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Protein

Membrane-associated progesterone receptor component 2

Gene

PGRMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for steroids.Curated

GO - Molecular functioni

  • heme binding Source: GO_Central
  • steroid binding Source: ProtInc
  • steroid hormone receptor activity Source: ProtInc

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2
Alternative name(s):
Progesterone membrane-binding protein
Steroid receptor protein DG6
Gene namesi
Name:PGRMC2
Synonyms:DG6, PMBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164040.16
HGNCiHGNC:16089 PGRMC2
MIMi607735 gene
neXtProtiNX_O15173

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 66HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10424
OpenTargetsiENSG00000164040

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217431 – 223Membrane-associated progesterone receptor component 2Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei210PhosphotyrosineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15173
MaxQBiO15173
PaxDbiO15173
PeptideAtlasiO15173
PRIDEiO15173
ProteomicsDBi48495
TopDownProteomicsiO15173-1 [O15173-1]

PTM databases

iPTMnetiO15173
PhosphoSitePlusiO15173
SwissPalmiO15173

Expressioni

Gene expression databases

BgeeiENSG00000164040 Expressed in 235 organ(s), highest expression level in jejunal mucosa
CleanExiHS_PGRMC2
ExpressionAtlasiO15173 baseline and differential
GenevisibleiO15173 HS

Organism-specific databases

HPAiHPA041172
HPA058652

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115693, 23 interactors
IntActiO15173, 95 interactors
MINTiO15173
STRINGi9606.ENSP00000429301

Structurei

3D structure databases

ProteinModelPortaliO15173
SMRiO15173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 201Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
GeneTreeiENSGT00730000110959
HOGENOMiHOG000187840
HOVERGENiHBG059971
InParanoidiO15173
KOiK17278
OMAiYTDEEDI
OrthoDBiEOG091G0PXT
PhylomeDBiO15173

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15173-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG
60 70 80 90 100
GGEMLLNVAL VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK
110 120 130 140 150
RDFSLEQLRQ YDGSRNPRIL LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD
160 170 180 190 200
ASRGLATFCL DKDALRDEYD DLSDLNAVQM ESVREWEMQF KEKYDYVGRL
210 220
LKPGEEPSEY TDEEDTKDHN KQD
Length:223
Mass (Da):23,818
Last modified:January 1, 1998 - v1
Checksum:iBE36229EDF0FF3AD
GO
Isoform 2 (identifier: O15173-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGGAGRGVGEGRGRGGGGRRWRAVM

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):26,170
Checksum:iB0D4D72618C79519
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQM0U3KQM0_HUMAN
Membrane-associated progesterone re...
PGRMC2 hCG_16401
91Annotation score:
D3DNX8D3DNX8_HUMAN
Membrane-associated progesterone re...
PGRMC2 hCG_16401
44Annotation score:
U3KQ70U3KQ70_HUMAN
Membrane-associated progesterone re...
PGRMC2
59Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535001M → MGGAGRGVGEGRGRGGGGRR WRAVM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002030 mRNA Translation: CAA05152.1
AK131272 mRNA No translation available.
DQ496105 Genomic DNA Translation: ABF47094.1
BC016692 mRNA Translation: AAH16692.1
BC092478 mRNA Translation: AAH92478.1
CCDSiCCDS3739.2 [O15173-2]
RefSeqiNP_006311.2, NM_006320.4 [O15173-2]
UniGeneiHs.507910

Genome annotation databases

EnsembliENST00000296425; ENSP00000296425; ENSG00000164040 [O15173-1]
ENST00000520121; ENSP00000429301; ENSG00000164040 [O15173-2]
ENST00000613358; ENSP00000481886; ENSG00000164040 [O15173-2]
GeneIDi10424
KEGGihsa:10424
UCSCiuc003igg.4 human [O15173-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002030 mRNA Translation: CAA05152.1
AK131272 mRNA No translation available.
DQ496105 Genomic DNA Translation: ABF47094.1
BC016692 mRNA Translation: AAH16692.1
BC092478 mRNA Translation: AAH92478.1
CCDSiCCDS3739.2 [O15173-2]
RefSeqiNP_006311.2, NM_006320.4 [O15173-2]
UniGeneiHs.507910

3D structure databases

ProteinModelPortaliO15173
SMRiO15173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115693, 23 interactors
IntActiO15173, 95 interactors
MINTiO15173
STRINGi9606.ENSP00000429301

PTM databases

iPTMnetiO15173
PhosphoSitePlusiO15173
SwissPalmiO15173

Proteomic databases

EPDiO15173
MaxQBiO15173
PaxDbiO15173
PeptideAtlasiO15173
PRIDEiO15173
ProteomicsDBi48495
TopDownProteomicsiO15173-1 [O15173-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296425; ENSP00000296425; ENSG00000164040 [O15173-1]
ENST00000520121; ENSP00000429301; ENSG00000164040 [O15173-2]
ENST00000613358; ENSP00000481886; ENSG00000164040 [O15173-2]
GeneIDi10424
KEGGihsa:10424
UCSCiuc003igg.4 human [O15173-1]

Organism-specific databases

CTDi10424
DisGeNETi10424
EuPathDBiHostDB:ENSG00000164040.16
GeneCardsiPGRMC2
H-InvDBiHIX0004497
HGNCiHGNC:16089 PGRMC2
HPAiHPA041172
HPA058652
MIMi607735 gene
neXtProtiNX_O15173
OpenTargetsiENSG00000164040
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
GeneTreeiENSGT00730000110959
HOGENOMiHOG000187840
HOVERGENiHBG059971
InParanoidiO15173
KOiK17278
OMAiYTDEEDI
OrthoDBiEOG091G0PXT
PhylomeDBiO15173

Miscellaneous databases

ChiTaRSiPGRMC2 human
GenomeRNAii10424
PROiPR:O15173
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164040 Expressed in 235 organ(s), highest expression level in jejunal mucosa
CleanExiHS_PGRMC2
ExpressionAtlasiO15173 baseline and differential
GenevisibleiO15173 HS

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGRC2_HUMAN
AccessioniPrimary (citable) accession number: O15173
Secondary accession number(s): Q569H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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