Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Secretory carrier-associated membrane protein 1

Gene

SCAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • post-Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi8.A.103.1.1 the secretory carrier-associated membrane protein (scamp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 1
Short name:
Secretory carrier membrane protein 1
Gene namesi
Name:SCAMP1
Synonyms:SCAMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000085365.17
HGNCiHGNC:10563 SCAMP1
MIMi606911 gene
neXtProtiNX_O15126

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 155CytoplasmicSequence analysisAdd BLAST154
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 181LumenalSequence analysis5
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 261LumenalSequence analysisAdd BLAST22
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 338CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9522
OpenTargetsiENSG00000085365
PharmGKBiPA34976

Polymorphism and mutation databases

BioMutaiSCAMP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001912502 – 338Secretory carrier-associated membrane protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei45PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO15126
MaxQBiO15126
PeptideAtlasiO15126
PRIDEiO15126
ProteomicsDBi48463
48464 [O15126-2]

PTM databases

iPTMnetiO15126
PhosphoSitePlusiO15126
SwissPalmiO15126

Expressioni

Tissue specificityi

Widely expressed, with highest expression in brain.

Gene expression databases

BgeeiENSG00000085365 Expressed in 242 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SCAMP1
ExpressionAtlasiO15126 baseline and differential
GenevisibleiO15126 HS

Organism-specific databases

HPAiCAB079009
HPA044753

Interactioni

Subunit structurei

Interacts with SYNRG and ITSN1 (By similarity). Interacts with SLC9A7.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114899, 33 interactors
CORUMiO15126
IntActiO15126, 24 interactors

Structurei

3D structure databases

ProteinModelPortaliO15126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000014393
HOGENOMiHOG000207630
HOVERGENiHBG071938
InParanoidiO15126
KOiK19995
OMAiLAIFYTM
OrthoDBiEOG091G0ID2
PhylomeDBiO15126

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15126-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDFDSNPFA DPDLNNPFKD PSVTQVTRNV PPGLDEYNPF SDSRTPPPGG
60 70 80 90 100
VKMPNVPNTQ PAIMKPTEEH PAYTQIAKEH ALAQAELLKR QEELERKAAE
110 120 130 140 150
LDRREREMQN LSQHGRKNNW PPLPSNFPVG PCFYQDFSVD IPVEFQKTVK
160 170 180 190 200
LMYYLWMFHA VTLFLNIFGC LAWFCVDSAR AVDFGLSILW FLLFTPCSFV
210 220 230 240 250
CWYRPLYGAF RSDSSFRFFV FFFVYICQFA VHVLQAAGFH NWGNCGWISS
260 270 280 290 300
LTGLNQNIPV GIMMIIIAAL FTASAVISLV MFKKVHGLYR TTGASFEKAQ
310 320 330
QEFATGVMSN KTVQTAAANA ASTAASSAAQ NAFKGNQI
Length:338
Mass (Da):37,920
Last modified:June 20, 2002 - v2
Checksum:iC5745732744BE3C7
GO
Isoform 2 (identifier: O15126-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-338: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:157
Mass (Da):18,042
Checksum:i2A9462644E1AD684
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXB0A0A087WXB0_HUMAN
Secretory carrier-associated membra...
SCAMP1
312Annotation score:
A0A087WU14A0A087WU14_HUMAN
Secretory carrier-associated membra...
SCAMP1
206Annotation score:
A0A087WZA6A0A087WZA6_HUMAN
Secretory carrier-associated membra...
SCAMP1
119Annotation score:
A0A087WTX8A0A087WTX8_HUMAN
Secretory carrier-associated membra...
SCAMP1
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119N → I in AAC39864 (PubMed:9653160).Curated1
Sequence conflicti136D → E in AAC39864 (PubMed:9653160).Curated1
Sequence conflicti247W → L in AAB62722 (PubMed:9378760).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004380158 – 338Missing in isoform 2. 1 PublicationAdd BLAST181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005037 mRNA Translation: AAB62722.1
AF038966 mRNA Translation: AAC39864.1
CR542286 mRNA Translation: CAG47081.1
BC009787 mRNA No translation available.
CH471084 Genomic DNA Translation: EAW95814.1
BC015065 mRNA Translation: AAH15065.1
BC034048 mRNA Translation: AAH34048.1
CCDSiCCDS75264.1 [O15126-1]
RefSeqiNP_001277158.1, NM_001290229.1
NP_004857.4, NM_004866.5 [O15126-1]
UniGeneiHs.482587

Genome annotation databases

EnsembliENST00000614488; ENSP00000478071; ENSG00000085365 [O15126-2]
ENST00000621999; ENSP00000481022; ENSG00000085365 [O15126-1]
GeneIDi9522
KEGGihsa:9522
UCSCiuc032uzx.2 human [O15126-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005037 mRNA Translation: AAB62722.1
AF038966 mRNA Translation: AAC39864.1
CR542286 mRNA Translation: CAG47081.1
BC009787 mRNA No translation available.
CH471084 Genomic DNA Translation: EAW95814.1
BC015065 mRNA Translation: AAH15065.1
BC034048 mRNA Translation: AAH34048.1
CCDSiCCDS75264.1 [O15126-1]
RefSeqiNP_001277158.1, NM_001290229.1
NP_004857.4, NM_004866.5 [O15126-1]
UniGeneiHs.482587

3D structure databases

ProteinModelPortaliO15126
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114899, 33 interactors
CORUMiO15126
IntActiO15126, 24 interactors

Protein family/group databases

TCDBi8.A.103.1.1 the secretory carrier-associated membrane protein (scamp) family

PTM databases

iPTMnetiO15126
PhosphoSitePlusiO15126
SwissPalmiO15126

Polymorphism and mutation databases

BioMutaiSCAMP1

Proteomic databases

EPDiO15126
MaxQBiO15126
PeptideAtlasiO15126
PRIDEiO15126
ProteomicsDBi48463
48464 [O15126-2]

Protocols and materials databases

DNASUi9522
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614488; ENSP00000478071; ENSG00000085365 [O15126-2]
ENST00000621999; ENSP00000481022; ENSG00000085365 [O15126-1]
GeneIDi9522
KEGGihsa:9522
UCSCiuc032uzx.2 human [O15126-1]

Organism-specific databases

CTDi9522
DisGeNETi9522
EuPathDBiHostDB:ENSG00000085365.17
GeneCardsiSCAMP1
HGNCiHGNC:10563 SCAMP1
HPAiCAB079009
HPA044753
MIMi606911 gene
neXtProtiNX_O15126
OpenTargetsiENSG00000085365
PharmGKBiPA34976
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000014393
HOGENOMiHOG000207630
HOVERGENiHBG071938
InParanoidiO15126
KOiK19995
OMAiLAIFYTM
OrthoDBiEOG091G0ID2
PhylomeDBiO15126

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSCAMP1 human
GeneWikiiSCAMP1
GenomeRNAii9522
PROiPR:O15126
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085365 Expressed in 242 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SCAMP1
ExpressionAtlasiO15126 baseline and differential
GenevisibleiO15126 HS

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM1_HUMAN
AccessioniPrimary (citable) accession number: O15126
Secondary accession number(s): O43587
, Q6FG23, Q96BX1, Q96QK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again