UniProtKB - O15111 (IKKA_HUMAN)
Inhibitor of nuclear factor kappa-B kinase subunit alpha
CHUK
Functioni
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576).
Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576).
These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576).
In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576).
Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415).
Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937).
In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128).
Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342).
Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).
Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973).
1 PublicationBy similarity10 PublicationsCatalytic activityi
- EC:2.7.11.103 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 44 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 144 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 29 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- IkappaB kinase activity Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: GO_Central
- scaffold protein binding Source: MGI
- transferrin receptor binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- cellular response to cadmium ion Source: CAFA
- cellular response to reactive oxygen species Source: CAFA
- cellular response to tumor necrosis factor Source: UniProtKB
- cellular response to virus Source: CAFA
- I-kappaB kinase/NF-kappaB signaling Source: CAFA
- I-kappaB phosphorylation Source: ProtInc
- immune response Source: ProtInc
- inflammatory response Source: UniProtKB
- innate immune response Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- NIK/NF-kappaB signaling Source: CAFA
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
- positive regulation of interferon-alpha production Source: CAFA
- positive regulation of NF-kappaB transcription factor activity Source: GO_Central
- positive regulation of transcription, DNA-templated Source: CAFA
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- response to virus Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.10, 2681 |
PathwayCommonsi | O15111 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1236974, ER-Phagosome pathway R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5602636, IKBKB deficiency causes SCID R-HSA-5603027, IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
SABIO-RKi | O15111 |
SignaLinki | O15111 |
SIGNORi | O15111 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC:2.7.11.103 Publications)Short name: I-kappa-B kinase alpha Short name: IKK-A Short name: IKK-alpha Short name: IkBKA Short name: IkappaB kinase Alternative name(s): Conserved helix-loop-helix ubiquitous kinase I-kappa-B kinase 1 Short name: IKK1 Nuclear factor NF-kappa-B inhibitor kinase alpha Short name: NFKBIKA Transcription factor 16 Short name: TCF-16 |
Gene namesi | Name:CHUK Synonyms:IKKA, TCF16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1974, CHUK |
MIMi | 600664, gene |
neXtProti | NX_O15111 |
VEuPathDBi | HostDB:ENSG00000213341 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
- IkappaB kinase complex Source: GO_Central
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- CD40 receptor complex Source: BHF-UCL
- cytoplasmic side of plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Cocoon syndrome (COCOS)1 Publication
Bartsocas-Papas syndrome 2 (BPS2)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 23 | T → A: Loss of phosphorylation and decrease of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 44 | K → A: Loss of kinase activity. 2 Publications | 1 | |
Mutagenesisi | 44 | K → M: Loss of autophosphorylation. 2 Publications | 1 | |
Mutagenesisi | 176 | S → A: Loss of phosphorylation and of activity. 2 Publications | 1 | |
Mutagenesisi | 176 | S → E: Full activation. 2 Publications | 1 | |
Mutagenesisi | 179 | T → A: No change in phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 180 | S → A: No change in phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1147 |
MalaCardsi | CHUK |
MIMi | 613630, phenotype 619339, phenotype |
OpenTargetsi | ENSG00000213341 |
Orphaneti | 465824, Fetal encasement syndrome |
PharmGKBi | PA26510 |
Miscellaneous databases
Pharosi | O15111, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3476 |
DrugBanki | DB06151, Acetylcysteine DB00233, Aminosalicylic acid DB00244, Mesalazine DB00795, Sulfasalazine |
DrugCentrali | O15111 |
GuidetoPHARMACOLOGYi | 1989 |
Genetic variation databases
BioMutai | CHUK |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086011 | 1 – 745 | Inhibitor of nuclear factor kappa-B kinase subunit alphaAdd BLAST | 745 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | Phosphothreonine; by PKB/AKT1 and SGK12 Publications | 1 | |
Modified residuei | 176 | Phosphoserine; by MAP3K141 Publication | 1 | |
Modified residuei | 179 | (Microbial infection) O-acetylthreonine; by Yersinia YopJ1 Publication | 1 | |
Modified residuei | 180 | Phosphoserine; by SGK11 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1220 CPTAC-1221 |
EPDi | O15111 |
jPOSTi | O15111 |
MassIVEi | O15111 |
MaxQBi | O15111 |
PaxDbi | O15111 |
PeptideAtlasi | O15111 |
PRIDEi | O15111 |
ProteomicsDBi | 48449 |
PTM databases
GlyGeni | O15111, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O15111 |
PhosphoSitePlusi | O15111 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000213341, Expressed in islet of Langerhans and 118 other tissues |
Genevisiblei | O15111, HS |
Organism-specific databases
HPAi | ENSG00000213341, Low tissue specificity |
Interactioni
Subunit structurei
Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits (PubMed:32935379). The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:10195894, PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity).
Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985).
Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (PubMed:9751059). Directly interacts with TRPC4AP (By similarity). May interact with TRAF2 (PubMed:19150425).
Interacts with NALP2 (PubMed:15456791). May interact with MAVS/IPS1 (PubMed:16177806).
Interacts with ARRB1 and ARRB2 (PubMed:15173580).
Interacts with NLRC5; prevents CHUK phosphorylation and kinase activity (PubMed:20434986).
Interacts with PIAS1; this interaction induces PIAS1 phosphorylation (PubMed:17540171).
Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055).
Interacts with FOXO3 (PubMed:15084260).
Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375).
Interacts with LRRC14 (PubMed:27426725).
Interacts with SASH1 (PubMed:23776175). Directly interacts with DDX3X after the physiological activation of the TLR7 and TLR8 pathways; this interaction enhances CHUK autophosphorylation (PubMed:30341167).
By similarity17 Publications(Microbial infection) Interacts with InlC of Listeria monocytogenes.
1 PublicationBinary interactionsi
O15111
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- scaffold protein binding Source: MGI
- transferrin receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 107569, 181 interactors |
ComplexPortali | CPX-3269, IkappaB kinase complex |
CORUMi | O15111 |
DIPi | DIP-27526N |
ELMi | O15111 |
IntActi | O15111, 74 interactors |
MINTi | O15111 |
STRINGi | 9606.ENSP00000359424 |
Chemistry databases
BindingDBi | O15111 |
Miscellaneous databases
RNActi | O15111, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O15111 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O15111 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 302 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 455 – 476 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 738 – 743 | NEMO-binding | 6 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_2_1 |
InParanoidi | O15111 |
OMAi | RMMNLDW |
OrthoDBi | 1013139at2759 |
PhylomeDBi | O15111 |
TreeFami | TF324269 |
Family and domain databases
IDEALi | IID00526 |
InterProi | View protein in InterPro IPR041185, IKBKB_SDD IPR022007, IKKbetaNEMObind IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF18397, IKBKB_SDD, 1 hit PF12179, IKKbetaNEMObind, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM01239, IKKbetaNEMObind, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL
60 70 80 90 100
STKNRERWCH EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG
110 120 130 140 150
GDLRKLLNKP ENCCGLKESQ ILSLLSDIGS GIRYLHENKI IHRDLKPENI
160 170 180 190 200
VLQDVGGKII HKIIDLGYAK DVDQGSLCTS FVGTLQYLAP ELFENKPYTA
210 220 230 240 250
TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK CIFACEEMSG
260 270 280 290 300
EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC
310 320 330 340 350
FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG
360 370 380 390 400
SQELLSETGI SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS
410 420 430 440 450
RSLSDCVNYI VQDSKIQLPI IQLRKVWAEA VHYVSGLKED YSRLFQGQRA
460 470 480 490 500
AMLSLLRYNA NLTKMKNTLI SASQQLKAKL EFFHKSIQLD LERYSEQMTY
510 520 530 540 550
GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE IMELQKSPYG
560 570 580 590 600
RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV
610 620 630 640 650
LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI
660 670 680 690 700
WHLLKIACTQ SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP
710 720 730 740
QDGETSAQMI EENLNCLGHL STIIHEANEE QGNSMMNLDW SWLTE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 543 | E → G in AAC51671 (PubMed:9252186).Curated | 1 | |
Sequence conflicti | 604 | L → R in AAC50713 (PubMed:8777433).Curated | 1 | |
Sequence conflicti | 679 – 680 | TS → AY in AAC50713 (PubMed:8777433).Curated | 2 | |
Sequence conflicti | 684 | P → A no nucleotide entry (PubMed:9346484).Curated | 1 | |
Sequence conflicti | 684 | P → A in AAC50713 (PubMed:8777433).Curated | 1 | |
Sequence conflicti | 686 – 687 | TS → DL in AAC50713 (PubMed:8777433).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040565 | 126 | S → C1 PublicationCorresponds to variant dbSNP:rs34427437Ensembl. | 1 | |
Natural variantiVAR_040566 | 155 | V → A1 PublicationCorresponds to variant dbSNP:rs2230803Ensembl. | 1 | |
Natural variantiVAR_021359 | 268 | V → I6 PublicationsCorresponds to variant dbSNP:rs2230804Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012890 mRNA Translation: AAC51662.1 AF009225 mRNA Translation: AAC51671.1 AF080157 mRNA Translation: AAD08996.1 AY652653 Genomic DNA Translation: AAT49098.1 AL138921 Genomic DNA No translation available. U22512 mRNA Translation: AAC50713.1 |
CCDSi | CCDS7488.1 |
RefSeqi | NP_001269.3, NM_001278.4 |
Genome annotation databases
Ensembli | ENST00000370397; ENSP00000359424; ENSG00000213341 |
GeneIDi | 1147 |
KEGGi | hsa:1147 |
MANE-Selecti | ENST00000370397.8; ENSP00000359424.6; NM_001278.5; NP_001269.3 |
UCSCi | uc001kqp.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012890 mRNA Translation: AAC51662.1 AF009225 mRNA Translation: AAC51671.1 AF080157 mRNA Translation: AAD08996.1 AY652653 Genomic DNA Translation: AAT49098.1 AL138921 Genomic DNA No translation available. U22512 mRNA Translation: AAC50713.1 |
CCDSi | CCDS7488.1 |
RefSeqi | NP_001269.3, NM_001278.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BRT | X-ray | 2.25 | A/C | 732-745 | [»] | |
5EBZ | X-ray | 4.50 | A/B/C/D/E/F/G/H/I/J/K/L | 10-660 | [»] | |
5TQW | electron microscopy | 5.60 | A/B | 10-660 | [»] | |
5TQX | electron microscopy | 5.40 | A/B | 10-660 | [»] | |
5TQY | electron microscopy | 5.20 | A/B | 10-660 | [»] | |
SMRi | O15111 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107569, 181 interactors |
ComplexPortali | CPX-3269, IkappaB kinase complex |
CORUMi | O15111 |
DIPi | DIP-27526N |
ELMi | O15111 |
IntActi | O15111, 74 interactors |
MINTi | O15111 |
STRINGi | 9606.ENSP00000359424 |
Chemistry databases
BindingDBi | O15111 |
ChEMBLi | CHEMBL3476 |
DrugBanki | DB06151, Acetylcysteine DB00233, Aminosalicylic acid DB00244, Mesalazine DB00795, Sulfasalazine |
DrugCentrali | O15111 |
GuidetoPHARMACOLOGYi | 1989 |
PTM databases
GlyGeni | O15111, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O15111 |
PhosphoSitePlusi | O15111 |
Genetic variation databases
BioMutai | CHUK |
Proteomic databases
CPTACi | CPTAC-1220 CPTAC-1221 |
EPDi | O15111 |
jPOSTi | O15111 |
MassIVEi | O15111 |
MaxQBi | O15111 |
PaxDbi | O15111 |
PeptideAtlasi | O15111 |
PRIDEi | O15111 |
ProteomicsDBi | 48449 |
Protocols and materials databases
Antibodypediai | 801, 1483 antibodies from 50 providers |
DNASUi | 1147 |
Genome annotation databases
Ensembli | ENST00000370397; ENSP00000359424; ENSG00000213341 |
GeneIDi | 1147 |
KEGGi | hsa:1147 |
MANE-Selecti | ENST00000370397.8; ENSP00000359424.6; NM_001278.5; NP_001269.3 |
UCSCi | uc001kqp.4, human |
Organism-specific databases
CTDi | 1147 |
DisGeNETi | 1147 |
GeneCardsi | CHUK |
HGNCi | HGNC:1974, CHUK |
HPAi | ENSG00000213341, Low tissue specificity |
MalaCardsi | CHUK |
MIMi | 600664, gene 613630, phenotype 619339, phenotype |
neXtProti | NX_O15111 |
OpenTargetsi | ENSG00000213341 |
Orphaneti | 465824, Fetal encasement syndrome |
PharmGKBi | PA26510 |
VEuPathDBi | HostDB:ENSG00000213341 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_2_1 |
InParanoidi | O15111 |
OMAi | RMMNLDW |
OrthoDBi | 1013139at2759 |
PhylomeDBi | O15111 |
TreeFami | TF324269 |
Enzyme and pathway databases
BRENDAi | 2.7.11.10, 2681 |
PathwayCommonsi | O15111 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1236974, ER-Phagosome pathway R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5602636, IKBKB deficiency causes SCID R-HSA-5603027, IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-933543, NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
SABIO-RKi | O15111 |
SignaLinki | O15111 |
SIGNORi | O15111 |
Miscellaneous databases
BioGRID-ORCSi | 1147, 32 hits in 1082 CRISPR screens |
ChiTaRSi | CHUK, human |
EvolutionaryTracei | O15111 |
GeneWikii | CHUK |
GenomeRNAii | 1147 |
Pharosi | O15111, Tchem |
PROi | PR:O15111 |
RNActi | O15111, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213341, Expressed in islet of Langerhans and 118 other tissues |
Genevisiblei | O15111, HS |
Family and domain databases
IDEALi | IID00526 |
InterProi | View protein in InterPro IPR041185, IKBKB_SDD IPR022007, IKKbetaNEMObind IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF18397, IKBKB_SDD, 1 hit PF12179, IKKbetaNEMObind, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM01239, IKKbetaNEMObind, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IKKA_HUMAN | |
Accessioni | O15111Primary (citable) accession number: O15111 Secondary accession number(s): O14666 Q92467 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 228 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families