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Protein

ERC protein 2

Gene

ERC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ERC protein 2
Gene namesi
Name:ERC2
Synonyms:KIAA0378
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000187672.12
HGNCiHGNC:31922 ERC2
neXtProtiNX_O15083

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi26059
OpenTargetsiENSG00000187672
PharmGKBiPA162385249

Polymorphism and mutation databases

BioMutaiERC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000870021 – 957ERC protein 2Add BLAST957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei666PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15083
MaxQBiO15083
PaxDbiO15083
PeptideAtlasiO15083
PRIDEiO15083
ProteomicsDBi48436

PTM databases

iPTMnetiO15083
PhosphoSitePlusiO15083

Expressioni

Gene expression databases

BgeeiENSG00000187672 Expressed in 126 organ(s), highest expression level in frontal cortex
CleanExiHS_ERC2
ExpressionAtlasiO15083 baseline and differential
GenevisibleiO15083 HS

Organism-specific databases

HPAiHPA073739

Interactioni

Subunit structurei

Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBP102422EBI-2684336,EBI-298355

Protein-protein interaction databases

BioGridi117521, 17 interactors
IntActiO15083, 5 interactors
MINTiO15083
STRINGi9606.ENSP00000288221

Structurei

3D structure databases

ProteinModelPortaliO15083
SMRiO15083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 917Sequence analysisAdd BLAST778

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Gly7
Compositional biasi129 – 133Poly-His5
Compositional biasi879 – 882Poly-Lys4
Compositional biasi920 – 932Poly-HisAdd BLAST13

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
GeneTreeiENSGT00650000093320
HOGENOMiHOG000236353
HOVERGENiHBG051496
InParanoidiO15083
KOiK19878
OMAiTDNSQHL
OrthoDBiEOG091G01EN
PhylomeDBiO15083
TreeFamiTF324969

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
IPR030625 ERC2
PANTHERiPTHR18861:SF3 PTHR18861:SF3, 1 hit
PfamiView protein in Pfam
PF10174 Cast, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O15083-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGSARTITN LEGSPSRSPR LPRSPRLGHR RTSSGGGGGT GKTLSMENIQ
60 70 80 90 100
SLNAAYATSG PMYLSDHEGV ASTTYPKGTM TLGRATNRAV YGGRVTAMGS
110 120 130 140 150
SPNIASAGLS HTDVLSYTDQ HGGLTGSSHH HHHQVPSMLR QVRDSTMLDL
160 170 180 190 200
QAQLKELQRE NDLLRKELDI KDSKLGSSMN SIKTFWSPEL KKERVLRKEE
210 220 230 240 250
AARMSVLKEQ MRVSHEENQH LQLTIQALQD ELRTQRDLNH LLQQESGNRG
260 270 280 290 300
AEHFTIELTE ENFRRLQAEH DRQAKELFLL RKTLEEMELR IETQKQTLNA
310 320 330 340 350
RDESIKKLLE MLQSKGLPSK SLEDDNERTR RMAEAESQVS HLEVILDQKE
360 370 380 390 400
KENIHLREEL HRRSQLQPEP AKTKALQTVI EMKDTKIASL ERNIRDLEDE
410 420 430 440 450
IQMLKANGVL NTEDREEEIK QIEVYKSHSK FMKTKIDQLK QELSKKESEL
460 470 480 490 500
LALQTKLETL SNQNSDCKQH IEVLKESLTA KEQRAAILQT EVDALRLRLE
510 520 530 540 550
EKESFLNKKT KQLQDLTEEK GTLAGEIRDM KDMLEVKERK INVLQKKIEN
560 570 580 590 600
LQEQLRDKDK QLTNLKDRVK SLQTDSSNTD TALATLEEAL SEKERIIERL
610 620 630 640 650
KEQRERDDRE RLEEIESFRK ENKDLKEKVN ALQAELTEKE SSLIDLKEHA
660 670 680 690 700
SSLASAGLKR DSKLKSLEIA IEQKKEECSK LEAQLKKAHN IEDDSRMNPE
710 720 730 740 750
FADQIKQLDK EASYYRDECG KAQAEVDRLL EILKEVENEK NDKDKKIAEL
760 770 780 790 800
ESLTLRHMKD QNKKVANLKH NQQLEKKKNA QLLEEVRRRE DSMADNSQHL
810 820 830 840 850
QIEELMNALE KTRQELDATK ARLASTQQSL AEKEAHLANL RIERRKQLEE
860 870 880 890 900
ILEMKQEALL AAISEKDANI ALLELSASKK KKTQEEVMAL KREKDRLVHQ
910 920 930 940 950
LKQQTQNRMK LMADNYDDDH HHYHHHHHHH HHRSPGRSQH SNHRPSPDQD

DEEGIWA
Length:957
Mass (Da):110,558
Last modified:August 31, 2004 - v3
Checksum:iACE9310F27C6079D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4G9H7C4G9_HUMAN
ERC protein 2
ERC2
528Annotation score:

Sequence cautioni

The sequence BAA20832 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050973542N → S. Corresponds to variant dbSNP:rs12488237Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002376 mRNA Translation: BAA20832.2 Different initiation.
BC046212 mRNA No translation available.
BC111550 mRNA Translation: AAI11551.1
BC112391 mRNA Translation: AAI12392.1
CCDSiCCDS46851.1
RefSeqiNP_056391.1, NM_015576.2
XP_016861647.1, XM_017006158.1
UniGeneiHs.476389

Genome annotation databases

EnsembliENST00000288221; ENSP00000288221; ENSG00000187672
ENST00000460849; ENSP00000417445; ENSG00000187672
ENST00000612797; ENSP00000483127; ENSG00000187672
GeneIDi26059
KEGGihsa:26059
UCSCiuc062kue.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002376 mRNA Translation: BAA20832.2 Different initiation.
BC046212 mRNA No translation available.
BC111550 mRNA Translation: AAI11551.1
BC112391 mRNA Translation: AAI12392.1
CCDSiCCDS46851.1
RefSeqiNP_056391.1, NM_015576.2
XP_016861647.1, XM_017006158.1
UniGeneiHs.476389

3D structure databases

ProteinModelPortaliO15083
SMRiO15083
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117521, 17 interactors
IntActiO15083, 5 interactors
MINTiO15083
STRINGi9606.ENSP00000288221

PTM databases

iPTMnetiO15083
PhosphoSitePlusiO15083

Polymorphism and mutation databases

BioMutaiERC2

Proteomic databases

EPDiO15083
MaxQBiO15083
PaxDbiO15083
PeptideAtlasiO15083
PRIDEiO15083
ProteomicsDBi48436

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288221; ENSP00000288221; ENSG00000187672
ENST00000460849; ENSP00000417445; ENSG00000187672
ENST00000612797; ENSP00000483127; ENSG00000187672
GeneIDi26059
KEGGihsa:26059
UCSCiuc062kue.1 human

Organism-specific databases

CTDi26059
DisGeNETi26059
EuPathDBiHostDB:ENSG00000187672.12
GeneCardsiERC2
HGNCiHGNC:31922 ERC2
HPAiHPA073739
neXtProtiNX_O15083
OpenTargetsiENSG00000187672
PharmGKBiPA162385249
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
GeneTreeiENSGT00650000093320
HOGENOMiHOG000236353
HOVERGENiHBG051496
InParanoidiO15083
KOiK19878
OMAiTDNSQHL
OrthoDBiEOG091G01EN
PhylomeDBiO15083
TreeFamiTF324969

Miscellaneous databases

ChiTaRSiERC2 human
GeneWikiiERC2_(gene)
GenomeRNAii26059
PROiPR:O15083

Gene expression databases

BgeeiENSG00000187672 Expressed in 126 organ(s), highest expression level in frontal cortex
CleanExiHS_ERC2
ExpressionAtlasiO15083 baseline and differential
GenevisibleiO15083 HS

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
IPR030625 ERC2
PANTHERiPTHR18861:SF3 PTHR18861:SF3, 1 hit
PfamiView protein in Pfam
PF10174 Cast, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERC2_HUMAN
AccessioniPrimary (citable) accession number: O15083
Secondary accession number(s): Q2T9F6, Q86TK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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