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Protein

Axin-1

Gene

AXIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiO15169
SIGNORiO15169

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Short name:
hAxin
Gene namesi
Name:AXIN1
Synonyms:AXIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103126.14
HGNCiHGNC:903 AXIN1
MIMi603816 gene
neXtProtiNX_O15169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Hepatocellular carcinoma (HCC)1 Publication
The gene represented in this entry is involved in disease pathogenesis.
Disease descriptionA primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
See also OMIM:114550
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015589106L → R in HCC. 1 Publication1
Natural variantiVAR_015590345P → L in HCC. 1 PublicationCorresponds to variant dbSNP:rs779951904Ensembl.1
Natural variantiVAR_015591425G → S in HCC. 1 PublicationCorresponds to variant dbSNP:rs116350678Ensembl.1
Natural variantiVAR_015592650G → S in HCC; also found in hepatoblastoma. 1 PublicationCorresponds to variant dbSNP:rs117208012Ensembl.1
Caudal duplication anomaly (CADUA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Caudal duplication anomaly is associated with hypermethylation of the AXIN1 promoter.
Disease descriptionA condition characterized by the occurrence of duplications of different organs in the caudal region.
See also OMIM:607864

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi8312
MalaCardsiAXIN1
MIMi114550 phenotype
607864 phenotype
OpenTargetsiENSG00000103126
PharmGKBiPA25195

Chemistry databases

ChEMBLiCHEMBL1255127

Polymorphism and mutation databases

BioMutaiAXIN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208881 – 862Axin-1Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Phosphoserine; by CK11 Publication1
Modified residuei77Phosphoserine; by CK1Combined sources1 Publication1
Modified residuei217Phosphoserine; by CK11 Publication1
Modified residuei469Phosphoserine; by CK11 Publication1
Modified residuei481Phosphothreonine; by GSK3-betaBy similarity1
Modified residuei486PhosphoserineCombined sources1
Modified residuei493PhosphoserineBy similarity1
Modified residuei511PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Cross-linki857Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki860Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.2 Publications
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.1 Publication
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-857 and Lys-860 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.2 Publications

Keywords - PTMi

ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15169
MaxQBiO15169
PaxDbiO15169
PeptideAtlasiO15169
PRIDEiO15169
ProteomicsDBi48492
48493 [O15169-2]

PTM databases

iPTMnetiO15169
PhosphoSitePlusiO15169

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000103126 Expressed in 131 organ(s), highest expression level in blood
CleanExiHS_AXIN1
ExpressionAtlasiO15169 baseline and differential
GenevisibleiO15169 HS

Organism-specific databases

HPAiCAB012987

Interactioni

Subunit structurei

Homodimer. Interacts with ZBED3; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations (By similarity). Component of the beta-catenin destruction complex, containing at least, CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination. Interacts with CTNNB1 (via the armadillo repeats 2-7). Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction (PubMed:17318175, PubMed:12554650). Component of the AXIN1-HIPK2-TP53 complex (PubMed:17210684). Interacts directly in the complex with TP53 and HIPK2 (PubMed:17210684). Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation (PubMed:17210684). Also binds APC, SMAD6, SMAD7 and RNF111 (PubMed:16601693, PubMed:10811618). Interacts with DIXDC1; prevents interaction with MAP3K1 (PubMed:15262978). Interacts with MAP3K4 (PubMed:15262978). Interacts with ANKRD6 and AIDA (By similarity). Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation (PubMed:12192039). Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N-terminal kinase (JNK) activation (PubMed:12192039). Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling (PubMed:11336703). Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B (PubMed:9920888). Interacts with PPP2CA; the interaction dephosphorylates AXIN1 (PubMed:9920888). Interacts with MACF1 (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with TNKS (PubMed:19759537, PubMed:21478859, PubMed:21799911). Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction (PubMed:12805222). Interacts with WDR26 (PubMed:27098453). Interacts with GID8 (PubMed:28829046).By similarity15 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-710484,EBI-710484
G2XKQ03EBI-710484,EBI-10175576
AMER1Q5JTC67EBI-710484,EBI-6169747
ANP32AP396872EBI-710484,EBI-359234
apcP700392EBI-710484,EBI-8069633From Xenopus laevis.
ARRB1P494072EBI-710484,EBI-743313
CALCOCO2Q131373EBI-710484,EBI-739580
CARD9Q9H257-23EBI-710484,EBI-11530605
CCDC57Q2TAC2-23EBI-710484,EBI-10961624
CRMP1Q141942EBI-710484,EBI-473101
CSNK1EP496745EBI-710484,EBI-749343
CTNNB1P3522244EBI-710484,EBI-491549
Ctnnb1Q022485EBI-710484,EBI-397872From Mus musculus.
DAB2IPQ5VWQ8-22EBI-710484,EBI-9543020
DVL2O146413EBI-710484,EBI-740850
FBXW11Q9UKB14EBI-710484,EBI-355189
GOLGA2Q083793EBI-710484,EBI-618309
GSK3AP498403EBI-710484,EBI-1044067
GSK3BG1T8E22EBI-710484,EBI-3833365From Oryctolagus cuniculus.
GSK3BP4984150EBI-710484,EBI-373586
JUPP149234EBI-710484,EBI-702484
KRT40Q6A1623EBI-710484,EBI-10171697
KRTAP4-12Q9BQ663EBI-710484,EBI-739863
KRTAP4-2Q9BYR53EBI-710484,EBI-10172511
LHX4Q969G23EBI-710484,EBI-2865388
LRP6O755813EBI-10987526,EBI-910915
MDFIQ997503EBI-710484,EBI-724076
MEOX2Q6FHY53EBI-710484,EBI-16439278
MID2Q9UJV3-23EBI-710484,EBI-10172526
MTUS2Q5JR59-33EBI-710484,EBI-11522433
MYCP0110610EBI-710484,EBI-447544
PPM1AP358132EBI-710484,EBI-989143
PPP1CAP621364EBI-710484,EBI-357253
PSTPIP1O435863EBI-710484,EBI-1050964
RNF111Q6ZNA42EBI-710484,EBI-2129175
Rnf111Q99ML95EBI-710484,EBI-646015From Mus musculus.
SCYL1Q96KG9-43EBI-710484,EBI-12023020
SMAD7O151058EBI-710484,EBI-3861591
STX11O755583EBI-710484,EBI-714135
SUMO1P631653EBI-710484,EBI-80140
TFIP11Q9UBB93EBI-710484,EBI-1105213
TGIF1Q155834EBI-710484,EBI-714215
TNKS2Q9H2K22EBI-710484,EBI-4398527
TP53P046374EBI-710484,EBI-366083
TRAF2Q129333EBI-710484,EBI-355744
TRIM15Q9C0193EBI-710484,EBI-2342111
TRIM27P143733EBI-710484,EBI-719493
TRIM29Q141342EBI-710484,EBI-702370
TRIM37O949723EBI-710484,EBI-741602
TRIP6Q156546EBI-710484,EBI-742327
TUBG1P232584EBI-710484,EBI-302589
WDR26Q9H7D74EBI-710484,EBI-1046864
YAP1P4693711EBI-710484,EBI-1044059
ZBTB26Q9HCK03EBI-710484,EBI-3918996
ZFYVE19Q96K21-33EBI-710484,EBI-10187928

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113909, 75 interactors
ComplexPortaliCPX-107 Beta-catenin destruction core complex, variant 5
CPX-109 Beta-catenin destruction core complex, variant 1
CPX-442 Beta-catenin destruction core complex, variant 6
CPX-99 Beta-catenin destruction core complex, variant 2
CORUMiO15169
DIPiDIP-34630N
IntActiO15169, 120 interactors
MINTiO15169
STRINGi9606.ENSP00000262320

Structurei

Secondary structure

1862
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00959
ProteinModelPortaliO15169
SMRiO15169
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15169

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 211RGSPROSITE-ProRule annotationAdd BLAST124
Domaini780 – 862DIXPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 338Interaction with TP53By similarityAdd BLAST130
Regioni348 – 433Interaction with GSK3BBy similarityAdd BLAST86
Regioni434 – 502Interaction with CTNNB1By similarityAdd BLAST69
Regioni507 – 757Interaction with RNF1111 PublicationAdd BLAST251
Regioni575 – 789Interaction with PPP2CA1 PublicationAdd BLAST215
Regioni677 – 752Interaction with HIPK2By similarityAdd BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 29Tankyrase-binding motif10

Domaini

The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.1 Publication

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00390000010011
HOVERGENiHBG004324
InParanoidiO15169
KOiK02157
OMAiIMQWIIE
OrthoDBiEOG091G0ABG
PhylomeDBiO15169
TreeFamiTF315454

Family and domain databases

CDDicd11582 Axin_TNKS_binding, 1 hit
Gene3Di1.10.196.10, 2 hits
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR029797 AXIN1
IPR014936 Axin_b-cat-bd
IPR032101 Axin_TNKS-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10845:SF11 PTHR10845:SF11, 1 hit
PfamiView protein in Pfam
PF16646 AXIN1_TNKS_BD, 1 hit
PF08833 Axin_b-cat_bind, 1 hit
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPA SYSFCSGKGV
60 70 80 90 100
GIKGETSTAT PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIS
110 120 130 140 150
LFRTFLKQEG CADLLDFWFA CTGFRKLEPC DSNEEKRLKL ARAIYRKYIL
160 170 180 190 200
DNNGIVSRQT KPATKSFIKG CIMKQLIDPA MFDQAQTEIQ ATMEENTYPS
210 220 230 240 250
FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGISGYLPT LNEDEEWKCD
260 270 280 290 300
QDMDEDDGRD AAPPGRLPQK LLLETAAPRV SSSRRYSEGR EFRYGSWREP
310 320 330 340 350
VNPYYVNAGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK
360 370 380 390 400
QHRREMQESV QVNGRVPLPH IPRTYRVPKE VRVEPQKFAE ELIHRLEAVQ
410 420 430 440 450
RTREAEEKLE ERLKRVRMEE EGEDGDPSSG PPGPCHKLPP APAWHHFPPR
460 470 480 490 500
CVDMGCAGLR DAHEENPESI LDEHVQRVLR TPGRQSPGPG HRSPDSGHVA
510 520 530 540 550
KMPVALGGAA SGHGKHVPKS GAKLDAAGLH HHRHVHHHVH HSTARPKEQV
560 570 580 590 600
EAEATRRAQS SFAWGLEPHS HGARSRGYSE SVGAAPNASD GLAHSGKVGV
610 620 630 640 650
ACKRNAKKAE SGKSASTEVP GASEDAEKNQ KIMQWIIEGE KEISRHRRTG
660 670 680 690 700
HGSSGTRKPQ PHENSRPLSL EHPWAGPQLR TSVQPSHLFI QDPTMPPHPA
710 720 730 740 750
PNPLTQLEEA RRRLEEEEKR ASRAPSKQRY VQEVMRRGRA CVRPACAPVL
760 770 780 790 800
HVVPAVSDME LSETETRSQR KVGGGSAQPC DSIVVAYYFC GEPIPYRTLV
810 820 830 840 850
RGRAVTLGQF KELLTKKGSY RYYFKKVSDE FDCGVVFEEV REDEAVLPVF
860
EEKIIGKVEK VD
Length:862
Mass (Da):95,635
Last modified:May 10, 2002 - v2
Checksum:i10779173F5092F3F
GO
Isoform 2 (identifier: O15169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     730-765: Missing.

Show »
Length:826
Mass (Da):91,653
Checksum:i4AA4187D70A5863D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y830H0Y830_HUMAN
Axin-1
AXIN1
102Annotation score:

Sequence cautioni

The sequence AAC51624 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360V → A in AAC51624 (PubMed:9230313).Curated1
Sequence conflicti451 – 455CVDMG → LCWTWA in AAC51624 (PubMed:9230313).Curated5
Sequence conflicti482P → T in AAC51624 (PubMed:9230313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015589106L → R in HCC. 1 Publication1
Natural variantiVAR_015590345P → L in HCC. 1 PublicationCorresponds to variant dbSNP:rs779951904Ensembl.1
Natural variantiVAR_015591425G → S in HCC. 1 PublicationCorresponds to variant dbSNP:rs116350678Ensembl.1
Natural variantiVAR_015592650G → S in HCC; also found in hepatoblastoma. 1 PublicationCorresponds to variant dbSNP:rs117208012Ensembl.1
Natural variantiVAR_015593841R → Q in hepatoblastoma. 1 PublicationCorresponds to variant dbSNP:rs34015754Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019398730 – 765Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009674 mRNA Translation: AAC51624.1 Different initiation.
AE006463 Genomic DNA Translation: AAK61224.1
Z69667, AC005202, Z99754 Genomic DNA Translation: CAI95589.2
Z69667, AC005202, Z99754 Genomic DNA Translation: CAI95590.2
Z99754, AC005202, Z69667 Genomic DNA Translation: CAI95600.2
Z99754, AC005202, Z69667 Genomic DNA Translation: CAI95601.2
BC017447 mRNA Translation: AAH17447.1
BC044648 mRNA Translation: AAH44648.1
CCDSiCCDS10405.1 [O15169-1]
CCDS10406.1 [O15169-2]
RefSeqiNP_003493.1, NM_003502.3 [O15169-1]
NP_851393.1, NM_181050.2 [O15169-2]
UniGeneiHs.592082

Genome annotation databases

EnsembliENST00000262320; ENSP00000262320; ENSG00000103126 [O15169-1]
ENST00000354866; ENSP00000346935; ENSG00000103126 [O15169-2]
GeneIDi8312
KEGGihsa:8312
UCSCiuc002cgp.3 human [O15169-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009674 mRNA Translation: AAC51624.1 Different initiation.
AE006463 Genomic DNA Translation: AAK61224.1
Z69667, AC005202, Z99754 Genomic DNA Translation: CAI95589.2
Z69667, AC005202, Z99754 Genomic DNA Translation: CAI95590.2
Z99754, AC005202, Z69667 Genomic DNA Translation: CAI95600.2
Z99754, AC005202, Z69667 Genomic DNA Translation: CAI95601.2
BC017447 mRNA Translation: AAH17447.1
BC044648 mRNA Translation: AAH44648.1
CCDSiCCDS10405.1 [O15169-1]
CCDS10406.1 [O15169-2]
RefSeqiNP_003493.1, NM_003502.3 [O15169-1]
NP_851393.1, NM_181050.2 [O15169-2]
UniGeneiHs.592082

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DK8X-ray1.57A74-220[»]
1EMUX-ray1.90A80-211[»]
1O9UX-ray2.40B383-400[»]
3ZDIX-ray2.64B383-400[»]
4B7TX-ray2.77B383-400[»]
4NM0X-ray2.50B383-402[»]
4NM3X-ray2.10B383-402[»]
4NM5X-ray2.30B383-402[»]
4NM7X-ray2.30B383-402[»]
4NU1X-ray2.50B383-402[»]
5WZZX-ray2.10E/F/G/H375-394[»]
DisProtiDP00959
ProteinModelPortaliO15169
SMRiO15169
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113909, 75 interactors
ComplexPortaliCPX-107 Beta-catenin destruction core complex, variant 5
CPX-109 Beta-catenin destruction core complex, variant 1
CPX-442 Beta-catenin destruction core complex, variant 6
CPX-99 Beta-catenin destruction core complex, variant 2
CORUMiO15169
DIPiDIP-34630N
IntActiO15169, 120 interactors
MINTiO15169
STRINGi9606.ENSP00000262320

Chemistry databases

ChEMBLiCHEMBL1255127

PTM databases

iPTMnetiO15169
PhosphoSitePlusiO15169

Polymorphism and mutation databases

BioMutaiAXIN1

Proteomic databases

EPDiO15169
MaxQBiO15169
PaxDbiO15169
PeptideAtlasiO15169
PRIDEiO15169
ProteomicsDBi48492
48493 [O15169-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262320; ENSP00000262320; ENSG00000103126 [O15169-1]
ENST00000354866; ENSP00000346935; ENSG00000103126 [O15169-2]
GeneIDi8312
KEGGihsa:8312
UCSCiuc002cgp.3 human [O15169-1]

Organism-specific databases

CTDi8312
DisGeNETi8312
EuPathDBiHostDB:ENSG00000103126.14
GeneCardsiAXIN1
HGNCiHGNC:903 AXIN1
HPAiCAB012987
MalaCardsiAXIN1
MIMi114550 phenotype
603816 gene
607864 phenotype
neXtProtiNX_O15169
OpenTargetsiENSG00000103126
PharmGKBiPA25195
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00390000010011
HOVERGENiHBG004324
InParanoidiO15169
KOiK02157
OMAiIMQWIIE
OrthoDBiEOG091G0ABG
PhylomeDBiO15169
TreeFamiTF315454

Enzyme and pathway databases

ReactomeiR-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiO15169
SIGNORiO15169

Miscellaneous databases

ChiTaRSiAXIN1 human
EvolutionaryTraceiO15169
GeneWikiiAXIN1
GenomeRNAii8312
PROiPR:O15169
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103126 Expressed in 131 organ(s), highest expression level in blood
CleanExiHS_AXIN1
ExpressionAtlasiO15169 baseline and differential
GenevisibleiO15169 HS

Family and domain databases

CDDicd11582 Axin_TNKS_binding, 1 hit
Gene3Di1.10.196.10, 2 hits
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR029797 AXIN1
IPR014936 Axin_b-cat-bd
IPR032101 Axin_TNKS-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10845:SF11 PTHR10845:SF11, 1 hit
PfamiView protein in Pfam
PF16646 AXIN1_TNKS_BD, 1 hit
PF08833 Axin_b-cat_bind, 1 hit
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAXIN1_HUMAN
AccessioniPrimary (citable) accession number: O15169
Secondary accession number(s): Q4TT26
, Q4TT27, Q86YA7, Q8WVW6, Q96S28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: October 10, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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