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Protein

Actin-related protein 2/3 complex subunit 3

Gene

ARPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).2 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15145

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:ARPC3
Synonyms:ARC21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111229.15
HGNCiHGNC:706 ARPC3
MIMi604225 gene
neXtProtiNX_O15145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10094
OpenTargetsiENSG00000111229
PharmGKBiPA25000

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240422 – 178Actin-related protein 2/3 complex subunit 3Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei47PhosphotyrosineCombined sources1
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei61N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15145
MaxQBiO15145
PaxDbiO15145
PeptideAtlasiO15145
PRIDEiO15145
ProteomicsDBi48470
TopDownProteomicsiO15145

2D gel databases

OGPiO15145

PTM databases

iPTMnetiO15145
PhosphoSitePlusiO15145
SwissPalmiO15145

Expressioni

Gene expression databases

BgeeiENSG00000111229 Expressed in 125 organ(s), highest expression level in leukocyte
ExpressionAtlasiO15145 baseline and differential
GenevisibleiO15145 HS

Organism-specific databases

HPAiHPA006550

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115401, 89 interactors
CORUMiO15145
DIPiDIP-33187N
IntActiO15145, 71 interactors
MINTiO15145
STRINGi9606.ENSP00000228825

Structurei

3D structure databases

ProteinModelPortaliO15145
SMRiO15145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
InParanoidiO15145
KOiK05756
OMAiPSKWWMS
OrthoDBiEOG091G0OUM
PhylomeDBiO15145
TreeFamiTF314598

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15145-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD
160 170
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,547
Last modified:January 23, 2007 - v3
Checksum:i7149F598B48F0EAC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZD1C9JZD1_HUMAN
Actin-related protein 2/3 complex s...
ARPC3
99Annotation score:
F8VR50F8VR50_HUMAN
Actin-related protein 2/3 complex s...
ARPC3
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134Q → P in AAB61466 (PubMed:9359840).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004561 mRNA Translation: AAB61466.1
AF006086 mRNA Translation: AAB64191.1
CR407667 mRNA Translation: CAG28595.1
BC067747 mRNA Translation: AAH67747.1
BC078162 mRNA Translation: AAH78162.1
CCDSiCCDS9146.1
RefSeqiNP_001265485.1, NM_001278556.1
NP_001274151.1, NM_001287222.1
UniGeneiHs.524741

Genome annotation databases

EnsembliENST00000228825; ENSP00000228825; ENSG00000111229
GeneIDi10094
KEGGihsa:10094
UCSCiuc001tqq.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004561 mRNA Translation: AAB61466.1
AF006086 mRNA Translation: AAB64191.1
CR407667 mRNA Translation: CAG28595.1
BC067747 mRNA Translation: AAH67747.1
BC078162 mRNA Translation: AAH78162.1
CCDSiCCDS9146.1
RefSeqiNP_001265485.1, NM_001278556.1
NP_001274151.1, NM_001287222.1
UniGeneiHs.524741

3D structure databases

ProteinModelPortaliO15145
SMRiO15145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115401, 89 interactors
CORUMiO15145
DIPiDIP-33187N
IntActiO15145, 71 interactors
MINTiO15145
STRINGi9606.ENSP00000228825

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM databases

iPTMnetiO15145
PhosphoSitePlusiO15145
SwissPalmiO15145

2D gel databases

OGPiO15145

Proteomic databases

EPDiO15145
MaxQBiO15145
PaxDbiO15145
PeptideAtlasiO15145
PRIDEiO15145
ProteomicsDBi48470
TopDownProteomicsiO15145

Protocols and materials databases

DNASUi10094
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228825; ENSP00000228825; ENSG00000111229
GeneIDi10094
KEGGihsa:10094
UCSCiuc001tqq.5 human

Organism-specific databases

CTDi10094
DisGeNETi10094
EuPathDBiHostDB:ENSG00000111229.15
GeneCardsiARPC3
HGNCiHGNC:706 ARPC3
HPAiHPA006550
MIMi604225 gene
neXtProtiNX_O15145
OpenTargetsiENSG00000111229
PharmGKBiPA25000
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3155 Eukaryota
ENOG4111FTG LUCA
GeneTreeiENSGT00390000018018
HOGENOMiHOG000161465
HOVERGENiHBG050581
InParanoidiO15145
KOiK05756
OMAiPSKWWMS
OrthoDBiEOG091G0OUM
PhylomeDBiO15145
TreeFamiTF314598

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15145

Miscellaneous databases

ChiTaRSiARPC3 human
GeneWikiiARPC3
GenomeRNAii10094
PROiPR:O15145
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111229 Expressed in 125 organ(s), highest expression level in leukocyte
ExpressionAtlasiO15145 baseline and differential
GenevisibleiO15145 HS

Family and domain databases

Gene3Di1.10.1760.10, 1 hit
InterProiView protein in InterPro
IPR007204 ARPC3
IPR036753 ARPC3_sf
PANTHERiPTHR12391 PTHR12391, 1 hit
PfamiView protein in Pfam
PF04062 P21-Arc, 1 hit
PIRSFiPIRSF016315 ARP2/3_P21-Arc, 1 hit
SUPFAMiSSF69060 SSF69060, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARPC3_HUMAN
AccessioniPrimary (citable) accession number: O15145
Secondary accession number(s): O00554
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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