystica 397927 Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome 268384 Thoracolumbosacral spina bifida aperta 268752 Thoracolumbosacral spina bifida cystica 268377 Total spina bifida aperta 268748 Total spina bifida cystica 268740 Upper thoracic spina bifida aperta 268770 Upper thoracic spina bifida cystica
PharmGKBⁱ	PA36296

Polymorphism and mutation databases

BioMutaⁱ	T

BioMutaⁱ

T

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184414	1 – 435	T-box transcription factor TAdd BLAST		435

Proteomic databases

PaxDbⁱ	O15178
PeptideAtlas More...PeptideAtlasⁱ	O15178
PRIDEⁱ	O15178
ProteomicsDBⁱ	48496

PTM databases

iPTMnetⁱ	O15178
PhosphoSitePlusⁱ	O15178

Expressionⁱ

Tissue specificityⁱ

Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000164458 Expressed in 99 organ(s), highest expression level in embryo
CleanExⁱ	HS_T
ExpressionAtlasⁱ	O15178 baseline and differential
Genevisibleⁱ	O15178 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003322

HPAⁱ

HPA003322

Interactionⁱ

Subunit structureⁱ

Monomer.By similarity

GO - Molecular functionⁱ

RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 22164283
RNA polymerase II transcription factor binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ELMⁱ	O15178
IntActⁱ	O15178, 1 interactor
STRINGⁱ	9606.ENSP00000296946

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	43 – 48	Combined sources	6
Helixⁱ	49 – 57	Combined sources	9
Beta strandⁱ	61 – 63	Combined sources	3
Beta strandⁱ	65 – 67	Combined sources	3
Beta strandⁱ	76 – 82	Combined sources	7
Beta strandⁱ	86 – 97	Combined sources	12
Beta strandⁱ	103 – 105	Combined sources	3
Beta strandⁱ	108 – 110	Combined sources	3
Beta strandⁱ	130 – 132	Combined sources	3
Helixⁱ	133 – 138	Combined sources	6
Beta strandⁱ	147 – 151	Combined sources	5
Beta strandⁱ	154 – 159	Combined sources	6
Beta strandⁱ	165 – 174	Combined sources	10
Beta strandⁱ	176 – 179	Combined sources	4
Beta strandⁱ	182 – 186	Combined sources	5
Helixⁱ	188 – 190	Combined sources	3
Beta strandⁱ	192 – 197	Combined sources	6
Helixⁱ	201 – 210	Combined sources	10
Helixⁱ	212 – 214	Combined sources	3
Helixⁱ	215 – 223	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O15178
SMRⁱ	O15178
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG3585 Eukaryota ENOG410XSTS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140847
HOGENOMⁱ	HOG000063663
HOVERGENⁱ	HBG004599
InParanoidⁱ	O15178
KEGG Orthology (KO) More...KOⁱ	K10172
OMAⁱ	APSCVYI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05OC
PhylomeDBⁱ	O15178
TreeFamⁱ	TF106341

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00182 TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR036960 T-box_sf IPR002070 TF_Brachyury IPR001699 TF_T-box IPR018186 TF_T-box_CS
PANTHERⁱ	PTHR11267 PTHR11267, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00907 T-box, 1 hit
PRINTSⁱ	PR00938 BRACHYURY PR00937 TBOX
SMARTⁱ	View protein in SMART SM00425 TBOX, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283 TBOX_1, 1 hit PS01264 TBOX_2, 1 hit PS50252 TBOX_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15178-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPGTESAG KSLQYRVDHL LSAVENELQA GSEKGDPTER ELRVGLEESE 
        60         70         80         90        100
LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH 
       110        120        130        140        150
RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN 
       160        170        180        190        200
KLNGGGQIML NSLHKYEPRI HIVRVGGPQR MITSHCFPET QFIAVTAYQN 
       210        220        230        240        250
EEITALKIKY NPFAKAFLDA KERSDHKEMM EEPGDSQQPG YSQWGWLLPG 
       260        270        280        290        300
TSTLCPPANP HPQFGGALSL PSTHSCDRYP TLRSHRSSPY PSPYAHRNNS 
       310        320        330        340        350
PTYSDNSPAC LSMLQSHDNW SSLGMPAHPS MLPVSHNASP PTSSSQYPSL 
       360        370        380        390        400
WSVSNGAVTP GSQAAAVSNG LGAQFFRGSP AHYTPLTHPV SAPSSSGSPL 
       410        420        430 
YEGAAAATDI VDSQYDAAAQ GRLIASWTPV SPPSM

Length:435

Mass (Da):47,443

Last modified:January 1, 1998 - v1

Checksum:ⁱ9D470088C8602631

GO

Isoform 2 (identifier: O15178-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
244-302: WGWLLPGTSTLCPPANPHPQFGGALSLPSTHSCDRYPTLRSHRSSPYPSPYAHRNNSPT → S

« Hide

        10         20         30         40         50
MSSPGTESAG KSLQYRVDHL LSAVENELQA GSEKGDPTER ELRVGLEESE 
        60         70         80         90        100
LWLRFKELTN EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH 
       110        120        130        140        150
RWKYVNGEWV PGGKPEPQAP SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN 
       160        170        180        190        200
KLNGGGQIML NSLHKYEPRI HIVRVGGPQR MITSHCFPET QFIAVTAYQN 
       210        220        230        240        250
EEITALKIKY NPFAKAFLDA KERSDHKEMM EEPGDSQQPG YSQSYSDNSP 
       260        270        280        290        300
ACLSMLQSHD NWSSLGMPAH PSMLPVSHNA SPPTSSSQYP SLWSVSNGAV 
       310        320        330        340        350
TPGSQAAAVS NGLGAQFFRG SPAHYTPLTH PVSAPSSSGS PLYEGAAAAT 
       360        370 
DIVDSQYDAA AQGRLIASWT PVSPPSM

Note: No experimental confirmation available.

Show »

Length:377

Mass (Da):41,078

Checksum:ⁱ28A89725810C9002

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KP65	J3KP65_HUMAN	T-box transcription factor T T-box transcription factor T	TBXT	403	Annotation score:
H0YM91	H0YM91_HUMAN	T-box transcription factor T T-box transcription factor T	TBXT	243	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071251	171	H → R in SAVA; reduced DNA binding activity; increased cell growth; altered expression of genes involved in ossification and notochord maintenance. 1 PublicationCorresponds to variant dbSNP:rs587777303EnsemblClinVar.	1
Natural variantⁱVAR_021982	177	G → D1 PublicationCorresponds to variant dbSNP:rs2305089Ensembl.	1
Natural variantⁱVAR_024656	356	G → S. Corresponds to variant dbSNP:rs3127328Ensembl.	1
Natural variantⁱVAR_063239	358	V → I. Corresponds to variant dbSNP:rs77703807Ensembl.	1
Natural variantⁱVAR_032457	367	V → M. Corresponds to variant dbSNP:rs35292451Ensembl.	1
Natural variantⁱVAR_020250	369	N → S. Corresponds to variant dbSNP:rs3816300Ensembl.	1
Natural variantⁱVAR_032458	402	E → K. Corresponds to variant dbSNP:rs34517945Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044795	244 – 302	WGWLL…NNSPT → S in isoform 2. 1 PublicationAdd BLAST		59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ001699 mRNA Translation: CAA04938.1 AL627443 Genomic DNA No translation available. BC098425 mRNA Translation: AAH98425.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5290.1 [O15178-1] CCDS59045.1 [O15178-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001257413.1, NM_001270484.1 [O15178-2] NP_003172.1, NM_003181.3 [O15178-1]
UniGeneⁱ	Hs.389457 Hs.742027

Genome annotation databases

Ensemblⁱ	ENST00000296946; ENSP00000296946; ENSG00000164458 [O15178-1] ENST00000366871; ENSP00000355836; ENSG00000164458 [O15178-2]
GeneIDⁱ	6862
KEGGⁱ	hsa:6862
UCSC genome browser More...UCSCⁱ	uc003quu.4 human [O15178-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15178	T-box transcription factor T		MOUSE		436	UniRef90_P20293
Uncharacterized protein		NEOLE		474
Brachyury protein isoform 2		HETGA		436
T, brachyury homolog (Mouse) (Predicted), isoform CRA_b		RAT		436
Uncharacterized protein		MACMU		435
+60
O15178-2	Uncharacterized protein		NOMLE		377	UniRef90_A0A2I3H5H5
Uncharacterized protein		PROCO		377
T isoform 2		PANTR		377
Uncharacterized protein		PANPA		377
T-box transcription factor T		GORGO		377
+37

Protein	Similar proteins		Species	Score	Length	Source
O15178	T-box transcription factor T		MOUSE		436	UniRef50_P20293
T-box transcription factor T homolog		HEMPU		434
T-box transcription factor T	)	XENLA		432
T-box transcription factor T homolog 1		BRAFL		448
T-box transcription factor T		CHICK		433
+332
O15178-2	T-box transcription factor T		MYOLU		373	UniRef50_G1PHX1
brachyury protein		ERIEU		388
Uncharacterized protein		LATCH		373
brachyury protein isoform X1		Austrofundulus limnaeus		460
T-box transcription factor T		SAIBB		376
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ001699 mRNA Translation: CAA04938.1 AL627443 Genomic DNA No translation available. BC098425 mRNA Translation: AAH98425.1
CCDSⁱ	CCDS5290.1 [O15178-1] CCDS59045.1 [O15178-2]
RefSeqⁱ	NP_001257413.1, NM_001270484.1 [O15178-2] NP_003172.1, NM_003181.3 [O15178-1]
UniGeneⁱ	Hs.389457 Hs.742027

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6F58	X-ray	2.25	A/B	40-224	[»]
	6F59	X-ray	2.15	A/B	41-224	[»]
ProteinModelPortalⁱ	O15178
SMRⁱ	O15178
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	O15178
IntActⁱ	O15178, 1 interactor
STRINGⁱ	9606.ENSP00000296946

PTM databases

iPTMnetⁱ	O15178
PhosphoSitePlusⁱ	O15178

Polymorphism and mutation databases

BioMutaⁱ	T

BioMutaⁱ

T

Proteomic databases

PaxDbⁱ	O15178
PeptideAtlasⁱ	O15178
PRIDEⁱ	O15178
ProteomicsDBⁱ	48496

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296946; ENSP00000296946; ENSG00000164458 [O15178-1] ENST00000366871; ENSP00000355836; ENSG00000164458 [O15178-2]
GeneIDⁱ	6862
KEGGⁱ	hsa:6862
UCSCⁱ	uc003quu.4 human [O15178-1]

Organism-specific databases

CTDⁱ	6862
DisGeNETⁱ	6862
EuPathDBⁱ	HostDB:ENSG00000164458.9
GeneCardsⁱ	TBXT
HGNCⁱ	HGNC:11515 TBXT
HPAⁱ	HPA003322
MalaCardsⁱ	TBXT
MIMⁱ	182940 phenotype 215400 phenotype 601397 gene 615709 phenotype
neXtProtⁱ	NX_O15178
OpenTargetsⁱ	ENSG00000164458
Orphanetⁱ	268392 Cervical spina bifida aperta 268762 Cervical spina bifida cystica 268397 Cervicothoracic spina bifida aperta 268766 Cervicothoracic spina bifida cystica 178 Chordoma 268388 Lumbosacral spina bifida aperta 268758 Lumbosacral spina bifida cystica 397927 Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome 268384 Thoracolumbosacral spina bifida aperta 268752 Thoracolumbosacral spina bifida cystica 268377 Total spina bifida aperta 268748 Total spina bifida cystica 268740 Upper thoracic spina bifida aperta 268770 Upper thoracic spina bifida cystica
PharmGKBⁱ	PA36296
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3585 Eukaryota ENOG410XSTS LUCA
GeneTreeⁱ	ENSGT00900000140847
HOGENOMⁱ	HOG000063663
HOVERGENⁱ	HBG004599
InParanoidⁱ	O15178
KOⁱ	K10172
OMAⁱ	APSCVYI
OrthoDBⁱ	EOG091G05OC
PhylomeDBⁱ	O15178
TreeFamⁱ	TF106341

Enzyme and pathway databases

SIGNORⁱ	O15178

SIGNORⁱ

O15178

Miscellaneous databases

GeneWikiⁱ	Brachyury
GenomeRNAiⁱ	6862
Protein Ontology More...PROⁱ	PR:O15178
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164458 Expressed in 99 organ(s), highest expression level in embryo
CleanExⁱ	HS_T
ExpressionAtlasⁱ	O15178 baseline and differential
Genevisibleⁱ	O15178 HS

Family and domain databases

CDDⁱ	cd00182 TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR036960 T-box_sf IPR002070 TF_Brachyury IPR001699 TF_T-box IPR018186 TF_T-box_CS
PANTHERⁱ	PTHR11267 PTHR11267, 1 hit
Pfamⁱ	View protein in Pfam PF00907 T-box, 1 hit
PRINTSⁱ	PR00938 BRACHYURY PR00937 TBOX
SMARTⁱ	View protein in SMART SM00425 TBOX, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283 TBOX_1, 1 hit PS01264 TBOX_2, 1 hit PS50252 TBOX_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBXT_HUMAN
Accessionⁱ	O15178Primary (citable) accession number: O15178 Secondary accession number(s): E7ERD6, Q4KMP4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15178 (TBXT_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

T-box transcription factor T

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ