DCLK1

Functionⁱ

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	419	ATPPROSITE-ProRule annotation		1
Active siteⁱ	511	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	396 – 404	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 9747029
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon extension Source: Ensembl
central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 10051403
central nervous system projection neuron axonogenesis Source: Ensembl
dendrite morphogenesis Source: Ensembl
endosomal transport
Source: UniProtKB
Non-traceable author statementⁱ
- 14613930
forebrain development Source: Ensembl
intracellular signal transduction Source: InterPro
negative regulation of protein localization to nucleus Source: Ensembl
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 10036192
neuron migration Source: Ensembl
peptidyl-serine phosphorylation Source: Ensembl
protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 9747029
response to virus
Source: UniProtKB
Inferred from expression patternⁱ
- 16548883

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Differentiation, Neurogenesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
SignaLinkⁱ	O15075

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1) Alternative name(s): Doublecortin domain-containing protein 3A Doublecortin-like and CAM kinase-like 1 Doublecortin-like kinase 1
Gene namesⁱ	Name:DCLK1 Synonyms:DCAMKL1, DCDC3A, KIAA0369
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133083.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2700 DCLK1
MIMⁱ	604742 gene
neXtProtⁱ	NX_O15075

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9201
Open Targets More...OpenTargetsⁱ	ENSG00000133083
PharmGKBⁱ	PA162383325

Chemistry databases

ChEMBLⁱ	CHEMBL5683

ChEMBLⁱ

CHEMBL5683

Polymorphism and mutation databases

BioMutaⁱ	DCLK1

BioMutaⁱ

DCLK1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085919	1 – 740	Serine/threonine-protein kinase DCLK1Add BLAST		740

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	32	PhosphoserineBy similarity	1
Modified residueⁱ	36	PhosphoserineBy similarity	1
Modified residueⁱ	46	PhosphothreonineBy similarity	1
Modified residueⁱ	305	PhosphoserineBy similarity	1
Modified residueⁱ	307	PhosphoserineBy similarity	1
Modified residueⁱ	330	PhosphoserineBy similarity	1
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	334	PhosphoserineBy similarity	1
Modified residueⁱ	337	PhosphoserineBy similarity	1
Modified residueⁱ	347	PhosphoserineBy similarity	1
Modified residueⁱ	352	PhosphoserineCombined sources	1
Modified residueⁱ	353	PhosphoserineBy similarity	1
Modified residueⁱ	355	PhosphoserineBy similarity	1
Modified residueⁱ	364	PhosphoserineBy similarity	1
Modified residueⁱ	376	PhosphoserineBy similarity	1
Modified residueⁱ	520	PhosphotyrosineBy similarity	1
Modified residueⁱ	726	PhosphoserineBy similarity	1
Modified residueⁱ	735	PhosphoserineBy similarity	1
Modified residueⁱ	738	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O15075
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15075
PaxDbⁱ	O15075
PeptideAtlas More...PeptideAtlasⁱ	O15075
PRIDEⁱ	O15075
ProteomicsDBⁱ	48428 48429 [O15075-2] 48430 [O15075-3] 48431 [O15075-4]

PTM databases

CarbonylDBⁱ	O15075
iPTMnetⁱ	O15075
PhosphoSitePlusⁱ	O15075
SwissPalmⁱ	O15075

Expressionⁱ

Tissue specificityⁱ

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.1 Publication

Inductionⁱ

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000133083 Expressed in 210 organ(s), highest expression level in parietal lobe
CleanExⁱ	HS_DCLK1
ExpressionAtlasⁱ	O15075 baseline and differential
Genevisibleⁱ	O15075 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB012405 HPA015040 HPA015655

HPAⁱ

CAB012405
HPA015040
HPA015655

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114635, 78 interactors
IntActⁱ	O15075, 8 interactors
STRINGⁱ	9606.ENSP00000255448

Chemistry databases

BindingDBⁱ

O15075

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	53 – 55	Combined sources	3
Beta strandⁱ	56 – 63	Combined sources	8
Beta strandⁱ	72 – 76	Combined sources	5
Turnⁱ	78 – 80	Combined sources	3
Helixⁱ	84 – 95	Combined sources	12
Beta strandⁱ	98 – 101	Combined sources	4
Beta strandⁱ	107 – 110	Combined sources	4
Helixⁱ	120 – 122	Combined sources	3
Beta strandⁱ	128 – 135	Combined sources	8
Turnⁱ	142 – 145	Combined sources	4
Helixⁱ	148 – 151	Combined sources	4
Helixⁱ	384 – 389	Combined sources	6
Beta strandⁱ	390 – 398	Combined sources	9
Beta strandⁱ	400 – 409	Combined sources	10
Turnⁱ	410 – 412	Combined sources	3
Beta strandⁱ	415 – 422	Combined sources	8
Beta strandⁱ	427 – 429	Combined sources	3
Helixⁱ	436 – 440	Combined sources	5
Beta strandⁱ	451 – 456	Combined sources	6
Beta strandⁱ	458 – 466	Combined sources	9
Helixⁱ	473 – 480	Combined sources	8
Helixⁱ	485 – 504	Combined sources	20
Helixⁱ	514 – 516	Combined sources	3
Beta strandⁱ	517 – 521	Combined sources	5
Beta strandⁱ	527 – 531	Combined sources	5
Turnⁱ	551 – 553	Combined sources	3
Helixⁱ	556 – 560	Combined sources	5
Helixⁱ	568 – 582	Combined sources	15
Helixⁱ	596 – 603	Combined sources	8
Turnⁱ	610 – 615	Combined sources	6
Helixⁱ	618 – 627	Combined sources	10
Turnⁱ	632 – 634	Combined sources	3
Helixⁱ	638 – 643	Combined sources	6
Helixⁱ	645 – 647	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O15075
SMRⁱ	O15075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O15075

EvolutionaryTraceⁱ

O15075

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	57 – 143	Doublecortin 1PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	186 – 269	Doublecortin 2PROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	390 – 647	Protein kinasePROSITE-ProRule annotationAdd BLAST	258

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	288 – 340	Pro/Ser-richAdd BLAST		53
Compositional biasⁱ	698 – 701	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota KOG3757 Eukaryota ENOG410YA63 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG003790
InParanoidⁱ	O15075
KEGG Orthology (KO) More...KOⁱ	K08805
OMAⁱ	CASIEPY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02RF
PhylomeDBⁱ	O15075
TreeFamⁱ	TF318770

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01617 DCX, 2 hits
Gene3Dⁱ	3.10.20.230, 2 hits
InterProⁱ	View protein in InterPro IPR003533 Doublecortin_dom IPR036572 Doublecortin_dom_sf IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03607 DCX, 2 hits PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00537 DCX, 2 hits SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit SSF89837 SSF89837, 2 hits
PROSITEⁱ	View protein in PROSITE PS50309 DC, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 2 (identifier: O15075-1) [UniParc]FASTA Add to basket

Also known as: AL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL 
        60         70         80         90        100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN 
       110        120        130        140        150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW 
       160        170        180        190        200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA 
       210        220        230        240        250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG 
       260        270        280        290        300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
       310        320        330        340        350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG 
       360        370        380        390        400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN 
       410        420        430        440        450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL 
       460        470        480        490        500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK 
       510        520        530        540        550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT 
       560        570        580        590        600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 
       610        620        630        640        650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD 
       660        670        680        690        700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR 
       710        720        730        740
RNQDVRSRYK AQPAPPELNS ESEDYSPSSS ETVRSPNSPF

Length:740

Mass (Da):82,224

Last modified:May 30, 2000 - v2

Checksum:ⁱD7B6D855099A315C

GO

Isoform 1 (identifier: O15075-2) [UniParc]FASTA Add to basket

Also known as: AS

The sequence of this isoform differs from the canonical sequence as follows:
687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

« Hide

        10         20         30         40         50
MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL 
        60         70         80         90        100
SSEKKAKKVR FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN 
       110        120        130        140        150
LPQGVRTIYT IDGLKKISSL DQLVEGESYV CGSIEPFKKL EYTKNVNPNW 
       160        170        180        190        200
SVNVKTTSAS RAVSSLATAK GSPSEVRENK DFIRPKLVTI IRSGVKPRKA 
       210        220        230        240        250
VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK QVMCLQDFFG 
       260        270        280        290        300
DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 
       310        320        330        340        350
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG 
       360        370        380        390        400
GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN 
       410        420        430        440        450
FAVVKECVER STAREYALKI IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL 
       460        470        480        490        500
LIEEMDVPTE LYLVMELVKG GDLFDAITST NKYTERDASG MLYNLASAIK 
       510        520        530        540        550
YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV DGPLYTVCGT 
       560        570        580        590        600
PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 
       610        620        630        640        650
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD 
       660        670        680        690        700
GLPENEHQLS VAGKIKKHFN TGPKPNSTAA GVSVIALDHG FTIKRSGSLD 
       710        720 
YYQQPGMYWI RPPLLIRRGR FSDEDATRM

Show »

Length:729

Mass (Da):81,100

Checksum:ⁱ32C685F6B308A6BD

GO

Isoform 3 (identifier: O15075-3) [UniParc]FASTA Add to basket

Also known as: BS

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-313: PASTSS → MLELIE
     687-740: TTALDKERQV...ETVRSPNSPF → LDHGFTIKRS...RFSDEDATRM

« Hide

        10         20         30         40         50
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRSS QHGGSSTSLA 
        60         70         80         90        100
STKVCSSMDE NDGPGEEVSE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC 
       110        120        130        140        150
VERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV 
       160        170        180        190        200
PTELYLVMEL VKGGDLFDAI TSTNKYTERD ASGMLYNLAS AIKYLHSLNI 
       210        220        230        240        250
VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE 
       260        270        280        290        300
IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 
       310        320        330        340        350
FPSPYWDNVS DSAKELITMM LLVDVDQRFS AVQVLEHPWV NDDGLPENEH 
       360        370        380        390        400
QLSVAGKIKK HFNTGPKPNS TAAGVSVIAL DHGFTIKRSG SLDYYQQPGM 
       410        420 
YWIRPPLLIR RGRFSDEDAT RM

Show »

Length:422

Mass (Da):46,557

Checksum:ⁱ945DC91D48ECDB3A

GO

Isoform 4 (identifier: O15075-4) [UniParc]FASTA Add to basket

Also known as: BL

The sequence of this isoform differs from the canonical sequence as follows:
1-307: Missing.
308-313: PASTSS → MLELIE

« Hide

        10         20         30         40         50
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRSS QHGGSSTSLA 
        60         70         80         90        100
STKVCSSMDE NDGPGEEVSE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC 
       110        120        130        140        150
VERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV 
       160        170        180        190        200
PTELYLVMEL VKGGDLFDAI TSTNKYTERD ASGMLYNLAS AIKYLHSLNI 
       210        220        230        240        250
VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE 
       260        270        280        290        300
IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 
       310        320        330        340        350
FPSPYWDNVS DSAKELITMM LLVDVDQRFS AVQVLEHPWV NDDGLPENEH 
       360        370        380        390        400
QLSVAGKIKK HFNTGPKPNS TAAGVSVIAT TALDKERQVF RRRRNQDVRS 
       410        420        430 
RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF

Show »

Length:433

Mass (Da):47,681

Checksum:ⁱ7EA1B5E565ADFC9A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5VZY9	Q5VZY9_HUMAN		Serine/threonine-protein kinase DCL... Serine/threonine-protein kinase DCLK1	DCLK1	363	Annotation score:

Sequence cautionⁱ

The sequence BAA20824 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_045673	29	G → C in a gastric adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_045674	46	T → M in a gastric adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_045675	93	R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_045676	291	S → F in a gastric adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_045677	292	R → H1 PublicationCorresponds to variant dbSNP:rs56185003Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004905	1 – 307	Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	307
Alternative sequenceⁱVSP_004906	308 – 313	PASTSS → MLELIE in isoform 3 and isoform 4. 2 Publications	6
Alternative sequenceⁱVSP_004907	687 – 740	TTALD…PNSPF → LDHGFTIKRSGSLDYYQQPG MYWIRPPLLIRRGRFSDEDA TRM in isoform 1 and isoform 3. 5 PublicationsAdd BLAST	54

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002367 mRNA Translation: BAA20824.2 Different initiation. AL157760 , AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70167.1 AL157760 Genomic DNA Translation: CAH70170.1 AK295777 mRNA Translation: BAH12185.1 AL157760 , AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70168.1 AL160392 , AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70261.1 AL160392 , AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70262.1 AL157694 , AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70656.1 AL157694 , AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70657.1 AL390029 , AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15720.1 AL390029 , AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15721.1 CH471075 Genomic DNA Translation: EAX08550.1 CH471075 Genomic DNA Translation: EAX08551.1 BC152456 mRNA Translation: AAI52457.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55895.1 [O15075-4] CCDS73561.1 [O15075-3] CCDS81762.1 [O15075-1] CCDS9354.1 [O15075-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182344.1, NM_001195415.1 [O15075-3] NP_001182345.1, NM_001195416.1 [O15075-4] NP_001317000.1, NM_001330071.1 [O15075-1] NP_001317001.1, NM_001330072.1 [O15075-1] NP_004725.1, NM_004734.4 [O15075-2]
UniGeneⁱ	Hs.507755 Hs.728619

Genome annotation databases

Ensemblⁱ	ENST00000255448; ENSP00000255448; ENSG00000133083 [O15075-2] ENST00000360631; ENSP00000353846; ENSG00000133083 [O15075-1] ENST00000379893; ENSP00000369223; ENSG00000133083 [O15075-4] ENST00000615680; ENSP00000484452; ENSG00000133083 [O15075-3]
GeneIDⁱ	9201
KEGGⁱ	hsa:9201
UCSC genome browser More...UCSCⁱ	uc001uve.4 human [O15075-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O15075	Uncharacterized protein		CERAT		751	UniRef100_O15075
DCLK1 isoform 1		PANTR		740
Doublecortin like kinase 1		MACMU		740
Doublecortin like kinase 1		MACFA		740
Doublecortin like kinase 1		SAIBB		740
+14
O15075-2	Doublecortin like kinase 1		MACMU		729	UniRef100_F7CZC3
Doublecortin like kinase 1		CALJA		729
DCLK1 isoform 3		PANTR		729
Doublecortin like kinase 1		SAIBB		729
Uncharacterized protein		Cebus capucinus imitator		729
+12
O15075-3	Serine/threonine-protein kinase DCLK1 isoform 2		CALJA		422	UniRef100_U3EL01
DCLK1 isoform 1		PONAB		422
DCLK1 isoform 4		PANTR		422
serine/threonine-protein kinase DCLK1 isoform X3		NEOSC		422
O15075-4	Doublecortin like kinase 1		CALJA		433	UniRef100_F6U1Q8
DCLK1 isoform 6		PANTR		433
Doublecortin like kinase 1		SAIBB		433
Uncharacterized protein		Cebus capucinus imitator		433
Uncharacterized protein		COLAP		433
+12

Protein	Similar proteins		Species	Score	Length	Source
O15075	Serine/threonine-protein kinase DCLK1		MOUSE		756	UniRef90_O15075
Uncharacterized protein		CERAT		751
DCLK1 isoform 1		PANTR		740
Doublecortin like kinase 1		MACMU		740
Doublecortin like kinase 1		MACFA		740
+321
O15075-3	CLICK-I		MOUSE		421	UniRef90_Q1EDH1
Doublecortin like kinase 1		PIG		423
Uncharacterized protein		BOVIN		423
Uncharacterized protein		ICTTR		422
serine/threonine-protein kinase DCLK1 isoform X4		ODORO		422
+47
O15075-4	Serine/threonine-protein kinase DCLK1		RAT		433	UniRef90_O08875
Uncharacterized protein		PELSI		502
Serine/threonine-protein kinase DCLK1 (Fragment)		CALAN		500
serine/threonine-protein kinase DCLK1 isoform X2		DIPOR		498
Serine/threonine-protein kinase DCLK1		TUPCH		497
+123

Protein	Similar proteins		Species	Score	Length	Source
O15075	Serine/threonine-protein kinase DCLK2		MOUSE		756	UniRef50_Q6PGN3
Serine/threonine-protein kinase DCLK2		AILME		784
Serine/threonine-protein kinase DCLK2		RAT		767
Serine/threonine-protein kinase DCLK2		HUMAN		766
Uncharacterized protein		PIG		790
+863
O15075-3	CLICK-I		MOUSE		421	UniRef50_Q1EDH1
Doublecortin like kinase 1		PIG		423
Uncharacterized protein		BOVIN		423
Uncharacterized protein		CAVPO		422
Uncharacterized protein		FELCA		422
+63
O15075-4	Serine/threonine-protein kinase DCLK1		RAT		433	UniRef50_O08875
Uncharacterized protein		PELSI		502
Serine/threonine-protein kinase DCLK1 (Fragment)		CALAN		500
serine/threonine-protein kinase DCLK1 isoform X2		DIPOR		498
Serine/threonine-protein kinase DCLK1		TUPCH		497
+173

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002367 mRNA Translation: BAA20824.2 Different initiation. AL157760 , AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70167.1 AL157760 Genomic DNA Translation: CAH70170.1 AK295777 mRNA Translation: BAH12185.1 AL157760 , AL157694, AL160392, AL390029 Genomic DNA Translation: CAH70168.1 AL160392 , AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70261.1 AL160392 , AL157694, AL157760, AL390029 Genomic DNA Translation: CAH70262.1 AL157694 , AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70656.1 AL157694 , AL157760, AL160392, AL390029 Genomic DNA Translation: CAH70657.1 AL390029 , AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15720.1 AL390029 , AL157694, AL157760, AL160392 Genomic DNA Translation: CAI15721.1 CH471075 Genomic DNA Translation: EAX08550.1 CH471075 Genomic DNA Translation: EAX08551.1 BC152456 mRNA Translation: AAI52457.1
CCDSⁱ	CCDS55895.1 [O15075-4] CCDS73561.1 [O15075-3] CCDS81762.1 [O15075-1] CCDS9354.1 [O15075-2]
RefSeqⁱ	NP_001182344.1, NM_001195415.1 [O15075-3] NP_001182345.1, NM_001195416.1 [O15075-4] NP_001317000.1, NM_001330071.1 [O15075-1] NP_001317001.1, NM_001330072.1 [O15075-1] NP_004725.1, NM_004734.4 [O15075-2]
UniGeneⁱ	Hs.507755 Hs.728619

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1MFW	X-ray	1.60	A	49-154	[»]
	1MG4	X-ray	1.50	A	49-154	[»]
	1UF0	NMR	-	A	54-156	[»]
	5JZJ	X-ray	1.71	A/B	372-649	[»]
	5JZN	X-ray	2.85	A/B	372-649	[»]
ProteinModelPortalⁱ	O15075
SMRⁱ	O15075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114635, 78 interactors
IntActⁱ	O15075, 8 interactors
STRINGⁱ	9606.ENSP00000255448

Chemistry databases

BindingDBⁱ	O15075
ChEMBLⁱ	CHEMBL5683

PTM databases

CarbonylDBⁱ	O15075
iPTMnetⁱ	O15075
PhosphoSitePlusⁱ	O15075
SwissPalmⁱ	O15075

Polymorphism and mutation databases

BioMutaⁱ	DCLK1

BioMutaⁱ

DCLK1

Proteomic databases

EPDⁱ	O15075
MaxQBⁱ	O15075
PaxDbⁱ	O15075
PeptideAtlasⁱ	O15075
PRIDEⁱ	O15075
ProteomicsDBⁱ	48428 48429 [O15075-2] 48430 [O15075-3] 48431 [O15075-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9201
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000255448; ENSP00000255448; ENSG00000133083 [O15075-2] ENST00000360631; ENSP00000353846; ENSG00000133083 [O15075-1] ENST00000379893; ENSP00000369223; ENSG00000133083 [O15075-4] ENST00000615680; ENSP00000484452; ENSG00000133083 [O15075-3]
GeneIDⁱ	9201
KEGGⁱ	hsa:9201
UCSCⁱ	uc001uve.4 human [O15075-1]

Organism-specific databases

CTDⁱ	9201
DisGeNETⁱ	9201
EuPathDBⁱ	HostDB:ENSG00000133083.14
GeneCardsⁱ	DCLK1
HGNCⁱ	HGNC:2700 DCLK1
HPAⁱ	CAB012405 HPA015040 HPA015655
MIMⁱ	604742 gene
neXtProtⁱ	NX_O15075
OpenTargetsⁱ	ENSG00000133083
PharmGKBⁱ	PA162383325
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota KOG3757 Eukaryota ENOG410YA63 LUCA
GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG003790
InParanoidⁱ	O15075
KOⁱ	K08805
OMAⁱ	CASIEPY
OrthoDBⁱ	EOG091G02RF
PhylomeDBⁱ	O15075
TreeFamⁱ	TF318770

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
SignaLinkⁱ	O15075

Miscellaneous databases

ChiTaRSⁱ	DCLK1 human
EvolutionaryTraceⁱ	O15075
GeneWikiⁱ	DCLK1
GenomeRNAiⁱ	9201
Protein Ontology More...PROⁱ	PR:O15075
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133083 Expressed in 210 organ(s), highest expression level in parietal lobe
CleanExⁱ	HS_DCLK1
ExpressionAtlasⁱ	O15075 baseline and differential
Genevisibleⁱ	O15075 HS

Family and domain databases

CDDⁱ	cd01617 DCX, 2 hits
Gene3Dⁱ	3.10.20.230, 2 hits
InterProⁱ	View protein in InterPro IPR003533 Doublecortin_dom IPR036572 Doublecortin_dom_sf IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF03607 DCX, 2 hits PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00537 DCX, 2 hits SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit SSF89837 SSF89837, 2 hits
PROSITEⁱ	View protein in PROSITE PS50309 DC, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCLK1_HUMAN
Accessionⁱ	O15075Primary (citable) accession number: O15075 Secondary accession number(s): B7Z3E9 , Q5VZY8, Q5VZZ0, Q5VZZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - O15075 (DCLK1_HUMAN)

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Serine/threonine-protein kinase DCLK1

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

GO - Molecular functionⁱ

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Pathology & Biotechⁱ

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Keywords - PTMⁱ

Expressionⁱ

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Keywords - Domainⁱ

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Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ