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UniProtKB - O15084 (ANR28_HUMAN)

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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Gene

ANKRD28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.2 Publications

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Short name:
PP6-ARS-A
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
Alternative name(s):
Ankyrin repeat domain-containing protein 28
Phosphatase interactor targeting protein hnRNP K
Short name:
PITK
Gene namesi
Name:ANKRD28
Synonyms:KIAA0379
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000206560.10
HGNCiHGNC:29024 ANKRD28
MIMi611122 gene
neXtProtiNX_O15084

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1007 – 1011SKTVS → AKTVA: Marked decrease in phosphorylation. Increased PPP1C-binding. No effect on HNRPK-binding. 1 Publication5

Organism-specific databases

DisGeNETi23243
OpenTargetsiENSG00000206560
PharmGKBiPA134880251

Polymorphism and mutation databases

BioMutaiANKRD28

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669191 – 1053Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit AAdd BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1007Phosphoserine1 Publication1
Modified residuei1011PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15084
PaxDbiO15084
PeptideAtlasiO15084
PRIDEiO15084
ProteomicsDBi48437
48438 [O15084-1]
48439 [O15084-2]
48440 [O15084-4]

PTM databases

iPTMnetiO15084
PhosphoSitePlusiO15084

Expressioni

Gene expression databases

BgeeiENSG00000206560
CleanExiHS_ANKRD28
ExpressionAtlasiO15084 baseline and differential
GenevisibleiO15084 HS

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116847, 91 interactors
CORUMiO15084
DIPiDIP-27583N
IntActiO15084, 99 interactors
MINTiO15084
STRINGi9606.ENSP00000382379

Structurei

3D structure databases

ProteinModelPortaliO15084
SMRiO15084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 69ANK 1Add BLAST30
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati139 – 168ANK 4Add BLAST30
Repeati172 – 201ANK 5Add BLAST30
Repeati205 – 234ANK 6Add BLAST30
Repeati238 – 267ANK 7Add BLAST30
Repeati271 – 301ANK 8Add BLAST31
Repeati305 – 334ANK 9Add BLAST30
Repeati338 – 367ANK 10Add BLAST30
Repeati371 – 400ANK 11Add BLAST30
Repeati404 – 433ANK 12Add BLAST30
Repeati437 – 466ANK 13Add BLAST30
Repeati470 – 500ANK 14Add BLAST31
Repeati504 – 534ANK 15Add BLAST31
Repeati549 – 578ANK 16Add BLAST30
Repeati582 – 611ANK 17Add BLAST30
Repeati616 – 645ANK 18Add BLAST30
Repeati652 – 681ANK 19Add BLAST30
Repeati685 – 714ANK 20Add BLAST30
Repeati718 – 747ANK 21Add BLAST30
Repeati755 – 784ANK 22Add BLAST30
Repeati787 – 817ANK 23Add BLAST31
Repeati822 – 851ANK 24Add BLAST30
Repeati855 – 885ANK 25Add BLAST31
Repeati889 – 918ANK 26Add BLAST30
Repeati925 – 954ANK 27Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000033959
HOVERGENiHBG067697
InParanoidiO15084
KOiK15502
OMAiEHSSYCS
OrthoDBiEOG091G02S4
TreeFamiTF312824

Family and domain databases

CDDicd00204 ANK, 7 hits
Gene3Di1.25.40.20, 10 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 8 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 28 hits
SUPFAMiSSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 24 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15084-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY 
        60         70         80         90        100
LGDAEIIELL ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV 
       110        120        130        140        150
NARDKNWQTP LHIAAANKAV KCAEALVPLL SNVNVSDRAG RTALHHAAFS 
       160        170        180        190        200
GHGEMVKLLL SRGANINAFD KKDRRAIHWA AYMGHIEVVK LLVSHGAEVT 
       210        220        230        240        250
CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN TPLHVACYNG 
       260        270        280        290        300
QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN 
       310        320        330        340        350
MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG 
       360        370        380        390        400
HELLINTLIT SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT 
       410        420        430        440        450
PDDFGRTCLH AAAAGGNLEC LNLLLNTGAD FNKKDKFGRS PLHYAAANCN 
       460        470        480        490        500
YQCLFALVGS GASVNDLDER GCTPLHYAAT SDTDGKCLEY LLRNDANPGI 
       510        520        530        540        550
RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD MLSDSDNRAT 
       560        570        580        590        600
ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD 
       610        620        630        640        650
VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD 
       660        670        680        690        700
GNGQTPLMLS VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE 
       710        720        730        740        750
CVDALLQHGA KCLLRDSRGR TPIHLSAACG HIGVLGALLQ SAASMDANPA 
       760        770        780        790        800
TADNHGYTAL HWACYNGHET CVELLLEQEV FQKTEGNAFS PLHCAVINDN 
       810        820        830        840        850
EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ LLLSHNAQVN 
       860        870        880        890        900
SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK 
       910        920        930        940        950
GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA 
       960        970        980        990       1000
SVLAVDENGY TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI 
      1010       1020       1030       1040       1050
NRYTNTSKTV SFEALPIMRN EPSSYCSFNN IGGEQEYLYT DVDELNDSDS 

ETY
Length:1,053
Mass (Da):112,966
Last modified:May 3, 2011 - v5
Checksum:iBDB4855193364585
GO
Isoform 2 (identifier: O15084-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:899
Mass (Da):96,161
Checksum:iE06723898ABF4B08
GO
Isoform 3 (identifier: O15084-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRY

Show »
Length:1,086
Mass (Da):116,543
Checksum:i47A3F97E5C72F0E8
GO
Isoform 4 (identifier: O15084-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVL

Note: No experimental confirmation available.
Show »
Length:1,083
Mass (Da):116,124
Checksum:i349BC9338F251E08
GO

Sequence cautioni

The sequence AAQ72374 differs from that shown. Reason: Frameshift at position 408.Curated
The sequence BAA20833 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86737 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293V → A in AAQ72374 (Ref. 1) Curated1
Sequence conflicti500I → V in AAQ72374 (Ref. 1) Curated1
Sequence conflicti500I → V in BAC86737 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124331 – 154Missing in isoform 2. 2 PublicationsAdd BLAST154
Alternative sequenceiVSP_0410131 – 9MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVLV RY in isoform 3. 2 Publications9
Alternative sequenceiVSP_0410141 – 9MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVL in isoform 4. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367056 mRNA Translation: AAQ72374.1 Frameshift.
AB002377 mRNA Translation: BAA20833.2 Different initiation.
AK126888 mRNA Translation: BAC86737.1 Sequence problems.
AK293770 mRNA Translation: BAG57186.1
BC106948 mRNA Translation: AAI06949.2
BC113868 mRNA Translation: AAI13869.1
BC114476 mRNA Translation: AAI14477.1
CCDSiCCDS46769.1 [O15084-3]
CCDS74908.1 [O15084-2]
RefSeqiNP_001182027.1, NM_001195098.1 [O15084-2]
NP_001182028.1, NM_001195099.1 [O15084-2]
NP_056014.2, NM_015199.3 [O15084-3]
XP_005265053.1, XM_005264996.3
XP_011531842.1, XM_011533540.2
XP_016861515.1, XM_017006026.1 [O15084-2]
XP_016861516.1, XM_017006027.1
UniGeneiHs.335239

Genome annotation databases

EnsembliENST00000399451; ENSP00000382379; ENSG00000206560 [O15084-3]
ENST00000412318; ENSP00000397341; ENSG00000206560 [O15084-3]
ENST00000624145; ENSP00000485421; ENSG00000206560 [O15084-2]
GeneIDi23243
KEGGihsa:23243
UCSCiuc003cai.2 human [O15084-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR28_HUMAN
AccessioniPrimary (citable) accession number: O15084
Secondary accession number(s): B4DES5
, Q1WWL4, Q29RW6, Q3B857, Q6ULS0, Q6ZT57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 3, 2011
Last modified: July 18, 2018
This is version 167 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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