UniProtKB - O15156 (ZBT7B_HUMAN)
Zinc finger and BTB domain-containing protein 7B
ZBTB7B
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 346 – 368 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 374 – 396 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 402 – 424 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 454 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: GO_Central
- histone deacetylase binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- adaptive thermogenesis Source: UniProtKB
- ectoderm development Source: ProtInc
- interleukin-17 production Source: UniProtKB
- lactation Source: UniProtKB
- negative regulation of CD8-positive, alpha-beta T cell differentiation Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of NK T cell proliferation Source: UniProtKB
- negative regulation of T-helper 17 cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- NK T cell differentiation Source: UniProtKB
- positive regulation of brown fat cell differentiation Source: UniProtKB
- positive regulation of CD4-positive, alpha-beta T cell differentiation Source: UniProtKB
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of gene expression Source: UniProtKB
- positive regulation of histone deacetylation Source: UniProtKB
- positive regulation of insulin receptor signaling pathway Source: UniProtKB
- positive regulation of SREBP signaling pathway Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription involved in cell fate commitment Source: UniProtKB
- response to insulin Source: UniProtKB
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Differentiation, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O15156 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 7BCuratedAlternative name(s): Krueppel-related zinc finger protein cKrox Short name: hcKrox T-helper-inducing POZ/Krueppel-like factor Zinc finger and BTB domain-containing protein 15 Zinc finger protein 67 homolog Short name: Zfp-67 Zinc finger protein 857B Zinc finger protein Th-POK |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160685.13 |
HGNCi | HGNC:18668, ZBTB7B |
MIMi | 607646, gene |
neXtProti | NX_O15156 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51043 |
OpenTargetsi | ENSG00000160685 |
PharmGKBi | PA38630 |
Miscellaneous databases
Pharosi | O15156, Tbio |
Polymorphism and mutation databases
BioMutai | ZBTB7B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047719 | 1 – 539 | Zinc finger and BTB domain-containing protein 7BAdd BLAST | 539 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 150 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | N6-acetyllysine; by EP300; alternateBy similarity | 1 | |
Cross-linki | 206 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 212 | N6-acetyllysine; by EP300; alternateBy similarity | 1 | |
Cross-linki | 212 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 335 | N6-acetyllysine; by EP300; alternateBy similarity | 1 | |
Cross-linki | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 369 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15156 |
jPOSTi | O15156 |
MassIVEi | O15156 |
MaxQBi | O15156 |
PaxDbi | O15156 |
PeptideAtlasi | O15156 |
PRIDEi | O15156 |
ProteomicsDBi | 48480 [O15156-1] |
PTM databases
iPTMneti | O15156 |
PhosphoSitePlusi | O15156 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160685, Expressed in esophagus mucosa and 201 other tissues |
Genevisiblei | O15156, HS |
Organism-specific databases
HPAi | ENSG00000160685, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Homodimerizes.
Interacts with NCL, NEDD4 and YBX1.
Interacts with HNRNPU (via RNA-binding RGG-box region); the interaction facilitates the recruitment of long non-coding RNA Blnc1 by ZBTB7B.
Interacts with HDAC4 and HDAC5; the interaction allows the recruitment of HDAC4 and HDAC5 on CD8 loci for deacetylation and possible inhibition of CD8 genes expression.
By similarityBinary interactionsi
Hide detailsO15156
Isoform 2 [O15156-2]
GO - Molecular functioni
- histone deacetylase binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119242, 58 interactors |
IntActi | O15156, 27 interactors |
MINTi | O15156 |
STRINGi | 9606.ENSP00000406286 |
Miscellaneous databases
RNActi | O15156, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 115 | BTBPROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 400 | Required for interaction with and acetylation by EP300By similarityAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 181 – 196 | Pro-richAdd BLAST | 16 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 346 – 368 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 374 – 396 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 402 – 424 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 454 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160219 |
HOGENOMi | CLU_025627_0_0_1 |
InParanoidi | O15156 |
OMAi | PNGDDSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15156 |
TreeFami | TF331824 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA
60 70 80 90 100
VLAACSHYFK KLFTEGGGGA VMGAGGSGTA TGGAGAGVCE LDFVGPEALG
110 120 130 140 150
ALLEFAYTAT LTTSSANMPA VLQAARLLEI PCVIAACMEI LQGSGLEAPS
160 170 180 190 200
PDEDDCERAR QYLEAFATAT ASGVPNGEDS PPQVPLPPPP PPPPRPVARR
210 220 230 240 250
SRKPRKAFLQ TKGARANHLV PEVPTVPAHP LTYEEEEVAG RVGSSGGSGP
260 270 280 290 300
GDSYSPPTGT ASPPEGPQSY EPYEGEEEEE ELVYPPAYGL AQGGGPPLSP
310 320 330 340 350
EELGSDEDAI DPDLMAYLSS LHQDNLAPGL DSQDKLVRKR RSQMPQECPV
360 370 380 390 400
CHKIIHGAGK LPRHMRTHTG EKPFACEVCG VRFTRNDKLK IHMRKHTGER
410 420 430 440 450
PYSCPHCPAR FLHSYDLKNH MHLHTGDRPY ECHLCHKAFA KEDHLQRHLK
460 470 480 490 500
GQNCLEVRTR RRRKDDAPPH YPPPSTAAAS PAGLDLSNGH LDTFRLSLAR
510 520 530
FWEQSAPTGP PVSTPGPPDD DEEEGAPTTP QAEGAMESS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | E → K in BAG65517 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 235 | E → G in BAG65517 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 437 | K → R in AAC51847 (PubMed:9370309).Curated | 1 | |
Sequence conflicti | 480 | S → F in AAC51847 (PubMed:9370309).Curated | 1 | |
Sequence conflicti | 509 – 510 | GP → WA in AAC51847 (PubMed:9370309).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044721 | 1 | M → MLQPGPHPPSPQAAAPGEAW PGPSQAPWQSLEEKM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007833 mRNA Translation: AAC51847.1 AK304762 mRNA Translation: BAG65517.1 CR749303 mRNA Translation: CAH18158.1 AL451085 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53149.1 CH471121 Genomic DNA Translation: EAW53150.1 CH471121 Genomic DNA Translation: EAW53151.1 BC012070 mRNA Translation: AAH12070.1 |
CCDSi | CCDS1081.1 [O15156-1] CCDS58030.1 [O15156-2] |
RefSeqi | NP_001239335.1, NM_001252406.2 [O15156-2] NP_001243384.1, NM_001256455.1 [O15156-1] XP_006711412.2, XM_006711349.2 XP_006711416.1, XM_006711353.1 XP_006711417.1, XM_006711354.1 [O15156-1] XP_006711419.1, XM_006711356.3 [O15156-1] XP_006711420.1, XM_006711357.1 [O15156-1] XP_006711421.1, XM_006711358.1 [O15156-1] XP_006711422.1, XM_006711359.2 [O15156-1] XP_011507900.1, XM_011509598.2 [O15156-2] XP_011507901.1, XM_011509599.2 [O15156-1] |
Genome annotation databases
Ensembli | ENST00000292176; ENSP00000292176; ENSG00000160685 [O15156-1] ENST00000368426; ENSP00000357411; ENSG00000160685 [O15156-1] ENST00000417934; ENSP00000406286; ENSG00000160685 [O15156-2] ENST00000535420; ENSP00000438647; ENSG00000160685 [O15156-1] |
GeneIDi | 51043 |
KEGGi | hsa:51043 |
UCSCi | uc001fgk.5, human [O15156-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007833 mRNA Translation: AAC51847.1 AK304762 mRNA Translation: BAG65517.1 CR749303 mRNA Translation: CAH18158.1 AL451085 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53149.1 CH471121 Genomic DNA Translation: EAW53150.1 CH471121 Genomic DNA Translation: EAW53151.1 BC012070 mRNA Translation: AAH12070.1 |
CCDSi | CCDS1081.1 [O15156-1] CCDS58030.1 [O15156-2] |
RefSeqi | NP_001239335.1, NM_001252406.2 [O15156-2] NP_001243384.1, NM_001256455.1 [O15156-1] XP_006711412.2, XM_006711349.2 XP_006711416.1, XM_006711353.1 XP_006711417.1, XM_006711354.1 [O15156-1] XP_006711419.1, XM_006711356.3 [O15156-1] XP_006711420.1, XM_006711357.1 [O15156-1] XP_006711421.1, XM_006711358.1 [O15156-1] XP_006711422.1, XM_006711359.2 [O15156-1] XP_011507900.1, XM_011509598.2 [O15156-2] XP_011507901.1, XM_011509599.2 [O15156-1] |
3D structure databases
SMRi | O15156 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119242, 58 interactors |
IntActi | O15156, 27 interactors |
MINTi | O15156 |
STRINGi | 9606.ENSP00000406286 |
PTM databases
iPTMneti | O15156 |
PhosphoSitePlusi | O15156 |
Polymorphism and mutation databases
BioMutai | ZBTB7B |
Proteomic databases
EPDi | O15156 |
jPOSTi | O15156 |
MassIVEi | O15156 |
MaxQBi | O15156 |
PaxDbi | O15156 |
PeptideAtlasi | O15156 |
PRIDEi | O15156 |
ProteomicsDBi | 48480 [O15156-1] |
Protocols and materials databases
ABCDi | O15156, 4 sequenced antibodies |
Antibodypediai | 20407, 272 antibodies |
DNASUi | 51043 |
Genome annotation databases
Ensembli | ENST00000292176; ENSP00000292176; ENSG00000160685 [O15156-1] ENST00000368426; ENSP00000357411; ENSG00000160685 [O15156-1] ENST00000417934; ENSP00000406286; ENSG00000160685 [O15156-2] ENST00000535420; ENSP00000438647; ENSG00000160685 [O15156-1] |
GeneIDi | 51043 |
KEGGi | hsa:51043 |
UCSCi | uc001fgk.5, human [O15156-1] |
Organism-specific databases
CTDi | 51043 |
DisGeNETi | 51043 |
EuPathDBi | HostDB:ENSG00000160685.13 |
GeneCardsi | ZBTB7B |
HGNCi | HGNC:18668, ZBTB7B |
HPAi | ENSG00000160685, Tissue enhanced (intestine) |
MIMi | 607646, gene |
neXtProti | NX_O15156 |
OpenTargetsi | ENSG00000160685 |
PharmGKBi | PA38630 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160219 |
HOGENOMi | CLU_025627_0_0_1 |
InParanoidi | O15156 |
OMAi | PNGDDSP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15156 |
TreeFami | TF331824 |
Enzyme and pathway databases
PathwayCommonsi | O15156 |
Miscellaneous databases
BioGRID-ORCSi | 51043, 36 hits in 870 CRISPR screens |
ChiTaRSi | ZBTB7B, human |
GeneWikii | ZBTB7B |
GenomeRNAii | 51043 |
Pharosi | O15156, Tbio |
PROi | PR:O15156 |
RNActi | O15156, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160685, Expressed in esophagus mucosa and 201 other tissues |
Genevisiblei | O15156, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT7B_HUMAN | |
Accessioni | O15156Primary (citable) accession number: O15156 Secondary accession number(s): B4E3K5 Q96EP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM