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Entry version 171 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Membrane-associated progesterone receptor component 2

Gene

PGRMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, reduces labile heme in the nucleus and increases stability of the heme-responsive transcriptional repressors NR1D1 and BACH1 (PubMed:28111073).By similarity1 Publication1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O15173

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2Curated
Alternative name(s):
Progesterone membrane-binding protein
Steroid receptor protein DG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGRMC2Imported
Synonyms:DG61 Publication, PMBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000164040.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16089, PGRMC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607735, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15173

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 66HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10424

Open Targets

More...
OpenTargetsi
ENSG00000164040

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O15173, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PGRMC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001217431 – 223Membrane-associated progesterone receptor component 2Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei210PhosphotyrosineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15173

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15173

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O15173

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15173

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15173

PeptideAtlas

More...
PeptideAtlasi
O15173

PRoteomics IDEntifications database

More...
PRIDEi
O15173

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48495 [O15173-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O15173-1 [O15173-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15173

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
O15173

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15173

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O15173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by endometrial glands and stroma (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164040, Expressed in jejunal mucosa and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15173, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15173, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164040, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PGRMC1 (By similarity).

Interacts with AAAS (PubMed:27754849).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O15173
With#Exp.IntAct
AQP10 [Q96PS8]3EBI-1050125,EBI-12820279
ART5 [A0A024RCD1]3EBI-1050125,EBI-18958976
BAG4 [O95429]5EBI-1050125,EBI-2949658
C16orf58 [Q96GQ5]3EBI-1050125,EBI-8636004
C5 [P01031]3EBI-1050125,EBI-8558308
COX20 [Q5RI15]3EBI-1050125,EBI-2834035
CYB561D2 [O14569]3EBI-1050125,EBI-717654
CYP4F2 [P78329]3EBI-1050125,EBI-1752413
DGAT2L6 [Q6ZPD8]3EBI-1050125,EBI-12831978
DHRSX [Q8N5I4]3EBI-1050125,EBI-3923585
EI24 [O14681]3EBI-1050125,EBI-2339413
FA2H [Q7L5A8]3EBI-1050125,EBI-11337888
FAXDC2 [Q96IV6]3EBI-1050125,EBI-12142299
FXYD6 [Q9H0Q3]3EBI-1050125,EBI-713304
GET3 [O43681]3EBI-1050125,EBI-2515857
GHITM [Q9H3K2]3EBI-1050125,EBI-2868909
GPR151 [Q8TDV0]3EBI-1050125,EBI-11955647
ITGAM [P11215]3EBI-1050125,EBI-2568251
ITPRIP [Q8IWB1]3EBI-1050125,EBI-2556412
LPAR3 [Q9UBY5]3EBI-1050125,EBI-12033434
MALL [Q13021]3EBI-1050125,EBI-750078
MFSD5 [Q6N075]3EBI-1050125,EBI-3920969
ORMDL1 [Q9P0S3]3EBI-1050125,EBI-1054848
PEX16 [Q9Y5Y5]3EBI-1050125,EBI-981985
PGRMC1 [O00264]3EBI-1050125,EBI-1045534
PLLP [Q9Y342]3EBI-1050125,EBI-3919291
PMP22 [Q01453]3EBI-1050125,EBI-2845982
RNF8 [O76064]3EBI-1050125,EBI-373337
SFXN1 [Q9H9B4]3EBI-1050125,EBI-355861
SLC16A13 [Q7RTY0]3EBI-1050125,EBI-12243266
SLC30A8 [Q8IWU4]3EBI-1050125,EBI-10262251
SLC38A1 [Q9H2H9]3EBI-1050125,EBI-9978441
SLC39A13 [Q96H72]3EBI-1050125,EBI-10287091
SLC9B2 [Q86UD5]3EBI-1050125,EBI-9916342
SMPD2 [O60906]3EBI-1050125,EBI-12828299
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-1050125,EBI-12908338
STX3 [Q13277]3EBI-1050125,EBI-1394295
TAS2R19 [P59542]3EBI-1050125,EBI-12847034
TECR [Q9NZ01]3EBI-1050125,EBI-2877718
TF [P02787]3EBI-1050125,EBI-714319
TMEM107 [Q6UX40]3EBI-1050125,EBI-12845616
TMEM187 [Q14656]3EBI-1050125,EBI-13046724
TMEM189-UBE2V1 [I3L0A0]3EBI-1050125,EBI-12213001
TMEM19 [Q96HH6]3EBI-1050125,EBI-741829
TMEM208 [Q9BTX3]3EBI-1050125,EBI-12876824
TMEM60 [Q9H2L4]3EBI-1050125,EBI-2852148
TMEM86A [Q8N2M4]3EBI-1050125,EBI-12015604
TMEM86B [Q8N661]3EBI-1050125,EBI-2548832
TSPAN2 [O60636]3EBI-1050125,EBI-3914288
UBXN8 [O00124]3EBI-1050125,EBI-1993850
VAPA [Q9P0L0]3EBI-1050125,EBI-1059156
YIPF2 [Q9BWQ6]3EBI-1050125,EBI-751204
ZDHHC21 [Q8IVQ6]3EBI-1050125,EBI-2849773
ZFPL1 [O95159]3EBI-1050125,EBI-718439
Fech [P22315] from Mus musculus.2EBI-1050125,EBI-7174007

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115693, 47 interactors

Protein interaction database and analysis system

More...
IntActi
O15173, 127 interactors

Molecular INTeraction database

More...
MINTi
O15173

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429301

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O15173, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15173

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 201Cytochrome b5 heme-bindingAdd BLAST100

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1110, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_042860_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15173

KEGG Orthology (KO)

More...
KOi
K17278

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRLYLRW

Database of Orthologous Groups

More...
OrthoDBi
1331617at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00173, Cyt-b5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01117, Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55856, SSF55856, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15173-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG
60 70 80 90 100
GGEMLLNVAL VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK
110 120 130 140 150
RDFSLEQLRQ YDGSRNPRIL LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD
160 170 180 190 200
ASRGLATFCL DKDALRDEYD DLSDLNAVQM ESVREWEMQF KEKYDYVGRL
210 220
LKPGEEPSEY TDEEDTKDHN KQD
Length:223
Mass (Da):23,818
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE36229EDF0FF3AD
GO
Isoform 2 (identifier: O15173-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGGAGRGVGEGRGRGGGGRRWRAVM

Show »
Length:247
Mass (Da):26,170
Checksum:iB0D4D72618C79519
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ70U3KQ70_HUMAN
Membrane-associated progesterone re...
PGRMC2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQM0U3KQM0_HUMAN
Membrane-associated progesterone re...
PGRMC2 hCG_16401
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPU8U3KPU8_HUMAN
Membrane-associated progesterone re...
PGRMC2 hCG_16401
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0535001M → MGGAGRGVGEGRGRGGGGRR WRAVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ002030 mRNA Translation: CAA05152.1
AK131272 mRNA No translation available.
DQ496105 Genomic DNA Translation: ABF47094.1
BC016692 mRNA Translation: AAH16692.1
BC092478 mRNA Translation: AAH92478.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3739.2 [O15173-1]

NCBI Reference Sequences

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RefSeqi
NP_006311.2, NM_006320.4 [O15173-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296425; ENSP00000296425; ENSG00000164040 [O15173-1]
ENST00000520121; ENSP00000429301; ENSG00000164040 [O15173-1]
ENST00000613358; ENSP00000481886; ENSG00000164040 [O15173-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10424

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10424

UCSC genome browser

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UCSCi
uc003igg.4, human [O15173-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002030 mRNA Translation: CAA05152.1
AK131272 mRNA No translation available.
DQ496105 Genomic DNA Translation: ABF47094.1
BC016692 mRNA Translation: AAH16692.1
BC092478 mRNA Translation: AAH92478.1
CCDSiCCDS3739.2 [O15173-1]
RefSeqiNP_006311.2, NM_006320.4 [O15173-1]

3D structure databases

SMRiO15173
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115693, 47 interactors
IntActiO15173, 127 interactors
MINTiO15173
STRINGi9606.ENSP00000429301

PTM databases

iPTMnetiO15173
MetOSiteiO15173
PhosphoSitePlusiO15173
SwissPalmiO15173

Polymorphism and mutation databases

BioMutaiPGRMC2

Proteomic databases

EPDiO15173
jPOSTiO15173
MassIVEiO15173
MaxQBiO15173
PaxDbiO15173
PeptideAtlasiO15173
PRIDEiO15173
ProteomicsDBi48495 [O15173-1]
TopDownProteomicsiO15173-1 [O15173-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27009, 261 antibodies

Genome annotation databases

EnsembliENST00000296425; ENSP00000296425; ENSG00000164040 [O15173-1]
ENST00000520121; ENSP00000429301; ENSG00000164040 [O15173-1]
ENST00000613358; ENSP00000481886; ENSG00000164040 [O15173-2]
GeneIDi10424
KEGGihsa:10424
UCSCiuc003igg.4, human [O15173-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10424
DisGeNETi10424
EuPathDBiHostDB:ENSG00000164040.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PGRMC2
HGNCiHGNC:16089, PGRMC2
HPAiENSG00000164040, Low tissue specificity
MIMi607735, gene
neXtProtiNX_O15173
OpenTargetsiENSG00000164040

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1110, Eukaryota
GeneTreeiENSGT00940000159744
HOGENOMiCLU_042860_1_0_1
InParanoidiO15173
KOiK17278
OMAiYRLYLRW
OrthoDBi1331617at2759
PhylomeDBiO15173

Enzyme and pathway databases

PathwayCommonsiO15173

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10424, 28 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PGRMC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10424
PharosiO15173, Tbio

Protein Ontology

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PROi
PR:O15173
RNActiO15173, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164040, Expressed in jejunal mucosa and 247 other tissues
ExpressionAtlasiO15173, baseline and differential
GenevisibleiO15173, HS

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173, Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117, Cyt-b5, 1 hit
SUPFAMiSSF55856, SSF55856, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGRC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15173
Secondary accession number(s): Q569H1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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