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UniProtKB - O15075 (DCLK1_HUMAN)

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Protein

Serine/threonine-protein kinase DCLK1

Gene

DCLK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei419ATPPROSITE-ProRule annotation1
Active sitei511Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi396 – 404ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • axon extension Source: Ensembl
  • central nervous system development Source: ProtInc
  • central nervous system projection neuron axonogenesis Source: Ensembl
  • dendrite morphogenesis Source: Ensembl
  • endosomal transport Source: UniProtKB
  • forebrain development Source: Ensembl
  • intracellular signal transduction Source: GO_Central
  • negative regulation of protein localization to nucleus Source: Ensembl
  • nervous system development Source: ProtInc
  • neuron migration Source: Ensembl
  • neuron projection morphogenesis Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • peptidyl-threonine phosphorylation Source: GO_Central
  • protein phosphorylation Source: ProtInc
  • response to virus Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiO15075

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Doublecortin domain-containing protein 3A
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:DCLK1
Synonyms:DCAMKL1, DCDC3A, KIAA0369
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133083.14
HGNCiHGNC:2700 DCLK1
MIMi604742 gene
neXtProtiNX_O15075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9201
OpenTargetsiENSG00000133083
PharmGKBiPA162383325

Chemistry databases

ChEMBLiCHEMBL5683
GuidetoPHARMACOLOGYi2005

Polymorphism and mutation databases

BioMutaiDCLK1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859191 – 740Serine/threonine-protein kinase DCLK1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei305PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei353PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei520PhosphotyrosineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15075
MaxQBiO15075
PaxDbiO15075
PeptideAtlasiO15075
PRIDEiO15075
ProteomicsDBi48428
48429 [O15075-2]
48430 [O15075-3]
48431 [O15075-4]

PTM databases

CarbonylDBiO15075
iPTMnetiO15075
PhosphoSitePlusiO15075
SwissPalmiO15075

Expressioni

Tissue specificityi

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000133083
CleanExiHS_DCLK1
ExpressionAtlasiO15075 baseline and differential
GenevisibleiO15075 HS

Organism-specific databases

HPAiCAB012405
HPA015040
HPA015655

Interactioni

Protein-protein interaction databases

BioGridi114635, 78 interactors
IntActiO15075, 71 interactors
STRINGi9606.ENSP00000255448

Chemistry databases

BindingDBiO15075

Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 55Combined sources3
Beta strandi56 – 63Combined sources8
Beta strandi72 – 76Combined sources5
Turni78 – 80Combined sources3
Helixi84 – 95Combined sources12
Beta strandi98 – 101Combined sources4
Beta strandi107 – 110Combined sources4
Helixi120 – 122Combined sources3
Beta strandi128 – 135Combined sources8
Turni142 – 145Combined sources4
Helixi148 – 151Combined sources4
Helixi384 – 389Combined sources6
Beta strandi390 – 398Combined sources9
Beta strandi400 – 409Combined sources10
Turni410 – 412Combined sources3
Beta strandi415 – 422Combined sources8
Beta strandi427 – 429Combined sources3
Helixi436 – 440Combined sources5
Beta strandi451 – 456Combined sources6
Beta strandi458 – 466Combined sources9
Helixi473 – 480Combined sources8
Helixi485 – 504Combined sources20
Helixi514 – 516Combined sources3
Beta strandi517 – 521Combined sources5
Beta strandi527 – 531Combined sources5
Turni551 – 553Combined sources3
Helixi556 – 560Combined sources5
Helixi568 – 582Combined sources15
Helixi596 – 603Combined sources8
Turni610 – 615Combined sources6
Helixi618 – 627Combined sources10
Turni632 – 634Combined sources3
Helixi638 – 643Combined sources6
Helixi645 – 647Combined sources3

3D structure databases

ProteinModelPortaliO15075
SMRiO15075
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15075

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 143Doublecortin 1PROSITE-ProRule annotationAdd BLAST87
Domaini186 – 269Doublecortin 2PROSITE-ProRule annotationAdd BLAST84
Domaini390 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi288 – 340Pro/Ser-richAdd BLAST53
Compositional biasi698 – 701Poly-Arg4

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG3757 Eukaryota
ENOG410YA63 LUCA
GeneTreeiENSGT00840000129744
HOGENOMiHOG000233016
HOVERGENiHBG003790
InParanoidiO15075
KOiK08805
OMAiCASIEPY
OrthoDBiEOG091G02RF
PhylomeDBiO15075
TreeFamiTF318770

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF03607 DCX, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.
Isoform 2 (identifier: O15075-1) [UniParc]FASTAAdd to basket
Also known as: AL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL 
        60         70         80         90        100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN 
       110        120        130        140        150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW 
       160        170        180        190        200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA 
       210        220        230        240        250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG 
       260        270        280        290        300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
       310        320        330        340        350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG 
       360        370        380        390        400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN 
       410        420        430        440        450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL 
       460        470        480        490        500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK 
       510        520        530        540        550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT 
       560        570        580        590        600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 
       610        620        630        640        650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD 
       660        670        680        690        700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR 
       710        720        730        740
RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF
Length:740
Mass (Da):82,224
Last modified:May 30, 2000 - v2
Checksum:iD7B6D855099A315C
GO
Isoform 1 (identifier: O15075-2) [UniParc]FASTAAdd to basket
Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:729
Mass (Da):81,100
Checksum:i32C685F6B308A6BD
GO
Isoform 3 (identifier: O15075-3) [UniParc]FASTAAdd to basket
Also known as: BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

Show »
Length:422
Mass (Da):46,557
Checksum:i945DC91D48ECDB3A
GO
Isoform 4 (identifier: O15075-4) [UniParc]FASTAAdd to basket
Also known as: BL

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE

Show »
Length:433
Mass (Da):47,681
Checksum:i7EA1B5E565ADFC9A
GO

Sequence cautioni

The sequence BAA20824 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04567329G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567446T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04567593R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_045676291S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_045677292R → H1 PublicationCorresponds to variant dbSNP:rs56185003Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0049051 – 307Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST307
Alternative sequenceiVSP_004906308 – 313PASTSS → MLELIE in isoform 3 and isoform 4. 2 Publications6
Alternative sequenceiVSP_004907687 – 740TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002367 mRNA Translation: BAA20824.2 Different initiation.
AL157760
, AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70167.1
AL157760 Genomic DNA Translation: CAH70170.1
AK295777 mRNA Translation: BAH12185.1
AL157760
, AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70168.1
AL160392
, AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70261.1
AL160392
, AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70262.1
AL157694
, AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70656.1
AL157694
, AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70657.1
AL390029
, AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15720.1
AL390029
, AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15721.1
CH471075 Genomic DNA Translation: EAX08550.1
CH471075 Genomic DNA Translation: EAX08551.1
BC152456 mRNA Translation: AAI52457.1
CCDSiCCDS55895.1 [O15075-4]
CCDS73561.1 [O15075-3]
CCDS81762.1 [O15075-1]
CCDS9354.1 [O15075-2]
RefSeqiNP_001182344.1, NM_001195415.1 [O15075-3]
NP_001182345.1, NM_001195416.1 [O15075-4]
NP_001317000.1, NM_001330071.1 [O15075-1]
NP_001317001.1, NM_001330072.1 [O15075-1]
NP_004725.1, NM_004734.4 [O15075-2]
UniGeneiHs.507755
Hs.728619

Genome annotation databases

EnsembliENST00000255448; ENSP00000255448; ENSG00000133083 [O15075-2]
ENST00000360631; ENSP00000353846; ENSG00000133083 [O15075-1]
ENST00000379893; ENSP00000369223; ENSG00000133083 [O15075-4]
ENST00000615680; ENSP00000484452; ENSG00000133083 [O15075-3]
GeneIDi9201
KEGGihsa:9201
UCSCiuc001uve.4 human [O15075-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCLK1_HUMAN
AccessioniPrimary (citable) accession number: O15075
Secondary accession number(s): B7Z3E9
, Q5VZY8, Q5VZZ0, Q5VZZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 18, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

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