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UniProtKB - O15075 (DCLK1_HUMAN)

Entry version 195 (12 Aug 2020)
Sequence version 2 (30 May 2000)
Previous versions | rss
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Protein

Serine/threonine-protein kinase DCLK1

Gene

DCLK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei419ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei511Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi396 – 404ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15075

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15075

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCLK1
Synonyms:DCAMKL1, DCDC3A, KIAA0369
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000133083.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:2700, DCLK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604742, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15075

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9201

Open Targets

More...OpenTargetsi		ENSG00000133083

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162383325

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15075, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5683

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		O15075

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DCLK1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859191 – 740Serine/threonine-protein kinase DCLK1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei305PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei353PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei520PhosphotyrosineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15075

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15075

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15075

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15075

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15075

PeptideAtlas

More...PeptideAtlasi		O15075

PRoteomics IDEntifications database

More...PRIDEi		O15075

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48428 [O15075-1]
48429 [O15075-2]
48430 [O15075-3]
48431 [O15075-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O15075

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15075

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15075

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O15075

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133083, Expressed in parietal lobe and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15075, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15075, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133083, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114635, 80 interactors

Protein interaction database and analysis system

More...IntActi		O15075, 17 interactors

Molecular INTeraction database

More...MINTi		O15075

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000255448

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O15075

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15075, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15075

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O15075

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 143Doublecortin 1PROSITE-ProRule annotationAdd BLAST87
Domaini186 – 269Doublecortin 2PROSITE-ProRule annotationAdd BLAST84
Domaini390 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi288 – 340Pro/Ser-richAdd BLAST53
Compositional biasi698 – 701Poly-Arg4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0032, Eukaryota
KOG3757, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154956

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_63_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15075

KEGG Orthology (KO)

More...KOi		K08805

Identification of Orthologs from Complete Genome Data

More...OMAi		PENLLXY

Database of Orthologous Groups

More...OrthoDBi		330091at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15075

TreeFam database of animal gene trees

More...TreeFami		TF318770

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.20.230, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03607, DCX, 2 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00537, DCX, 2 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit
SSF89837, SSF89837, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50309, DC, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: O15075-1) [UniParc]FASTAAdd to basket
Also known as: AL

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL 
        60         70         80         90        100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN 
       110        120        130        140        150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW 
       160        170        180        190        200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA 
       210        220        230        240        250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG 
       260        270        280        290        300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
       310        320        330        340        350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG 
       360        370        380        390        400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN 
       410        420        430        440        450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL 
       460        470        480        490        500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK 
       510        520        530        540        550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT 
       560        570        580        590        600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 
       610        620        630        640        650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD 
       660        670        680        690        700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR 
       710        720        730        740
RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF
Length:740
Mass (Da):82,224
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7B6D855099A315C
GO
Isoform 1 (identifier: O15075-2) [UniParc]FASTAAdd to basket
Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:729
Mass (Da):81,100
Checksum:i32C685F6B308A6BD
GO
Isoform 3 (identifier: O15075-3) [UniParc]FASTAAdd to basket
Also known as: BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:422
Mass (Da):46,557
Checksum:i945DC91D48ECDB3A
GO
Isoform 4 (identifier: O15075-4) [UniParc]FASTAAdd to basket
Also known as: BL

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE

Show »
Length:433
Mass (Da):47,681
Checksum:i7EA1B5E565ADFC9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VZY9Q5VZY9_HUMAN
Serine/threonine-protein kinase DCL...
DCLK1
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20824 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04567329G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567446T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567593R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1366698690Ensembl.1
Natural variantiVAR_045676291S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_045677292R → H1 PublicationCorresponds to variant dbSNP:rs56185003Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0049051 – 307Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST307
Alternative sequenceiVSP_004906308 – 313PASTSS → MLELIE in isoform 3 and isoform 4. 2 Publications6
Alternative sequenceiVSP_004907687 – 740TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB002367 mRNA Translation: BAA20824.2 Different initiation.
AL157760 AL390029 Genomic DNA Translation: CAH70167.1
AL157760 Genomic DNA Translation: CAH70170.1
AK295777 mRNA Translation: BAH12185.1
AL157760 AL390029 Genomic DNA Translation: CAH70168.1
AL160392 AL390029 Genomic DNA Translation: CAH70261.1
AL160392 AL390029 Genomic DNA Translation: CAH70262.1
AL157694 AL390029 Genomic DNA Translation: CAH70656.1
AL157694 AL390029 Genomic DNA Translation: CAH70657.1
AL390029 AL160392 Genomic DNA Translation: CAI15720.1
AL390029 AL160392 Genomic DNA Translation: CAI15721.1
CH471075 Genomic DNA Translation: EAX08550.1
CH471075 Genomic DNA Translation: EAX08551.1
BC152456 mRNA Translation: AAI52457.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55895.1 [O15075-4]
CCDS73561.1 [O15075-3]
CCDS81762.1 [O15075-1]
CCDS9354.1 [O15075-2]

NCBI Reference Sequences

More...RefSeqi		NP_001182344.1, NM_001195415.1 [O15075-3]
NP_001182345.1, NM_001195416.1 [O15075-4]
NP_001317000.1, NM_001330071.1 [O15075-1]
NP_001317001.1, NM_001330072.1 [O15075-1]
NP_004725.1, NM_004734.4 [O15075-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255448; ENSP00000255448; ENSG00000133083 [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083 [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083 [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083 [O15075-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9201

UCSC genome browser

More...UCSCi		uc001uve.4, human [O15075-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA Translation: BAA20824.2 Different initiation.
AL157760 AL390029 Genomic DNA Translation: CAH70167.1
AL157760 Genomic DNA Translation: CAH70170.1
AK295777 mRNA Translation: BAH12185.1
AL157760 AL390029 Genomic DNA Translation: CAH70168.1
AL160392 AL390029 Genomic DNA Translation: CAH70261.1
AL160392 AL390029 Genomic DNA Translation: CAH70262.1
AL157694 AL390029 Genomic DNA Translation: CAH70656.1
AL157694 AL390029 Genomic DNA Translation: CAH70657.1
AL390029 AL160392 Genomic DNA Translation: CAI15720.1
AL390029 AL160392 Genomic DNA Translation: CAI15721.1
CH471075 Genomic DNA Translation: EAX08550.1
CH471075 Genomic DNA Translation: EAX08551.1
BC152456 mRNA Translation: AAI52457.1
CCDSiCCDS55895.1 [O15075-4]
CCDS73561.1 [O15075-3]
CCDS81762.1 [O15075-1]
CCDS9354.1 [O15075-2]
RefSeqiNP_001182344.1, NM_001195415.1 [O15075-3]
NP_001182345.1, NM_001195416.1 [O15075-4]
NP_001317000.1, NM_001330071.1 [O15075-1]
NP_001317001.1, NM_001330072.1 [O15075-1]
NP_004725.1, NM_004734.4 [O15075-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MFWX-ray1.60A49-154[»]
1MG4X-ray1.50A49-154[»]
1UF0NMR-A54-156[»]
5JZJX-ray1.71A/B372-649[»]
5JZNX-ray2.85A/B372-649[»]
SMRiO15075
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114635, 80 interactors
IntActiO15075, 17 interactors
MINTiO15075
STRINGi9606.ENSP00000255448

Chemistry databases

BindingDBiO15075
ChEMBLiCHEMBL5683
DrugBankiDB12010, Fostamatinib
DrugCentraliO15075

PTM databases

CarbonylDBiO15075
iPTMnetiO15075
PhosphoSitePlusiO15075
SwissPalmiO15075

Polymorphism and mutation databases

BioMutaiDCLK1

Proteomic databases

EPDiO15075
jPOSTiO15075
MassIVEiO15075
MaxQBiO15075
PaxDbiO15075
PeptideAtlasiO15075
PRIDEiO15075
ProteomicsDBi48428 [O15075-1]
48429 [O15075-2]
48430 [O15075-3]
48431 [O15075-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23046, 409 antibodies

The DNASU plasmid repository

More...DNASUi		9201

Genome annotation databases

EnsembliENST00000255448; ENSP00000255448; ENSG00000133083 [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083 [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083 [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083 [O15075-3]
GeneIDi9201
KEGGihsa:9201
UCSCiuc001uve.4, human [O15075-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9201
DisGeNETi9201
EuPathDBiHostDB:ENSG00000133083.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		DCLK1
HGNCiHGNC:2700, DCLK1
HPAiENSG00000133083, Tissue enriched (brain)
MIMi604742, gene
neXtProtiNX_O15075
OpenTargetsiENSG00000133083
PharmGKBiPA162383325

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
KOG3757, Eukaryota
GeneTreeiENSGT00940000154956
HOGENOMiCLU_000288_63_0_1
InParanoidiO15075
KOiK08805
OMAiPENLLXY
OrthoDBi330091at2759
PhylomeDBiO15075
TreeFamiTF318770

Enzyme and pathway databases

BRENDAi2.7.11.1, 2681
PathwayCommonsiO15075
SignaLinkiO15075

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9201, 5 hits in 900 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DCLK1, human
EvolutionaryTraceiO15075

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DCLK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9201
PharosiO15075, Tchem

Protein Ontology

More...PROi		PR:O15075
RNActiO15075, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133083, Expressed in parietal lobe and 222 other tissues
ExpressionAtlasiO15075, baseline and differential
GenevisibleiO15075, HS

Family and domain databases

Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR003533, Doublecortin_dom
IPR036572, Doublecortin_dom_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF03607, DCX, 2 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00537, DCX, 2 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
SSF89837, SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309, DC, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCLK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15075
Secondary accession number(s): B7Z3E9
, Q5VZY8, Q5VZZ0, Q5VZZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: August 12, 2020
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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