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UniProtKB - O15062 (ZBTB5_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 5
Gene
ZBTB5
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 613 – 635 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 641 – 664 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O15062 |
SignaLinki | O15062 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 5 |
Gene namesi | Name:ZBTB5 Synonyms:KIAA0354 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23836, ZBTB5 |
MIMi | 616590, gene |
neXtProti | NX_O15062 |
VEuPathDBi | HostDB:ENSG00000168795 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9925 |
OpenTargetsi | ENSG00000168795 |
PharmGKBi | PA134969268 |
Miscellaneous databases
Pharosi | O15062, Tbio |
Genetic variation databases
BioMutai | ZBTB5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047713 | 1 – 677 | Zinc finger and BTB domain-containing protein 5Add BLAST | 677 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 234 | PhosphoserineCombined sources | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 322 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 330 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Cross-linki | 404 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 415 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 541 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 594 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 597 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 645 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 658 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15062 |
jPOSTi | O15062 |
MassIVEi | O15062 |
PaxDbi | O15062 |
PeptideAtlasi | O15062 |
PRIDEi | O15062 |
ProteomicsDBi | 48414 |
PTM databases
iPTMneti | O15062 |
PhosphoSitePlusi | O15062 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168795, Expressed in esophagus squamous epithelium and 224 other tissues |
ExpressionAtlasi | O15062, baseline and differential |
Genevisiblei | O15062, HS |
Organism-specific databases
HPAi | ENSG00000168795, Low tissue specificity |
Interactioni
Binary interactionsi
O15062
Protein-protein interaction databases
BioGRIDi | 115253, 40 interactors |
DIPi | DIP-41566N |
IntActi | O15062, 25 interactors |
MINTi | O15062 |
STRINGi | 9606.ENSP00000307604 |
Miscellaneous databases
RNActi | O15062, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 93 | BTBPROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 252 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 287 – 312 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 331 – 387 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 447 – 474 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 552 – 585 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 158 – 181 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 191 – 209 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 287 – 308 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 337 – 354 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 552 – 584 | Polar residuesSequence analysisAdd BLAST | 33 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 613 – 635 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 641 – 664 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160246 |
HOGENOMi | CLU_407055_0_0_1 |
InParanoidi | O15062 |
OMAi | QLMMNAA |
OrthoDBi | 339939at2759 |
PhylomeDBi | O15062 |
TreeFami | TF330979 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
O15062-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALNS SQNGEEQPAP MSSSMRSNLD QRTPFPMRRL HKRKQSAEER
210 220 230 240 250
ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI VDNPKADGMT
260 270 280 290 300
DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD
310 320 330 340 350
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA
360 370 380 390 400
EGSESVEVEG VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN
410 420 430 440 450
LEHKSTFSIS NFLNKSRGNN FTANQNNDDN IPNTTSDCRL ESEAPYLLSP
460 470 480 490 500
EAGPAGGPSS APGSHVENPF SEPADSHFVR PMQEVMGLPC VQTSGYQGGE
510 520 530 540 550
QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP KMPVVTSVRS
560 570 580 590 600
SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS
610 620 630 640 650
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF
660 670
SQSSHLYKHS KTTCLRWQSS NLPSTLL
Sequence cautioni
The sequence BAA20811 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052915 | 300 | D → G. Corresponds to variant dbSNP:rs17502738Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002352 mRNA Translation: BAA20811.2 Different initiation. BC010007 mRNA Translation: AAH10007.1 |
CCDSi | CCDS6610.1 |
RefSeqi | NP_055687.1, NM_014872.2 XP_005251691.1, XM_005251634.1 |
Genome annotation databases
Ensembli | ENST00000307750; ENSP00000307604; ENSG00000168795 |
GeneIDi | 9925 |
KEGGi | hsa:9925 |
MANE-Selecti | ENST00000307750.5; ENSP00000307604.4; NM_014872.3; NP_055687.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002352 mRNA Translation: BAA20811.2 Different initiation. BC010007 mRNA Translation: AAH10007.1 |
CCDSi | CCDS6610.1 |
RefSeqi | NP_055687.1, NM_014872.2 XP_005251691.1, XM_005251634.1 |
3D structure databases
SMRi | O15062 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115253, 40 interactors |
DIPi | DIP-41566N |
IntActi | O15062, 25 interactors |
MINTi | O15062 |
STRINGi | 9606.ENSP00000307604 |
PTM databases
iPTMneti | O15062 |
PhosphoSitePlusi | O15062 |
Genetic variation databases
BioMutai | ZBTB5 |
Proteomic databases
EPDi | O15062 |
jPOSTi | O15062 |
MassIVEi | O15062 |
PaxDbi | O15062 |
PeptideAtlasi | O15062 |
PRIDEi | O15062 |
ProteomicsDBi | 48414 |
Protocols and materials databases
Antibodypediai | 26273, 141 antibodies from 24 providers |
DNASUi | 9925 |
Genome annotation databases
Ensembli | ENST00000307750; ENSP00000307604; ENSG00000168795 |
GeneIDi | 9925 |
KEGGi | hsa:9925 |
MANE-Selecti | ENST00000307750.5; ENSP00000307604.4; NM_014872.3; NP_055687.1 |
Organism-specific databases
CTDi | 9925 |
DisGeNETi | 9925 |
GeneCardsi | ZBTB5 |
HGNCi | HGNC:23836, ZBTB5 |
HPAi | ENSG00000168795, Low tissue specificity |
MIMi | 616590, gene |
neXtProti | NX_O15062 |
OpenTargetsi | ENSG00000168795 |
PharmGKBi | PA134969268 |
VEuPathDBi | HostDB:ENSG00000168795 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160246 |
HOGENOMi | CLU_407055_0_0_1 |
InParanoidi | O15062 |
OMAi | QLMMNAA |
OrthoDBi | 339939at2759 |
PhylomeDBi | O15062 |
TreeFami | TF330979 |
Enzyme and pathway databases
PathwayCommonsi | O15062 |
SignaLinki | O15062 |
Miscellaneous databases
BioGRID-ORCSi | 9925, 7 hits in 1087 CRISPR screens |
ChiTaRSi | ZBTB5, human |
GenomeRNAii | 9925 |
Pharosi | O15062, Tbio |
PROi | PR:O15062 |
RNActi | O15062, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168795, Expressed in esophagus squamous epithelium and 224 other tissues |
ExpressionAtlasi | O15062, baseline and differential |
Genevisiblei | O15062, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBTB5_HUMAN | |
Accessioni | O15062Primary (citable) accession number: O15062 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot