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Protein

U6 snRNA-associated Sm-like protein LSm1

Gene

LSM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • pre-mRNA binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • RNA cap binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm1
Alternative name(s):
Cancer-associated Sm-like
Small nuclear ribonuclear CaSm
Gene namesi
Name:LSM1
Synonyms:CASM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000175324.9
HGNCiHGNC:20472 LSM1
MIMi607281 gene
neXtProtiNX_O15116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27257
OpenTargetsiENSG00000175324
PharmGKBiPA134864226

Polymorphism and mutation databases

BioMutaiLSM1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255541 – 133U6 snRNA-associated Sm-like protein LSm1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineCombined sources1
Modified residuei129PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15116
MaxQBiO15116
PaxDbiO15116
PeptideAtlasiO15116
PRIDEiO15116
ProteomicsDBi48450
TopDownProteomicsiO15116

PTM databases

iPTMnetiO15116
PhosphoSitePlusiO15116

Expressioni

Gene expression databases

BgeeiENSG00000175324 Expressed in 234 organ(s), highest expression level in myocardium
CleanExiHS_LSM1
ExpressionAtlasiO15116 baseline and differential
GenevisibleiO15116 HS

Organism-specific databases

HPAiHPA024601

Interactioni

Subunit structurei

Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase (PubMed:18172165). LSm subunits form a heteromer with a donut shape (By similarity).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi118104, 41 interactors
CORUMiO15116
DIPiDIP-31130N
IntActiO15116, 31 interactors
STRINGi9606.ENSP00000310596

Structurei

3D structure databases

ProteinModelPortaliO15116
SMRiO15116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1782 Eukaryota
ENOG411224Q LUCA
GeneTreeiENSGT00730000111133
HOGENOMiHOG000223544
HOVERGENiHBG027238
InParanoidiO15116
KOiK12620
OMAiFHQTVER
OrthoDBiEOG091G0UEO
PhylomeDBiO15116
TreeFamiTF105846

Family and domain databases

CDDicd01728 LSm1, 1 hit
InterProiView protein in InterPro
IPR034104 Lsm1
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI
60 70 80 90 100
HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR
110 120 130
VEQQTKLEAE KLKVQALKDR GLSIPRADTL DEY
Length:133
Mass (Da):15,179
Last modified:January 1, 1998 - v1
Checksum:iFF798CDA9447037A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJ47E5RJ47_HUMAN
U6 snRNA-associated Sm-like protein...
LSM1
44Annotation score:
E5RH18E5RH18_HUMAN
LSM1-like protein U6 small nuclear ...
LSM1
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000177 mRNA Translation: AAB62189.1
AJ238094 mRNA Translation: CAB45865.1
AK312159 mRNA Translation: BAG35093.1
CH471080 Genomic DNA Translation: EAW63332.1
BC001767 mRNA Translation: AAH01767.1
CCDSiCCDS6103.1
RefSeqiNP_055277.1, NM_014462.2
UniGeneiHs.425311

Genome annotation databases

EnsembliENST00000311351; ENSP00000310596; ENSG00000175324
GeneIDi27257
KEGGihsa:27257
UCSCiuc003xkw.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000177 mRNA Translation: AAB62189.1
AJ238094 mRNA Translation: CAB45865.1
AK312159 mRNA Translation: BAG35093.1
CH471080 Genomic DNA Translation: EAW63332.1
BC001767 mRNA Translation: AAH01767.1
CCDSiCCDS6103.1
RefSeqiNP_055277.1, NM_014462.2
UniGeneiHs.425311

3D structure databases

ProteinModelPortaliO15116
SMRiO15116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118104, 41 interactors
CORUMiO15116
DIPiDIP-31130N
IntActiO15116, 31 interactors
STRINGi9606.ENSP00000310596

PTM databases

iPTMnetiO15116
PhosphoSitePlusiO15116

Polymorphism and mutation databases

BioMutaiLSM1

Proteomic databases

EPDiO15116
MaxQBiO15116
PaxDbiO15116
PeptideAtlasiO15116
PRIDEiO15116
ProteomicsDBi48450
TopDownProteomicsiO15116

Protocols and materials databases

DNASUi27257
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311351; ENSP00000310596; ENSG00000175324
GeneIDi27257
KEGGihsa:27257
UCSCiuc003xkw.4 human

Organism-specific databases

CTDi27257
DisGeNETi27257
EuPathDBiHostDB:ENSG00000175324.9
GeneCardsiLSM1
HGNCiHGNC:20472 LSM1
HPAiHPA024601
MIMi607281 gene
neXtProtiNX_O15116
OpenTargetsiENSG00000175324
PharmGKBiPA134864226
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1782 Eukaryota
ENOG411224Q LUCA
GeneTreeiENSGT00730000111133
HOGENOMiHOG000223544
HOVERGENiHBG027238
InParanoidiO15116
KOiK12620
OMAiFHQTVER
OrthoDBiEOG091G0UEO
PhylomeDBiO15116
TreeFamiTF105846

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

ChiTaRSiLSM1 human
GeneWikiiLSM1
GenomeRNAii27257
PROiPR:O15116
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175324 Expressed in 234 organ(s), highest expression level in myocardium
CleanExiHS_LSM1
ExpressionAtlasiO15116 baseline and differential
GenevisibleiO15116 HS

Family and domain databases

CDDicd01728 LSm1, 1 hit
InterProiView protein in InterPro
IPR034104 Lsm1
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM1_HUMAN
AccessioniPrimary (citable) accession number: O15116
Secondary accession number(s): B2R5E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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