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Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).2 Publications

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15144

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:ARPC2
Synonyms:ARC34
ORF Names:PRO2446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163466.15
HGNCiHGNC:705 ARPC2
MIMi604224 gene
neXtProtiNX_O15144

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10109
OpenTargetsiENSG00000163466
PharmGKBiPA24999

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240331 – 300Actin-related protein 2/3 complex subunit 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-acetyllysineCombined sources1
Modified residuei295N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO15144
MaxQBiO15144
PaxDbiO15144
PeptideAtlasiO15144
PRIDEiO15144
ProteomicsDBi48469
TopDownProteomicsiO15144

2D gel databases

OGPiO15144

PTM databases

iPTMnetiO15144
PhosphoSitePlusiO15144
SwissPalmiO15144

Expressioni

Gene expression databases

BgeeiENSG00000163466 Expressed in 237 organ(s), highest expression level in bone marrow
CleanExiHS_ARPC2
ExpressionAtlasiO15144 baseline and differential
GenevisibleiO15144 HS

Organism-specific databases

HPAiCAB001994
HPA008352

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9230079, PubMed:11741539). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115415, 85 interactors
CORUMiO15144
DIPiDIP-33197N
IntActiO15144, 41 interactors
MINTiO15144
STRINGi9606.ENSP00000295685

Structurei

3D structure databases

ProteinModelPortaliO15144
SMRiO15144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiKOG2826 Eukaryota
ENOG410YKF6 LUCA
GeneTreeiENSGT00390000016794
HOGENOMiHOG000212535
HOVERGENiHBG050580
InParanoidiO15144
KOiK05758
OMAiEETMYVE
OrthoDBiEOG091G0BUH
PhylomeDBiO15144
TreeFamiTF315006

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O15144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Length:300
Mass (Da):34,333
Last modified:January 1, 1998 - v1
Checksum:i3BA57121BE9A05F2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9J0G5E9J0_HUMAN
Arp2/3 complex 34 kDa subunit
ARPC2 hCG_16304
91Annotation score:
H7C3F9H7C3F9_HUMAN
Arp2/3 complex 34 kDa subunit
ARPC2
165Annotation score:
C9JTV5C9JTV5_HUMAN
Arp2/3 complex 34 kDa subunit
ARPC2
89Annotation score:
G5E9S7G5E9S7_HUMAN
Actin related protein 2/3 complex, ...
ARPC2 hCG_16304
38Annotation score:

Sequence cautioni

The sequence AAC50874 differs from that shown. Reason: Frameshift at position 14.Curated
The sequence AAF71122 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72A → C in AAC50874 (PubMed:8812419).Curated1
Sequence conflicti289 – 300MKTIT…TFSSR → KI in AAF71122 (Ref. 6) CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006085 mRNA Translation: AAB64190.1
U50523 mRNA Translation: AAC50874.1 Frameshift.
BT006898 mRNA Translation: AAP35544.1
BC000590 mRNA Translation: AAH00590.1
AF116702 mRNA Translation: AAF71122.1 Different initiation.
CCDSiCCDS2410.1
RefSeqiNP_005722.1, NM_005731.3
NP_690601.1, NM_152862.2
UniGeneiHs.529303

Genome annotation databases

EnsembliENST00000295685; ENSP00000295685; ENSG00000163466
ENST00000315717; ENSP00000327137; ENSG00000163466
GeneIDi10109
KEGGihsa:10109

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006085 mRNA Translation: AAB64190.1
U50523 mRNA Translation: AAC50874.1 Frameshift.
BT006898 mRNA Translation: AAP35544.1
BC000590 mRNA Translation: AAH00590.1
AF116702 mRNA Translation: AAF71122.1 Different initiation.
CCDSiCCDS2410.1
RefSeqiNP_005722.1, NM_005731.3
NP_690601.1, NM_152862.2
UniGeneiHs.529303

3D structure databases

ProteinModelPortaliO15144
SMRiO15144
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115415, 85 interactors
CORUMiO15144
DIPiDIP-33197N
IntActiO15144, 41 interactors
MINTiO15144
STRINGi9606.ENSP00000295685

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM databases

iPTMnetiO15144
PhosphoSitePlusiO15144
SwissPalmiO15144

2D gel databases

OGPiO15144

Proteomic databases

EPDiO15144
MaxQBiO15144
PaxDbiO15144
PeptideAtlasiO15144
PRIDEiO15144
ProteomicsDBi48469
TopDownProteomicsiO15144

Protocols and materials databases

DNASUi10109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295685; ENSP00000295685; ENSG00000163466
ENST00000315717; ENSP00000327137; ENSG00000163466
GeneIDi10109
KEGGihsa:10109

Organism-specific databases

CTDi10109
DisGeNETi10109
EuPathDBiHostDB:ENSG00000163466.15
GeneCardsiARPC2
HGNCiHGNC:705 ARPC2
HPAiCAB001994
HPA008352
MIMi604224 gene
neXtProtiNX_O15144
OpenTargetsiENSG00000163466
PharmGKBiPA24999
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2826 Eukaryota
ENOG410YKF6 LUCA
GeneTreeiENSGT00390000016794
HOGENOMiHOG000212535
HOVERGENiHBG050580
InParanoidiO15144
KOiK05758
OMAiEETMYVE
OrthoDBiEOG091G0BUH
PhylomeDBiO15144
TreeFamiTF315006

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15144

Miscellaneous databases

ChiTaRSiARPC2 human
GeneWikiiARPC2
GenomeRNAii10109
PROiPR:O15144
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163466 Expressed in 237 organ(s), highest expression level in bone marrow
CleanExiHS_ARPC2
ExpressionAtlasiO15144 baseline and differential
GenevisibleiO15144 HS

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiARPC2_HUMAN
AccessioniPrimary (citable) accession number: O15144
Secondary accession number(s): Q92801, Q9P1D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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