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Entry version 125 (08 May 2019)
Sequence version 2 (23 Sep 2008)
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Protein

Uncharacterized protein KIAA0355

Gene

KIAA0355

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein KIAA0355
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29016 KIAA0355

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15063

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000166398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927016

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA0355

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507481 – 1070Uncharacterized protein KIAA0355Add BLAST1070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei723PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15063

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15063

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15063

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15063

PeptideAtlas

More...
PeptideAtlasi
O15063

PRoteomics IDEntifications database

More...
PRIDEi
O15063

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48415

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15063

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15063

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166398 Expressed in 220 organ(s), highest expression level in tibia

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15063 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15063 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014570

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115061, 12 interactors

Protein interaction database and analysis system

More...
IntActi
O15063, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299505

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi551 – 555Poly-Ser5
Compositional biasi695 – 700Poly-Pro6
Compositional biasi1037 – 1044Poly-Pro8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFZG Eukaryota
ENOG4110CME LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113145

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15063

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCFAEVV

Database of Orthologous Groups

More...
OrthoDBi
1533370at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15063

TreeFam database of animal gene trees

More...
TreeFami
TF328377

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031813 DUF4745

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15923 DUF4745, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O15063-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYCCSAQDSK MDYKRRFLLG GSKQKVQQHQ QYPMPELGRA LSAPLASTAT
60 70 80 90 100
TAPLGSLTAA GSCHHAMPHT TPIADIQQGI SKYLDALNVF CRASTFLTDL
110 120 130 140 150
FSTVFRNSHY SKAATQLKDV QEHVMEAASR LTSAIKPEIA KMLMELSAGA
160 170 180 190 200
ANFTDQKEFS LQDIEVLGRC FLTVVQVHFQ FLTHALQKVQ PVAHSCFAEV
210 220 230 240 250
IVPEKKNSGS GGGLSGMGHT PEVEEAVRSW RGAAEATSRL RERGCDGCLA
260 270 280 290 300
GIEVQQLFCS QSAAIPEHQL KELNIKIDSA LQAYKIALES LGHCEYAMKA
310 320 330 340 350
GFHLNPKAIE ASLQGCCSEA EAQQTGRRQT PPQPMQCELP TVPVQIGSHF
360 370 380 390 400
LKGVSFNESA ADNLKLKTHT MLQLMKEAGC YNGITSRDDF PVTEVLNQVC
410 420 430 440 450
PSTWRGACKT AVQLLFGQAG LVVVDTAQIE NKEAYAPQIS LEGSRIVVQV
460 470 480 490 500
PSTWCLKEDP ATMSLLQRSL DPEKTLGLVD VLYTAVLDLN RWRAGREQAL
510 520 530 540 550
PCIQIQLQRE ICDFGNQADL PSGNGNKSSG GLQKTFSKLT SRFTKKASCT
560 570 580 590 600
SSSSSTNYSI QNTPSKNIFI AGCSEEKAKM PGNIDTRLQS ILNIGNFPRT
610 620 630 640 650
TDPSQSAQNS SNTVANGFLM ERRENFLHGD DGKDEKGMNL PTDQEMQEVI
660 670 680 690 700
DFLSGFNMGQ SHQGSPLVTR HNSAATAMVT EQKAGAMQPQ QPSLPVPPPP
710 720 730 740 750
RAPQAGAHTP LTPQPGLAPQ QQSPKQQQPQ VQYYQHLLQP IGPQQPPPQP
760 770 780 790 800
RAPGKWVHGS SQQPAQAVGA GLSPLGQWPG ISDLSSDLYS LGLVSSYMDN
810 820 830 840 850
VMSEVLGQKP QGPRNNTWPN RDQSDGVFGM LGEILPFDPA VGSDPEFARY
860 870 880 890 900
VAGVSQAMQQ KRQAQHGRRP GNPRGNWPPM DDAHRTWPFP EFFTEGDGLH
910 920 930 940 950
GGWSGAQGDS ASSSDETSSA NGDSLFSMFS GPDLVAAVKQ RRKHSSGEQD
960 970 980 990 1000
TSTLPSPPLL TTVEDVNQDN KTKTWPPKAP WQHPSPLPST LPSPSAPLYA
1010 1020 1030 1040 1050
VTSPGSQWND TMQMLQSPVW AATNDCSAAA FSYVQTPPQP PPPPAHKAAP
1060 1070
KGFKAFPGKG ERRPAYLPQY
Length:1,070
Mass (Da):116,020
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8A0D57717F1D89C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPV0U3KPV0_HUMAN
Uncharacterized protein KIAA0355
KIAA0355
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPA0K7EPA0_HUMAN
Uncharacterized protein KIAA0355
KIAA0355
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQ76A0A0G2JQ76_HUMAN
Uncharacterized protein KIAA0355
KIAA0355
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQ84A0A0G2JQ84_HUMAN
Uncharacterized protein KIAA0355
KIAA0355
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXL1A0A0J9YXL1_HUMAN
Uncharacterized protein KIAA0355
KIAA0355
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20812 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127A → V in BAA20812 (PubMed:9205841).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB002353 mRNA Translation: BAA20812.2 Different initiation.
BC104761 mRNA Translation: AAI04762.1
BC104763 mRNA Translation: AAI04764.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12436.1

NCBI Reference Sequences

More...
RefSeqi
NP_055501.2, NM_014686.3
XP_005259501.1, XM_005259444.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299505; ENSP00000299505; ENSG00000166398

Database of genes from NCBI RefSeq genomes

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GeneIDi
9710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9710

UCSC genome browser

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UCSCi
uc002nvd.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002353 mRNA Translation: BAA20812.2 Different initiation.
BC104761 mRNA Translation: AAI04762.1
BC104763 mRNA Translation: AAI04764.1
CCDSiCCDS12436.1
RefSeqiNP_055501.2, NM_014686.3
XP_005259501.1, XM_005259444.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115061, 12 interactors
IntActiO15063, 6 interactors
STRINGi9606.ENSP00000299505

PTM databases

iPTMnetiO15063
PhosphoSitePlusiO15063

Polymorphism and mutation databases

BioMutaiKIAA0355

Proteomic databases

EPDiO15063
jPOSTiO15063
MaxQBiO15063
PaxDbiO15063
PeptideAtlasiO15063
PRIDEiO15063
ProteomicsDBi48415

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299505; ENSP00000299505; ENSG00000166398
GeneIDi9710
KEGGihsa:9710
UCSCiuc002nvd.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9710

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA0355
HGNCiHGNC:29016 KIAA0355
HPAiHPA014570
neXtProtiNX_O15063
OpenTargetsiENSG00000166398
PharmGKBiPA134927016

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFZG Eukaryota
ENOG4110CME LUCA
GeneTreeiENSGT00390000003210
HOGENOMiHOG000113145
InParanoidiO15063
OMAiSCFAEVV
OrthoDBi1533370at2759
PhylomeDBiO15063
TreeFamiTF328377

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0355 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9710

Protein Ontology

More...
PROi
PR:O15063

Gene expression databases

BgeeiENSG00000166398 Expressed in 220 organ(s), highest expression level in tibia
ExpressionAtlasiO15063 baseline and differential
GenevisibleiO15063 HS

Family and domain databases

InterProiView protein in InterPro
IPR031813 DUF4745
PfamiView protein in Pfam
PF15923 DUF4745, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK0355_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15063
Secondary accession number(s): Q2M3W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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