ZBTB5

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	613 – 635	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	641 – 664	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 19491398
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 19491398

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 19491398
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 5
Gene namesⁱ	Name:ZBTB5 Synonyms:KIAA0354
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168795.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23836 ZBTB5
MIMⁱ	616590 gene
neXtProtⁱ	NX_O15062

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9925
Open Targets More...OpenTargetsⁱ	ENSG00000168795
PharmGKBⁱ	PA134969268

Polymorphism and mutation databases

BioMutaⁱ	ZBTB5

BioMutaⁱ

ZBTB5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047713	1 – 677	Zinc finger and BTB domain-containing protein 5Add BLAST		677

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	234	PhosphoserineCombined sources	1
Cross-linkⁱ	239	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	322	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	330	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	371	PhosphoserineCombined sources	1
Cross-linkⁱ	404	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	415	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	541	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	594	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	597	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	645	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	658	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O15062
PaxDbⁱ	O15062
PeptideAtlas More...PeptideAtlasⁱ	O15062
PRIDEⁱ	O15062
ProteomicsDBⁱ	48414

PTM databases

iPTMnetⁱ	O15062
PhosphoSitePlusⁱ	O15062

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168795 Expressed in 212 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_ZBTB5
ExpressionAtlasⁱ	O15062 baseline and differential
Genevisibleⁱ	O15062 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021521

HPAⁱ

HPA021521

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DCX	O43602	3	EBI-722671,EBI-8646694
SWAP70	Q9UH65	3	EBI-722671,EBI-310749
ZBTB7B	O15156	3	EBI-722671,EBI-740434

Protein-protein interaction databases

BioGridⁱ	115253, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-41566N
IntActⁱ	O15062, 16 interactors
Molecular INTeraction database More...MINTⁱ	O15062
STRINGⁱ	9606.ENSP00000307604

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15062
SMRⁱ	O15062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 93	BTBPROSITE-ProRule annotationAdd BLAST		70

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	613 – 635	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	641 – 664	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000234181
HOVERGENⁱ	HBG058500
InParanoidⁱ	O15062
KEGG Orthology (KO) More...KOⁱ	K10492
OMAⁱ	MMGSPRG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0570
PhylomeDBⁱ	O15062
TreeFamⁱ	TF330979

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

O15062-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR 
        60         70         80         90        100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL 
       110        120        130        140        150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG 
       160        170        180        190        200
LSIVSSALNS SQNGEEQPAP MSSSMRSNLD QRTPFPMRRL HKRKQSAEER 
       210        220        230        240        250
ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI VDNPKADGMT 
       260        270        280        290        300
DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD 
       310        320        330        340        350
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA 
       360        370        380        390        400
EGSESVEVEG VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN 
       410        420        430        440        450
LEHKSTFSIS NFLNKSRGNN FTANQNNDDN IPNTTSDCRL ESEAPYLLSP 
       460        470        480        490        500
EAGPAGGPSS APGSHVENPF SEPADSHFVR PMQEVMGLPC VQTSGYQGGE 
       510        520        530        540        550
QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP KMPVVTSVRS 
       560        570        580        590        600
SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS 
       610        620        630        640        650
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF 
       660        670 
SQSSHLYKHS KTTCLRWQSS NLPSTLL

Length:677

Mass (Da):74,278

Last modified:January 1, 1998 - v1

Checksum:ⁱ0F17A0AEE3FD827B

GO

Sequence cautionⁱ

The sequence BAA20811 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052915	300	D → G. Corresponds to variant dbSNP:rs17502738Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002352 mRNA Translation: BAA20811.2 Different initiation. BC010007 mRNA Translation: AAH10007.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6610.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055687.1, NM_014872.2 XP_005251691.1, XM_005251634.1
UniGeneⁱ	Hs.161276

Genome annotation databases

Ensemblⁱ	ENST00000307750; ENSP00000307604; ENSG00000168795
GeneIDⁱ	9925
KEGGⁱ	hsa:9925

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15062	Zinc finger and BTB domain containing 5		HUMAN		677	UniRef100_O15062

Protein	Similar proteins		Species	Score	Length	Source
O15062	Zinc finger and BTB domain-containing protein 5		MOUSE		670	UniRef90_O15062
Zinc finger and BTB domain containing 5		HUMAN		677
zinc finger and BTB domain-containing protein 5 isoform X1		MESAU		744
zinc finger and BTB domain-containing protein 5 isoform X1		TURTR		680
Uncharacterized protein		AOTNA		677
+91

Protein	Similar proteins		Species	Score	Length	Source
O15062	Zinc finger and BTB domain-containing protein 5		MOUSE		670	UniRef50_O15062
Zinc finger and BTB domain containing 5		HUMAN		677
zinc finger and BTB domain-containing protein 5 isoform X1		MESAU		744
zinc finger and BTB domain-containing protein 5 isoform X1		TURTR		680
Uncharacterized protein		CERAT		677
+178

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002352 mRNA Translation: BAA20811.2 Different initiation. BC010007 mRNA Translation: AAH10007.1
CCDSⁱ	CCDS6610.1
RefSeqⁱ	NP_055687.1, NM_014872.2 XP_005251691.1, XM_005251634.1
UniGeneⁱ	Hs.161276

3D structure databases

ProteinModelPortalⁱ	O15062
SMRⁱ	O15062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115253, 23 interactors
DIPⁱ	DIP-41566N
IntActⁱ	O15062, 16 interactors
MINTⁱ	O15062
STRINGⁱ	9606.ENSP00000307604

PTM databases

iPTMnetⁱ	O15062
PhosphoSitePlusⁱ	O15062

Polymorphism and mutation databases

BioMutaⁱ	ZBTB5

BioMutaⁱ

ZBTB5

Proteomic databases

EPDⁱ	O15062
PaxDbⁱ	O15062
PeptideAtlasⁱ	O15062
PRIDEⁱ	O15062
ProteomicsDBⁱ	48414

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9925
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000307750; ENSP00000307604; ENSG00000168795
GeneIDⁱ	9925
KEGGⁱ	hsa:9925

Organism-specific databases

CTDⁱ	9925
DisGeNETⁱ	9925
EuPathDBⁱ	HostDB:ENSG00000168795.4
GeneCardsⁱ	ZBTB5
HGNCⁱ	HGNC:23836 ZBTB5
HPAⁱ	HPA021521
MIMⁱ	616590 gene
neXtProtⁱ	NX_O15062
OpenTargetsⁱ	ENSG00000168795
PharmGKBⁱ	PA134969268
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000234181
HOVERGENⁱ	HBG058500
InParanoidⁱ	O15062
KOⁱ	K10492
OMAⁱ	MMGSPRG
OrthoDBⁱ	EOG091G0570
PhylomeDBⁱ	O15062
TreeFamⁱ	TF330979

Miscellaneous databases

ChiTaRSⁱ	ZBTB5 human
GenomeRNAiⁱ	9925
Protein Ontology More...PROⁱ	PR:O15062
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168795 Expressed in 212 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_ZBTB5
ExpressionAtlasⁱ	O15062 baseline and differential
Genevisibleⁱ	O15062 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBTB5_HUMAN
Accessionⁱ	O15062Primary (citable) accession number: O15062
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	January 1, 1998
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15062 (ZBTB5_HUMAN)

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Zinc finger and BTB domain-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ