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Protein

Syntaphilin

Gene

SNPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits SNARE complex formation by absorbing free syntaxin-1.1 Publication

GO - Molecular functioni

  • syntaxin-1 binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaphilin
Gene namesi
Name:SNPH
Synonyms:KIAA0374
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101298.13
HGNCiHGNC:15931 SNPH
MIMi604942 gene
neXtProtiNX_O15079

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei425 – 444HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101298
PharmGKBiPA38053

Polymorphism and mutation databases

BioMutaiSNPH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720301 – 494SyntaphilinAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei219PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15079
MaxQBiO15079
PaxDbiO15079
PeptideAtlasiO15079
PRIDEiO15079
ProteomicsDBi48434
48435 [O15079-2]

PTM databases

iPTMnetiO15079
PhosphoSitePlusiO15079

Expressioni

Tissue specificityi

Brain specific. Found in synapses.1 Publication

Gene expression databases

BgeeiENSG00000101298 Expressed in 198 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SNPH
GenevisibleiO15079 HS

Organism-specific databases

HPAiHPA049393

Interactioni

Subunit structurei

Binds to syntaxin-1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115099, 1 interactor
IntActiO15079, 3 interactors
STRINGi9606.ENSP00000371297

Structurei

3D structure databases

ProteinModelPortaliO15079
SMRiO15079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 161Sequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 42Poly-SerAdd BLAST11
Compositional biasi405 – 409Poly-Glu5

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGP3 Eukaryota
ENOG410XQEB LUCA
GeneTreeiENSGT00520000055634
HOGENOMiHOG000148964
HOVERGENiHBG006785
InParanoidiO15079
OMAiYWSRHFI
OrthoDBiEOG091G07I1
PhylomeDBiO15079
TreeFamiTF332407

Family and domain databases

InterProiView protein in InterPro
IPR026196 Syntaphilin
IPR028197 Syntaphilin/Syntabulin
PANTHERiPTHR16208 PTHR16208, 1 hit
PTHR16208:SF1 PTHR16208:SF1, 1 hit
PfamiView protein in Pfam
PF15290 Syntaphilin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O15079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP
60 70 80 90 100
TPRRSMKYTL CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL
110 120 130 140 150
QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIKQLKQVID
160 170 180 190 200
TVKNNLIDKD KGLQKYFVDI NIQNKKLETL LHSMEVAQNG MAKEDGTGES
210 220 230 240 250
AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG ADSGFAAADD
260 270 280 290 300
TLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM
310 320 330 340 350
EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGT DPESGDRCPE
360 370 380 390 400
LDAHPSGPRD PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV
410 420 430 440 450
VCPMEEEEEA AVAEKEPKSY WSRHYIVDLL AVVVPAVPTV AWLCRSQRRQ
460 470 480 490
GQPIYNISSL LRGCCTVALH SIRRISCRSL SQPSPSPAGG GSQL
Length:494
Mass (Da):53,537
Last modified:June 16, 2009 - v2
Checksum:iCD6269CB66792D2C
GO
Isoform 2 (identifier: O15079-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGSGPSERMTWPGPALSAGPPTRPLSSAPGIPPIPPLTRTHSLM

Show »
Length:538
Mass (Da):57,990
Checksum:i9A22618F39049E07
GO

Sequence cautioni

The sequence BAA20829 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0374381M → MPGSGPSERMTWPGPALSAG PPTRPLSSAPGIPPIPPLTR THSLM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187733 mRNA Translation: AAF29901.1
AB002372 mRNA Translation: BAA20829.2 Different initiation.
AL136531 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10643.1
BC035788 mRNA Translation: AAH35788.1
CCDSiCCDS13012.1 [O15079-1]
CCDS82590.1 [O15079-2]
RefSeqiNP_001305163.1, NM_001318234.1 [O15079-2]
NP_055538.2, NM_014723.3 [O15079-1]
UniGeneiHs.323833

Genome annotation databases

EnsembliENST00000381867; ENSP00000371291; ENSG00000101298 [O15079-2]
ENST00000381873; ENSP00000371297; ENSG00000101298 [O15079-1]
ENST00000614659; ENSP00000479696; ENSG00000101298 [O15079-2]
GeneIDi9751
KEGGihsa:9751
UCSCiuc002wes.4 human [O15079-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187733 mRNA Translation: AAF29901.1
AB002372 mRNA Translation: BAA20829.2 Different initiation.
AL136531 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10643.1
BC035788 mRNA Translation: AAH35788.1
CCDSiCCDS13012.1 [O15079-1]
CCDS82590.1 [O15079-2]
RefSeqiNP_001305163.1, NM_001318234.1 [O15079-2]
NP_055538.2, NM_014723.3 [O15079-1]
UniGeneiHs.323833

3D structure databases

ProteinModelPortaliO15079
SMRiO15079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115099, 1 interactor
IntActiO15079, 3 interactors
STRINGi9606.ENSP00000371297

PTM databases

iPTMnetiO15079
PhosphoSitePlusiO15079

Polymorphism and mutation databases

BioMutaiSNPH

Proteomic databases

EPDiO15079
MaxQBiO15079
PaxDbiO15079
PeptideAtlasiO15079
PRIDEiO15079
ProteomicsDBi48434
48435 [O15079-2]

Protocols and materials databases

DNASUi9751
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381867; ENSP00000371291; ENSG00000101298 [O15079-2]
ENST00000381873; ENSP00000371297; ENSG00000101298 [O15079-1]
ENST00000614659; ENSP00000479696; ENSG00000101298 [O15079-2]
GeneIDi9751
KEGGihsa:9751
UCSCiuc002wes.4 human [O15079-1]

Organism-specific databases

CTDi9751
EuPathDBiHostDB:ENSG00000101298.13
GeneCardsiSNPH
HGNCiHGNC:15931 SNPH
HPAiHPA049393
MIMi604942 gene
neXtProtiNX_O15079
OpenTargetsiENSG00000101298
PharmGKBiPA38053
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGP3 Eukaryota
ENOG410XQEB LUCA
GeneTreeiENSGT00520000055634
HOGENOMiHOG000148964
HOVERGENiHBG006785
InParanoidiO15079
OMAiYWSRHFI
OrthoDBiEOG091G07I1
PhylomeDBiO15079
TreeFamiTF332407

Miscellaneous databases

ChiTaRSiSNPH human
GenomeRNAii9751
PROiPR:O15079
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101298 Expressed in 198 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SNPH
GenevisibleiO15079 HS

Family and domain databases

InterProiView protein in InterPro
IPR026196 Syntaphilin
IPR028197 Syntaphilin/Syntabulin
PANTHERiPTHR16208 PTHR16208, 1 hit
PTHR16208:SF1 PTHR16208:SF1, 1 hit
PfamiView protein in Pfam
PF15290 Syntaphilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNPH_HUMAN
AccessioniPrimary (citable) accession number: O15079
Secondary accession number(s): Q8IYI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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