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Protein

Synaptojanin-2

Gene

SYNJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2 (EC:3.1.3.36By similarity)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Gene namesi
Name:SYNJ2
Synonyms:KIAA0348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000078269.13
HGNCiHGNC:11504 SYNJ2
MIMi609410 gene
neXtProtiNX_O15056

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8871
OpenTargetsiENSG00000078269
PharmGKBiPA36286

Polymorphism and mutation databases

BioMutaiSYNJ2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097331 – 1496Synaptojanin-2Add BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1124PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15056
MaxQBiO15056
PaxDbiO15056
PeptideAtlasiO15056
PRIDEiO15056
ProteomicsDBi48407
48408 [O15056-2]
48409 [O15056-3]

PTM databases

DEPODiO15056
iPTMnetiO15056
PhosphoSitePlusiO15056

Expressioni

Gene expression databases

BgeeiENSG00000078269 Expressed in 236 organ(s), highest expression level in inferior vagus X ganglion
CleanExiHS_SYNJ2
ExpressionAtlasiO15056 baseline and differential
GenevisibleiO15056 HS

Organism-specific databases

HPAiHPA031575

Interactioni

Subunit structurei

Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114391, 10 interactors
IntActiO15056, 10 interactors
MINTiO15056
STRINGi9606.ENSP00000347792

Structurei

Secondary structure

11496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15056
SMRiO15056
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15056

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 444SACPROSITE-ProRule annotationAdd BLAST325
Domaini889 – 968RRMPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni450 – ?CatalyticBy similarity

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1099 – 1114Pro-richAdd BLAST16
Compositional biasi1209 – 1334Pro-richAdd BLAST126

Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG0566 Eukaryota
COG5329 LUCA
COG5411 LUCA
GeneTreeiENSGT00760000119075
HOVERGENiHBG079225
InParanoidiO15056
KOiK20279
OMAiGSEAYDT
OrthoDBiEOG091G011G
PhylomeDBiO15056
TreeFamiTF354311

Family and domain databases

CDDicd12720 RRM_SYNJ2, 1 hit
Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047 DUF1866
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR002013 SAC_dom
IPR034974 SYNJ2
IPR034973 SYNJ2_RRM
PANTHERiPTHR11200:SF148 PTHR11200:SF148, 1 hit
PfamiView protein in Pfam
PF08952 DUF1866, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF02383 Syja_N, 1 hit
SMARTiView protein in SMART
SM01165 DUF1866, 1 hit
SM00128 IPPc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50275 SAC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2B2 (identifier: O15056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI
60 70 80 90 100
KGQYGKLTDA YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT
110 120 130 140 150
ATDFYPLQEE AKEEERLIAL KKILSSGVFY FSWPNDGSRF DLTVRTQKQG
160 170 180 190 200
DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW LLKIICGVVT IRTVYASHKQ
210 220 230 240 250
AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY MDDGVSSFVQ
260 270 280 290 300
IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV
310 320 330 340 350
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE
360 370 380 390 400
TLLRPQLKLH WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI
410 420 430 440 450
ALEVLHLQLK TLGLSSKPIV DRFVESFKAM WSLNGHSLSK VFTGSRALEG
460 470 480 490 500
KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA IKLLLVGDVY GEEVADKGGM
510 520 530 540 550
LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN GGKQFRSNVL
560 570 580 590 600
RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS
610 620 630 640 650
TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA
660 670 680 690 700
IDTVKTGMGG KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY
710 720 730 740 750
KEITQKLCFP MGRNVFSHDY VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL
760 770 780 790 800
LEFDQLQLQK SSGKIFKDFH EGAINFGPTY KYDVGSAAYD TSDKCRTPAW
810 820 830 840 850
TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG ALQYYGRAEL
860 870 880 890 900
QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT
910 920 930 940 950
LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD
960 970 980 990 1000
VDGMKVKGRA VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN
1010 1020 1030 1040 1050
FDFTSLDYES EGDILEDDED YLVDEFNQPG VSDSELGGDD LSDVPGPTAL
1060 1070 1080 1090 1100
APPSKSPALT KKKQHPTYKD DADLVELKRE LEAVGEFRHR SPSRSLSVPN
1110 1120 1130 1140 1150
RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ TARLLPGAPQ
1160 1170 1180 1190 1200
QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP
1210 1220 1230 1240 1250
RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL
1260 1270 1280 1290 1300
SPEEQFEQQT VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER
1310 1320 1330 1340 1350
PSHRKPASDE APPGAGASVP PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ
1360 1370 1380 1390 1400
SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ GDFLSTSSAT SPDSDGTKAM
1410 1420 1430 1440 1450
KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG TRSPKRDPID
1460 1470 1480 1490
PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT
Length:1,496
Mass (Da):165,538
Last modified:March 1, 2005 - v3
Checksum:i7CC9E368585ACF21
GO
Isoform 2B1 (identifier: O15056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1114: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,434
Checksum:i42E19A35A791EA6A
GO
Isoform 2A (identifier: O15056-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
     1289-1496: Missing.

Show »
Length:1,288
Mass (Da):143,445
Checksum:i9A4EAA3AA9AE2451
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEV8H0YEV8_HUMAN
Synaptojanin-2
SYNJ2
165Annotation score:
E7ER60E7ER60_HUMAN
Synaptojanin-2
SYNJ2
839Annotation score:
A0A1W2PR85A0A1W2PR85_HUMAN
Synaptojanin-2
SYNJ2
1,259Annotation score:
Q5TA15Q5TA15_HUMAN
Synaptojanin-2
SYNJ2
136Annotation score:
H7BY56H7BY56_HUMAN
Synaptojanin-2
SYNJ2
136Annotation score:

Sequence cautioni

The sequence AAH43277 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0245071468E → G1 PublicationCorresponds to variant dbSNP:rs2502601Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129111070 – 1114Missing in isoform 2B1. CuratedAdd BLAST45
Alternative sequenceiVSP_0129121249 – 1288PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0129131289 – 1496Missing in isoform 2A. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA Translation: AAN73051.1
AF318616 mRNA Translation: AAG46036.1
AL139330 Genomic DNA No translation available.
AF039945 mRNA Translation: AAD02178.1
AB002346 mRNA Translation: BAA20805.2
BC043277 mRNA Translation: AAH43277.1 Different initiation.
CCDSiCCDS5254.1 [O15056-1]
RefSeqiNP_001171559.1, NM_001178088.1
NP_003889.1, NM_003898.3 [O15056-1]
XP_006715655.1, XM_006715592.3 [O15056-3]
XP_011534527.1, XM_011536225.1
UniGeneiHs.434494

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269 [O15056-1]
ENST00000640338; ENSP00000492532; ENSG00000078269 [O15056-3]
GeneIDi8871
KEGGihsa:8871
UCSCiuc003qqx.3 human [O15056-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA Translation: AAN73051.1
AF318616 mRNA Translation: AAG46036.1
AL139330 Genomic DNA No translation available.
AF039945 mRNA Translation: AAD02178.1
AB002346 mRNA Translation: BAA20805.2
BC043277 mRNA Translation: AAH43277.1 Different initiation.
CCDSiCCDS5254.1 [O15056-1]
RefSeqiNP_001171559.1, NM_001178088.1
NP_003889.1, NM_003898.3 [O15056-1]
XP_006715655.1, XM_006715592.3 [O15056-3]
XP_011534527.1, XM_011536225.1
UniGeneiHs.434494

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
ProteinModelPortaliO15056
SMRiO15056
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114391, 10 interactors
IntActiO15056, 10 interactors
MINTiO15056
STRINGi9606.ENSP00000347792

PTM databases

DEPODiO15056
iPTMnetiO15056
PhosphoSitePlusiO15056

Polymorphism and mutation databases

BioMutaiSYNJ2

Proteomic databases

EPDiO15056
MaxQBiO15056
PaxDbiO15056
PeptideAtlasiO15056
PRIDEiO15056
ProteomicsDBi48407
48408 [O15056-2]
48409 [O15056-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269 [O15056-1]
ENST00000640338; ENSP00000492532; ENSG00000078269 [O15056-3]
GeneIDi8871
KEGGihsa:8871
UCSCiuc003qqx.3 human [O15056-1]

Organism-specific databases

CTDi8871
DisGeNETi8871
EuPathDBiHostDB:ENSG00000078269.13
GeneCardsiSYNJ2
HGNCiHGNC:11504 SYNJ2
HPAiHPA031575
MIMi609410 gene
neXtProtiNX_O15056
OpenTargetsiENSG00000078269
PharmGKBiPA36286
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0566 Eukaryota
COG5329 LUCA
COG5411 LUCA
GeneTreeiENSGT00760000119075
HOVERGENiHBG079225
InParanoidiO15056
KOiK20279
OMAiGSEAYDT
OrthoDBiEOG091G011G
PhylomeDBiO15056
TreeFamiTF354311

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiSYNJ2 human
EvolutionaryTraceiO15056
GenomeRNAii8871
PROiPR:O15056
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078269 Expressed in 236 organ(s), highest expression level in inferior vagus X ganglion
CleanExiHS_SYNJ2
ExpressionAtlasiO15056 baseline and differential
GenevisibleiO15056 HS

Family and domain databases

CDDicd12720 RRM_SYNJ2, 1 hit
Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047 DUF1866
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR002013 SAC_dom
IPR034974 SYNJ2
IPR034973 SYNJ2_RRM
PANTHERiPTHR11200:SF148 PTHR11200:SF148, 1 hit
PfamiView protein in Pfam
PF08952 DUF1866, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF02383 Syja_N, 1 hit
SMARTiView protein in SMART
SM01165 DUF1866, 1 hit
SM00128 IPPc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50275 SAC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYNJ2_HUMAN
AccessioniPrimary (citable) accession number: O15056
Secondary accession number(s): Q5TA13
, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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