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Protein

Zinc finger protein 536

Gene

ZNF536

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri779 – 801C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 536
Gene namesi
Name:ZNF536
Synonyms:KIAA0390
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198597.8
HGNCiHGNC:29025 ZNF536
MIMi618037 gene
neXtProtiNX_O15090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9745
OpenTargetsiENSG00000198597
PharmGKBiPA134920047

Polymorphism and mutation databases

BioMutaiZNF536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710411 – 1300Zinc finger protein 536Add BLAST1300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei826PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15090
PaxDbiO15090
PeptideAtlasiO15090
PRIDEiO15090
ProteomicsDBi48443

PTM databases

iPTMnetiO15090
PhosphoSitePlusiO15090

Expressioni

Gene expression databases

BgeeiENSG00000198597 Expressed in 140 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_ZNF536
ExpressionAtlasiO15090 baseline and differential
GenevisibleiO15090 HS

Organism-specific databases

HPAiHPA077341

Interactioni

Protein-protein interaction databases

BioGridi115093, 6 interactors
IntActiO15090, 3 interactors
MINTiO15090
STRINGi9606.ENSP00000347730

Structurei

3D structure databases

ProteinModelPortaliO15090
SMRiO15090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri779 – 801C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000155801
HOVERGENiHBG080712
InParanoidiO15090
OMAiRDKQMKS
OrthoDBiEOG091G00MV
PhylomeDBiO15090
TreeFamiTF332241

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O15090-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL
60 70 80 90 100
HPRPNPEEKP PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV
110 120 130 140 150
DLQQFLNGQN LGIMSQMSDI EDDARKNRKY PCPLCGKRFR FNSILSLHMR
160 170 180 190 200
THTGEKPFKC PYCDHRAAQK GNLKIHLRTH KLGNLGKGRG RVREENRLLH
210 220 230 240 250
ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL ALQANHSVPD
260 270 280 290 300
VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY
310 320 330 340 350
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC
360 370 380 390 400
GQVFSQAWFL KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS
410 420 430 440 450
VKNKSPSDPE VPVPMGGMSQ EAHANLYSRY LSCLQSGFMT PDKAGLSEPS
460 470 480 490 500
QLYGKGELPM KEKEALGKLL SPISSMAHGV PEGDKHSLLG CLNLVPPLKS
510 520 530 540 550
SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK EHPLQRNHED
560 570 580 590 600
TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP
610 620 630 640 650
LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS
660 670 680 690 700
RVHKRDRKGE EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV
710 720 730 740 750
GGGLSQTGSA QEDSPHPSSP SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM
760 770 780 790 800
KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK CPHCDYAGTQ SASLKYHLER
810 820 830 840 850
HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG AFKGLPGIDF
860 870 880 890 900
RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI
910 920 930 940 950
GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH
960 970 980 990 1000
GVDGGEEKPS GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW
1010 1020 1030 1040 1050
HGCLFCAFTT SSMELMALHL QANHLGKAKR KDNTIGVTVN CKDQAREASK
1060 1070 1080 1090 1100
MALLPSLQSN KDLGLSNMIS SLDSASEKMA QGQLKETLGE QKSGAWTGHV
1110 1120 1130 1140 1150
DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH SEEDVPILIP
1160 1170 1180 1190 1200
ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD
1210 1220 1230 1240 1250
SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK
1260 1270 1280 1290 1300
PERGPQSLDK PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK
Length:1,300
Mass (Da):141,417
Last modified:January 9, 2007 - v3
Checksum:i858B5B7047653664
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKT4K7EKT4_HUMAN
Zinc finger protein 536
ZNF536
949Annotation score:
K7EQN6K7EQN6_HUMAN
Zinc finger protein 536
ZNF536
137Annotation score:
K7EJP8K7EJP8_HUMAN
Zinc finger protein 536
ZNF536
138Annotation score:

Sequence cautioni

The sequence BAA20844 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002388 mRNA Translation: BAA20844.2 Different initiation.
BC132720 mRNA Translation: AAI32721.1
BC132722 mRNA Translation: AAI32723.1
BC146757 mRNA Translation: AAI46758.1
CCDSiCCDS32984.1
RefSeqiNP_055532.1, NM_014717.2
XP_016883031.1, XM_017027542.1
UniGeneiHs.378901

Genome annotation databases

EnsembliENST00000355537; ENSP00000347730; ENSG00000198597
GeneIDi9745
KEGGihsa:9745
UCSCiuc002nsu.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002388 mRNA Translation: BAA20844.2 Different initiation.
BC132720 mRNA Translation: AAI32721.1
BC132722 mRNA Translation: AAI32723.1
BC146757 mRNA Translation: AAI46758.1
CCDSiCCDS32984.1
RefSeqiNP_055532.1, NM_014717.2
XP_016883031.1, XM_017027542.1
UniGeneiHs.378901

3D structure databases

ProteinModelPortaliO15090
SMRiO15090
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115093, 6 interactors
IntActiO15090, 3 interactors
MINTiO15090
STRINGi9606.ENSP00000347730

PTM databases

iPTMnetiO15090
PhosphoSitePlusiO15090

Polymorphism and mutation databases

BioMutaiZNF536

Proteomic databases

MaxQBiO15090
PaxDbiO15090
PeptideAtlasiO15090
PRIDEiO15090
ProteomicsDBi48443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355537; ENSP00000347730; ENSG00000198597
GeneIDi9745
KEGGihsa:9745
UCSCiuc002nsu.2 human

Organism-specific databases

CTDi9745
DisGeNETi9745
EuPathDBiHostDB:ENSG00000198597.8
GeneCardsiZNF536
HGNCiHGNC:29025 ZNF536
HPAiHPA077341
MIMi618037 gene
neXtProtiNX_O15090
OpenTargetsiENSG00000198597
PharmGKBiPA134920047
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000155801
HOVERGENiHBG080712
InParanoidiO15090
OMAiRDKQMKS
OrthoDBiEOG091G00MV
PhylomeDBiO15090
TreeFamiTF332241

Miscellaneous databases

ChiTaRSiZNF536 human
GenomeRNAii9745
PROiPR:O15090
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198597 Expressed in 140 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_ZNF536
ExpressionAtlasiO15090 baseline and differential
GenevisibleiO15090 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN536_HUMAN
AccessioniPrimary (citable) accession number: O15090
Secondary accession number(s): A2RU18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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