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Protein

Secretory carrier-associated membrane protein 2

Gene

SCAMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Biological processi

  • post-Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi8.A.103.1.2 the secretory carrier-associated membrane protein (scamp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 2
Short name:
Secretory carrier membrane protein 2
Gene namesi
Name:SCAMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140497.16
HGNCiHGNC:10564 SCAMP2
MIMi606912 gene
neXtProtiNX_O15127

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 153CytoplasmicSequence analysisAdd BLAST153
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 181LumenalSequence analysis7
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 262LumenalSequence analysisAdd BLAST23
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 329CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10066
OpenTargetsiENSG00000140497
PharmGKBiPA34977

Polymorphism and mutation databases

BioMutaiSCAMP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912541 – 329Secretory carrier-associated membrane protein 2Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15127
MaxQBiO15127
PaxDbiO15127
PeptideAtlasiO15127
PRIDEiO15127
ProteomicsDBi48465

PTM databases

iPTMnetiO15127
PhosphoSitePlusiO15127
SwissPalmiO15127

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000140497 Expressed in 226 organ(s), highest expression level in esophagus mucosa
CleanExiHS_SCAMP2
ExpressionAtlasiO15127 baseline and differential
GenevisibleiO15127 HS

Organism-specific databases

HPAiHPA014699
HPA019194

Interactioni

Subunit structurei

Interacts with SLC6A4 and SLC9A7.2 Publications

Protein-protein interaction databases

BioGridi115377, 23 interactors
CORUMiO15127
IntActiO15127, 10 interactors
MINTiO15127
STRINGi9606.ENSP00000268099

Structurei

3D structure databases

ProteinModelPortaliO15127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 218Interaction with SLC9A71 PublicationAdd BLAST16

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiO15127
KOiK19995
OMAiFIFFCQI
OrthoDBiEOG091G0ID2
PhylomeDBiO15127
TreeFamiTF313797

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O15127-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QGGLAEFNPF SETNAATTVP
60 70 80 90 100
VTQLPGSSQP AVLQPSVEPT QPTPQAVVSA AQAGLLRQQE ELDRKAAELE
110 120 130 140 150
RKERELQNTV ANLHVRQNNW PPLPSWCPVK PCFYQDFSTE IPADYQRICK
160 170 180 190 200
MLYYLWMLHS VTLFLNLLAC LAWFSGNSSK GVDFGLSILW FLIFTPCAFL
210 220 230 240 250
CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYIIQLVGIP GLGDSGWIAA
260 270 280 290 300
LSTLDNHSLA ISVIMMVVAG FFTLCAVLSV FLLQRVHSLY RRTGASFQQA
310 320
QEEFSQGIFS SRTFHRAASS AAQGAFQGN
Length:329
Mass (Da):36,649
Last modified:July 11, 2001 - v2
Checksum:i046ACB926FD951DD
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUB6H3BUB6_HUMAN
Secretory carrier-associated membra...
SCAMP2
254Annotation score:
H3BN93H3BN93_HUMAN
Secretory carrier-associated membra...
SCAMP2
236Annotation score:
H3BV04H3BV04_HUMAN
Secretory carrier-associated membra...
SCAMP2
194Annotation score:
H3BPL9H3BPL9_HUMAN
Secretory carrier-associated membra...
SCAMP2
278Annotation score:
H3BMN2H3BMN2_HUMAN
Secretory carrier-associated membra...
SCAMP2
93Annotation score:
H3BQW2H3BQW2_HUMAN
Secretory carrier-associated membra...
SCAMP2
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005038 mRNA Translation: AAB62723.2
AK315516 mRNA Translation: BAG37897.1
CH471136 Genomic DNA Translation: EAW99300.1
BC001376 mRNA Translation: AAH01376.1
BC004385 mRNA Translation: AAH04385.1
CCDSiCCDS10271.1
RefSeqiNP_005688.2, NM_005697.4
UniGeneiHs.458917

Genome annotation databases

EnsembliENST00000268099; ENSP00000268099; ENSG00000140497
GeneIDi10066
KEGGihsa:10066
UCSCiuc002azb.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005038 mRNA Translation: AAB62723.2
AK315516 mRNA Translation: BAG37897.1
CH471136 Genomic DNA Translation: EAW99300.1
BC001376 mRNA Translation: AAH01376.1
BC004385 mRNA Translation: AAH04385.1
CCDSiCCDS10271.1
RefSeqiNP_005688.2, NM_005697.4
UniGeneiHs.458917

3D structure databases

ProteinModelPortaliO15127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115377, 23 interactors
CORUMiO15127
IntActiO15127, 10 interactors
MINTiO15127
STRINGi9606.ENSP00000268099

Protein family/group databases

TCDBi8.A.103.1.2 the secretory carrier-associated membrane protein (scamp) family

PTM databases

iPTMnetiO15127
PhosphoSitePlusiO15127
SwissPalmiO15127

Polymorphism and mutation databases

BioMutaiSCAMP2

Proteomic databases

EPDiO15127
MaxQBiO15127
PaxDbiO15127
PeptideAtlasiO15127
PRIDEiO15127
ProteomicsDBi48465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268099; ENSP00000268099; ENSG00000140497
GeneIDi10066
KEGGihsa:10066
UCSCiuc002azb.2 human

Organism-specific databases

CTDi10066
DisGeNETi10066
EuPathDBiHostDB:ENSG00000140497.16
GeneCardsiSCAMP2
HGNCiHGNC:10564 SCAMP2
HPAiHPA014699
HPA019194
MIMi606912 gene
neXtProtiNX_O15127
OpenTargetsiENSG00000140497
PharmGKBiPA34977
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiO15127
KOiK19995
OMAiFIFFCQI
OrthoDBiEOG091G0ID2
PhylomeDBiO15127
TreeFamiTF313797

Miscellaneous databases

ChiTaRSiSCAMP2 human
GeneWikiiSCAMP2
GenomeRNAii10066
PROiPR:O15127
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140497 Expressed in 226 organ(s), highest expression level in esophagus mucosa
CleanExiHS_SCAMP2
ExpressionAtlasiO15127 baseline and differential
GenevisibleiO15127 HS

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM2_HUMAN
AccessioniPrimary (citable) accession number: O15127
Secondary accession number(s): B2RDF0, Q9BQE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 11, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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