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UniProtKB - O15084 (ANR28_HUMAN)

>sp|O15084|ANR28_HUMAN Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL
ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV
KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA
AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN
TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN
MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT
SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC
LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT
SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD
MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD
VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS
VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR
TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV
FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ
LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK
GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY
TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN
EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY

Entry version 191 (23 Feb 2022)
Sequence version 5 (03 May 2011)
Previous versions | rss

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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Gene

ANKRD28

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

2 Publications

Enzyme and pathway databases

PathwayCommonsⁱ	O15084
Reactomeⁱ	R-HSA-171319, Telomere Extension By Telomerase R-HSA-204005, COPII-mediated vesicle transport
SignaLinkⁱ	O15084
SIGNORⁱ	O15084

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A Short name: PP6-ARS-A Short name: Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A Alternative name(s): Ankyrin repeat domain-containing protein 28 Phosphatase interactor targeting protein hnRNP K Short name: PITK
Gene namesⁱ	Name:ANKRD28 Synonyms:KIAA0379
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29024, ANKRD28
MIMⁱ	611122, gene
neXtProtⁱ	NX_O15084
VEuPathDBⁱ	HostDB:ENSG00000206560

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1007 – 1011	SKTVS → AKTVA: Marked decrease in phosphorylation. Increased PPP1C-binding. No effect on HNRPK-binding. 1 Publication		5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23243
Open Targets More...OpenTargetsⁱ	ENSG00000206560
PharmGKBⁱ	PA134880251

Miscellaneous databases

Pharosⁱ	O15084, Tbio

Pharosⁱ

O15084, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL4105921

ChEMBLⁱ

CHEMBL4105921

Genetic variation databases

BioMutaⁱ	ANKRD28

BioMutaⁱ

ANKRD28

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066919	1 – 1053	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit AAdd BLAST		1053

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1007	Phosphoserine1 Publication		1
Modified residueⁱ	1011	PhosphoserineCombined sources1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15084
jPOSTⁱ	O15084
MassIVEⁱ	O15084
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15084
PaxDbⁱ	O15084
PeptideAtlas More...PeptideAtlasⁱ	O15084
PRIDEⁱ	O15084
ProteomicsDBⁱ	48437 [O15084-3] 48438 [O15084-1] 48439 [O15084-2] 48440 [O15084-4]

PTM databases

GlyGenⁱ	O15084, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	O15084
PhosphoSitePlusⁱ	O15084

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000206560, Expressed in caput epididymis and 237 other tissues
ExpressionAtlasⁱ	O15084, baseline and differential
Genevisibleⁱ	O15084, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000206560, Low tissue specificity

HPAⁱ

ENSG00000206560, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).

Interacts with PPP1C and HNRPK.

Interacts with PPP6C, PPP6R1 and PPP6R3.

2 Publications

Binary interactionsⁱ

Hide details

O15084

With	#Exp.	IntAct
DOCK1 [Q14185]	4	EBI-359567,EBI-446740
EIF3D [O15371]	3	EBI-359567,EBI-353818
GADD45GIP1 [Q8TAE8]	3	EBI-359567,EBI-372506
INCA1 [Q0VD86]	3	EBI-359567,EBI-6509505
KCNV2 [Q8TDN2]	3	EBI-359567,EBI-12014650
MGC50722 [Q8IVT4]	3	EBI-359567,EBI-14086479
PIBF1 [Q4G0R1]	3	EBI-359567,EBI-14066006
PPP6C [O00743]	10	EBI-359567,EBI-359751
PPP6R1 [Q9UPN7]	10	EBI-359567,EBI-359745
PPP6R2 [O75170]	7	EBI-359567,EBI-359739
PPP6R3 [Q5H9R7]	5	EBI-359567,EBI-355498
PTRH1 [Q86Y79]	3	EBI-359567,EBI-2602515
THAP7 [Q9BT49]	3	EBI-359567,EBI-741350
TNKS2 [Q9H2K2]	3	EBI-359567,EBI-4398527
YTHDC1 [Q96MU7]	3	EBI-359567,EBI-2849854

Protein-protein interaction databases

BioGRIDⁱ	116847, 197 interactors
CORUMⁱ	O15084
Database of interacting proteins More...DIPⁱ	DIP-27583N
IntActⁱ	O15084, 119 interactors
Molecular INTeraction database More...MINTⁱ	O15084
STRINGⁱ	9606.ENSP00000382379

Miscellaneous databases

RNActⁱ	O15084, protein

RNActⁱ

O15084, protein

Structureⁱ

3D structure databases

SMRⁱ	O15084
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	40 – 69	ANK 1Add BLAST	30
Repeatⁱ	73 – 102	ANK 2Add BLAST	30
Repeatⁱ	106 – 135	ANK 3Add BLAST	30
Repeatⁱ	139 – 168	ANK 4Add BLAST	30
Repeatⁱ	172 – 201	ANK 5Add BLAST	30
Repeatⁱ	205 – 234	ANK 6Add BLAST	30
Repeatⁱ	238 – 267	ANK 7Add BLAST	30
Repeatⁱ	271 – 301	ANK 8Add BLAST	31
Repeatⁱ	305 – 334	ANK 9Add BLAST	30
Repeatⁱ	338 – 367	ANK 10Add BLAST	30
Repeatⁱ	371 – 400	ANK 11Add BLAST	30
Repeatⁱ	404 – 433	ANK 12Add BLAST	30
Repeatⁱ	437 – 466	ANK 13Add BLAST	30
Repeatⁱ	470 – 500	ANK 14Add BLAST	31
Repeatⁱ	504 – 534	ANK 15Add BLAST	31
Repeatⁱ	549 – 578	ANK 16Add BLAST	30
Repeatⁱ	582 – 611	ANK 17Add BLAST	30
Repeatⁱ	616 – 645	ANK 18Add BLAST	30
Repeatⁱ	652 – 681	ANK 19Add BLAST	30
Repeatⁱ	685 – 714	ANK 20Add BLAST	30
Repeatⁱ	718 – 747	ANK 21Add BLAST	30
Repeatⁱ	755 – 784	ANK 22Add BLAST	30
Repeatⁱ	787 – 817	ANK 23Add BLAST	31
Repeatⁱ	822 – 851	ANK 24Add BLAST	30
Repeatⁱ	855 – 885	ANK 25Add BLAST	31
Repeatⁱ	889 – 918	ANK 26Add BLAST	30
Repeatⁱ	925 – 954	ANK 27Add BLAST	30

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000182908
HOGENOMⁱ	CLU_000134_58_0_1
InParanoidⁱ	O15084
OMAⁱ	YNGHLEM
Database of Orthologous Groups More...OrthoDBⁱ	1115202at2759
TreeFamⁱ	TF312824

Family and domain databases

Gene3Dⁱ	1.25.40.20, 12 hits
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00023, Ank, 3 hits PF12796, Ank_2, 8 hits PF13637, Ank_4, 2 hits
PRINTSⁱ	PR01415, ANKYRIN
SMARTⁱ	View protein in SMART SM00248, ANK, 28 hits
SUPFAMⁱ	SSF48403, SSF48403, 4 hits
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 24 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15084-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY 
        60         70         80         90        100
LGDAEIIELL ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV 
       110        120        130        140        150
NARDKNWQTP LHIAAANKAV KCAEALVPLL SNVNVSDRAG RTALHHAAFS 
       160        170        180        190        200
GHGEMVKLLL SRGANINAFD KKDRRAIHWA AYMGHIEVVK LLVSHGAEVT 
       210        220        230        240        250
CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN TPLHVACYNG 
       260        270        280        290        300
QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN 
       310        320        330        340        350
MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG 
       360        370        380        390        400
HELLINTLIT SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT 
       410        420        430        440        450
PDDFGRTCLH AAAAGGNLEC LNLLLNTGAD FNKKDKFGRS PLHYAAANCN 
       460        470        480        490        500
YQCLFALVGS GASVNDLDER GCTPLHYAAT SDTDGKCLEY LLRNDANPGI 
       510        520        530        540        550
RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD MLSDSDNRAT 
       560        570        580        590        600
ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD 
       610        620        630        640        650
VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD 
       660        670        680        690        700
GNGQTPLMLS VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE 
       710        720        730        740        750
CVDALLQHGA KCLLRDSRGR TPIHLSAACG HIGVLGALLQ SAASMDANPA 
       760        770        780        790        800
TADNHGYTAL HWACYNGHET CVELLLEQEV FQKTEGNAFS PLHCAVINDN 
       810        820        830        840        850
EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ LLLSHNAQVN 
       860        870        880        890        900
SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK 
       910        920        930        940        950
GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA 
       960        970        980        990       1000
SVLAVDENGY TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI 
      1010       1020       1030       1040       1050
NRYTNTSKTV SFEALPIMRN EPSSYCSFNN IGGEQEYLYT DVDELNDSDS 

ETY

Length:1,053

Mass (Da):112,966

Last modified:May 3, 2011 - v5

Checksum:ⁱBDB4855193364585

Isoform 2 (identifier: O15084-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-154: Missing.

« Hide

        10         20         30         40         50
MVKLLLSRGA NINAFDKKDR RAIHWAAYMG HIEVVKLLVS HGAEVTCKDK 
        60         70         80         90        100
KSYTPLHAAA SSGMISVVKY LLDLGVDMNE PNAYGNTPLH VACYNGQDVV 
       110        120        130        140        150
VNELIDCGAI VNQKNEKGFT PLHFAAASTH GALCLELLVG NGADVNMKSK 
       160        170        180        190        200
DGKTPLHMTA LHGRFSRSQT IIQSGAVIDC EDKNGNTPLH IAARYGHELL 
       210        220        230        240        250
INTLITSGAD TAKRGIHGMF PLHLAALSGF SDCCRKLLSS GFDIDTPDDF 
       260        270        280        290        300
GRTCLHAAAA GGNLECLNLL LNTGADFNKK DKFGRSPLHY AAANCNYQCL 
       310        320        330        340        350
FALVGSGASV NDLDERGCTP LHYAATSDTD GKCLEYLLRN DANPGIRDKQ 
       360        370        380        390        400
GYNAVHYSAA YGHRLCLQLI ASETPLDVLM ETSGTDMLSD SDNRATISPL 
       410        420        430        440        450
HLAAYHGHHQ ALEVLVQSLL DLDVRNSSGR TPLDLAAFKG HVECVDVLIN 
       460        470        480        490        500
QGASILVKDY ILKRTPIHAA ATNGHSECLR LLIGNAEPQN AVDIQDGNGQ 
       510        520        530        540        550
TPLMLSVLNG HTDCVYSLLN KGANVDAKDK WGRTALHRGA VTGHEECVDA 
       560        570        580        590        600
LLQHGAKCLL RDSRGRTPIH LSAACGHIGV LGALLQSAAS MDANPATADN 
       610        620        630        640        650
HGYTALHWAC YNGHETCVEL LLEQEVFQKT EGNAFSPLHC AVINDNEGAA 
       660        670        680        690        700
EMLIDTLGAS IVNATDSKGR TPLHAAAFTD HVECLQLLLS HNAQVNSVDS 
       710        720        730        740        750
TGKTPLMMAA ENGQTNTVEM LVSSASAELT LQDNSKNTAL HLACSKGHET 
       760        770        780        790        800
SALLILEKIT DRNLINATNA ALQTPLHVAA RNGLTMVVQE LLGKGASVLA 
       810        820        830        840        850
VDENGYTPAL ACAPNKDVAD CLALILATMM PVSSSSPLSS LTFNAINRYT 
       860        870        880        890 
NTSKTVSFEA LPIMRNEPSS YCSFNNIGGE QEYLYTDVDE LNDSDSETY

Note: Produced by alternative promoter usage.Curated

Show »

Length:899

Mass (Da):96,161

Checksum:ⁱE06723898ABF4B08

Isoform 3 (identifier: O15084-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRY

« Hide

        10         20         30         40         50
MSRVCIVVLE EVEDESPAFI SKLPQENKSL HSPPSGNVLV RYPSLVQAIF 
        60         70         80         90        100
NGDPDEVRAL IFKKEDVNFQ DNEKRTPLHA AAYLGDAEII ELLILSGARV 
       110        120        130        140        150
NAKDSKWLTP LHRAVASCSE EAVQVLLKHS ADVNARDKNW QTPLHIAAAN 
       160        170        180        190        200
KAVKCAEALV PLLSNVNVSD RAGRTALHHA AFSGHGEMVK LLLSRGANIN 
       210        220        230        240        250
AFDKKDRRAI HWAAYMGHIE VVKLLVSHGA EVTCKDKKSY TPLHAAASSG 
       260        270        280        290        300
MISVVKYLLD LGVDMNEPNA YGNTPLHVAC YNGQDVVVNE LIDCGAIVNQ 
       310        320        330        340        350
KNEKGFTPLH FAAASTHGAL CLELLVGNGA DVNMKSKDGK TPLHMTALHG 
       360        370        380        390        400
RFSRSQTIIQ SGAVIDCEDK NGNTPLHIAA RYGHELLINT LITSGADTAK 
       410        420        430        440        450
RGIHGMFPLH LAALSGFSDC CRKLLSSGFD IDTPDDFGRT CLHAAAAGGN 
       460        470        480        490        500
LECLNLLLNT GADFNKKDKF GRSPLHYAAA NCNYQCLFAL VGSGASVNDL 
       510        520        530        540        550
DERGCTPLHY AATSDTDGKC LEYLLRNDAN PGIRDKQGYN AVHYSAAYGH 
       560        570        580        590        600
RLCLQLIASE TPLDVLMETS GTDMLSDSDN RATISPLHLA AYHGHHQALE 
       610        620        630        640        650
VLVQSLLDLD VRNSSGRTPL DLAAFKGHVE CVDVLINQGA SILVKDYILK 
       660        670        680        690        700
RTPIHAAATN GHSECLRLLI GNAEPQNAVD IQDGNGQTPL MLSVLNGHTD 
       710        720        730        740        750
CVYSLLNKGA NVDAKDKWGR TALHRGAVTG HEECVDALLQ HGAKCLLRDS 
       760        770        780        790        800
RGRTPIHLSA ACGHIGVLGA LLQSAASMDA NPATADNHGY TALHWACYNG 
       810        820        830        840        850
HETCVELLLE QEVFQKTEGN AFSPLHCAVI NDNEGAAEML IDTLGASIVN 
       860        870        880        890        900
ATDSKGRTPL HAAAFTDHVE CLQLLLSHNA QVNSVDSTGK TPLMMAAENG 
       910        920        930        940        950
QTNTVEMLVS SASAELTLQD NSKNTALHLA CSKGHETSAL LILEKITDRN 
       960        970        980        990       1000
LINATNAALQ TPLHVAARNG LTMVVQELLG KGASVLAVDE NGYTPALACA 
      1010       1020       1030       1040       1050
PNKDVADCLA LILATMMPVS SSSPLSSLTF NAINRYTNTS KTVSFEALPI 
      1060       1070       1080 
MRNEPSSYCS FNNIGGEQEY LYTDVDELND SDSETY

Show »

Length:1,086

Mass (Da):116,543

Checksum:ⁱ47A3F97E5C72F0E8

Isoform 4 (identifier: O15084-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: MAFLKLRDQ → MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVL

« Hide

        10         20         30         40         50
MSRVCIVVLE EVEDESPAFI SKLPQENKSL HSPPSGNVLP SLVQAIFNGD 
        60         70         80         90        100
PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL ILSGARVNAK 
       110        120        130        140        150
DSKWLTPLHR AVASCSEEAV QVLLKHSADV NARDKNWQTP LHIAAANKAV 
       160        170        180        190        200
KCAEALVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD 
       210        220        230        240        250
KKDRRAIHWA AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS 
       260        270        280        290        300
VVKYLLDLGV DMNEPNAYGN TPLHVACYNG QDVVVNELID CGAIVNQKNE 
       310        320        330        340        350
KGFTPLHFAA ASTHGALCLE LLVGNGADVN MKSKDGKTPL HMTALHGRFS 
       360        370        380        390        400
RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT SGADTAKRGI 
       410        420        430        440        450
HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC 
       460        470        480        490        500
LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER 
       510        520        530        540        550
GCTPLHYAAT SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC 
       560        570        580        590        600
LQLIASETPL DVLMETSGTD MLSDSDNRAT ISPLHLAAYH GHHQALEVLV 
       610        620        630        640        650
QSLLDLDVRN SSGRTPLDLA AFKGHVECVD VLINQGASIL VKDYILKRTP 
       660        670        680        690        700
IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS VLNGHTDCVY 
       710        720        730        740        750
SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR 
       760        770        780        790        800
TPIHLSAACG HIGVLGALLQ SAASMDANPA TADNHGYTAL HWACYNGHET 
       810        820        830        840        850
CVELLLEQEV FQKTEGNAFS PLHCAVINDN EGAAEMLIDT LGASIVNATD 
       860        870        880        890        900
SKGRTPLHAA AFTDHVECLQ LLLSHNAQVN SVDSTGKTPL MMAAENGQTN 
       910        920        930        940        950
TVEMLVSSAS AELTLQDNSK NTALHLACSK GHETSALLIL EKITDRNLIN 
       960        970        980        990       1000
ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY TPALACAPNK 
      1010       1020       1030       1040       1050
DVADCLALIL ATMMPVSSSS PLSSLTFNAI NRYTNTSKTV SFEALPIMRN 
      1060       1070       1080 
EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY

Show »

Length:1,083

Mass (Da):116,124

Checksum:ⁱ349BC9338F251E08

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DIW9	B4DIW9_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (cDNA FLJ54784, highly similar to Ankyrin repeat domain-containing protein 28)	ANKRD28	722	Annotation score:
F8WDU2	F8WDU2_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A	ANKRD28	14	Annotation score:

Sequence cautionⁱ

The sequence AAQ72374 differs from that shown. Reason: Frameshift.Curated

The sequence BAA20833 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence BAC86737 differs from that shown. Intron retention.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	293	V → A in AAQ72374 (Ref. 1) Curated	1
Sequence conflictⁱ	500	I → V in AAQ72374 (Ref. 1) Curated	1
Sequence conflictⁱ	500	I → V in BAC86737 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012433	1 – 154	Missing in isoform 2. 2 PublicationsAdd BLAST	154
Alternative sequenceⁱVSP_041013	1 – 9	MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVLV RY in isoform 3. 2 Publications	9
Alternative sequenceⁱVSP_041014	1 – 9	MAFLKLRDQ → MSRVCIVVLEEVEDESPAFI SKLPQENKSLHSPPSGNVL in isoform 4. 1 Publication	9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY367056 mRNA Translation: AAQ72374.1 Frameshift. AB002377 mRNA Translation: BAA20833.2 Different initiation. AK126888 mRNA Translation: BAC86737.1 Sequence problems. AK293770 mRNA Translation: BAG57186.1 BC106948 mRNA Translation: AAI06949.2 BC113868 mRNA Translation: AAI13869.1 BC114476 mRNA Translation: AAI14477.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46769.1 [O15084-3] CCDS74908.1 [O15084-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182027.1, NM_001195098.1 [O15084-2] NP_001182028.1, NM_001195099.1 [O15084-2] NP_056014.2, NM_015199.3 [O15084-3] XP_005265053.1, XM_005264996.3 XP_011531842.1, XM_011533540.2 XP_016861515.1, XM_017006026.1 XP_016861516.1, XM_017006027.1

Genome annotation databases

Ensemblⁱ	ENST00000399451; ENSP00000382379; ENSG00000206560 ENST00000412318; ENSP00000397341; ENSG00000206560 ENST00000624145; ENSP00000485421; ENSG00000206560 [O15084-2] ENST00000683139; ENSP00000508086; ENSG00000206560 [O15084-4]
GeneIDⁱ	23243
KEGGⁱ	hsa:23243
MANE-Selectⁱ	ENST00000683139.1; ENSP00000508086.1; NM_001349278.2; NP_001336207.1 [O15084-4]
UCSC genome browser More...UCSCⁱ	uc003cai.2, human [O15084-3]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15084	Ankyrin repeat domain 28, isoform CRA_c		HUMAN		1053	UniRef100_O15084
ANKRD28 isoform 1		PONAB		1053
O15084-2	Ankyrin repeat domain 28		PONAB		1226	UniRef100_H2PBD8
Uncharacterized protein		NOMLE		1044
Transcription factor SNF5 homolog INI1 (Fragment)		MACMU		16
ANKRD28 isoform 2		PONAB		899
+2

Protein	Similar proteins		Species	Score	Length	Source
O15084	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A		MOUSE		1053	UniRef90_O15084
Ankyrin repeat domain 28, isoform CRA_c		HUMAN		1053
ANKRD28 isoform 1		PONAB		1053
Uncharacterized protein		NOMLE		1044
Transcription factor SNF5 homolog INI1 (Fragment)		MACMU		16
+1270

Protein	Similar proteins		Species	Score	Length	Source
O15084	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A		MOUSE		1053	UniRef50_O15084
Ankyrin repeat domain 28, isoform CRA_c		HUMAN		1053
ANKRD28 isoform 1		PONAB		1053
Uncharacterized protein		NOMLE		1044
Transcription factor SNF5 homolog INI1 (Fragment)		MACMU		16
+1273

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY367056 mRNA Translation: AAQ72374.1 Frameshift. AB002377 mRNA Translation: BAA20833.2 Different initiation. AK126888 mRNA Translation: BAC86737.1 Sequence problems. AK293770 mRNA Translation: BAG57186.1 BC106948 mRNA Translation: AAI06949.2 BC113868 mRNA Translation: AAI13869.1 BC114476 mRNA Translation: AAI14477.1
CCDSⁱ	CCDS46769.1 [O15084-3] CCDS74908.1 [O15084-2]
RefSeqⁱ	NP_001182027.1, NM_001195098.1 [O15084-2] NP_001182028.1, NM_001195099.1 [O15084-2] NP_056014.2, NM_015199.3 [O15084-3] XP_005265053.1, XM_005264996.3 XP_011531842.1, XM_011533540.2 XP_016861515.1, XM_017006026.1 XP_016861516.1, XM_017006027.1

3D structure databases

SMRⁱ	O15084
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	116847, 197 interactors
CORUMⁱ	O15084
DIPⁱ	DIP-27583N
IntActⁱ	O15084, 119 interactors
MINTⁱ	O15084
STRINGⁱ	9606.ENSP00000382379

Chemistry databases

ChEMBLⁱ	CHEMBL4105921

ChEMBLⁱ

CHEMBL4105921

PTM databases

GlyGenⁱ	O15084, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	O15084
PhosphoSitePlusⁱ	O15084

Genetic variation databases

BioMutaⁱ	ANKRD28

BioMutaⁱ

ANKRD28

Proteomic databases

EPDⁱ	O15084
jPOSTⁱ	O15084
MassIVEⁱ	O15084
MaxQBⁱ	O15084
PaxDbⁱ	O15084
PeptideAtlasⁱ	O15084
PRIDEⁱ	O15084
ProteomicsDBⁱ	48437 [O15084-3] 48438 [O15084-1] 48439 [O15084-2] 48440 [O15084-4]

Protocols and materials databases

Antibodypediaⁱ	26857, 107 antibodies from 21 providers
The DNASU plasmid repository More...DNASUⁱ	23243

Genome annotation databases

Ensemblⁱ	ENST00000399451; ENSP00000382379; ENSG00000206560 ENST00000412318; ENSP00000397341; ENSG00000206560 ENST00000624145; ENSP00000485421; ENSG00000206560 [O15084-2] ENST00000683139; ENSP00000508086; ENSG00000206560 [O15084-4]
GeneIDⁱ	23243
KEGGⁱ	hsa:23243
MANE-Selectⁱ	ENST00000683139.1; ENSP00000508086.1; NM_001349278.2; NP_001336207.1 [O15084-4]
UCSCⁱ	uc003cai.2, human [O15084-3]

Organism-specific databases

CTDⁱ	23243
DisGeNETⁱ	23243
GeneCardsⁱ	ANKRD28
HGNCⁱ	HGNC:29024, ANKRD28
HPAⁱ	ENSG00000206560, Low tissue specificity
MIMⁱ	611122, gene
neXtProtⁱ	NX_O15084
OpenTargetsⁱ	ENSG00000206560
PharmGKBⁱ	PA134880251
VEuPathDBⁱ	HostDB:ENSG00000206560
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota
GeneTreeⁱ	ENSGT00950000182908
HOGENOMⁱ	CLU_000134_58_0_1
InParanoidⁱ	O15084
OMAⁱ	YNGHLEM
OrthoDBⁱ	1115202at2759
TreeFamⁱ	TF312824

Enzyme and pathway databases

PathwayCommonsⁱ	O15084
Reactomeⁱ	R-HSA-171319, Telomere Extension By Telomerase R-HSA-204005, COPII-mediated vesicle transport
SignaLinkⁱ	O15084
SIGNORⁱ	O15084

Miscellaneous databases

BioGRID-ORCSⁱ	23243, 10 hits in 1053 CRISPR screens
ChiTaRSⁱ	ANKRD28, human
GenomeRNAiⁱ	23243
Pharosⁱ	O15084, Tbio
Protein Ontology More...PROⁱ	PR:O15084
RNActⁱ	O15084, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000206560, Expressed in caput epididymis and 237 other tissues
ExpressionAtlasⁱ	O15084, baseline and differential
Genevisibleⁱ	O15084, HS

Family and domain databases

Gene3Dⁱ	1.25.40.20, 12 hits
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf
Pfamⁱ	View protein in Pfam PF00023, Ank, 3 hits PF12796, Ank_2, 8 hits PF13637, Ank_4, 2 hits
PRINTSⁱ	PR01415, ANKYRIN
SMARTⁱ	View protein in SMART SM00248, ANK, 28 hits
SUPFAMⁱ	SSF48403, SSF48403, 4 hits
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 24 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANR28_HUMAN
Accessionⁱ	O15084Primary (citable) accession number: O15084 Secondary accession number(s): B4DES5 , Q1WWL4, Q29RW6, Q3B857, Q6ULS0, Q6ZT57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	May 3, 2011
	Last modified:	February 23, 2022
	This is version 191 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O15084 (ANR28_HUMAN)

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Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

ANKRD28

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

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Keywords - PTMi

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O15084

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Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

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Keywords - Coding sequence diversityi

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Functionⁱ

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Pathology & Biotechⁱ

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Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ