We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O15172 (PSPHL_HUMAN)
Protein
Putative phosphoserine phosphatase-like protein
Gene
PSPHP1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- magnesium ion binding Source: GO_Central
GO - Biological processi
- dephosphorylation Source: GO_Central
- L-serine biosynthetic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-HSA-9707616, Heme signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Putative phosphoserine phosphatase-like proteinAlternative name(s): L-3-phosphoserine-phosphatase homolog |
Gene namesi | Name:PSPHP1 Synonyms:CO9, PSPHL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9578, PSPHP1 |
MIMi | 604239, gene |
neXtProti | NX_O15172 |
Subcellular locationi
Nucleus
- nuclear envelope Source: Reactome
- nucleoplasm Source: Reactome
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Miscellaneous databases
Pharosi | O15172, Tdark |
Genetic variation databases
BioMutai | HGNC:9578 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318579 | 1 – 72 | Putative phosphoserine phosphatase-like proteinAdd BLAST | 72 |
Proteomic databases
MassIVEi | O15172 |
MaxQBi | O15172 |
PeptideAtlasi | O15172 |
PRIDEi | O15172 |
ProteomicsDBi | 48494 |
Expressioni
Tissue specificityi
Highly expressed in FA (Fanconi's anemia) B-cells of complementation group A and Raji cells. Not expressed in B-cells of other FA complementation groups.1 Publication
i Sequence
Sequence statusi: Complete.
O15172-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASASCSPGG ALASPEPGRK ILPRMISHSE LRKLFYSADA VCFDVDSTVI
60 70
SEEGIGCFHW IWRKCDQATS QG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 – 72 | CFHWI…ATSQG → RSLALSPGWSAMVQSRLTAT SASWVQAILLPPPPE in AAP35307 (Ref. 2) CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001612 mRNA Translation: CAA04865.1 BT006661 mRNA Translation: AAP35307.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ001612 mRNA Translation: CAA04865.1 BT006661 mRNA Translation: AAP35307.1 |
3D structure databases
SMRi | O15172 |
ModBasei | Search... |
Genetic variation databases
BioMutai | HGNC:9578 |
Proteomic databases
MassIVEi | O15172 |
MaxQBi | O15172 |
PeptideAtlasi | O15172 |
PRIDEi | O15172 |
ProteomicsDBi | 48494 |
Protocols and materials databases
CPTCi | O15172, 3 antibodies |
Organism-specific databases
GeneCardsi | PSPHP1 |
HGNCi | HGNC:9578, PSPHP1 |
MIMi | 604239, gene |
neXtProti | NX_O15172 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | O15172 |
Enzyme and pathway databases
Reactomei | R-HSA-9707616, Heme signaling |
Miscellaneous databases
ChiTaRSi | PSPHP1, human |
Pharosi | O15172, Tdark |
RNActi | O15172, protein |
SOURCEi | Search... |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | PSPHL_HUMAN | |
Accessioni | O15172Primary (citable) accession number: O15172 Secondary accession number(s): Q86U85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families