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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

ARPC1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).3 Publications

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkiO15143
SIGNORiO15143

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARPC1BImported
Synonyms:ARC41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000130429.12
HGNCiHGNC:704 ARPC1B
MIMi604223 gene
neXtProtiNX_O15143

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases.
See also OMIM:617718
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080353105A → V in PLTEID; unknown pathological significance. 1 Publication1
Natural variantiVAR_080354238A → T in PLTEID; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs147238850Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10095
MalaCardsiARPC1B
MIMi617718 phenotype
OpenTargetsiENSG00000130429
PharmGKBiPA24998

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

Polymorphism and mutation databases

BioMutaiARPC1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000508552 – 372Actin-related protein 2/3 complex subunit 1BAdd BLAST371

Proteomic databases

EPDiO15143
MaxQBiO15143
PaxDbiO15143
PeptideAtlasiO15143
PRIDEiO15143
ProteomicsDBi48468

PTM databases

iPTMnetiO15143
PhosphoSitePlusiO15143
SwissPalmiO15143

Expressioni

Gene expression databases

BgeeiENSG00000130429 Expressed in 229 organ(s), highest expression level in blood
CleanExiHS_ARPC1B
ExpressionAtlasiO15143 baseline and differential
GenevisibleiO15143 HS

Organism-specific databases

HPAiHPA004832

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115402, 75 interactors
CORUMiO15143
DIPiDIP-41254N
IntActiO15143, 39 interactors
MINTiO15143
STRINGi9606.ENSP00000252725

Structurei

3D structure databases

ProteinModelPortaliO15143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati94 – 135WD 3Add BLAST42
Repeati140 – 179WD 4Add BLAST40
Repeati242 – 280WD 5Add BLAST39
Repeati324 – 367WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiO15143
KOiK05757
OMAiVLFTYDS
OrthoDBiEOG091G096H
PhylomeDBiO15143
TreeFamiTF315041

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

O15143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAL
260 270 280 290 300
TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):40,950
Last modified:January 23, 2007 - v3
Checksum:i1939F5B63D40BD27
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBJ7C9JBJ7_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
102Annotation score:
C9J4Z7C9J4Z7_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
128Annotation score:
C9JTT6C9JTT6_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
82Annotation score:
F8VXW2F8VXW2_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
130Annotation score:
C9J6C8C9J6C8_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
132Annotation score:
C9JQM8C9JQM8_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
132Annotation score:
C9JFG9C9JFG9_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
132Annotation score:
C9K057C9K057_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
352Annotation score:
C9JEY1C9JEY1_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
334Annotation score:
C9JM51C9JM51_HUMAN
Actin-related protein 2/3 complex s...
ARPC1B
30Annotation score:
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01447737K → N. Corresponds to variant dbSNP:rs1045012Ensembl.1
Natural variantiVAR_080353105A → V in PLTEID; unknown pathological significance. 1 Publication1
Natural variantiVAR_080354238A → T in PLTEID; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs147238850Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006084 mRNA Translation: AAB64189.1
AC004922 Genomic DNA No translation available.
BC002562 mRNA Translation: AAH02562.1
BC002988 mRNA Translation: AAH02988.2
BC007555 mRNA Translation: AAH07555.1
CCDSiCCDS5661.1
RefSeqiNP_005711.1, NM_005720.3
XP_006715888.1, XM_006715825.1
XP_006715889.1, XM_006715826.1
UniGeneiHs.489284

Genome annotation databases

EnsembliENST00000252725; ENSP00000252725; ENSG00000130429
ENST00000427217; ENSP00000403211; ENSG00000130429
ENST00000431816; ENSP00000398110; ENSG00000130429
ENST00000451682; ENSP00000389631; ENSG00000130429
ENST00000455009; ENSP00000410238; ENSG00000130429
ENST00000458033; ENSP00000388802; ENSG00000130429
ENST00000645391; ENSP00000494033; ENSG00000130429
ENST00000646101; ENSP00000496599; ENSG00000130429
GeneIDi10095
KEGGihsa:10095
UCSCiuc003upz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006084 mRNA Translation: AAB64189.1
AC004922 Genomic DNA No translation available.
BC002562 mRNA Translation: AAH02562.1
BC002988 mRNA Translation: AAH02988.2
BC007555 mRNA Translation: AAH07555.1
CCDSiCCDS5661.1
RefSeqiNP_005711.1, NM_005720.3
XP_006715888.1, XM_006715825.1
XP_006715889.1, XM_006715826.1
UniGeneiHs.489284

3D structure databases

ProteinModelPortaliO15143
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115402, 75 interactors
CORUMiO15143
DIPiDIP-41254N
IntActiO15143, 39 interactors
MINTiO15143
STRINGi9606.ENSP00000252725

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

PTM databases

iPTMnetiO15143
PhosphoSitePlusiO15143
SwissPalmiO15143

Polymorphism and mutation databases

BioMutaiARPC1B

Proteomic databases

EPDiO15143
MaxQBiO15143
PaxDbiO15143
PeptideAtlasiO15143
PRIDEiO15143
ProteomicsDBi48468

Protocols and materials databases

DNASUi10095
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252725; ENSP00000252725; ENSG00000130429
ENST00000427217; ENSP00000403211; ENSG00000130429
ENST00000431816; ENSP00000398110; ENSG00000130429
ENST00000451682; ENSP00000389631; ENSG00000130429
ENST00000455009; ENSP00000410238; ENSG00000130429
ENST00000458033; ENSP00000388802; ENSG00000130429
ENST00000645391; ENSP00000494033; ENSG00000130429
ENST00000646101; ENSP00000496599; ENSG00000130429
GeneIDi10095
KEGGihsa:10095
UCSCiuc003upz.4 human

Organism-specific databases

CTDi10095
DisGeNETi10095
EuPathDBiHostDB:ENSG00000130429.12
GeneCardsiARPC1B
HGNCiHGNC:704 ARPC1B
HPAiHPA004832
MalaCardsiARPC1B
MIMi604223 gene
617718 phenotype
neXtProtiNX_O15143
OpenTargetsiENSG00000130429
PharmGKBiPA24998
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiO15143
KOiK05757
OMAiVLFTYDS
OrthoDBiEOG091G096H
PhylomeDBiO15143
TreeFamiTF315041

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkiO15143
SIGNORiO15143

Miscellaneous databases

ChiTaRSiARPC1B human
GeneWikiiARPC1B
GenomeRNAii10095
PROiPR:O15143
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130429 Expressed in 229 organ(s), highest expression level in blood
CleanExiHS_ARPC1B
ExpressionAtlasiO15143 baseline and differential
GenevisibleiO15143 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARC1B_HUMAN
AccessioniPrimary (citable) accession number: O15143
Secondary accession number(s): Q9BU00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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