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UniProtKB - O15091 (MRPP3_HUMAN)

Entry version 155 (07 Apr 2021)
Sequence version 2 (20 Jan 2009)
Previous versions | rss
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Protein

Mitochondrial ribonuclease P catalytic subunit

Gene

PRORP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 Mg2+ or Mg2+ ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi348ZincCombined sources1 Publication1
Metal bindingi351ZincCombined sources1 Publication1
Metal bindingi409Magnesium or manganese 1; catalytic1 Publication1
Metal bindingi478Magnesium or manganese 1; catalytic1 Publication1
Metal bindingi479Magnesium or manganese 2; catalytic1 Publication1
Metal bindingi499Magnesium or manganese 2; catalytic1 Publication1
Metal bindingi557Zinc; via tele nitrogenCombined sources1 Publication1
Metal bindingi578ZincCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ribonuclease P activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nuclease
Biological processtRNA processing
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15091

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6785470, tRNA processing in the mitochondrion
R-HSA-6787450, tRNA modification in the mitochondrion
R-HSA-8868766, rRNA processing in the mitochondrion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial ribonuclease P catalytic subunit (EC:3.1.26.51 Publication)
Alternative name(s):
Mitochondrial ribonuclease P protein 31 Publication
Short name:
Mitochondrial RNase P protein 31 Publication
Protein only RNase P catalytic subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRORPImported
Synonyms:KIAA0391, MRPP31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19958, PRORP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609947, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15091

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100890.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi409D → N: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi478D → N: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi479D → N: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi480P → G: Does not affect ribonuclease activity. 1 Publication1
Mutagenesisi498R → D or N: Does not affect ribonuclease activity. 1 Publication1
Mutagenesisi499D → N: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi569S → A: Does not affect ribonuclease activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9692

Open Targets

More...OpenTargetsi		ENSG00000100890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134879499

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15091, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIAA0391

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005074946 – 583Mitochondrial ribonuclease P catalytic subunitAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15091

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15091

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15091

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15091

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15091

PeptideAtlas

More...PeptideAtlasi		O15091

PRoteomics IDEntifications database

More...PRIDEi		O15091

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48444 [O15091-1]
48445 [O15091-2]
48446 [O15091-3]
48447 [O15091-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15091

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15091

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated following mitochondrial unfolded protein response.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100890, Expressed in tonsil and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15091, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15091, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100890, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3 (PubMed:18984158).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115044, 81 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6155, Mitochondrial ribonuclease P complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15091

Protein interaction database and analysis system

More...IntActi		O15091, 21 interactors

Molecular INTeraction database

More...MINTi		O15091

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000440915

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15091, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15091

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini342 – 578PRORPAdd BLAST237

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPR family. P subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRKG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033070_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15091

Identification of Orthologs from Complete Genome Data

More...OMAi		APYDCVI

Database of Orthologous Groups

More...OrthoDBi		1247650at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15091

TreeFam database of animal gene trees

More...TreeFami		TF324726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033495, MRPP3
IPR031595, PRORP_C
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13547:SF1, PTHR13547:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16953, PRORP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15091-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT 
        60         70         80         90        100
MSPQNTKATN LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT 
       110        120        130        140        150
EDHALAPVRN TIQLPTQPLN SEEWDKLKED LKENTGKTSF ESWIISQMAG 
       160        170        180        190        200
CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK YLYLCVFHMQ TSEVIDVFEI 
       210        220        230        240        250
MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI TPSKKNYNDC 
       260        270        280        290        300
IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK 
       310        320        330        340        350
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG 
       360        370        380        390        400
CGKTIESIQL SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS 
       410        420        430        440        450
RPPFDVVIDG LNVAKMFPKV RESQLLLNVV SQLAKRNLRL LVLGRKHMLR 
       460        470        480        490        500
RSSQWSRDEM EEVQKQASCF FADDISEDDP FLLYATLHSG NHCRFITRDL 
       510        520        530        540        550
MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ RILSYDTVVQ 
       560        570        580 
TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT
Length:583
Mass (Da):67,315
Last modified:January 20, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AB17E7E8820D818
GO
Isoform 2 (identifier: O15091-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-344: Missing.

Show »
Length:567
Mass (Da):65,486
Checksum:i67B870DEBE05F5CC
GO
Isoform 3 (identifier: O15091-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-372: Missing.

Show »
Length:211
Mass (Da):24,787
Checksum:iD8B8A46D9244A3BD
GO
Isoform 4 (identifier: O15091-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:488
Mass (Da):56,487
Checksum:iEF0D334CD9099547
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTQ0A0A0A0MTQ0_HUMAN
Mitochondrial ribonuclease P cataly...
PRORP
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3S1S4R3S1_HUMAN
Mitochondrial ribonuclease P cataly...
PRORP
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3T4S4R3T4_HUMAN
Mitochondrial ribonuclease P cataly...
PRORP
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R416S4R416_HUMAN
Mitochondrial ribonuclease P cataly...
PRORP
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20845 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti315P → L in BAG63351 (PubMed:14702039).Curated1
Sequence conflicti453S → F in BAG64540 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054212437N → S2 PublicationsCorresponds to variant dbSNP:rs11156878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0362011 – 372Missing in isoform 3. 2 PublicationsAdd BLAST372
Alternative sequenceiVSP_0362021 – 95Missing in isoform 4. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_036203329 – 344Missing in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB002389 mRNA Translation: BAA20845.2 Different initiation.
BX161394 mRNA Translation: CAD61881.1
BX161487 mRNA Translation: CAD61937.1
AK301931 mRNA Translation: BAG63351.1
AK303508 mRNA Translation: BAG64540.1
AK304066 mRNA Translation: BAG64973.1
AL121594 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65878.1
CH471078 Genomic DNA Translation: EAW65882.1
CH471078 Genomic DNA Translation: EAW65879.1
CH471078 Genomic DNA Translation: EAW65880.1
CH471078 Genomic DNA Translation: EAW65881.1
CH471078 Genomic DNA Translation: EAW65883.1
CH471078 Genomic DNA Translation: EAW65884.1
BC032221 mRNA Translation: AAH32221.1
BC044580 mRNA Translation: AAH44580.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32063.1 [O15091-1]
CCDS58312.1 [O15091-2]
CCDS58313.1 [O15091-4]
CCDS58314.1 [O15091-3]

NCBI Reference Sequences

More...RefSeqi		NP_001243607.1, NM_001256678.1 [O15091-2]
NP_001243608.1, NM_001256679.1 [O15091-4]
NP_001243609.1, NM_001256680.1 [O15091-3]
NP_001243610.1, NM_001256681.1 [O15091-3]
NP_055487.2, NM_014672.3 [O15091-1]
XP_005268294.1, XM_005268237.3 [O15091-1]
XP_011535711.1, XM_011537409.2
XP_011535712.1, XM_011537410.2 [O15091-1]
XP_016877324.1, XM_017021835.1
XP_016877325.1, XM_017021836.1 [O15091-2]
XP_016877326.1, XM_017021837.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000250377; ENSP00000250377; ENSG00000100890 [O15091-2]
ENST00000321130; ENSP00000324697; ENSG00000100890 [O15091-3]
ENST00000534898; ENSP00000440915; ENSG00000100890 [O15091-1]
ENST00000603544; ENSP00000473856; ENSG00000100890 [O15091-2]
ENST00000604948; ENSP00000474620; ENSG00000100890 [O15091-4]
ENST00000605870; ENSP00000474299; ENSG00000100890 [O15091-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9692

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9692

UCSC genome browser

More...UCSCi		uc001wsy.3, human [O15091-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002389 mRNA Translation: BAA20845.2 Different initiation.
BX161394 mRNA Translation: CAD61881.1
BX161487 mRNA Translation: CAD61937.1
AK301931 mRNA Translation: BAG63351.1
AK303508 mRNA Translation: BAG64540.1
AK304066 mRNA Translation: BAG64973.1
AL121594 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65878.1
CH471078 Genomic DNA Translation: EAW65882.1
CH471078 Genomic DNA Translation: EAW65879.1
CH471078 Genomic DNA Translation: EAW65880.1
CH471078 Genomic DNA Translation: EAW65881.1
CH471078 Genomic DNA Translation: EAW65883.1
CH471078 Genomic DNA Translation: EAW65884.1
BC032221 mRNA Translation: AAH32221.1
BC044580 mRNA Translation: AAH44580.1
CCDSiCCDS32063.1 [O15091-1]
CCDS58312.1 [O15091-2]
CCDS58313.1 [O15091-4]
CCDS58314.1 [O15091-3]
RefSeqiNP_001243607.1, NM_001256678.1 [O15091-2]
NP_001243608.1, NM_001256679.1 [O15091-4]
NP_001243609.1, NM_001256680.1 [O15091-3]
NP_001243610.1, NM_001256681.1 [O15091-3]
NP_055487.2, NM_014672.3 [O15091-1]
XP_005268294.1, XM_005268237.3 [O15091-1]
XP_011535711.1, XM_011537409.2
XP_011535712.1, XM_011537410.2 [O15091-1]
XP_016877324.1, XM_017021835.1
XP_016877325.1, XM_017021836.1 [O15091-2]
XP_016877326.1, XM_017021837.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ROUX-ray2.71A/B274-583[»]
4XGLX-ray1.80A207-583[»]
4XGMX-ray1.98A207-583[»]
SMRiO15091
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115044, 81 interactors
ComplexPortaliCPX-6155, Mitochondrial ribonuclease P complex
CORUMiO15091
IntActiO15091, 21 interactors
MINTiO15091
STRINGi9606.ENSP00000440915

PTM databases

iPTMnetiO15091
PhosphoSitePlusiO15091

Genetic variation databases

BioMutaiKIAA0391

Proteomic databases

EPDiO15091
jPOSTiO15091
MassIVEiO15091
MaxQBiO15091
PaxDbiO15091
PeptideAtlasiO15091
PRIDEiO15091
ProteomicsDBi48444 [O15091-1]
48445 [O15091-2]
48446 [O15091-3]
48447 [O15091-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23191, 127 antibodies

Genome annotation databases

EnsembliENST00000250377; ENSP00000250377; ENSG00000100890 [O15091-2]
ENST00000321130; ENSP00000324697; ENSG00000100890 [O15091-3]
ENST00000534898; ENSP00000440915; ENSG00000100890 [O15091-1]
ENST00000603544; ENSP00000473856; ENSG00000100890 [O15091-2]
ENST00000604948; ENSP00000474620; ENSG00000100890 [O15091-4]
ENST00000605870; ENSP00000474299; ENSG00000100890 [O15091-3]
GeneIDi9692
KEGGihsa:9692
UCSCiuc001wsy.3, human [O15091-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9692
DisGeNETi9692

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRORP
HGNCiHGNC:19958, PRORP
HPAiENSG00000100890, Low tissue specificity
MIMi609947, gene
neXtProtiNX_O15091
OpenTargetsiENSG00000100890
PharmGKBiPA134879499
VEuPathDBiHostDB:ENSG00000100890.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRKG, Eukaryota
GeneTreeiENSGT00390000002201
HOGENOMiCLU_033070_1_0_1
InParanoidiO15091
OMAiAPYDCVI
OrthoDBi1247650at2759
PhylomeDBiO15091
TreeFamiTF324726

Enzyme and pathway databases

PathwayCommonsiO15091
ReactomeiR-HSA-6785470, tRNA processing in the mitochondrion
R-HSA-6787450, tRNA modification in the mitochondrion
R-HSA-8868766, rRNA processing in the mitochondrion

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9692, 306 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIAA0391, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9692
PharosiO15091, Tbio

Protein Ontology

More...PROi		PR:O15091
RNActiO15091, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100890, Expressed in tonsil and 131 other tissues
ExpressionAtlasiO15091, baseline and differential
GenevisibleiO15091, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033495, MRPP3
IPR031595, PRORP_C
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR13547:SF1, PTHR13547:SF1, 1 hit
PfamiView protein in Pfam
PF16953, PRORP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRPP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15091
Secondary accession number(s): B4DXD9
, B4E0S8, B4E211, C4AM93, D3DS99, D3DSA1, Q86SZ4, Q86YB5, Q8N5L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 20, 2009
Last modified: April 7, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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