Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 193 (13 Feb 2019)
Sequence version 2 (27 Sep 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Protein Mdm4

Gene

MDM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri300 – 329RanBP2-typePROSITE-ProRule annotationAdd BLAST30
Zinc fingeri437 – 478RING-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: Reactome
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6804760 Regulation of TP53 Activity through Methylation
R-HSA-69541 Stabilization of p53

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O15151

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
O15151 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Mdm4
Alternative name(s):
Double minute 4 protein
Mdm2-like p53-binding protein
Protein Mdmx
p53-binding protein Mdm4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDM4
Synonyms:MDMX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198625.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6974 MDM4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602704 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15151

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi437C → G: Fails to interact with MDM2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4194

Open Targets

More...
OpenTargetsi
ENSG00000198625

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30719

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1255126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MDM4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001573361 – 490Protein Mdm4Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei342Phosphoserine; by CHEK2Combined sources1 Publication1
Modified residuei367Phosphoserine; by CHEK1 and CHEK2Combined sources2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent.3 Publications
Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15151

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15151

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15151

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15151

PeptideAtlas

More...
PeptideAtlasi
O15151

PRoteomics IDEntifications database

More...
PRIDEi
O15151

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48474
48475 [O15151-2]
48476 [O15151-3]
48477 [O15151-4]
48478 [O15151-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15151

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15151

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O15151

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested with high levels in thymus.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by cisplatin (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198625 Expressed in 219 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15151 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15151 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018919
HPA048821

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110359, 88 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O15151

Database of interacting proteins

More...
DIPi
DIP-24199N

Protein interaction database and analysis system

More...
IntActi
O15151, 38 interactors

Molecular INTeraction database

More...
MINTi
O15151

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356150

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15151

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CR8NMR-A300-339[»]
2MWYNMR-A23-111[»]
2N06NMR-A23-111[»]
2N0UNMR-A23-111[»]
2N0WNMR-A23-111[»]
2N14NMR-A23-111[»]
2VJEX-ray2.20B/D428-490[»]
2VJFX-ray2.30B/D428-490[»]
2VYRX-ray2.00A/B/C/D16-116[»]
3DABX-ray1.90A/C/E/G23-111[»]
3EQYX-ray1.63A/B24-108[»]
3FDOX-ray1.40A23-111[»]
3FE7X-ray1.35A14-111[»]
3FEAX-ray1.33A14-111[»]
3JZOX-ray1.80A23-111[»]
3JZPX-ray1.74A23-111[»]
3JZQX-ray1.80A/B23-111[»]
3LBJX-ray1.50E23-111[»]
3MQRX-ray1.80B395-404[»]
3U15X-ray1.80A/B/C/D14-111[»]
4RXZX-ray1.55A/B24-108[»]
5MNJX-ray2.16D/H427-490[»]
5UMLX-ray3.00A/B/E/G24-108[»]
5VK1X-ray2.69A/C/E/G/I/K/M/O24-108[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15151

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15151

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O15151

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 106SWIBAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni246 – 332Region IIAdd BLAST87
Regioni393 – 490Necessary for interaction with USP21 PublicationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi442 – 445Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi243 – 308Asp/Glu-rich (acidic)Add BLAST66

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MDM2/MDM4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri300 – 329RanBP2-typePROSITE-ProRule annotationAdd BLAST30
Zinc fingeri437 – 478RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE9V Eukaryota
ENOG410XSWN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293341

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013472

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15151

KEGG Orthology (KO)

More...
KOi
K10127

Identification of Orthologs from Complete Genome Data

More...
OMAi
HGRTSHL

Database of Orthologous Groups

More...
OrthoDBi
1329283at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15151

TreeFam database of animal gene trees

More...
TreeFami
TF105306

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.245.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015458 MDM4
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR13844:SF20 PTHR13844:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500699 MDM4, 1 hit
PIRSF006748 p53_MDM_2/4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47592 SSF47592, 1 hit
SSF90209 SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK
60 70 80 90 100
EVMHYLGQYI MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD
110 120 130 140 150
MLRKNLVTLA TATTDAAQTL ALAQDHSMDI PSQDQLKQSA EESSTSRKRT
160 170 180 190 200
TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ DETSRLDLGF EEWDVAGLPW
210 220 230 240 250
WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF LNESVSEQLG
260 270 280 290 300
VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
310 320 330 340 350
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP
360 370 380 390 400
EKENEGNDVP DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS
410 420 430 440 450
SESQETISSM GEQLDNLSEQ RTDTENMEDC QNLLKPCSLC EKRPRDGNII
460 470 480 490
HGRTGHLVTC FHCARRLKKA GASCPICKKE IQLVIKVFIA
Length:490
Mass (Da):54,864
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i415E6FA5A0C69857
GO
Isoform 2 (identifier: O15151-2) [UniParc]FASTAAdd to basket
Also known as: MDMX-S

The sequence of this isoform differs from the canonical sequence as follows:
     109-490: LATATTDAAQ...IQLVIKVFIA → SASNNTARCNRILQSQKKN

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,185
Checksum:i59649D26B113EFB4
GO
Isoform 3 (identifier: O15151-3) [UniParc]FASTAAdd to basket
Also known as: MDMX

The sequence of this isoform differs from the canonical sequence as follows:
     109-490: LATATTDAAQ...IQLVIKVFIA → SASNNTDAAQTLALAQDHT

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):13,981
Checksum:i0A00E52B32331543
GO
Isoform HDMX211 (identifier: O15151-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-352: Missing.

Note: Cancer-specific isoform, may counteract MDM2/MDM4-mediated p53 degradation.
Show »
Length:164
Mass (Da):18,195
Checksum:i1C39025CBD527C11
GO
Isoform 5 (identifier: O15151-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-274: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):49,541
Checksum:iBB377C938A8C3D1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTR9A0A087WTR9_HUMAN
Protein Mdm4
MDM4
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ58A0A087WZ58_HUMAN
Protein Mdm4
MDM4
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0Y3Q5T0Y3_HUMAN
Protein Mdm4
MDM4
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q68DC0Q68DC0_HUMAN
MDM4 protein variant G
MDM4 DKFZp781B1423
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0Y2Q5T0Y2_HUMAN
Protein Mdm4
MDM4
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUE3A0A087WUE3_HUMAN
Protein Mdm4
MDM4
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0Y4Q5T0Y4_HUMAN
Protein Mdm4
MDM4
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6MZR7Q6MZR7_HUMAN
Protein Mdm4
MDM4 DKFZp686B01123
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94D → N in AAB62928 (PubMed:9226370).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 54863.3 Da from positions 1 - 490. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017106175I → T1 PublicationCorresponds to variant dbSNP:rs4252716Ensembl.1
Natural variantiVAR_017107406T → I1 PublicationCorresponds to variant dbSNP:rs4252741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04256327 – 352Missing in isoform HDMX211. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_035669109 – 490LATAT…KVFIA → SASNNTARCNRILQSQKKN in isoform 2. CuratedAdd BLAST382
Alternative sequenceiVSP_035670109 – 490LATAT…KVFIA → SASNNTDAAQTLALAQDHT in isoform 3. CuratedAdd BLAST382
Alternative sequenceiVSP_043145225 – 274Missing in isoform 5. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007111 mRNA Translation: AAB62928.1
AY923176 mRNA Translation: AAY22054.1
AK223228 mRNA Translation: BAD96948.1
AY207458 Genomic DNA Translation: AAO13494.1
AL512306 Genomic DNA No translation available.
BC067299 mRNA Translation: AAH67299.1
BC105106 mRNA Translation: AAI05107.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1447.1 [O15151-1]
CCDS55674.1 [O15151-5]
CCDS55675.1 [O15151-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001191100.1, NM_001204171.1 [O15151-5]
NP_001191101.1, NM_001204172.1 [O15151-4]
NP_001265445.1, NM_001278516.1
NP_001265446.1, NM_001278517.1
NP_001265447.1, NM_001278518.1
NP_001265448.1, NM_001278519.1
NP_002384.2, NM_002393.4 [O15151-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497492
Hs.715871

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367182; ENSP00000356150; ENSG00000198625 [O15151-1]
ENST00000367183; ENSP00000356151; ENSG00000198625 [O15151-4]
ENST00000454264; ENSP00000396840; ENSG00000198625 [O15151-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4194

UCSC genome browser

More...
UCSCi
uc001hay.3 human [O15151-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007111 mRNA Translation: AAB62928.1
AY923176 mRNA Translation: AAY22054.1
AK223228 mRNA Translation: BAD96948.1
AY207458 Genomic DNA Translation: AAO13494.1
AL512306 Genomic DNA No translation available.
BC067299 mRNA Translation: AAH67299.1
BC105106 mRNA Translation: AAI05107.1
CCDSiCCDS1447.1 [O15151-1]
CCDS55674.1 [O15151-5]
CCDS55675.1 [O15151-4]
RefSeqiNP_001191100.1, NM_001204171.1 [O15151-5]
NP_001191101.1, NM_001204172.1 [O15151-4]
NP_001265445.1, NM_001278516.1
NP_001265446.1, NM_001278517.1
NP_001265447.1, NM_001278518.1
NP_001265448.1, NM_001278519.1
NP_002384.2, NM_002393.4 [O15151-1]
UniGeneiHs.497492
Hs.715871

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CR8NMR-A300-339[»]
2MWYNMR-A23-111[»]
2N06NMR-A23-111[»]
2N0UNMR-A23-111[»]
2N0WNMR-A23-111[»]
2N14NMR-A23-111[»]
2VJEX-ray2.20B/D428-490[»]
2VJFX-ray2.30B/D428-490[»]
2VYRX-ray2.00A/B/C/D16-116[»]
3DABX-ray1.90A/C/E/G23-111[»]
3EQYX-ray1.63A/B24-108[»]
3FDOX-ray1.40A23-111[»]
3FE7X-ray1.35A14-111[»]
3FEAX-ray1.33A14-111[»]
3JZOX-ray1.80A23-111[»]
3JZPX-ray1.74A23-111[»]
3JZQX-ray1.80A/B23-111[»]
3LBJX-ray1.50E23-111[»]
3MQRX-ray1.80B395-404[»]
3U15X-ray1.80A/B/C/D14-111[»]
4RXZX-ray1.55A/B24-108[»]
5MNJX-ray2.16D/H427-490[»]
5UMLX-ray3.00A/B/E/G24-108[»]
5VK1X-ray2.69A/C/E/G/I/K/M/O24-108[»]
ProteinModelPortaliO15151
SMRiO15151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110359, 88 interactors
CORUMiO15151
DIPiDIP-24199N
IntActiO15151, 38 interactors
MINTiO15151
STRINGi9606.ENSP00000356150

Chemistry databases

BindingDBiO15151
ChEMBLiCHEMBL1255126

Protein family/group databases

MoonDBiO15151 Predicted

PTM databases

iPTMnetiO15151
PhosphoSitePlusiO15151

Polymorphism and mutation databases

BioMutaiMDM4

Proteomic databases

EPDiO15151
jPOSTiO15151
MaxQBiO15151
PaxDbiO15151
PeptideAtlasiO15151
PRIDEiO15151
ProteomicsDBi48474
48475 [O15151-2]
48476 [O15151-3]
48477 [O15151-4]
48478 [O15151-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367182; ENSP00000356150; ENSG00000198625 [O15151-1]
ENST00000367183; ENSP00000356151; ENSG00000198625 [O15151-4]
ENST00000454264; ENSP00000396840; ENSG00000198625 [O15151-5]
GeneIDi4194
KEGGihsa:4194
UCSCiuc001hay.3 human [O15151-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4194
DisGeNETi4194
EuPathDBiHostDB:ENSG00000198625.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MDM4
HGNCiHGNC:6974 MDM4
HPAiHPA018919
HPA048821
MIMi602704 gene
neXtProtiNX_O15151
OpenTargetsiENSG00000198625
PharmGKBiPA30719

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE9V Eukaryota
ENOG410XSWN LUCA
GeneTreeiENSGT00530000063539
HOGENOMiHOG000293341
HOVERGENiHBG013472
InParanoidiO15151
KOiK10127
OMAiHGRTSHL
OrthoDBi1329283at2759
PhylomeDBiO15151
TreeFamiTF105306

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6804760 Regulation of TP53 Activity through Methylation
R-HSA-69541 Stabilization of p53
SIGNORiO15151

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MDM4 human
EvolutionaryTraceiO15151

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MDM4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4194
PMAP-CutDBiO15151

Protein Ontology

More...
PROi
PR:O15151

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198625 Expressed in 219 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO15151 baseline and differential
GenevisibleiO15151 HS

Family and domain databases

Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015458 MDM4
IPR016495 p53_neg-reg_MDM_2/4
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF20 PTHR13844:SF20, 1 hit
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
PF00641 zf-RanBP, 1 hit
PIRSFiPIRSF500699 MDM4, 1 hit
PIRSF006748 p53_MDM_2/4, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15151
Secondary accession number(s): Q2M2Y2
, Q32SL2, Q6GS18, Q8IV83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 27, 2005
Last modified: February 13, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again