Zinc finger protein 536

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• metal ion binding Source: UniProtKB-KW
• proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19398580
• retinoic acid-responsive element binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • 19398580

GO - Biological processⁱ

• negative regulation of neuron differentiation Source: Ensembl
• negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • 19398580

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL 
        60         70         80         90        100
HPRPNPEEKP PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV 
       110        120        130        140        150
DLQQFLNGQN LGIMSQMSDI EDDARKNRKY PCPLCGKRFR FNSILSLHMR 
       160        170        180        190        200
THTGEKPFKC PYCDHRAAQK GNLKIHLRTH KLGNLGKGRG RVREENRLLH 
       210        220        230        240        250
ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL ALQANHSVPD 
       260        270        280        290        300
VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY 
       310        320        330        340        350
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC 
       360        370        380        390        400
GQVFSQAWFL KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS 
       410        420        430        440        450
VKNKSPSDPE VPVPMGGMSQ EAHANLYSRY LSCLQSGFMT PDKAGLSEPS 
       460        470        480        490        500
QLYGKGELPM KEKEALGKLL SPISSMAHGV PEGDKHSLLG CLNLVPPLKS 
       510        520        530        540        550
SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK EHPLQRNHED 
       560        570        580        590        600
TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP 
       610        620        630        640        650
LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS 
       660        670        680        690        700
RVHKRDRKGE EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV 
       710        720        730        740        750
GGGLSQTGSA QEDSPHPSSP SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM 
       760        770        780        790        800
KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK CPHCDYAGTQ SASLKYHLER 
       810        820        830        840        850
HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG AFKGLPGIDF 
       860        870        880        890        900
RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI 
       910        920        930        940        950
GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH 
       960        970        980        990       1000
GVDGGEEKPS GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW 
      1010       1020       1030       1040       1050
HGCLFCAFTT SSMELMALHL QANHLGKAKR KDNTIGVTVN CKDQAREASK 
      1060       1070       1080       1090       1100
MALLPSLQSN KDLGLSNMIS SLDSASEKMA QGQLKETLGE QKSGAWTGHV 
      1110       1120       1130       1140       1150
DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH SEEDVPILIP 
      1160       1170       1180       1190       1200
ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD 
      1210       1220       1230       1240       1250
SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK 
      1260       1270       1280       1290       1300
PERGPQSLDK PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK 

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. Human chromosome 19
   Human chromosome 19: entries, gene names and cross-references to MIM