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Protein

Phosphoribosylformylglycinamidine synthase

Gene

PFAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (PFAS)
  2. Trifunctional purine biosynthetic protein adenosine-3 (GART), Trifunctional purine biosynthetic protein adenosine-3, Trifunctional purine biosynthetic protein adenosine-3 (GART)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei706ATP; via carbonyl oxygenBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi707MagnesiumBy similarity1
Metal bindingi746MagnesiumBy similarity1
Metal bindingi750MagnesiumBy similarity1
Metal bindingi909MagnesiumBy similarity1
Binding sitei911ATPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1158NucleophileBy similarity1
Active sitei1297By similarity1
Active sitei1299By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi322 – 333ATPSequence analysisAdd BLAST12
Nucleotide bindingi402 – 404ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • phosphoribosylformylglycinamidine synthase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS11329-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00074;UER00128

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C56.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3)
Short name:
FGAM synthase
Short name:
FGAMS
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Short name:
FGAR amidotransferase
Short name:
FGAR-AT
Formylglycinamide ribotide amidotransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PFAS
Synonyms:KIAA0361
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178921.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8863 PFAS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602133 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15067

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5198

Open Targets

More...
OpenTargetsi
ENSG00000178921

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00142 L-Glutamic Acid
DB00130 L-Glutamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PFAS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001004011 – 1338Phosphoribosylformylglycinamidine synthaseAdd BLAST1338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei215PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei619PhosphothreonineCombined sources1
Modified residuei623PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15067

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15067

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15067

PeptideAtlas

More...
PeptideAtlasi
O15067

PRoteomics IDEntifications database

More...
PRIDEi
O15067

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48417

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15067

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15067

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178921 Expressed in 205 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_PFAS

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15067 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15067 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022140
HPA022886

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111221, 79 interactors

Protein interaction database and analysis system

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IntActi
O15067, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15067

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15067

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1064 – 1302Glutamine amidotransferase type-1Add BLAST239

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the FGAMS family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1907 Eukaryota
COG0046 LUCA
COG0047 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261358

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108309

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15067

KEGG Orthology (KO)

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KOi
K01952

Identification of Orthologs from Complete Genome Data

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OMAi
SLSANWM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00SI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15067

TreeFam database of animal gene trees

More...
TreeFami
TF106371

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.10, 2 hits
3.40.50.880, 1 hit
3.90.650.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00419 PurL_1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010073 PRibForGlyAmidine_synth
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR036921 PurM-like_N_sf
IPR036604 PurS-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02769 AIRS_C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317 SSF52317, 1 hit
SSF55326 SSF55326, 2 hits
SSF56042 SSF56042, 2 hits
SSF82697 SSF82697, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01735 FGAM_synt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O15067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPVLHFYVR PSGHEGAAPG HTRRKLQGKL PELQGVETEL CYNVNWTAEA
60 70 80 90 100
LPSAEETKKL MWLFGCPLLL DDVARESWLL PGSNDLLLEV GPRLNFSTPT
110 120 130 140 150
STNIVSVCRA TGLGPVDRVE TTRRYRLSFA HPPSAEVEAI ALATLHDRMT
160 170 180 190 200
EQHFPHPIQS FSPESMPEPL NGPINILGEG RLALEKANQE LGLALDSWDL
210 220 230 240 250
DFYTKRFQEL QRNPSTVEAF DLAQSNSEHS RHWFFKGQLH VDGQKLVHSL
260 270 280 290 300
FESIMSTQES SNPNNVLKFC DNSSAIQGKE VRFLRPEDPT RPSRFQQQQG
310 320 330 340 350
LRHVVFTAET HNFPTGVCPF SGATTGTGGR IRDVQCTGRG AHVVAGTAGY
360 370 380 390 400
CFGNLHIPGY NLPWEDPSFQ YPGNFARPLE VAIEASNGAS DYGNKFGEPV
410 420 430 440 450
LAGFARSLGL QLPDGQRREW IKPIMFSGGI GSMEADHISK EAPEPGMEVV
460 470 480 490 500
KVGGPVYRIG VGGGAASSVQ VQGDNTSDLD FGAVQRGDPE MEQKMNRVIR
510 520 530 540 550
ACVEAPKGNP ICSLHDQGAG GNGNVLKELS DPAGAIIYTS RFQLGDPTLN
560 570 580 590 600
ALEIWGAEYQ ESNALLLRSP NRDFLTHVSA RERCPACFVG TITGDRRIVL
610 620 630 640 650
VDDRECPVRR NGQGDAPPTP LPTPVDLELE WVLGKMPRKE FFLQRKPPML
660 670 680 690 700
QPLALPPGLS VHQALERVLR LPAVASKRYL TNKVDRSVGG LVAQQQCVGP
710 720 730 740 750
LQTPLADVAV VALSHEELIG AATALGEQPV KSLLDPKVAA RLAVAEALTN
760 770 780 790 800
LVFALVTDLR DVKCSGNWMW AAKLPGEGAA LADACEAMVA VMAALGVAVD
810 820 830 840 850
GGKDSLSMAA RVGTETVRAP GSLVISAYAV CPDITATVTP DLKHPEGRGH
860 870 880 890 900
LLYVALSPGQ HRLGGTALAQ CFSQLGEHPP DLDLPENLVR AFSITQGLLK
910 920 930 940 950
DRLLCSGHDV SDGGLVTCLL EMAFAGNCGL QVDVPVPRVD VLSVLFAEEP
960 970 980 990 1000
GLVLEVQEPD LAQVLKRYRD AGLHCLELGH TGEAGPHAMV RVSVNGAVVL
1010 1020 1030 1040 1050
EEPVGELRAL WEETSFQLDR LQAEPRCVAE EERGLRERMG PSYCLPPTFP
1060 1070 1080 1090 1100
KASVPREPGG PSPRVAILRE EGSNGDREMA DAFHLAGFEV WDVTMQDLCS
1110 1120 1130 1140 1150
GAIGLDTFRG VAFVGGFSYA DVLGSAKGWA AAVTFHPRAG AELRRFRKRP
1160 1170 1180 1190 1200
DTFSLGVCNG CQLLALLGWV GGDPNEDAAE MGPDSQPARP GLLLRHNLSG
1210 1220 1230 1240 1250
RYESRWASVR VGPGPALMLR GMEGAVLPVW SAHGEGYVAF SSPELQAQIE
1260 1270 1280 1290 1300
ARGLAPLHWA DDDGNPTEQY PLNPNGSPGG VAGICSCDGR HLAVMPHPER
1310 1320 1330
AVRPWQWAWR PPPFDTLTTS PWLQLFINAR NWTLEGSC
Length:1,338
Mass (Da):144,734
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i273405025B701DAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGH1H0YGH1_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT98J3KT98_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTQ5J3KTQ5_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTL4J3KTL4_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSH6J3QSH6_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSG0J3QSG0_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL39J3QL39_HUMAN
Phosphoribosylformylglycinamidine s...
PFAS
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20816 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1326F → S (PubMed:10548741).Curated1
Sequence conflicti1326F → S in BAA20816 (PubMed:9205841).Curated1
Sequence conflicti1326F → S in AAI46769 (PubMed:15489334).Curated1
Sequence conflicti1326F → S in AAI67158 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05500819P → S3 PublicationsCorresponds to variant dbSNP:rs9891699Ensembl.1
Natural variantiVAR_055009367P → L3 PublicationsCorresponds to variant dbSNP:rs4791641Ensembl.1
Natural variantiVAR_055010481F → Y. Corresponds to variant dbSNP:rs35217368Ensembl.1
Natural variantiVAR_055011621L → PCombined sources3 PublicationsCorresponds to variant dbSNP:rs11078738Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB002359 mRNA Translation: BAA20816.1 Different initiation.
AC135178 Genomic DNA No translation available.
BC146768 mRNA Translation: AAI46769.1
BC167158 mRNA Translation: AAI67158.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11136.1

NCBI Reference Sequences

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RefSeqi
NP_036525.1, NM_012393.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.573976

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314666; ENSP00000313490; ENSG00000178921

Database of genes from NCBI RefSeq genomes

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GeneIDi
5198

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5198

UCSC genome browser

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UCSCi
uc002gkr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002359 mRNA Translation: BAA20816.1 Different initiation.
AC135178 Genomic DNA No translation available.
BC146768 mRNA Translation: AAI46769.1
BC167158 mRNA Translation: AAI67158.1
CCDSiCCDS11136.1
RefSeqiNP_036525.1, NM_012393.2
UniGeneiHs.573976

3D structure databases

ProteinModelPortaliO15067
SMRiO15067
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111221, 79 interactors
IntActiO15067, 11 interactors
STRINGi9606.ENSP00000313490

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
DB00130 L-Glutamine

Protein family/group databases

MEROPSiC56.972

PTM databases

iPTMnetiO15067
PhosphoSitePlusiO15067

Polymorphism and mutation databases

BioMutaiPFAS

Proteomic databases

EPDiO15067
MaxQBiO15067
PaxDbiO15067
PeptideAtlasiO15067
PRIDEiO15067
ProteomicsDBi48417

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314666; ENSP00000313490; ENSG00000178921
GeneIDi5198
KEGGihsa:5198
UCSCiuc002gkr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5198
DisGeNETi5198
EuPathDBiHostDB:ENSG00000178921.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PFAS

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0019361
HGNCiHGNC:8863 PFAS
HPAiHPA022140
HPA022886
MIMi602133 gene
neXtProtiNX_O15067
OpenTargetsiENSG00000178921

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1907 Eukaryota
COG0046 LUCA
COG0047 LUCA
GeneTreeiENSGT00390000007600
HOGENOMiHOG000261358
HOVERGENiHBG108309
InParanoidiO15067
KOiK01952
OMAiSLSANWM
OrthoDBiEOG091G00SI
PhylomeDBiO15067
TreeFamiTF106371

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00128

BioCyciMetaCyc:HS11329-MONOMER
ReactomeiR-HSA-73817 Purine ribonucleoside monophosphate biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PFAS human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5198

Protein Ontology

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PROi
PR:O15067

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000178921 Expressed in 205 organ(s), highest expression level in female gonad
CleanExiHS_PFAS
ExpressionAtlasiO15067 baseline and differential
GenevisibleiO15067 HS

Family and domain databases

Gene3Di3.30.1330.10, 2 hits
3.40.50.880, 1 hit
3.90.650.10, 2 hits
HAMAPiMF_00419 PurL_1, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010073 PRibForGlyAmidine_synth
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR036921 PurM-like_N_sf
IPR036604 PurS-like_sf
PfamiView protein in Pfam
PF02769 AIRS_C, 2 hits
SUPFAMiSSF52317 SSF52317, 1 hit
SSF55326 SSF55326, 2 hits
SSF56042 SSF56042, 2 hits
SSF82697 SSF82697, 1 hit
TIGRFAMsiTIGR01735 FGAM_synt, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUR4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15067
Secondary accession number(s): A6H8V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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