UniProtKB - O15130 (NPFF_HUMAN)
Pro-FMRFamide-related neuropeptide FF
NPFF
Functioni
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
1 PublicationGO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
- signaling receptor binding Source: ProtInc
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- excitatory postsynaptic potential Source: GO_Central
- neuropeptide signaling pathway Source: ProtInc
Keywordsi
Molecular function | Neuropeptide |
Enzyme and pathway databases
PathwayCommonsi | O15130 |
Reactomei | R-HSA-389397, Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | O15130 |
SIGNORi | O15130 |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-FMRFamide-related neuropeptide FFAlternative name(s): FMRFamide-related peptides Cleaved into the following 3 chains: |
Gene namesi | Name:NPFF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7901, NPFF |
MIMi | 604643, gene |
neXtProti | NX_O15130 |
VEuPathDBi | HostDB:ENSG00000139574 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- axon terminus Source: GO_Central
- dendrite Source: GO_Central
- perikaryon Source: GO_Central
- postsynapse Source: GOC
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 8620 |
OpenTargetsi | ENSG00000139574 |
PharmGKBi | PA31704 |
Miscellaneous databases
Pharosi | O15130, Tbio |
Genetic variation databases
BioMutai | NPFF |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000009898 | 21 – 65 | Add BLAST | 45 | |
PeptideiPRO_0000009899 | 66 – 76 | Neuropeptide SFAdd BLAST | 11 | |
PeptideiPRO_0000009900 | 69 – 76 | Neuropeptide FF | 8 | |
PropeptideiPRO_0000009901 | 79 – 92 | Add BLAST | 14 | |
PeptideiPRO_0000009902 | 93 – 110 | Neuropeptide AFAdd BLAST | 18 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | Phenylalanine amideBy similarity | 1 | |
Modified residuei | 110 | Phenylalanine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
PaxDbi | O15130 |
PeptideAtlasi | O15130 |
PRIDEi | O15130 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139574, Expressed in testis and 81 other tissues |
Genevisiblei | O15130, HS |
Organism-specific databases
HPAi | ENSG00000139574, Tissue enriched (epididymis) |
Interactioni
Binary interactionsi
Isoform 2 [O15130-2]
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 114175, 2 interactors |
IntActi | O15130, 7 interactors |
STRINGi | 9606.ENSP00000267017 |
Miscellaneous databases
RNActi | O15130, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 48 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S60B, Eukaryota |
GeneTreei | ENSGT01040000240601 |
HOGENOMi | CLU_2102411_0_0_1 |
InParanoidi | O15130 |
OMAi | GEFWSLA |
OrthoDBi | 1435009at2759 |
PhylomeDBi | O15130 |
TreeFami | TF330924 |
Family and domain databases
InterProi | View protein in InterPro IPR008065, NPFF |
PANTHERi | PTHR15044, PTHR15044, 1 hit |
Pfami | View protein in Pfam PF15085, NPFF, 1 hit |
PIRSFi | PIRSF038092, FMRFamid-rel_pep_precur, 1 hit |
PRINTSi | PR01682, FMRFAMIDEPEP |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSRQAAALL VLLLLIDGGC AEGPGGQQED QLSAEEDSEP LPPQDAQTSG
60 70 80 90 100
SLLHYLLQAM ERPGRSQAFL FQPQRFGRNT QGSWRNEWLS PRAGEGLNSQ
110
FWSLAAPQRF GKK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049183 | 88 | W → R. Corresponds to variant dbSNP:rs35822762EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056475 | 1 – 34 | MDSRQ…DQLSA → MVPQPPTTCPWKPVPSPCDL RVQGICPSSFPDTPLAQ in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF005271 mRNA Translation: AAB64288.1 AC023509 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96721.1 BC104234 mRNA Translation: AAI04235.1 BC104235 mRNA Translation: AAI04236.1 |
CCDSi | CCDS8862.1 [O15130-1] |
RefSeqi | NP_001307225.1, NM_001320296.1 [O15130-2] NP_003708.1, NM_003717.3 [O15130-1] |
Genome annotation databases
Ensembli | ENST00000267017; ENSP00000267017; ENSG00000139574 ENST00000448979; ENSP00000507090; ENSG00000139574 [O15130-2] |
GeneIDi | 8620 |
KEGGi | hsa:8620 |
MANE-Selecti | ENST00000267017.4; ENSP00000267017.3; NM_003717.4; NP_003708.1 |
UCSCi | uc001sdw.1, human [O15130-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF005271 mRNA Translation: AAB64288.1 AC023509 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96721.1 BC104234 mRNA Translation: AAI04235.1 BC104235 mRNA Translation: AAI04236.1 |
CCDSi | CCDS8862.1 [O15130-1] |
RefSeqi | NP_001307225.1, NM_001320296.1 [O15130-2] NP_003708.1, NM_003717.3 [O15130-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114175, 2 interactors |
IntActi | O15130, 7 interactors |
STRINGi | 9606.ENSP00000267017 |
Genetic variation databases
BioMutai | NPFF |
Proteomic databases
PaxDbi | O15130 |
PeptideAtlasi | O15130 |
PRIDEi | O15130 |
Protocols and materials databases
Antibodypediai | 15271, 136 antibodies from 23 providers |
DNASUi | 8620 |
Genome annotation databases
Ensembli | ENST00000267017; ENSP00000267017; ENSG00000139574 ENST00000448979; ENSP00000507090; ENSG00000139574 [O15130-2] |
GeneIDi | 8620 |
KEGGi | hsa:8620 |
MANE-Selecti | ENST00000267017.4; ENSP00000267017.3; NM_003717.4; NP_003708.1 |
UCSCi | uc001sdw.1, human [O15130-1] |
Organism-specific databases
CTDi | 8620 |
DisGeNETi | 8620 |
GeneCardsi | NPFF |
HGNCi | HGNC:7901, NPFF |
HPAi | ENSG00000139574, Tissue enriched (epididymis) |
MIMi | 604643, gene |
neXtProti | NX_O15130 |
OpenTargetsi | ENSG00000139574 |
PharmGKBi | PA31704 |
VEuPathDBi | HostDB:ENSG00000139574 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S60B, Eukaryota |
GeneTreei | ENSGT01040000240601 |
HOGENOMi | CLU_2102411_0_0_1 |
InParanoidi | O15130 |
OMAi | GEFWSLA |
OrthoDBi | 1435009at2759 |
PhylomeDBi | O15130 |
TreeFami | TF330924 |
Enzyme and pathway databases
PathwayCommonsi | O15130 |
Reactomei | R-HSA-389397, Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | O15130 |
SIGNORi | O15130 |
Miscellaneous databases
BioGRID-ORCSi | 8620, 6 hits in 1036 CRISPR screens |
GeneWikii | NPFF |
GenomeRNAii | 8620 |
Pharosi | O15130, Tbio |
PROi | PR:O15130 |
RNActi | O15130, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139574, Expressed in testis and 81 other tissues |
Genevisiblei | O15130, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008065, NPFF |
PANTHERi | PTHR15044, PTHR15044, 1 hit |
Pfami | View protein in Pfam PF15085, NPFF, 1 hit |
PIRSFi | PIRSF038092, FMRFamid-rel_pep_precur, 1 hit |
PRINTSi | PR01682, FMRFAMIDEPEP |
MobiDBi | Search... |
Entry informationi
Entry namei | NPFF_HUMAN | |
Accessioni | O15130Primary (citable) accession number: O15130 Secondary accession number(s): Q3SXL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families