UniProtKB - O15090 (ZN536_HUMAN)
Protein
Zinc finger protein 536
Gene
ZNF536
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 152 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 158 – 180 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 297 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 300 – 323 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 345 – 367 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 653 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 751 – 773 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 779 – 801 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- retinoic acid-responsive element binding Source: Ensembl
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 536 |
Gene namesi | Name:ZNF536 Synonyms:KIAA0390 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198597.8 |
HGNCi | HGNC:29025 ZNF536 |
MIMi | 618037 gene |
neXtProti | NX_O15090 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9745 |
OpenTargetsi | ENSG00000198597 |
PharmGKBi | PA134920047 |
Polymorphism and mutation databases
BioMutai | ZNF536 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271041 | 1 – 1300 | Zinc finger protein 536Add BLAST | 1300 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 826 | PhosphoserineCombined sources | 1 | |
Modified residuei | 827 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O15090 |
MaxQBi | O15090 |
PaxDbi | O15090 |
PeptideAtlasi | O15090 |
PRIDEi | O15090 |
ProteomicsDBi | 48443 |
PTM databases
iPTMneti | O15090 |
PhosphoSitePlusi | O15090 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198597 Expressed in 140 organ(s), highest expression level in pigmented layer of retina |
ExpressionAtlasi | O15090 baseline and differential |
Genevisiblei | O15090 HS |
Organism-specific databases
HPAi | HPA077341 |
Interactioni
Protein-protein interaction databases
BioGridi | 115093, 6 interactors |
IntActi | O15090, 5 interactors |
MINTi | O15090 |
STRINGi | 9606.ENSP00000347730 |
Structurei
3D structure databases
ProteinModelPortali | O15090 |
SMRi | O15090 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 130 – 152 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 158 – 180 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 297 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 300 – 323 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 345 – 367 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 653 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 751 – 773 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 779 – 801 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000156397 |
HOGENOMi | HOG000155801 |
HOVERGENi | HBG080712 |
InParanoidi | O15090 |
OMAi | RDKQMKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15090 |
TreeFami | TF332241 |
Family and domain databases
InterProi | View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00096 zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667 SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O15090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL
60 70 80 90 100
HPRPNPEEKP PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV
110 120 130 140 150
DLQQFLNGQN LGIMSQMSDI EDDARKNRKY PCPLCGKRFR FNSILSLHMR
160 170 180 190 200
THTGEKPFKC PYCDHRAAQK GNLKIHLRTH KLGNLGKGRG RVREENRLLH
210 220 230 240 250
ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL ALQANHSVPD
260 270 280 290 300
VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY
310 320 330 340 350
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC
360 370 380 390 400
GQVFSQAWFL KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS
410 420 430 440 450
VKNKSPSDPE VPVPMGGMSQ EAHANLYSRY LSCLQSGFMT PDKAGLSEPS
460 470 480 490 500
QLYGKGELPM KEKEALGKLL SPISSMAHGV PEGDKHSLLG CLNLVPPLKS
510 520 530 540 550
SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK EHPLQRNHED
560 570 580 590 600
TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP
610 620 630 640 650
LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS
660 670 680 690 700
RVHKRDRKGE EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV
710 720 730 740 750
GGGLSQTGSA QEDSPHPSSP SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM
760 770 780 790 800
KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK CPHCDYAGTQ SASLKYHLER
810 820 830 840 850
HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG AFKGLPGIDF
860 870 880 890 900
RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI
910 920 930 940 950
GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH
960 970 980 990 1000
GVDGGEEKPS GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW
1010 1020 1030 1040 1050
HGCLFCAFTT SSMELMALHL QANHLGKAKR KDNTIGVTVN CKDQAREASK
1060 1070 1080 1090 1100
MALLPSLQSN KDLGLSNMIS SLDSASEKMA QGQLKETLGE QKSGAWTGHV
1110 1120 1130 1140 1150
DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH SEEDVPILIP
1160 1170 1180 1190 1200
ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD
1210 1220 1230 1240 1250
SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK
1260 1270 1280 1290 1300
PERGPQSLDK PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKT4 | K7EKT4_HUMAN | Zinc finger protein 536 | ZNF536 | 949 | Annotation score: | ||
K7EQN6 | K7EQN6_HUMAN | Zinc finger protein 536 | ZNF536 | 137 | Annotation score: | ||
K7EJP8 | K7EJP8_HUMAN | Zinc finger protein 536 | ZNF536 | 138 | Annotation score: |
Sequence cautioni
The sequence BAA20844 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002388 mRNA Translation: BAA20844.2 Different initiation. BC132720 mRNA Translation: AAI32721.1 BC132722 mRNA Translation: AAI32723.1 BC146757 mRNA Translation: AAI46758.1 |
CCDSi | CCDS32984.1 |
RefSeqi | NP_055532.1, NM_014717.2 XP_016883031.1, XM_017027542.1 |
UniGenei | Hs.378901 |
Genome annotation databases
Ensembli | ENST00000355537; ENSP00000347730; ENSG00000198597 |
GeneIDi | 9745 |
KEGGi | hsa:9745 |
UCSCi | uc002nsu.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002388 mRNA Translation: BAA20844.2 Different initiation. BC132720 mRNA Translation: AAI32721.1 BC132722 mRNA Translation: AAI32723.1 BC146757 mRNA Translation: AAI46758.1 |
CCDSi | CCDS32984.1 |
RefSeqi | NP_055532.1, NM_014717.2 XP_016883031.1, XM_017027542.1 |
UniGenei | Hs.378901 |
3D structure databases
ProteinModelPortali | O15090 |
SMRi | O15090 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 115093, 6 interactors |
IntActi | O15090, 5 interactors |
MINTi | O15090 |
STRINGi | 9606.ENSP00000347730 |
PTM databases
iPTMneti | O15090 |
PhosphoSitePlusi | O15090 |
Polymorphism and mutation databases
BioMutai | ZNF536 |
Proteomic databases
jPOSTi | O15090 |
MaxQBi | O15090 |
PaxDbi | O15090 |
PeptideAtlasi | O15090 |
PRIDEi | O15090 |
ProteomicsDBi | 48443 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000355537; ENSP00000347730; ENSG00000198597 |
GeneIDi | 9745 |
KEGGi | hsa:9745 |
UCSCi | uc002nsu.2 human |
Organism-specific databases
CTDi | 9745 |
DisGeNETi | 9745 |
EuPathDBi | HostDB:ENSG00000198597.8 |
GeneCardsi | ZNF536 |
HGNCi | HGNC:29025 ZNF536 |
HPAi | HPA077341 |
MIMi | 618037 gene |
neXtProti | NX_O15090 |
OpenTargetsi | ENSG00000198597 |
PharmGKBi | PA134920047 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000156397 |
HOGENOMi | HOG000155801 |
HOVERGENi | HBG080712 |
InParanoidi | O15090 |
OMAi | RDKQMKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O15090 |
TreeFami | TF332241 |
Miscellaneous databases
ChiTaRSi | ZNF536 human |
GenomeRNAii | 9745 |
PROi | PR:O15090 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198597 Expressed in 140 organ(s), highest expression level in pigmented layer of retina |
ExpressionAtlasi | O15090 baseline and differential |
Genevisiblei | O15090 HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00096 zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355 ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667 SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | ZN536_HUMAN | |
Accessioni | O15090Primary (citable) accession number: O15090 Secondary accession number(s): A2RU18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 13, 2019 | |
This is version 149 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot