UniProtKB - O15155 (BET1_HUMAN)
Protein
BET1 homolog
Gene
BET1
Organism
Homo sapiens (Human)
Status
Functioni
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).By similarity
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
GO - Biological processi
- COPII vesicle coating Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- protein transport Source: UniProtKB-KW
- vesicle fusion with Golgi apparatus Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O15155 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport |
Names & Taxonomyi
Protein namesi | Recommended name: BET1 homologShort name: hBET1 Alternative name(s): Golgi vesicular membrane-trafficking protein p18 |
Gene namesi | Name:BET1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14562, BET1 |
MIMi | 605456, gene |
neXtProti | NX_O15155 |
VEuPathDBi | HostDB:ENSG00000105829.11 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane By similarity
- Golgi apparatus membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type IV membrane protein By similarity
Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: Reactome
- Golgi trans cisterna Source: GO_Central
- integral component of Golgi membrane Source: InterPro
Other locations
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- membrane Source: UniProtKB
- SNARE complex Source: GO_Central
- transport vesicle Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 94 | CytoplasmicSequence analysisAdd BLAST | 94 | |
Transmembranei | 95 – 115 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 116 – 118 | VesicularSequence analysis | 3 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10282 |
OpenTargetsi | ENSG00000105829 |
PharmGKBi | PA25338 |
Miscellaneous databases
Pharosi | O15155, Tdark |
Genetic variation databases
BioMutai | BET1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206884 | 1 – 118 | BET1 homologAdd BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 50 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O15155 |
jPOSTi | O15155 |
MassIVEi | O15155 |
PaxDbi | O15155 |
PeptideAtlasi | O15155 |
PRIDEi | O15155 |
ProteomicsDBi | 48479 [O15155-1] 76387 |
TopDownProteomicsi | O15155-1 [O15155-1] |
PTM databases
iPTMneti | O15155 |
MetOSitei | O15155 |
PhosphoSitePlusi | O15155 |
SwissPalmi | O15155 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105829, Expressed in testis and 233 other tissues |
ExpressionAtlasi | O15155, baseline and differential |
Genevisiblei | O15155, HS |
Organism-specific databases
HPAi | ENSG00000105829, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with STX17.
By similarityBinary interactionsi
Hide detailsO15155
Isoform 2 [O15155-2]
With | #Exp. | IntAct |
---|---|---|
ATN1 [Q86V38] | 3 | EBI-25846497,EBI-11954292 |
KLK6 [Q92876] | 3 | EBI-25846497,EBI-2432309 |
Protein-protein interaction databases
BioGRIDi | 115571, 338 interactors |
IntActi | O15155, 322 interactors |
MINTi | O15155 |
STRINGi | 9606.ENSP00000222547 |
Miscellaneous databases
RNActi | O15155, protein |
Structurei
3D structure databases
SMRi | O15155 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15155 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 88 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Sequence similaritiesi
Belongs to the BET1 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000162637 |
HOGENOMi | CLU_086133_2_1_1 |
InParanoidi | O15155 |
PhylomeDBi | O15155 |
TreeFami | TF323307 |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15155-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRAGLGEGV PPGNYGNYGY ANSGYSACEE ENERLTESLR SKVTAIKSLS
60 70 80 90 100
IEIGHEVKTQ NKLLAEMDSQ FDSTTGFLGK TMGKLKILSR GSQTKLLCYM
110
MLFSLFVFFI IYWIIKLR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C1N3 | H7C1N3_HUMAN | BET1 homolog | BET1 | 133 | Annotation score: | ||
Q68DU7 | Q68DU7_HUMAN | BET1 homolog | BET1 DKFZp781C0425 | 127 | Annotation score: | ||
C9JTT8 | C9JTT8_HUMAN | BET1 homolog | BET1 | 98 | Annotation score: | ||
A0A3B3IU16 | A0A3B3IU16_HUMAN | BET1 homolog | BET1 | 85 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056216 | 80 – 118 | KTMGK…IIKLR → LCPM in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007551 mRNA Translation: AAB62941.1 AC006378 Genomic DNA Translation: AAD47132.1 CH471091 Genomic DNA Translation: EAW76802.1 BC000899 mRNA Translation: AAH00899.1 BC012595 mRNA Translation: AAH12595.1 |
CCDSi | CCDS5635.1 [O15155-1] CCDS83203.1 [O15155-2] |
RefSeqi | NP_001304668.1, NM_001317739.1 [O15155-2] NP_005859.1, NM_005868.5 [O15155-1] |
Genome annotation databases
Ensembli | ENST00000222547; ENSP00000222547; ENSG00000105829 [O15155-1] ENST00000433727; ENSP00000391228; ENSG00000105829 [O15155-2] |
GeneIDi | 10282 |
KEGGi | hsa:10282 |
UCSCi | uc064fkr.1, human [O15155-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007551 mRNA Translation: AAB62941.1 AC006378 Genomic DNA Translation: AAD47132.1 CH471091 Genomic DNA Translation: EAW76802.1 BC000899 mRNA Translation: AAH00899.1 BC012595 mRNA Translation: AAH12595.1 |
CCDSi | CCDS5635.1 [O15155-1] CCDS83203.1 [O15155-2] |
RefSeqi | NP_001304668.1, NM_001317739.1 [O15155-2] NP_005859.1, NM_005868.5 [O15155-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EGX | X-ray | 3.30 | D | 24-32 | [»] | |
SMRi | O15155 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115571, 338 interactors |
IntActi | O15155, 322 interactors |
MINTi | O15155 |
STRINGi | 9606.ENSP00000222547 |
PTM databases
iPTMneti | O15155 |
MetOSitei | O15155 |
PhosphoSitePlusi | O15155 |
SwissPalmi | O15155 |
Genetic variation databases
BioMutai | BET1 |
Proteomic databases
EPDi | O15155 |
jPOSTi | O15155 |
MassIVEi | O15155 |
PaxDbi | O15155 |
PeptideAtlasi | O15155 |
PRIDEi | O15155 |
ProteomicsDBi | 48479 [O15155-1] 76387 |
TopDownProteomicsi | O15155-1 [O15155-1] |
Protocols and materials databases
Antibodypediai | 64131, 38 antibodies |
DNASUi | 10282 |
Genome annotation databases
Ensembli | ENST00000222547; ENSP00000222547; ENSG00000105829 [O15155-1] ENST00000433727; ENSP00000391228; ENSG00000105829 [O15155-2] |
GeneIDi | 10282 |
KEGGi | hsa:10282 |
UCSCi | uc064fkr.1, human [O15155-1] |
Organism-specific databases
CTDi | 10282 |
DisGeNETi | 10282 |
GeneCardsi | BET1 |
HGNCi | HGNC:14562, BET1 |
HPAi | ENSG00000105829, Low tissue specificity |
MIMi | 605456, gene |
neXtProti | NX_O15155 |
OpenTargetsi | ENSG00000105829 |
PharmGKBi | PA25338 |
VEuPathDBi | HostDB:ENSG00000105829.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000162637 |
HOGENOMi | CLU_086133_2_1_1 |
InParanoidi | O15155 |
PhylomeDBi | O15155 |
TreeFami | TF323307 |
Enzyme and pathway databases
PathwayCommonsi | O15155 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport |
Miscellaneous databases
BioGRID-ORCSi | 10282, 310 hits in 856 CRISPR screens |
ChiTaRSi | BET1, human |
EvolutionaryTracei | O15155 |
GeneWikii | BET1 |
GenomeRNAii | 10282 |
Pharosi | O15155, Tdark |
PROi | PR:O15155 |
RNActi | O15155, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105829, Expressed in testis and 233 other tissues |
ExpressionAtlasi | O15155, baseline and differential |
Genevisiblei | O15155, HS |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BET1_HUMAN | |
Accessioni | O15155Primary (citable) accession number: O15155 Secondary accession number(s): Q96EA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families