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UniProtKB - O15120 (PLCB_HUMAN)

Entry version 184 (02 Dec 2020)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

Gene

AGPAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=11.05 µM for C15:0-CoA1 Publication
  2. KM=523.97 µM for C18:0-CoA1 Publication
  3. KM=30.21 µM for C18:1-CoA1 Publication
  4. KM=8.29 µM for LPA sn-1 C18:11 Publication
  1. Vmax=51.61 nmol/min/mg enzyme for C15:0-CoA1 Publication
  2. Vmax=95.55 nmol/min/mg enzyme for C18:0-CoA1 Publication
  3. Vmax=73.81 nmol/min/mg enzyme for C18:1-CoA1 Publication
  4. Vmax=86.05 nmol/min/mg enzyme for LPA sn-1 C18:11 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), Lysocardiolipin acyltransferase 1 (LCLAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), CDP-diacylglycerol synthase (TAMM41), CDP-diacylglycerol synthase (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, CDP-diacylglycerol synthase (TAMM41), CDP-diacylglycerol synthase (TAMM41), Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09990-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.51, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15120

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483166, Synthesis of PA
R-HSA-6798695, Neutrophil degranulation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00557;UER00613

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000096

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC:2.3.1.514 Publications)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 2
Short name:
1-AGP acyltransferase 2
Short name:
1-AGPAT 2
Lysophosphatidic acid acyltransferase beta1 Publication
Short name:
LPAAT-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGPAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000169692.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:325, AGPAT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603100, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 29LumenalCurated6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 121CytoplasmicCuratedAdd BLAST71
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 278LumenalCuratedAdd BLAST136

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital generalized lipodystrophy 1 (CGL1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017328136G → R in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs797045222EnsemblClinVar.1
Natural variantiVAR_017326140Missing in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 Publications1
Natural variantiVAR_017327228L → P in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894100EnsemblClinVar.1
Natural variantiVAR_017325239A → V in CGL1; 90% of wild-type 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs145975461EnsemblClinVar.1

Keywords - Diseasei

Congenital generalized lipodystrophy, Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		10555

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		AGPAT2

MalaCards human disease database

More...MalaCardsi		AGPAT2
MIMi608594, phenotype

Open Targets

More...OpenTargetsi		ENSG00000169692

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		528, Berardinelli-Seip congenital lipodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24622

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15120, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4772

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGPAT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020819224 – 2781-acyl-sn-glycerol-3-phosphate acyltransferase betaAdd BLAST255

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15120

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15120

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15120

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15120

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15120

PeptideAtlas

More...PeptideAtlasi		O15120

PRoteomics IDEntifications database

More...PRIDEi		O15120

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48457 [O15120-1]
48458 [O15120-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15120

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15120

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in adipose tissue, pancreas and liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169692, Expressed in subcutaneous adipose tissue and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15120, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15120, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169692, Tissue enhanced (adipose tissue, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115806, 18 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15120

Protein interaction database and analysis system

More...IntActi		O15120, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360761

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15120

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15120, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15120

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi98 – 103HXXXXD motifBy similarity6
Motifi172 – 175EGTR motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2848, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027938_10_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15120

Identification of Orthologs from Complete Genome Data

More...OMAi		MPRPLCY

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15120

TreeFam database of animal gene trees

More...TreeFami		TF314867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004552, AGP_acyltrans
IPR002123, Plipid/glycerol_acylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01553, Acyltransferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00563, PlsC, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00530, AGP_acyltrn, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O15120-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL 
        60         70         80         90        100
RHGGRTVENM SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS 
       110        120        130        140        150
ILDMMGLMEV LPERCVQIAK RELLFLGPVG LIMYLGGVFF INRQRSSTAM 
       160        170        180        190        200
TVMADLGERM VRENLKVWIY PEGTRNDNGD LLPFKKGAFY LAVQAQVPIV 
       210        220        230        240        250
PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD VPALVDTCHR 
       260        270 
AMRTTFLHIS KTPQENGATA GSGVQPAQ
Length:278
Mass (Da):30,914
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E58F537F703BE9F
GO
Isoform 2 (identifier: O15120-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-196: Missing.

Show »
Length:246
Mass (Da):27,279
Checksum:i2A6E877F48DC3FE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126L → V in AAB64299 (PubMed:9291118).Curated1
Sequence conflicti200V → F in AAH00026 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017328136G → R in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs797045222EnsemblClinVar.1
Natural variantiVAR_017326140Missing in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 Publications1
Natural variantiVAR_017327228L → P in CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894100EnsemblClinVar.1
Natural variantiVAR_017325239A → V in CGL1; 90% of wild-type 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs145975461EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005071165 – 196Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF000237 mRNA Translation: AAC51649.1
AF011374 mRNA Translation: AAB64299.1
U56418 mRNA Translation: AAB58776.2
AL590226 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88249.1
CH471090 Genomic DNA Translation: EAW88251.1
BC000026 mRNA Translation: AAH00026.1
BC004529 mRNA Translation: AAH04529.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35181.1 [O15120-2]
CCDS7003.1 [O15120-1]

NCBI Reference Sequences

More...RefSeqi		NP_001012745.1, NM_001012727.1 [O15120-2]
NP_006403.2, NM_006412.3 [O15120-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371694; ENSP00000360759; ENSG00000169692 [O15120-2]
ENST00000371696; ENSP00000360761; ENSG00000169692 [O15120-1]
ENST00000538402; ENSP00000438919; ENSG00000169692 [O15120-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10555

UCSC genome browser

More...UCSCi		uc004cii.2, human [O15120-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000237 mRNA Translation: AAC51649.1
AF011374 mRNA Translation: AAB64299.1
U56418 mRNA Translation: AAB58776.2
AL590226 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88249.1
CH471090 Genomic DNA Translation: EAW88251.1
BC000026 mRNA Translation: AAH00026.1
BC004529 mRNA Translation: AAH04529.1
CCDSiCCDS35181.1 [O15120-2]
CCDS7003.1 [O15120-1]
RefSeqiNP_001012745.1, NM_001012727.1 [O15120-2]
NP_006403.2, NM_006412.3 [O15120-1]

3D structure databases

SMRiO15120
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115806, 18 interactors
CORUMiO15120
IntActiO15120, 17 interactors
STRINGi9606.ENSP00000360761

Chemistry databases

BindingDBiO15120
ChEMBLiCHEMBL4772
SwissLipidsiSLP:000000096

PTM databases

iPTMnetiO15120
PhosphoSitePlusiO15120

Polymorphism and mutation databases

BioMutaiAGPAT2

Proteomic databases

EPDiO15120
jPOSTiO15120
MassIVEiO15120
MaxQBiO15120
PaxDbiO15120
PeptideAtlasiO15120
PRIDEiO15120
ProteomicsDBi48457 [O15120-1]
48458 [O15120-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18762, 169 antibodies

The DNASU plasmid repository

More...DNASUi		10555

Genome annotation databases

EnsembliENST00000371694; ENSP00000360759; ENSG00000169692 [O15120-2]
ENST00000371696; ENSP00000360761; ENSG00000169692 [O15120-1]
ENST00000538402; ENSP00000438919; ENSG00000169692 [O15120-1]
GeneIDi10555
KEGGihsa:10555
UCSCiuc004cii.2, human [O15120-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10555
DisGeNETi10555
EuPathDBiHostDB:ENSG00000169692.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGPAT2
GeneReviewsiAGPAT2
HGNCiHGNC:325, AGPAT2
HPAiENSG00000169692, Tissue enhanced (adipose tissue, liver)
MalaCardsiAGPAT2
MIMi603100, gene
608594, phenotype
neXtProtiNX_O15120
OpenTargetsiENSG00000169692
Orphaneti528, Berardinelli-Seip congenital lipodystrophy
PharmGKBiPA24622

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2848, Eukaryota
GeneTreeiENSGT00390000008726
HOGENOMiCLU_027938_10_1_1
InParanoidiO15120
OMAiMPRPLCY
PhylomeDBiO15120
TreeFamiTF314867

Enzyme and pathway databases

UniPathwayiUPA00557;UER00613
BioCyciMetaCyc:HS09990-MONOMER
BRENDAi2.3.1.51, 2681
PathwayCommonsiO15120
ReactomeiR-HSA-1483166, Synthesis of PA
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10555, 28 hits in 839 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AGPAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10555
PharosiO15120, Tchem

Protein Ontology

More...PROi		PR:O15120
RNActiO15120, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169692, Expressed in subcutaneous adipose tissue and 212 other tissues
ExpressionAtlasiO15120, baseline and differential
GenevisibleiO15120, HS

Family and domain databases

InterProiView protein in InterPro
IPR004552, AGP_acyltrans
IPR002123, Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553, Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563, PlsC, 1 hit
TIGRFAMsiTIGR00530, AGP_acyltrn, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15120
Secondary accession number(s): O00516
, O15106, Q5VUD3, Q5VUD4, Q9BSV7, Q9BWR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 2, 2020
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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